Tackling the primary healthcare workforce crisis: time to talk about health systems and governance—a comparative assessment of nine countries in the WHO European region by Ellen Kuhlmann, Michelle Falkenbach, Monica Georgina Brînzac, Tiago Correia, Maria Panagioti, Bernd Rechel, Anna Sagan, Milena Santric-Milicevic, Marius-Ionuț Ungureanu, Iris Wallenburg, Viola Burau

“…However, across all categories, Denmark, the Netherlands, and to a lesser extent Kazakhstan, depict closer alignment to this model than the other countries. Workforce composition and skill-mix vary strongly, while disparities persist in education and data availability, particularly within Social Health Insurance systems. …”
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Pre‐clinical enteropathy in healthy soft‐coated wheaten terriers by M. Katherine Tolbert, Jewels Darrow, Louise Grubb, Stuart Fitzgerald, Rebecca Bergee, Josh Price, Marcos Mariano, Michael Hong, Chi‐Hsuan Sung, Tracy Hill, Joerg M. Steiner, Jan S. Suchodolski

“…A repeated‐measures mixed model ANOVA was performed for blood lactulose:galactose area under the curve (AUC). …”
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Modulating ultrasound-assisted extraction of polysaccharide-protein complexes from β-glucan-rich medicinal mushrooms for enhanced antioxidant activity by Emily Wan Ting Tam, Yi Ching Cheung, Wesley Chin Ho Lung, Ching Ching Hui, William W.Y. Lam, Stella Siu Mui Ng, Franklin Wang Ngai Chow

“…The growing nutraceutical interest in polysaccharide-protein complexes (PSPs) from β-glucan-rich medicinal mushrooms necessitates efficient extraction methods. This study examined the impact of various ultrasound-assisted extraction (UAE) parameters, including ultrasound power, temperature, mushroom particle size, and solid-to-liquid ratio, on the composition and antioxidant activities of PSPs extracts from Lentinula edodes (L. edodes) and Grifola frondosa (G. frondosa). …”
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Reduced synaptic tagging by complement protein C3 is associated with elevated extracellular matrix in the middle-aged cerebellum of mice by Henning Peter Düsedau, Carla Cangalaya, Stoyan Stoyanov, Alexander Dityatev, Alexander Dityatev, Alexander Dityatev, Ildiko Rita Dunay, Ildiko Rita Dunay, Ildiko Rita Dunay, Ildiko Rita Dunay, Ildiko Rita Dunay

“…While the aging process affects all brain compartments at different velocities and one of the particularly affected regions is the cerebellum (CB), the underlying effects remain elusive.MethodsIn the present study, we harnessed a murine model of natural aging in males combined with orthogonal experimental approaches comprising of cytokine gene expression analysis, flow cytometry, immunohistochemistry, and flow synaptometry.ResultsWe report age-dependent morphological and phenotypic changes in microglia that are distinct in the cortex (CTX) and CB. …”
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Inoculation of the fungi-static C. iranensis ZJW-6 accelerates compost maturation, enhances fertilizer efficiency, and increases the abundance of target microbes in spring and autu... by Dongchao Wang, Jingqi He, Liangdong Li, Gaoyuan Wu, Zixian Jiang, Baifeng Cang, Meikang Wu, Min Nuo, Zichen Liu, Jiaxuan Li, Shengbo Xu, Xintong Ma, Zhihai Wu, Meiying Yang

“…This study initially investigated the effects of adding fungi-static C. iranensis (ZJW-6) on lignocellulose, humic acid, and bacterial communities during the spring and autumn composting of rice straw in Northeast China.MethodsZJW-6 is a cellulose degrading bacterium, which is used as the microorganism for composting inoculation. …”
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Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort Study by Noraidatulakma Abdullah, Ying‐Xian Goh, Aisyatul Najihah Khuzaimi, Azwa Shawani Kamalul Arifin, Nurul Ain Mhd Yusuf, Nazihah Abd Jalal, Norliza Ismail, Nurul Faeizah Husin, Mohd Arman Kamaruddin, Rahman Jamal

“…The Cox proportional hazards model evaluated the effect of Cre/BW ratio on developing incident diabetes. …”
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RGB and RGNIR image dataset for machine learning in plastic waste detectionZENODO by Owen Tamin, Ervin Gubin Moung, Jamal Ahmad Dargham, Samsul Ariffin Abdul Karim, Ashraf Osman Ibrahim, Nada Adam, Hadia Abdelgader Osman

“…Moreover, incorporating near-infrared (NIR) spectral data into machine learning models can reveal crucial information about plastic waste composition and structure that remains invisible in standard RGB images. …”
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Gut microbiota links to cognitive impairment in bipolar disorder via modulating synaptic plasticity by Anying Tang, Hangyuan Jiang, Jie Li, Yi Chen, Jinyu Zhang, Dandan Wang, Shaohua Hu, Jianbo Lai

“…Conclusions This study first characterized the gut microbiota in BD-CI patients and highlighted the potential role of gut microbiota in BD-related cognitive deficits by modulating neuronal plasticity in mice model.…”
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Chemical Characteristics of Stack Particulate Matter Emitted from Sintering Process of an Integrated Steel Mill and Resolution of Source Contributors on Boundary PM2.5 by Cheng-Tsung Shao, Yu-Lun Tseng, Chung-Shin Yuan, Wen-Hsi Cheng, Nian-Jie Li, Jia-Yi Zhao

“…The chemical mass balance (CMB) receptor model was then employed to identify emission sources and quantify their contributions. …”
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Changes of Microbiome in Human Papillomavirus Infection and Cervical Cancer: A Systematic Review and Meta‐Analysis by Wei Zhang, Yan Ge, Lihe Yao, Qingchun Yan, Jiuju Wei, Yanfei Yin, Bin Liu

“…Methods The PubMed, Embase, Web of Science, and Cochrane Library databases were systematically searched to include original studies. …”
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Mixture Containing 5% Polysaccharide Extract of <i>Cerioporus squamosus</i> (Huds.) Quélet, 5% Dexpanthenol, and 0.2% Hyaluronic Acid Shows In Vitro and In Vivo Wound Healing Prope... by Jovana D. Petrović, Tamara A. Carević Milićević, Jasmina M. Glamočlija, Jelena B. Kulaš, Ivana I. Mirkov

“…In vitro cytotoxicity tests ensured formulation safety, whereas in vivo wound healing was further investigated using an animal model. Gene expression analysis was performed to assess the molecular mechanisms involved. …”
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Whole genome comparisons reveal gut-to-lung translocation of Escherichia coli and Burkholderia cenocepacia in two cases of ventilator-associated pneumonia in ICU patients by Huihui Gao, Lei Xu, Yixin Liu, Xiaolong Wang, Siyuan Zhu, Huai Lin, Yuting Gao, Daqing Mao, Xing Lu, Yi Luo

“…However, the scarcity of reported cases with confirmed sources limits the ability to evaluate and manage VAP, which remains a major challenge for healthcare systems globally. Methods Pathogens were isolated from endotracheal aspirate (ETA) samples of VAP patients using conventional culture techniques. …”
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Single-cell RNA-sequencing uncovers the dynamic changes of tumour immune microenvironment in advanced lung adenocarcinoma by Lei Cheng, Tianqing Chu, Haijiao Lu, Jialin Qian, Yinchen Shen, Chaoxian Zhao

“…Background The heterogeneity of lung adenocarcinoma (LUAD) plays a vital role in determining the development of cancer and therapeutic sensitivity and significantly hinders the clinical treatment of LUAD.Objective To elucidate the cellular composition and reveal previously uncharacterised tumour microenvironment in LUAD using single-cell RNA-sequencing (scRNA-seq).Methods Two scRNA-seq datasets with 106 829 high-quality cells from 34 patients including 11 normal, 9 early (stage I and II) and 14 advanced (stage III and IV) LUAD were integrated and clustered to explore diagnostic and therapeutic cell populations and their biomarkers for diverse stages of LUAD. …”
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General principles of expanding the speed range of operation of autonomous power supply systems for passenger cars by S. L. Samoshkin, S. S. Mironov, O. S. Samoshkin, M. V. Khodenkov, A. S. Sarikov

“…It is solved by forcing the excitation of the generators.Analysis of modern systems of autonomous power supply of passenger cars showed that the expansion of the speed range of its operation can be achieved in three ways:•             raising the gear ratio of the gearbox to ensure it is switched on to the nominal mode at a carriage speed of 15 - 20 km/h without changing the parameters of the generator and the entire system of autonomous power supply;•             modernization of the electrical equipment complex for passenger cars to ensure the operation of the main power consumers and charge the battery while driving at low speeds (over 18 km/h) without changing the mechanical parameters and composition of the serial generator-drive unit;•             modernization of the generator in order to reduce its turnon revolutions to the power required to provide the main power consumers without changing the mechanical parameters of the drive.All three methods have its advantages and disadvantages, the choice of any of them is determined by the technical requirements for a specific car model.…”
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Anti-Obesity Properties of a <i>Latilactobacillus sakei</i> Strain in <i>C. elegans</i> and Diet-Induced Obese Rats by Ignacio Goyache, Paula Aranaz, Raquel Virto, Lorena Valdés, Miguel López-Yoldi, Ana Romo-Hualde, Fermin I. Milagro

“…Objective: we aim to characterize the effects of a novel probiotic strain of <i>Latilactobacillus sakei</i> (<i>L. sakei</i>) in two different animal models with adiposity excess. Methods: <i>Caenorhabditis elegans</i> was used as a starting in vivo model to analyse how the probiotics affect fat accumulation, oxidative stress, senescence, and lifespan when exposed to high-glucose conditions. …”
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Assessment of polyvinylpyrrolidone vinyl acetate effect on quercetin properties in binary solid dispersion prepared by hot melt extrussion by A. A. Danilova, K. A. Gusev, N. O. Arkhipova, L. G. Danilov, E. V. Vishnyakov, D. N. Maimistov, E. V. Flisyuk

“…In order to study the mentioned problem, we decided to use quercetin as model compound with extremely low water solubility and dissolution in gastrointestinal (GI) tract media. …”
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Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment by Ming Gao, Ming Gao, Jie Li, Jie Li, Xu Han, Beiyao Zhang, Jinting Chen, Jiadong Lang, Qiangqiang Zhang

“…MEL has been shown to modulate gut microbiota composition in diabetic model. However, the underlying mechanism through which the gut microbiome contributes to DCI remains unclear. …”
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High-Risk Consult Multidisciplinary Team in a Tertiary Maternity Unit: Changing Prevalence of Cases by Ng YHG, Wright A, Ng YYV, Kavalloor NV, Tan LK, Quek BH, Tan KH

“…The High-Risk Consult (HRC) brings together a multidisciplinary team of specialists, including maternal–fetal medicine specialists, neonatologists, anaesthesiologists, and relevant subspecialities to provide comprehensive, individualized care for these complex pregnancies. While this model of care delivery is increasingly adopted worldwide, data on the prevalence and patterns within such multidisciplinary services remains limited.Objective: To describe the types of high-risk antenatal cases managed by an HRC and compare the prevalence of these conditions across two distinct time periods.Methods: This retrospective observational study analyzed all cases discussed at the HRC of a single tertiary center, KK Women’s and Children’s Hospital (KKH), in Singapore. …”
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Innovative Resource-Saving Equipment for Safflower Processing to Improve Oil Quality by Maigul Mursalykova, Gulnara Kokayeva, Mukhtarbek Kakimov, Bożena Gajdzik, Radosław Wolniak, Damian Dzienniak, Michał Bembenek

“…A comparative analysis of the physicochemical and fatty acid profiles of safflower oil produced using traditional and combined grinding-pressing methods confirmed the superiority of the new approach. …”
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Biostimulant-Based Molecular Priming Improves Crop Quality and Enhances Yield of Raspberry and Strawberry Fruits by Petar Kazakov, Saleh Alseekh, Valentina Ivanova, Tsanko Gechev

“…Background/Objectives: The biostimulant SuperFifty, produced from the brown algae <i>Ascophyllum nodosum</i>, can improve crop quality and yield and mitigate stress tolerance in model and crop plants such as <i>Arabidopsis thaliana</i>, pepper, and tomato. …”
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