Intermittent supplementation with Akkermansia muciniphila and galactooligosaccharides modulates Alzheimer’s disease progression, gut microbiota, and colon short-chain fatty acid pr... by Arnas Kunevičius, Akshay Kumar Vijaya, Alessandro Atzeni, Jonas Mingaila, Ieva Šimoliūnė, Rapolas Jamontas, Emilija Keževičiūtė, Miguel Gueimonde, Rolandas Meškys, Daiva Baltriukienė, Silvia Arboleya, Aurelijus Burokas

“…Modulation of the gut microbiota by new-generation probiotics represents a novel treatment strategy to alleviate the symptoms and slow the progression of AD.MethodsIn this study, the therapeutic effect of the probiotic Akkermansia muciniphila and the prebiotic galactooligosaccharides (GOS) was investigated in the APP/PS1 mouse model. …”
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Metagenomic exploration and computational prediction of novel enzymes for polyethylene terephthalate degradation by Donya Afshar Jahanshahi, Mohammad Reza Rezaei Barzani, Mohammad Bahram, Shohreh Ariaeenejad, Kaveh Kavousi

“…We extended our approach by training machine learning models to discover candidate PET-degrading enzymes. …”
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Morphometric differences between basal cell carcinomas & melanomas of the head & neck versus other sites and their influence on neural networks by Jonas Hue, Jinendra Ekanayake, Jamshid Dehmeshki, Jagtar Dhanda

“…Morphometric features significantly influenced neural network accuracies in classifying BCCs, with a mix of H&N and other site training data resulting in the best models(P<0.05). Conclusion: Morphometric features and the anatomic composition of BCC training data may influence the accuracy of AI models. …”
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Design and bouncing performance study of spring slider type bouncing robots by LUO Jiman, SONG Yide, SONG Yucheng, WU Hao, LIU Fengyuan

“…Thirdly, a mechanism dynamics model was established based on the Lagrangian dynamics method, and the influence of the rotation angle and angular acceleration on the torque of each member was obtained. …”
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Analysis of Fly Fishing Rod Casting Dynamics by Gang Wang, Norman Wereley

“…An analysis of fly fishing rod casting dynamics was developed comprising of a nonlinear finite element representation of the composite fly rod and a lumped parameter model for the fly line. …”
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Effects of Steviol Glycosides on Mitochondrial Energy Metabolism and Oxidative Stress in Liver of Rats with Excessive Exercise Fatigue by Zejin GAO, Heng KANG, Qiao SONG

“…Objective: Using Stevia rebaudiana leaves as experimental materials, stevia glycoside (SG) was extracted and isolated, and its effects on mitochondrial energy metabolism and oxidative stress in the liver of rats with excessive exercise fatigue were investigated. Methods: High-performance liquid chromatography was used to analyze the monomer composition of SG. …”
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Omega-3 Polyunsaturated Fatty Acids Effect on Neuropathy of the Peripheral Nervous System in Dietary Obese Rats: Is the Source of These Fatty Acids Important for Outcome? by Davidson E, Obrosov O, Coppey L, Yorek M

“…However, other sources exist that could be a better environmental, safety, and/or economic choice.Methods: Male Sprague Dawley rats 12 weeks of age were fed a 45% kcal diet to induce obesity and model pre-diabetes. …”
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The association between plant-based diet indices and the risk of breast cancer: a case-control study by Fateme Souni, Fatemeh Mansouri, Fatemeh Jafari, Reza Sharifi, Sepideh PourvatanDoust, Zainab Shateri, Mehran Nouri, Bahram Rashidkhani

“…In addition, postmenopausal women in the second and last tertiles of hPDI had lower odds of BrC than those in the first tertile (T) (T2: OR = 0.342; 95% CI: 0.141–0.828; P = 0.017– T3: OR = 0.262; 95% CI: 0.107–0.639; P = 0.003) in the adjusted model. Furthermore, in premenopausal women in the highest tertile of uPDI, the odds of BrC were increased compared to the lowest tertile (OR = 2.546; 95% CI: 1.051–6.167; P = 0.038) in the adjusted model. …”
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A novel theoretical approach to predict the interannual variability of sulfur in Mercury’s exosphere and subsurface by S. Verkercke, J. Y. Chaufray, F. Leblanc, A. Georgiou, M. S. Phillips, G. Munaretto, J. Lewis, A. Ricketts, L. Morrissey

“…In this study, we use a unique theoretical approach that combines modeling methods across different dimensional scales to understand the presence of sulfur on Mercury. …”
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Single-cell sequencing unveils the transcriptomic landscape of castration-resistant prostate cancer-associated fibroblasts and their association with prognosis and immunotherapy re... by Yifeng Qiu, Yuhan Wang, Jiahe Liu, Kai Sun, Baohua Liu, Qi Hou

“…In addition, we examined the impact of CRPC-CAFs on the efficacy of immunotherapy and the composition of the tumor immune milieu. Furthermore, a subcutaneous PCa model was applied to determine the potential of TGF-β signaling blockade to augment the response to immunotherapeutic interventions. …”
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Lithofacies controls on gas accumulation in tight sandstone reservoirs: insights from the Permian Shihezi formation, south-western Ordos Basin, China by Xiaoming Wu, Xiaoming Wu, Zhongbin Chen, Zhicheng Shen, Yanxin Bao, Zheng Lan, Puxin Liu, Luxing Dou, Zhigang Wen

“…The sweet spot model has been validated through exploration practices and has guided the discovery of industrial gas flow wells.…”
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Effect of dietary approaches to stop hypertension and curcumin co-administration on glycemic parameters in polycystic ovary syndrome: An RCT by Tayebeh Zohrabi, Azadeh Nadjarzadeh, Sara Jambarsang, Mohammad Hasan Sheikhha, Abbas Aflatoonian, Hassan Mozaffari-Khosravi

“…Homeostasis model assessment of IR decreased significantly in the supplement intervention even after controlling for confounding factors in adjusted models. …”
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Fecal microbiota transplantation from Helicobacter pylori carriers following bismuth quadruple therapy exacerbates alcohol-related liver disease in mice via LPS-induced activation... by Huihui Gao, Hangming Bai, Yanyan Su, Yuting Gao, Hui Fang, Donghang Li, Youren Yu, Xing Lu, Dasheng Xia, Daqing Mao, Yi Luo

“…This study aims to characterize BQT-induced gut microbiota alterations in asymptomatic H. pylori carriers and evaluate their effect on an ALD mouse model. Methods Metagenomic sequencing was conducted to assess the gut microbiota composition of individuals before and after BQT. …”
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Specific Physical Performances of Young Male Basketball Players in Palestine: An Assessment by Maturity Status by Layla Jawabreh, Mohamed Tounsi, Ghazi Racil, Johnny Padulo, Gian Mario Migliaccio, Luca Russo, Yassine Trabelsi

“…Statistical analyses, including a full model and multiple regression analysis, were conducted to identify the anthropometric parameters that significantly influenced the performance variables. …”
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Visible and Near-Infrared Reflectance Spectroscopy for Investigating Soil Mineralogy: A Review by Qian Fang, Hanlie Hong, Lulu Zhao, Stephanie Kukolich, Ke Yin, Chaowen Wang

“…We further critically review applications of chemometric methods and related model building in spectroscopic soil mineral studies. …”
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Air-side Thermal-hydraulic Analysis and Parametric Optimization for Vertical-fin Microchannel Heat Exchanger by Zhao Rijing, Wei Xinghua, Huang Dong, Li Feng, Zhao Yongfeng

“…Finally, parametric optimization was conducted using the Taguchi method. The results show that under constant pumping power, the heat transfer enhancement of the composite fin with the front louver fin and the reversely connected rear wavy fin is the best. …”
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Identification of sepsis biomarkers through glutamine metabolism-mediated immune regulation: a comprehensive analysis employing mendelian randomization, multi-omics integration, an... by Zhuang’e Shi, Fuping Wang, Lishun Yang, Lishun Yang, Couwen Li, Bing Gong, Ruanxian Dai, Guobing Chen

“…This study aimed to identify biomarkers of sepsis through an integrated multi-method approach.MethodsMendelian randomization (MR) analysis was performed using data on 1400 plasma metabolites, 731 immune cell phenotypes, and sepsis genome-wide association studies. …”
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Lactational performance effects of 3-nitrooxypropanol supplementation to dairy cows: A meta-regression by L.F. Martins, M. Maigaard, M. Johansen, P. Lund, X. Ma, M. Niu, A.N. Hristov

“…Dose (± SD; 77.0 ± 33.17 mg 3-NOP/kg DMI), forage-to-concentrate ratio (FC; 58.9 ± 8.83%, expressed as average ± SD% of forage in the diet), dietary concentrations of CP, ether extract, NDF, and starch (16.3 ± 1.84%, 4.3 ± 1.03%, 33.7 ± 4.40%, and 20.9 ± 3.97%, as average ± SD% of DM, respectively), supplementation length (days), and DIM and BW of the cows at the beginning of the study were used as continuous explanatory variables. Mixed-effects models were fitted using the robust variance estimation method. …”
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Magnetically sensitive nanocomposites and magnetic liquids based on magnetite, gemcitabine, and antibody HER2 by A. L. Petranovska, M. V. Abramov, N. M. Оpanashchuk, S. P. Turanska, P. P. Gorbyk, N. V. Kusyak, A. P. Kusyak, N. Yu. Lukyanova, V. F. Chekhun

“…The average value of the thickness of the adsorbed layer of GC in the composition of Fe3O4@GC NC is 2.4±0.1 nm, as evaluated by the method of magnetic granulometry. …”
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The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and... by Dengxiong Hua, Qin Yang, Xiaowei Li, Xuexue Zhou, Yingqian Kang, Yan Zhao, Daoyan Wu, Zhengrong Zhang, Boyan Li, Xinxin Wang, Xiaolan Qi, Zhenghong Chen, Guzhen Cui, Wei Hong

“…In the colitis-associated CRC mice model, a combination of CB and AKK significantly alleviates weight loss and markedly reduces inflammatory infiltration of macrophages and cytotoxic T lymphocytes (CTLs) in the colon, thereby regulating anti-tumor immunity and inhibiting the occurrence of inflammation-induced CRC. …”
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