2bRAD-M reveals circulating microbiome in chronic antibody-mediated rejection (CAMR) and IgA nephropathy (IgAN) after kidney transplantation by Yan-Xin Tao, Er-Di Zhang, Jia-Xi Yue, Zheng-Li Wan, Ji-Wen Fan, Yi Li, Yu Fan, Lin Yan

“…Abstract Background Kidney transplantation is currently the most effective method for treating end-stage renal disease. However, postoperative-related rejection and IgA nephropathy remains a serious obstacle to the long-term survival of kidney transplant patients. …”
Get full text

Effect of forging sequence and heat treatment on microstructure of high-duty power-plant shaft made of Cr-Mo ultra-high strength steel by Skubisz P., Lisiecki Ł.

“…Mechanical and thermal processing cycles designed using the finite element method were fully verified physical modeling using a 16 ton forging block, including two alternative quenching strategies: oil vs. water spray and air. …”
Get full text

基于Kriging响应面法的盾构机行星架多目标优化 by 王红霞, 王盛, 刘强

“…In order to meet the requirements of lightweight design,the smallest of volume and minimum of rotary inertia multi-objective optimization model is established by considering its dynamic and static characteristics requirements.The design variables are taken correlation analysis under circumstance without non-sensitive factors to improve design efficiency.Using enhanced central composite design to get the proper design point,and the design point is simulated and analyzed by using the finite element method,then,a high-precise Kriging response surface model is established according to the simulation results.Sample points distributed evenly are taken out by using Shifted Hammersley sampling technology.After balancing pros and cons of the points,two Pareto optimal solutions are obtained under certain constraints.The volume and rotary inertia are decreased by 10% or more after optimization and the design target of planet carrier in volume and rotary inertia is achieved.…”
Get full text

Analysis of Settlement of Group Pile Foundation in Linear Viscoelastic Soil by Long Li, Yousheng Deng

“…The error between the field test results and computed data is 14.9%, the settlement calculated by the present method shows good agreement with the reported results, and the correlativity coefficients R2 are greater than 0.9223, which signifies that the present method is suitable for the theoretical calculation and prediction of the composite foundation settlement of linear viscoelastic soil when piles are used to strengthen the foundation. …”
Get full text

Optimal mixture design for organic Rankine cycle using machine learning algorithm by Valerio Mariani, Saverio Ottaviano, Davide Scampamorte, Andrea De Pascale, Giulio Cazzoli, Lisa Branchini, Gian Marco Bianchi

“…The proposed tool comprises a blend model for the thermophysical properties of the formulated mixtures, an ORC model to predict the performance of the mixtures in a specific application, and an optimizer based on the Bayesian inference method to identify the optimal mixtures compositions to be assessed. …”
Get full text

Reinforcement and MAO-A inhibition in heated tobacco products: flavor and brand variations by Xiangyu Li, Xiangyu Li, Zheng Ding, Zheng Ding, Xingyi Jiang, Xingyi Jiang, Hongjuan Wang, Hongjuan Wang, Yanbo Luo, Yanbo Luo, Huan Chen, Huan Chen, Yongqiang Pang, Yongqiang Pang, Hongwei Hou, Hongwei Hou, Qingyuan Hu, Qingyuan Hu

“…It also examines brand-specific differences in MAO-A inhibition to provide a deeper understanding of the role of non-nicotine constituents in HTP use.MethodsA rat self-administration model was used to evaluate the reinforcement patterns of HTP-T (tobacco flavor), HTP-M (menthol flavor), and nicotine under fixed-ratio schedules. …”
Get full text

Chemical Profiling and Assessment of Analgesic and Anti-Inflammatory Activity of <i>Ammoides verticillata</i> Essential Oil: In Vitro, In Vivo, and In Silico Studies by Imene Derardja, Redouane Rebai, Fethi Benbelaïd, Luc Jasmin, Abdennacer Boudah, Mohammed Esseddik Toumi, Salsabil Mebarki, Fethi Farouk Kebaili, Leila Bellebcir, Alain Muselli

“…<b>Methods</b>: The chemical composition of AVEO was determined using GC-MS analysis, and antioxidant capacity was assessed through in vitro assays. …”
Get full text

Differential effects of electroacupuncture and manual acupuncture on spontaneously hypertensive rats: insights from intestinal microbiota and metabolomics by Ji-Peng Liu, Long-Teng Tu, Ke-Zhen Yang, Yin-Yin Li, Yu Gong, Bing-Xuan Han, Chuan Liu, Tian-Qi Xia, Yu Liu, Xiao-Min Hao, Bing-Nan Yue, Jing Zhang, Bing-Hui Wang, Gui-Rong Luo, Qing-Guo Liu, Meng Xu

“…However, the precise antihypertensive mechanisms of acupuncture require further elucidation.MethodsIn this study, 30 male spontaneously hypertensive rats (SHRs) and 10 male Wistar Kyoto (WKY) rats were utilized as experimental models. …”
Get full text

KRM-II-81, a β3-Preferring GABA_A Receptor Potentiator, Blocks Handling-Induced Seizures in Theiler’s Murine Encephalomyelitis Virus-Infected Mice by Dishary Sharmin, Kamal P. Pandey, Lalit K. Golani, Sepideh Rezvanian, Md Yeunus Mian, Janet L. Fisher, Arnold Lippa, James M. Cook, Daniel P. Radin, Jodi L. Smith, Jeffrey M. Witkin, Hana Shafique, Rok Cerne

“…GABAARs with specific α subunit compositions have been studied in relation to the reduced side-effect liability of KRM-II-81; however, the role of β subunit composition has yet to be determined. …”
Get full text

Combined effects of aerobic exercise with ketogenic mediterranean and hypocaloric balanced diets on adolescents with polycystic ovarian syndrome by Reham Hamoda, Nada Elkady, Afaf Botla, Amir Gabr, Efrem Kentiba, Shaimaa Hamed

“…Mixed-model MANOVA evaluated time, treatment, and interaction effects. …”
Get full text

Microbial community profiling for forensic drowning diagnosis across locations and submersion times by Qin Su, Xiaofeng Zhang, Xiaohui Chen, Zhonghao Yu, Weibin Wu, Qingqing Xiang, Chengliang Yang, Jian Zhao, Ling Chen, Quyi Xu, Chao Liu

“…During drowning, microbial communities enter the lung tissue along with the water. Methods In this study, using a murine model, we collected samples from three rivers at random sites at postmortem intervals (PMI) of 1, 4, and 7 days‌ to comprehensively evaluate the differences in microbial communities between mice subjected to drowning versus postmortem immersion. …”
Get full text

Assessment of Hydrocarbon Losses in the Reservoir Formation T1-A During the Development of the Srednetyungsky Field by R. K. Katanova, E. I. Inyakina, E. Levitina, I. I. Krasnov

“…Experimental PVT studies of a multicomponent gas-condensate mixture to determine the loss of hydrocarbons in the presence of condensation water in the reservoir were carried out on recombined samples of separation gas, condensation water and saturated condensate. Materials and methods of the research. During the exploitation of an oil and gas condensate reservoir for depletion, the component composition (mixture of hydrocarbons and water vapor) of the produced gas condensate system changes, which affects the formation losses of hydrocarbons, as well as the properties of fluids and the dynamics of their phase behavior during field development. …”
Get full text

Particulate morphology of nanostructured materials by V. M. Gun'ko, O. I. Oranska, V. V. Paientko, I. Ya. Sulym

“…Two versions of the XRD treatment methods were used: (i) full profile analysis (FPA) of whole XRD patterns with a self-consistent regularization (SCR) procedure using models for spherical and lamellar crystallites that allows us to estimate relative contributions of crystallites of different shapes; and (ii) analysis of main pure XRD lines with consideration of corrections on an instrumental line profile and background using a regularization procedure with models of spherical or lamellar crystallites. …”
Get full text

Inversion analysis of constitutive relations of blade spar laminates with wrinkle defects by Ning Sun, Bo Zhou, Haocheng Zheng, Yingwei Wang

“…A hybrid optimization method integrating Bayesian regularized backpropagation neural networks and particle swarm optimization was developed to inversely determine the constitutive parameters of composite laminates. …”
Get full text

Multivariate Analyses with Two-Step Dimension Reduction for an Association Study Between ¹¹C-Pittsburgh Compound B and Magnetic Resonance Imaging in Alzheimer’s Disease... by Atsushi Kawaguchi, Fumio Yamashita

“…To study the relationship between Aβ deposition and brain structure, as determined using ¹¹C-Pittsburgh compound B (PiB) and magnetic resonance imaging (MRI), respectively, we developed a regression model with PiB and MRI data as the predictor and response variables, respectively, and proposed a regression method for studying the association between them based on a supervised sparse multivariate analysis with dimension reduction based on a composite paired basis function. …”
Get full text

Homogeneity Equation for the Effective Elastic Properties of Heterogenous Rocks Developed From Machine Learning by E. Maalouf, H. Kareem, H. Chebli

“…Abstract This study develops an artificial neural network (ANN) model designed to estimate the effective elastic properties of heterogeneous rocks with inclusions. …”
Get full text

Integrating Semantic Zoning Information with the Prediction of Road Link Speed Based on Taxi GPS Data by He Bing, Xu Zhifeng, Xu Yangjie, Hu Jinxing, Ma Zhanwu

“…The proposed method is compared with six baseline models on the same dataset generated by GPS equipped on taxis in Shenzhen, China, and the results show that our method has better prediction performance when semantic zoning information is added. …”
Get full text

Spatial Variability of Soil Organic Carbon Stock in Gurje Subwatershed, Hadiya Zone, Southern Ethiopia by Temesgen Addise, Bobe Bedadi, Alemayehu Regassa, Lemma Wogi, Samuel Feyissa

“…The ordinary kriging (OK) method was used as a geostatistical tool and applied to model the spatial variability of soil organic carbon in this study. …”
Get full text

Immigrants’ diminished protective effects of parental education and employment on youth mood disorders in Sweden by Shervin Assari, Mehdi Osooli, Henrik Ohlsson, Jan Sundquist, Kristina Sundquist

“…Sex and study year served as covariates, while immigration background acted as a moderator. Cox regression models were employed for statistical analysis. Results All SES indicators (higher parental education, parental employment, higher family income), and two-parent family composition were associated with a lower risk of mood disorders. …”
Get full text

Enhancement of oxaliplatin efficacy and amelioration of intestinal epithelial damage by Lactobacillus rhamnosus GG through modulation of gut microbiota by Zijie Zhang, Zijie Zhang, Rui Li, Yilin Ren, Yilin Ren, Yalan Ni, Yalan Ni, Xiaoyu Shen, Xiaoyu Shen, Deli Yi, Deli Yi, Zheng-hong Xu, Yan Geng, Yan Geng, Qingjun You, Qingjun You

“…Here, we explored the synergy between Lactobacillus rhamnosus GG (LGG), a probiotic, and the chemotherapeutic drug oxaliplatin (Oxp) in enhancing NSCLC treatment outcomes.MethodsWe utilized a BALB/c nude mouse subcutaneous tumor model to assess the therapeutic impacts of LGG and Oxp. …”
Get full text