Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice by Shiyue Sun, Tongtong Yu, Joo Young Huh, Yujie Cai, Somy Yoon, Hafiz Muhammad Ahmad Javaid

“…Abstract Background Duchenne muscular dystrophy (DMD) is a prevalent, fatal degenerative muscle disease with no effective treatments. Mdx mouse model of DMD exhibits impaired muscle performance, oxidative stress, and dysfunctional autophagy. …”
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In vitro and in vivo investigations of selected varieties of Areca catechu L - Phytochemical analysis, antiulcer, and wound healing activity by R. Deveswaran, D.J. Madhu Kumar, V. Madhavan, Soma Chaki, Misbah Khan, Govind R. Kadambi, B.V. Basavaraj, J. Anbu

“…Background: This study investigated the phytochemical composition and potential medicinal properties of arecanut grown in various regions of Karnataka. …”
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NT2-derived astrocyte–neuron co-culture reflects physiological relevance and offers research validity by Sylwia Kedracka-Krok, Ewelina Fic, Zuzanna Cepil, Piotr Rybczyński, Agata Szlaga, Radosław Cacała, Sławomir Lasota, Anna Blasiak, Marta Dziedzicka-Wasylewska

“…Ntera-2 cells and NT2 cells are used interchangeably in this publication. Methods Using an advanced proteomic approach, we assessed the protein composition and abundance of neuron and astrocyte co-cultures and discovered that the astrocytic protein profile in co-culture with neurons was more representative compared with that in pure astrocyte cultures. …”
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Chitosan/Sodium Tripolyphosphate/Sodium Alginate/miRNA-34c-5p Antagomir Scaffolds Promote the Functionality of Rabbit Cranial Parietal Repair by Lin C, Bai X, Zhang L

“…Subsequently, the in vivo efficacy of miR-34c-5p Agomir/Antagomir in regulating bone repair was evaluated in the rabbit cranial bone defect model, with micro-CT scanning and histological analysis conducted at 4, 8, and 12 weeks.Results: CTS scaffolds with a composition ratio of 1:0.2:0.1 were successfully synthesized, exhibiting a mean particle size of 360.1 nm. …”
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Multi-omics insights into beagle dog fed with a sucking-rewarded automatic feeding device by Yang Jiao, Xin Wang, Aizhen Yu, Li Wu, Hongping Li

“…The present study is designed to investigate the impacts of this innovative device, utilizing a multi-omics profiling approach, on beagle dogs as a surrogate model.MethodsThis study involved seven-day-old male newborn beagle puppies, carefully selected and matched in terms of body weights. …”
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Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile by Wei Chen, Lin Xu, Long Wang, Yu-nan Shan, Yan Li, Jin-shui Zhu

“…However, its molecular mechanisms remain unclear.PurposeThis study investigates the effects of QRHSD on DSS-induced colitis in mice, employing multi-omics analyses, including RNA-seq transcriptomics, 16S rRNA microbiomics, non-targeted metabolomics, and network pharmacology analysis.MethodsThe chemical composition of QRHSD was analyzed using quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). …”
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Gegen Qinlian Decoction Ameliorated DSS-Induced Colitis by Attenuating Inflammation, Restoring Intestinal Mucosal Barrier and Modulating Gut Microbiota by Wang Y, Yan R, Ye L, Tang C, Zhou H, Zhao G

“…However, the specific mechanisms by which GQD exerts its effects remain poorly understood, limiting its application in UC treatment.Purpose: In this study, we utilized a dextran sodium sulfate-induced colitis model in mice to evaluate the efficacy of GQD and to elucidate its underlying mechanisms.Methods: Network pharmacology was employed to explore the potential targets and signaling pathways of GQD, which were subsequently validated using Western blot. …”
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A myostatin inhibitory antibody combined with insulin, partially rescues the musculoskeletal phenotype of female insulin-deficient diabetic mice by R. Clay Bunn, Reuben Adatorwovor, Philip D. Ray, Alexander R. Keeble, Christopher S. Fry, Sasidhar Uppuganti, Jeffry S. Nyman, John L. Fowlkes, Evangelia Kalaitzoglou

“…At study end, body composition and in vivo contractile muscle function were assessed, systemic myostatin and glycated hemoglobin were quantified, gastrocnemii were weighed and analyzed for fiber type composition, and femur microarchitecture and biomechanical properties were analyzed.ResultsGlycated hemoglobin was significantly higher in diabetic mice compared to non-diabetic mice and diabetic mice treated with insulin. …”
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Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis by Hongming Wei, Lu Zhan, Xinhuang Lv, Yan Lin, Jie Zheng, Wenwen Yang, Jiaming Liu, Jing Sun, Songfang Chen

“…Recent studies have highlighted the important role of gut microbiota in both hyperuricemia and AIS, but there is little available data on the relationship between gut microbiota and the pathogenesis of AIS with hyperuricemia (HAS). Methods Here we profiled the gut microbiota composition in 63 HAS patients and 269 non-HAS patients through 16s rRNA sequencing. …”
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Designing the Forest of Tomorrow: Generating Virtual Trees with Adversarial Autoencoders by H. Hristova, C. Blattert, S. Puliti, J. Schweier

“…By leveraging remote sensing data, we aim to capture individual tree features and characteristics accurately, linking them to dynamic simulations of forest structures and composition. Employing a deep learning approach, we train models on existing 3D scanned data to produce diverse and realistic visual representations of specific tree species. …”
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Determinants of Sustainability Reporting in the Romanian Banking Sector by Mihaela CUREA, Maria Carmen HUIAN, Marilena MIRONIUC

“…Regression trees facilitate the identification and modeling of non-linear and conditional relationships between variables, enabling the detection of complex interactions that traditional fixed-effects regression models cannot capture. …”
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Full-length 16S rRNA Sequencing Reveals Gut Microbiome Signatures Predictive of MASLD in children with obesity by Yu-Cheng Lin, Chi-Chien Wu, Yun-Er Li, Chun-Liang Chen, Chia-Ray Lin, Yen-Hsuan Ni

“…The model's performance was evaluated by comparing the area under the receiver operating characteristic curve (AUC) through a tenfold cross-validation method. …”
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Refined Monitoring of Water Bodies in Built-Up Areas and Analysis and Evaluation of Water Color Characteristics in Complex Urban Backgrounds by Bin Li, Yong Xie, Zui Tao, Wen Shao, Gan Qin

“…Comparison with measured data reveals a root mean square error of 3.9° and an average absolute percentage error of 1.5%, validating the proposed method’s accuracy. Industrial location, population density, soil erosion, and other factors significantly affect water color, particularly as industrial activities and soil erosion alter water composition and suspended solids, directly impacting water color. …”
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Typology of the "Internal Form-Structure" Drawing upon Argan\'s Formal Approach (Case Study: Historical Bridge-Caravanserai in Iran) by Paryia Pourmohammadi, Farshad Mafakher, Asghar Saed Samiei, Mehrdad Matin

“…Using a descriptive - analytical method, the data were collected through desk and field studies.  …”
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Analisis Penerimaan SIMPUS Ditinjau dari Persepsi Pengguna di Puskesmas Mojoagung dengan Metode TAM by Mochammad Choirur Roziqin, Demiawan Rachmatta Putro Mudiono, Nuril Amalia

“…Penelitian ini memiliki tujuan untuk melakukan analisis tehadap penerimaan SIMPUS ditinjau dari persepsi pengguna di Puskesmas Mojoagung dengan menggunakan metode Technology Acceptance Model (TAM). Jenis penelitian yaitu analitik kuantitatif dengan pendekatan cross sectional. …”
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SUPERCRITICAL FLUID TREATMENT OF THREE-DIMENSIONAL HYDROGEL MATRICES, COMPOSED OF CHITOSAN DERIVATIVES by P. S. Timashev, K. N. Bardakova, S. N. Churbanov, L. I. Krotova, A. M. Grigoriev, M. M. Novikov, S. G. Lakeev, V. I. Sevastianov, V. N. Bagratashvili

“…Controlled treatment of the physico-chemical and mechanical properties of a three-dimensional crosslinked matrix based on reactive chitosan. Materials and methods. The three-dimensional matrices were obtained using photosensitive composition based on allyl chitosan (5 wt%), poly(ethylene glycol) diacrylate (8 wt%) and the photoinitiator Irgacure 2959 (1 wt%) by laser stereolithography setting. …”
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Development and Characterization of Dual-Loaded Niosomal Ion-Sensitive In Situ Gel for Ocular Delivery by Viliana Gugleva, Rositsa Mihaylova, Katya Kamenova, Dimitrina Zheleva-Dimitrova, Denitsa Stefanova, Virginia Tzankova, Maya Margaritova Zaharieva, Hristo Najdenski, Aleksander Forys, Barbara Trzebicka, Petar D. Petrov, Denitsa Momekova

“…The optimal composition was included in a gellan gum-based in situ gel, and the antimicrobial activity, in vitro toxicity in a suitable corneal epithelial model (HaCaT cell line), and antioxidant potential of the hybrid system were further assessed. …”
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Effects of anaerobic power bicycle training on the lower-limb anaerobic exercise ability of female basketball players by Haoyang Ding, Ruixue Zhao, JiaMeng Wang, Shuai Zhao

“…Multiple linear regression models for power cycling metrics were developed. Conclusions: The method proposed in this study is effective for developing training models, especially when physical assessments or experimental tools are unavailable. …”
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Observations of Optical Properties and Chlorophyll-a Concentration in Qiandao Lake Using Shipborne Lidar by Xuan Sang, Zhihua Mao, Youzhi Li, Xianliang Zhang, Chang Han, Longwei Zhang, Haiqing Huang

“…Lidar technology is increasingly applied to the inversion of oceanic biological parameters and optical properties based on empirical and semi-empirical bio-optical models. However, these models cannot be directly applied to inland waters due to their complex composition, and research on the biological parameters and optical properties of inland waters remains limited. …”
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Cold Stress Regulates Muscle Development and Promotes Muscle Fiber Transformation by Regulating Mib1/Notch Pathway by Minxing Zheng, Jiahui Qi, Xuanjing Wang, Tingting Fu, Ziqi Chang, Tong Zhao, Yaqin Sun, Jiayin Lu, Yi Yan, Haidong Wang

“…Methods: A cold stress model was established by subjecting mice to a 4 °C environment for 4 hours daily. …”
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