Single-cell transcriptomics reveal the prognostic roles of epithelial and T cells and DNA methylation-based prognostic models in pancreatic cancer by Jing Du, Yaqian Zhao, Jie Dong, Peng Li, Yan Hu, Hailang Fan, Feifan Zhang, Lanlan Sun, Dake Zhang, Yuhua Zhang

“…The TCGA dataset was used for validation, and cell composition was inferred from DNAm data. Prognostic models were constructed based on cell-type-specific DNAm markers, and genomic features were compared across risk groups. …”
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Ageing, multimorbidity, and quality of life: a mediation analysis using longitudinal ageing study in India by Bharti Singh, Ajay Kumar

“…The QoL score was constructed using Principal Component Analysis (PCA) by utilizing 21 factors under six domains (physical health, psychological health, social relationship, environmental satisfaction, life satisfaction and general health), with the composite QoL score ranging from 0 to 100. Further, the Structural equation model (SEM) was used to assess the role of multimorbidity as the intermediating risk factor for exogenous factors on QoL.ResultsDistributions of morbidities burden were skewed toward non-communicable diseases (NCDs) and sequentially escalated multimorbidity burden was observed among the oldest of old age groups. …”
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In vivo percutaneous microwave ablation with ECO system in swine kidney and liver: comparison of ablation-zone size to manufacturer predictions and assessment of new antenna design by Théo Bonnefoy, Georges Tarris, Kévin Guillen, Olivia Poupardin, Olivier Chevallier, Ludwig Serge Aho Glele, Jean-Michel Correas, Romaric Loffroy

“…Power and application time are chosen based on manufacturer-provided data, usually obtained from ex vivo animal models. However, ex vivo tissues differ from in vivo condition due to compositional changes and absence of heat dissipation by blood flow. …”
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Outcomes After Noncardiac Surgery Performed Within 2 Years of Percutaneous Coronary Intervention by Neel M. Butala, Annika Hebbe, Binita Shah, Nathaniel R. Smilowitz, Bilal Aijaz, Anezi Uzendu, Peter Boulos, Stephen W. Waldo

“…Methods and Results Patients in the Veterans Affairs Surgical Quality Improvement Program database who underwent noncardiac surgery between October 1, 2017 and September 30, 2021 were included. …”
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Construction of a predictive model for concurrent infection in liver failure patients based on prognostic nutritional index and inflammatory cytokine analysis by Hong Yang, Bin Zhang, Chun Yu, Xiao Zhu

“…Abstract Objective This study aimed to explore the relationship between the Prognostic Nutritional Index (PNI, a composite indicator of albumin and lymphocyte count reflecting nutritional and immune status) and inflammatory cytokines in predicting infections among liver failure patients, and to construct a predictive model based on these indicators. …”
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Identification of Plasma Metabolites Responding to Oxycodone Exposure in Rats by Thao Vu, Suneeta Godbole, Lieselot L. G. Carrette, Lisa Maturin, Olivier George, Laura M. Saba, Katerina Kechris

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Targeting early tau pathology: probiotic diet enhances cognitive function and reduces inflammation in a preclinical Alzheimer’s model by Cassandra M. Flynn, Tamunotonye Omoluabi, Alyssa M. Janes, Emma J. Rodgers, Sarah E. Torraville, Brenda L. Negandhi, Timothy E. Nobel, Shyamchand Mayengbam, Qi Yuan

“…Methods This study evaluates the effects of probiotics in a rat model of preclinical AD, specifically targeting hyperphosphorylated pretangle tau in the locus coeruleus. …”
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Using 3D and 4D digital human modeling in extended reality-based rehabilitation: a systematic review by Mengdi Lu, Wim Saeys, Wim Saeys, Maria Maryam, Inva Gjeleshi, Hoda Nazarahari, Steven Truijen, Sofia Scataglini

“…Recently, integrating digital human modeling (DHM) with XR has gained attention. This systematic review aimed to evaluate the effectiveness of combining 3D and 4D DHM with XR in rehabilitation.MethodsA systematic literature search was conducted according to PRISMA 2020 guidelines on the 28th of May 2024 in five databases (PubMed, IEEE Database, Cochrane Library, Web of Science, and Science Direct). …”
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Development of in vitro laboratory models of the tumor immune microenvironment to evaluate quality parameters and specific efficacy of the dendritic cell vaccine by T. L. Nekhaeva, A. B. Danilova, E. I. Fedoros, N. A. Efremova, N. V. Emelyanova, M. L. Blokhina, M. N. Yurova, M. L. Tyndyk, I. A. Baldueva

“…Purpose of the study: development of in vitro laboratory models to evaluate quality parameters and specific efficacy of dendritic cell vaccine (DCV).Material and Methods. …”
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Hybrid Approach of Finite Element Method, Kigring Metamodel, and Multiobjective Genetic Algorithm for Computational Optimization of a Flexure Elbow Joint for Upper-Limb Assistive D... by Duc Nam Nguyen, Thanh-Phong Dao, Ngoc Le Chau, Van Anh Dang

“…An efficient hybrid optimization approach of central composite design (CDD), finite element method (FEM), Kigring metamodel, and multiobjective genetic algorithm (MOGA) is developed. …”
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Muscle‐specific gene editing improves molecular and phenotypic defects in a mouse model of myotonic dystrophy type 1 by Mariapaola Izzo, Jonathan Battistini, Elisabetta Golini, Christine Voellenkle, Claudia Provenzano, Tiziana Orsini, Georgios Strimpakos, Ferdinando Scavizzi, Marcello Raspa, Denisa Baci, Svetlana Frolova, Spyros Tastsoglou, Germana Zaccagnini, Jose Manuel Garcia‐Manteiga, Genevieve Gourdon, Silvia Mandillo, Beatrice Cardinali, Fabio Martelli, Germana Falcone

“…The precision and efficiency of the molecular mechanisms are still under investigation in view of a possible use in clinical practice. Methods Here, we describe the application of the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) strategy to remove the CTG‐expansion in the DMPK gene in a mouse model carrying the human transgene from a DM1 patient. …”
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Solitary Wave Solutions to the Modified Zakharov–Kuznetsov and the (2 + 1)-Dimensional Calogero–Bogoyavlenskii–Schiff Models in Mathematical Physics by M. Al-Amin, M. Nurul Islam, Onur Alp İlhan, M. Ali Akbar, Danyal Soybaş

“…In this article, the dynamic, companionable, and further broad-spectrum exact solitary solitons are extracted to the formerly stated nonlinear models by the aid of the recently enhanced auxiliary equation method through the traveling wave transformation. …”
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Alternative graphemics. Aztec writing system as a case study towards an integrated, digitalised model of non-typographic graphemics by Antonio Perri, Luciano Perondi, Daniele Capo, Roberto Arista, Giampiero Dalai

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Advancing ship automatic navigation strategy with prior knowledge and hierarchical penalty in irregular obstacles: a reinforcement learning approach to enhanced efficiency and safe... by Hao Zhang, Jiawen Li, Jiawen Li, Jiawen Li, Jiawen Li, Liang Cao, Liang Cao, Liang Cao, Shucan Wang, Ronghui Li, Ronghui Li, Ronghui Li

“…The experimental results show that the GEPA model outperforms the existing methods in terms of navigating efficiency, training convergence speed, path smoothness, obstacle avoidance ability and safety, with the number of training rounds to complete the task reduced by 24.85%, the path length reduced by up to about 70 pixels, the safety distance improved by 70.6%, and the number of collisions decreased significantly. …”
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Enhanced efficacy of immune checkpoint inhibitors by folate-targeted multifunctional drug through synergistic therapy inducing ferroptosis and immunogenic cell death in bladder can... by Yibo Shi, Guangrui Fan, Enguang Yang, Yuanfeng Zhang, Hui Ding, Junqiang Tian, Liang Cheng, Hanzhang Wang, Tianzhi Hao, Baodui Wang, Zhiping Wang

“…Methods: DIFP-FA was synthesized via the W/O/W method. …”
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Determination of Biomechanical Parameters and Development of an Improved FEM Model for Perennial Alfalfa (<i>Medicago sativa</i> L.) Roots by Shuo Wang, Xuanting Liu, Hongyan Qi, Zihe Xu, Yunhai Ma

“…Our model conceptualizes the root as a composite structure of cortex and stele, applying transversely isotropic properties to the stele and isotropic properties to the cortex. …”
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Interplay between the gut microbiome and typhoid fever: insights from endemic countries and a controlled human infection model by Philip M. Ashton, Leonardos Mageiros, James E. Meiring, Angeziwa Chunga-Chirambo, Farhana Khanam, Sabina Dongol, Happy Banda, Abhilasha Karkey, Lorena Preciado-Llanes, Helena Thomaides-Brears, Malick Gibani, Nazmul Hasan Rajib, Nazia Rahman, Prasanta Kumar Biswas, Md Amirul Islam Bhuiyan, Sally Kay, Kate Auger, Olivier Seret, Nicholas R. Thomson, Andrew J. Pollard, Stephen Baker, Buddha Basnyat, John D. Clemens, Christiane Dolecek, Sarah J. Dunstan, Gordon Dougan, Robert S. Heyderman, Virginia E. Pitzer, Firdausi Qadri, Melita A. Gordon, Kathryn E. Holt, Thomas C. Darton, STRATAA Study Group

“…The putative protection provided by microbiome SCFA metabolism was supported by data from a controlled human infection model conducted in a UK population, in which participants who did not develop typhoid fever following ingestion of S. …”
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Integrating the circular economy model into the management and treatment of Fischer–Tropsch effluents—a conversion of waste to energy (biogas) opportunity by Mabatho Moreroa, Thapelo P. Malematja, Grace Nkechinyere Ijoma

“…Furthermore, the paper investigates ameliorative measures to overcome the limitations of one biological treatment method, anaerobic digestion of FT effluents by examining the combination of nutrient augmentation, microbial augmentation, and enrichment from the integration of wastes derived from other industrial sectors as pivotal to the implementation of circular economics modelling in FT effluents valuation. …”
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Evaluating the Acceptance and Success of Mobile Banking Systems Using a Combination of UTAUT2 and Delone & McLean Models by Novrinda Khairun Nisak, Ali Ibrahim, Ermatita

“…The research employed the SemPLS method, chosen due to its ability to handle complex models with multiple latent variables and assess intricate relationships between constructs. …”
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Assessing CNN and Semantic Segmentation Models for Coarse Resolution Satellite Image Classification in Subcontinental Scale Land Cover Mapping by Tesfaye Adugna, Wenbo Xu, Jinlong Fan, Haitao Jia, Xin Luo

“…Achieving the best and the second-best results using RF and 1-D CNN models, respectively, indicates the superiority of the pixel-based method and the insignificance of spatial information in coarse-resolution image classification. …”
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