Association between inflammatory score, healthy lifestyle, and cardiovascular disease: a national cohort study by Han-Qing Zhao, Han-Qing Zhao, Jia-Le Lv, Jia-Le Lv, Yuan-Zhi Gao, Bo Hu, Zong-Da Du, Zong-Da Du, Zong-Da Du, Yan Wang, Mei-Lin Wang, Mei-Lin Wang, Meng-Di Hou, Fang Li, Xue Xing, Ming-Hui Sun

“…BackgroundThe inflammation score is currently regarded as a reliable composite index for comprehensive assessment of inflammatory status. …”
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Prior metabolic surgery attenuates the weight-loss efficacy of liraglutide in patients with mild obesity by Yuqin Ouyang, Yuqin Ouyang, Xinyue Xiang, Xinyue Xiang, Xinyun Hu, Xinyun Hu, Xuehui Chu, Wenjuan Tang, Wenjuan Tang, Wenhuan Feng, Wenhuan Feng, Wenhuan Feng

“…We aimed to identify clinical predictors influencing differential treatment responses in patients with mild obesity.MethodsA retrospective analysis was conducted on 64 adults (BMI 28–32.5 kg/m²) undergoing a 12-week liraglutide intervention. …”
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Associations between triglyceride glucose-body mass index and 30-day mortality in patients with hemorrhagic stroke: analysis of the MIMIC-IV database by Yuexin Lu, Yuexin Lu, Enjie Song, Enjie Song, Ruilin Chen, Ruilin Chen, Long Jing, Long Jing, Jiahao Tang, Jiahao Tang, Shunan Shi, Shunan Shi, Ming Wang, Ming Wang, Ming Wang, Ming Wang, Shu Wan, Shu Wan, Shu Wan, Shu Wan

“…The triglyceride-glucose-body mass index (TyG-BMI), integrating lipid-glucose metabolism and obesity, has shown prognostic value in cardiovascular diseases but remains underexplored in HS populations.MethodsThis retrospective cohort study analyzed 413 HS patients from the MIMIC-IV database. …”
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Antiplatelet Use Prior to Anticoagulant Initiation in Patients With Atrial Fibrillation-Related Ischemic Stroke: An ELAN Trial Analysis by Alexandros A. Polymeris, Masatoshi Koga, Daniel Strbian, Adhiyaman Vedamurthy, Manju Krishnan, Mattia Branca, Thomas Horvath, Martina Goeldlin, Gek Shim, Christoph Gumbinger, Liqun Zhang, Espen Saxhaug Kristoffersen, Philippe Desfontaines, Peter Vanacker, Angelika Alonso, Sven Poli, Ana Paiva Nunes, Nicoletta G. Caracciolo, Markus Kneihsl, Timo Kahles, Daria Giudici, Silja Räty, Marjaana Tiainen, Jesse Dawson, Urs Fischer, for the ELAN Investigators

“…Here, we explored the risks and benefits of this approach. Methods A post-hoc analysis of ELAN (Early versus Late Initiation of Direct Oral Anticoagulants in Post-ischemic Stroke Patients with Atrial Fibrillation) trial data (NCT03148457) was conducted to compare the risk of recurrent ischemic stroke, systemic embolism, major bleeding (extracranial or intracranial hemorrhage [ICH]), and vascular death within 30 days (as a composite and as individual outcomes) in participants treated with and without antiplatelets before DOAC initiation after an AF-associated ischemic stroke. …”
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Neurodevelopment at 10 months and 2–3 years old after early and prolonged anaesthesia in infancy: General Anaesthesia & Brain Activity study (GABA) secondary analysis by Laura Cornelissen, Siobhan Coffman, Isabelle Kim, Ellen Underwood, Alice Tao, Maria G. Maloney, Carolina Donado, Kimberly Lobo, Charles A. Nelson, Takao K. Hensch, Laurel J. Gabard-Durnam, Charles B. Berde

“…Analyses used adjusted Welch's t-tests, linear regression, and linear mixed effects models. Results: BSID composite scores for cognition were similar between general anaesthesia and unexposed cohorts at 10 months (Padj=0.566, standardised mean difference [SMD]=0.27) and at 2–3 yr (Padj=0.651, SMD=0.25). …”
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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…This study aimed to investigate the differences in RV function and clinical outcomes between these two groups. Methods The study included 246 T2DM patients {141 patients without OCAD [T2DM(OCAD−)] and 105 with [T2DM(OCAD+)]} and 85 control subjects. …”
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Gypenosides Alleviate Hyperglycemia by Regulating Gut Microbiota Metabolites and Intestinal Permeability by Rong Wang, Xue-Feng Liu, Kuan Yang, Li-Li Yu, Shao-Jing Liu, Na-Na Wang, Yun-Mei Chen, Ya-Qi Hu, Bei Qin

“…The aim of this study is to clarify the molecular mechanisms of Gps in ameliorating glucose dysregulation. <b>Methods</b>: Qualitative and quantitative analyses on the chemical components of Gps were performed, respectively. …”
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Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study by Na Liu, Xiong‐Fei Pan, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Tangchun Wu, Zhengming Chen, An Pan, Liming Li

“…We examined this association in Chinese adults using data from the China Kadoorie Biobank study. Methods and Results Over 0.5 million adults aged 30 to 79 years were followed from baseline interview (2004–2008) until December 31, 2013. …”
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Allostatic Load/Chronic Stress and Cardiovascular Outcomes in Patients Diagnosed With Breast, Lung, or Colorectal Cancer by Nickolas Stabellini, Jennifer Cullen, Marcio S. Bittencourt, Justin X. Moore, Arnethea Sutton, Priyanshu Nain, Nelson Hamerschlak, Neal L. Weintraub, Susan Dent, Meng‐Han Tsai, Amitava Banerjee, Arjun K Ghosh, Diego Sadler, Steven S. Coughlin, Ana Barac, John Shanahan, Alberto J. Montero, Avirup Guha

“…AL was modeled as an ordinal measure (0–11). Adjusted Fine–Gray competing risks regressions estimated the impact of AL precancer diagnosis on 2‐year MACE (a composite of heart failure, ischemic stroke, acute coronary syndrome, and atrial fibrillation). …”
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Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia by Sanaz Sedaghat, Saeun Park, Rob F. Walker, Shuo Wang, Jialing Liu, Timothy M. Hughes, Behnam Sabayan, Weihong Tang, Josef Coresh, James S. Pankow, Keenan A. Walker, Ramon Casanova, Ruth Dubin, Rajat Deo, Jerome I. Rotter, Alexis C. Wood, Peter Ganz, Pamela L. Lutsey, Weihua Guan, Anna Prizment

“…Abstract Background: Biological age can be quantified by composite proteomic scores, called proteomics-based aging clocks (PACs). …”
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Associations Between Gene Variants of Lipid‐Lowering Drug Targets and Adverse Outcomes After Ischemic Stroke by Lulu Sun, Qilu Zhang, Mengyao Shi, Yang Liu, Zhengbao Zhu, Jing Zhang, Hao Peng, Aili Wang, Jing Chen, Tan Xu, Yonghong Zhang, Jiang He

“…However, the relationship between gene variants of lipid‐lowering drug targets and the adverse prognosis of ischemic stroke patients remains unclear. Methods and Results Multiple single‐nucleotide polymorphisms associated with 6 lipid‐lowering drug targets were genotyped for patients with ischemic stroke. …”
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Cardiovascular risk in childhood and young adulthood is associated with the hemodynamic response function in midlife: The Bogalusa Heart Study by Kai-Cheng Chuang, Maryam Naseri, Sreekrishna Ramakrishnapillai, Kaitlyn Madden, Julia St Amant, Kevin McKlveen, Kathryn Gwizdala, Ramasudhakar Dhullipudi, Lydia Bazzano, Owen Carmichael

“…Results: In multivariable models, faster and more efficient HRF characteristic was found in non-smoker compared to smokers (AUHRF, p = 0.029). …”
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Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD by Bernard Chan, Amanda Varghese, Sunil V. Badve, Roberto Pecoits-Filho, Murilo Guedes, Clare Arnott, Rebecca Kozor, Emma O’Lone, Min Jun, Sradha Kotwal, Geoffrey A. Block, Glenn M. Chertow, Scott D. Solomon, Muthiah Vaduganathan, Vlado Perkovic, Brendon L. Neuen

“…We evaluated the effects of iron versus usual care or placebo on the clinical outcomes in patients with CKD. Methods: We conducted a systematic review and meta-analysis of randomized trials on i.v. or oral iron in patients with CKD (PROSPERO CRD42023453468). …”
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Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. …”
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Sources of risk communication, knowledge and preventive practices toward Lassa fever in Bauchi State, Nigeria by Benjamin Bukky Ilesanmi, Nathanael Afolabi, Olayinka Badmus, Munkail Titilola, Abdulmajid Ahmad, Usman Inuwa, Matthew Okoh, Hajara Aliyu, Shittu Abdu-Aguye, Foyeke Oyedokun-Adebagbo

“…We examined the level and sources of risk communication influencing knowledge and preventive practices towards Lassa fever (KPLF) and determined its associated factors in Bauchi state. Methods A cross-sectional study was conducted. Multistage sampling technique was used to select the respondents. …”
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The Influence of Depression, Anxiety, and Stress on Ageism Among Undergraduates: Mediating Roles of Life Satisfaction, Gratitude, and Prosociality by Chen S, Wan Z

“…Following data cleaning, 1174 responses were included for analysis.Methods: Data were collected using online questionnaires. …”
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MORPHOLOGICAL CHANGES OF RAT PERIODONTIUM IN SUPRAOCCLUSAL RELATIONS OF INDIVIDUAL TEETH IN THE AGE ASPECT by S.M. Zviahin, Y.V. Lakhtin

“…Aim: to determine the morphological changes of periodontium in rats of different age groups in the supraocclusal relationship of individual teeth in the age aspect. Materials and methods of the study. The study was conducted on 60 white laboratory rats aged 4 to 22 months and weighing 90 to 330 g. …”
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The impact of deprivation and neighbourhood food environments on home food environments, parental feeding practices, child eating behaviours, food preferences and BMI: The Family F... by Andrea D Smith, Alice Kininmonth, Kristiane Tommerup, David Boniface, Chiara Gericke, Tiffany Denning, Carolyn Summerbell, Christina Vogel, Clare Llewellyn

“…This study, part of the Family Food Experience Study-London, aimed to investigate the impact of deprivation and neighbourhood food environments on home food environments, parental feeding practices, child eating behaviours, food preferences, and child BMI. Methods Families (n = 728) with primary school-aged children were recruited from four socioeconomically diverse London boroughs in 2022. …”
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Sodium-glucose cotransporter 2 inhibitors and cardiovascular events among patients with type 2 diabetes and low-to-normal body mass index: a nationwide cohort study by Yuichiro Mori, Toshiaki Komura, Motohiko Adomi, Ryuichiro Yagi, Shingo Fukuma, Naoki Kondo, Motoko Yanagita, O. Kenrik Duru, Katherine R. Tuttle, Kosuke Inoue

“…The primary outcome was a composite of all-cause death, myocardial infarction, stroke, or heart failure. …”
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Prediabetes: prevalence, associations with cardiovascular risk factors and contribution to survival in the Russian population by Yu. A. Balanova, S. A. Shalnova, A. E. Imaeva, V. A. Kutsenko, A. V. Kapustina, S. E. Evstifeeva, G. A. Muromtseva, R. V. Ievlev, R. N. Shepel, O. M. Drapkina

“…To study the contribution of carbohydrate metabolism disorders to mortality and the occurrence of cardiovascular events.Material and methods. We included data from cross-sectional studies ESSE-RF and ESSE-RF2. …”
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