Total and Structural Carotid Artery Stiffness Are Associated With Cognitive Decline and Structural Brain Abnormalities Related to Alzheimer Disease and Alzheimer Disease‐Related De... by Jeremy R. Williams, Theodore M. DeConne, Ryan Pewowaruk, Claudia Korcarz, Jordan Tanley, Cynthia Carlsson, Susan R. Heckbert, Mohamad Habes, Ilya Nasrallah, Samuel N. Lockhart, José A. Luchsinger, Jingzhong Ding, Kathleen M. Hayden, Timothy M. Hughes, Adam D. Gepner

“…Total pulse wave velocity can be subdivided into 2 main mechanisms: structural arterial stiffness (S‐PWV) due to intrinsic remodeling of the artery wall and load‐dependent arterial stiffness due to increased blood pressure. Methods and Results In this prospective cohort study, MESA (Multi‐Ethnic Study of Atherosclerosis) participants completed B‐mode carotid ultrasounds from which carotid total pulse wave velocity was calculated. …”
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Exercise Right Ventricular‐Pulmonary Arterial Coupling and Functional Outcome in Patients Undergoing Surgery for Secondary Ischemic Mitral Regurgitation by Carlo Fino, Diego Bellavia, Michele D'Alonzo, Maurizio Merlo, Vito D. Bruno, Julien Magne, Massimo Caputo, Amedeo Terzi, Michele Senni, Samuele Bichi, Caterina Simon, Edoardo Sciatti, Giovanni Marchetto, Attilio Iacovoni, Philippe Pibarot

“…Linear mixed models were used to evaluate the predictive value of preoperative echocardiographic parameters on the longitudinal distribution of the 6‐minute walking test. …”
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Association of mitochondrial RNA expression levels in saliva and plasma with interferon signature gene expression and disease activity in patients with Sjögren disease by Keun-Suh Kim, Joon Young Hyon, Yun Jong Lee, You-Jung Ha, Woo-Jin Jeong, Seunghee Cha, Yong Seok Choi, Eun Ha Kang, Se Rim Choi, Jimin Yoon, Doyeong Ku, Yoosik Kim

“…The expression levels of mt-RNAs and interferon-stimulated genes (ISGs) were quantified by real-time PCR. Composite mt-RNA and ISG scores were calculated using logistic regression models. …”
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Towards biomarkers for outcomes after pancreatic ductal adenocarcinoma and ischaemic stroke, with focus on (co)-morbidity and ageing/cellular senescence (SASKit): protocol for a pr... by Christian Junghanss, Daniel Palmer, Larissa Henze, Uwe Walter, Hugo Murua Escobar, Robert Jaster, Rüdiger Köhling, Falko Lange, Ali Salehzadeh-Yazdi, Olaf Wolkenhauer, Mohamed Hamed, Israel Barrantes, Steffen Möller, Axel Kowald, Nicole Heussen, Georg Fuellen

“…In some of the explorative analyses, we shall include insights from systems biology modelling as well as insights from preclinical animal models. …”
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Impact of Time-To-Treatment on Outcomes in Autoimmune Membranous Nephropathy by Patrick Hamilton, Sebastian Bate, Omar Ragy, Mrityunjay Hiremath, Samar Bukhari, Anirudh Rao, Arif Khwaja, Durga Anil K Kanigicherla

“…Immunosuppression is initiated after ''watchful-wait'' to avoid side effects in patients who might achieve spontaneous remission; however, the impact of this approach on kidney function is unclear. Methods: This was a retrospective longitudinal cohort study of patients with new consecutive aMN from 2003 to 2019 from 3 UK centers. …”
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Outpatient acute kidney disease detection by national and institutional health data by Hsiu-Yin Chiang, Hung-Chieh Yeh, Zi-Han Lin, Bradley Chen, David Ray Chang, I-Wen Ting, Jie-Sian Wang, Yun-Lun Chang, Hung-Lin Chen, Yu-Chih Liu, Mei-Chuan Hsieh, Tzu-Ling Karen Tzeng, Chin-Chi Kuo

“…In this retrospective cohort study, the associations between AKDOPT and composite kidney outcome (CKO; e.g., end-stage kidney disease, a >40% drop in estimated glomerular filtration rate, or a 2-fold or more increase in serum creatinine), all-cause mortality, and de novo non-dialysis chronic kidney disease (CKD-ND) were evaluated using multivariable Cox proportional hazards models. …”
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Genetic polymorphisms in SLC5A2 are associated with clinical outcomes and dapagliflozin response in heart failure patients by Ahmed Essam Abou Warda, Rylie M. Flohr, Rania M. Sarhan, Rania M. Sarhan, Mohamed Nabil Salem, Heba F. Salem, Heba F. Salem, Ayman N. Moharram, Abdullah S. Alanazi, Christelle Lteif, Brian E. Gawronski, Leanne Dumeny, Tariq G. Alsahli, Khaled Elenizi, Bassem Zarif, Neven Sarhan, Julio D. Duarte

“…Adjusted Cox proportional-hazard regression models were used to assess the effect of SLC5A2 variation on a primary composite outcome of cardiovascular (CV) hospitalization or all-cause mortality in SGLT2i-naïve patients, and HF hospitalization or CV death in dapagliflozin-treated patients. …”
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Efficacy and safety of direct oral anticoagulants compared with warfarin in antiphospholipid syndrome. Results of a multicenter retrospective cohort study by Maha A.T. Elsebaie, Zoe Wickham, Stephanie DeBragga, Stacey Fedewa, Mohamed Amgad, Jane Jungyoon Park, Allen Li, Ali Eshaghpour, Juan Li, Mark Crowther, Manila Gaddh

“…Objectives: This multicenter, retrospective cohort study conducted at Emory and McMaster University Medical Centers aimed to explore pattern of DOAC use among APS patients and compare the efficacy and safety of DOACs vs warfarin. Methods: We included APS patients aged ≥18 years who experienced acute thrombosis between 2012 and 2018 and initiated DOACs or warfarin. …”
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Remnant–to–LDL cholesterol discordance as a predictor of thromboembolic events in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF project... by Eva Soler-Espejo, Yang Chen, José Miguel Rivera-Caravaca, María Pilar Ramos-Bratos, Raquel López-Gálvez, Francisco Marín, Vanessa Roldán, Gregory Y.H. Lip

“…As atrial fibrillation (AF) is a common arrhythmia associated with increased thromboembolic risk even despite anticoagulation, we assessed the prognostic value of RC in AF, with a particular focus on its association with LDL-C discordance. Methods In this prospective cohort study, AF outpatients initiating oral anticoagulation between January 2016 and November 2021 were enrolled. …”
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Protocol for a multisite randomised controlled trial assessing the effect of the Telehealth for Early Developmental Intervention in babies born very preterm (TEDI-Prem) programme o... by Alicia J Spittle, Peter J Anderson, Angela T Morgan, Rachel Schembri, Li Huang, Kim Dalziel, Rod W Hunt, Katherine Lee, Anne E Holland, Karli Treyvaud, Abbey L Eeles, Stacey Dusing, Shaaron Brown, Susan M Fehring, Gillian Henty, Elizabeth Kozaris

“…Here we present the protocol outlining a multicentre, pragmatic, parallel-group, randomised controlled trial to determine the efficacy of TEDI-Prem plus usual care, compared with usual care alone.Methods and analysis We will recruit 466 VPT infants from the neonatal units of five hospitals in Victoria, Australia. …”
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Passive immunotherapy for adults hospitalized with COVID-19: An individual participant data meta-analysis of six randomized controlled trials. by Kirk U Knowlton, Lianne K Siegel, Christina E Barkauskas, Sanjay Bhagani, Nila J Dharan, Edward M Gardner, Robert L Gottlieb, Marie Helleberg, Helene C Highbarger, Thomas L Holland, Christian Kjer Heerfordt, Susana Lazarte, Lindsey M Leither, Joseph Lutaakome, Magdalena Ardelt, Eleftherios Mylonakis, Sean W X Ong, Jeffrey Scott Overcash, Hassan Taha, Phyllis C Tien, Barbara W Trautner, David Vallee, Amy C Weintrob, Giota Touloumi, Abdel G Babiker, STRIVE ACTIV-3/TICO Study Group

“…Within each trial, three major outcomes (sustained recovery, mortality, and a composite safety outcome) were compared between treatment and placebo using Fine-Gray and Cox proportional hazards models. …”
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Association Between Size of Left Ventricle and Long‐Term Cardiovascular Events by Yun‐Jiu Cheng, Zi‐Li Liao, Li‐Juan Liu, Yue‐Dong Ma, Xu‐Miao Chen, Ze‐Xuan Wu, Hui‐Qiang Wei, Wei‐Dong Lin, Yi‐Jian Liao, Su‐Hua Wu, Yu‐Mei Xue, Li‐Chun Wang, Yang Wu

“…Cox proportional hazards models were applied to evaluate the association between LV size and composite cardiovascular outcomes. …”
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Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation by Agnieszka Prytula, Rukshana Shroff, Ineke van Gremberghe, Kai Krupka, Justine Bacchetta, Elisa Benetti, Ryszard Grenda, Isabella Guzzo, Nele Kanzelmeyer, Bahar Büyükkaragöz, Birgitta Kranz, Hülya Nalçacıoğlu, Jun Oh, Lars Pape, Mohan Shenoy, Anne-Laure Sellier-Leclerc, Burkhard Tönshoff, Gema Ariceta, Atif Awan, Sevcan Bakkaloğlu, Marjolein Bonthuis, Charlotte Bootsma Robroeks, Antonia Bouts, Martin Christian, Marlies Cornelissen, Ali Duzova, Nasrin Esfandiar, Luciana Ghio, Ryszard Grenda, Isabella Guzzo, Maria Herrero Goni, Julien Hogan, Nattaphorn Hongsawong, Nele Kanzelmeyer, Aysun Karabay Bayazit, Gülşah Kaya Aksoy, Noel Knops, Linda Koster Kamphuis, Daniella Levy Erez, Victor Lopez-Baez, Alvaro Madrid, Stephen Marks, Anette Melk, Luisa Murer, Lars Pape, Licia Peruzzi, Edita Petrosyan, Evgenia Preka, Nikoleta Printza, Andreea Liana Rachisan, Ann Raes, Mohan Shenoy, Oguz Soylemezoglu, Luca Dello Strologo, Ana Teixeira, Rezan Topaloglu, Markus Weitz, Jakub Zieg, Galia Zlatanova, Christian Patry, Jerome Harambat, Ayşe Ağbaş, Varvara Askiti, Marina Avramescu, Justine Bacchetta, Sevcan Bakkaloglu, Marjolein Bontuis, Caroline Booth, Laurene Dehoux, Giacomo Dizazzo, Dorota Drozdz, Ismail Dursun, Michaela Gessner, Jaap Groothoff, Giuliana Guido, Isabella Guzzo, Aysun Karabay Bayazit, Guenter Klaus, Linda Koster-Kamphuis, Alexander Lalayiannis, Maren Leifheit-Nestler, Sinha Manish, Chiara Matteucci, Jun Oh, Ozan Ozkaya, Edita Petrosyan, Christine Pietrement, Agnieszka Prytula, George Reusz, Franz Schaefer, Claus Peter Schmitt, Anne Schön, Fatma Lale Sever, Stella Stabouli, Serra Sürmeli Döven, Camilla Tondel, Enrico Verrina, Enrico Vidal, Dean Wallace, Zainab Arslan, M. Bald, H. Fehrenbach, D. Haffner, M. Hansen, C. Hempel, U. John, G. Klaus, J. König, B. Lange-Sperandio, D. Müller, J. Oh, L. Pape, M. Pohl, K. Sauerstein, G. Schalk, H. Staude, P. Strotmann, L.T. Weber, M. Weitz, L. Berta, K. Heindl-Rusai

“…Introduction: We investigated the relationship between metabolic acidosis over time and allograft outcome in pediatric kidney transplantation (KTx). Methods: This registry study collected data up to 10 years posttransplant. …”
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Predictive Validity of Hospital-Associated Complications of Older People Identified Using Diagnosis Procedure Combination Data From an Acute Care Hospital in Japan: Observational S... by Seigo Mitsutake, Tatsuro Ishizaki, Shohei Yano, Takumi Hirata, Kae Ito, Ko Furuta, Yoshitomo Shimazaki, Hideki Ito, Alison Mudge, Kenji Toba

“…Generalized linear regression models were used to examine the associations between HAC-OP-DPC and LOS, and logistic regression models were used to examine the associations between HAC-OP-DPC and discharge to other hospitals and long-term care facilities (LTCFs). …”
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The bidirectional relationship between severity of obsessive-compulsive symptoms and lifestyle factors in patients with obsessive-compulsive disorder: a contemporaneous and prospec... by Johanna A. M. du Mortier, Anton J. L. M. van Balkom, Anton J. L. M. van Balkom, Jos W. R. Twisk, Patricia van Oppen, Patricia van Oppen, Henny A. D. Visser, Henny A. D. Visser

“…This study examines both the contemporaneous and two-year prospective relationships between lifestyle factors and OCD symptom severity, as well as the reverse relationship—namely, the influence of OCD severity on lifestyle factors.MethodsLongitudinal data spanning six consecutive years were obtained from the Netherlands Obsessive Compulsive Disorder Association study (NOCDA). …”
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Impact of Medical Conditions and Area Deprivation on Fundraising Success in Online Crowdfunding: Cross-Sectional Study by Steven S Doerstling, Matthew M Engelhard, Dennis Akrobetu, Caroline E Sloan, Ada Campagna, Thuy-Vi Nguyen, Farrah Madanay, Felicia Chen, Peter A Ubel

“…Last, we sought to understand the effect of these features on donation behavior in terms of number of donations and donation amount. MethodsWeb scraping was used to collect medical crowdfunding campaigns on GoFundMe that were based in the United States and created between 2010 and 2020. …”
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Impact of systemic immune inflammation index and systemic inflammation response index on all-cause and cardiovascular mortality in cardiovascular-kidney-metabolic syndrome by Yongwei Huang, Xiaoshuang Yin, Zongping Li

“…This study seeks to address the associations between SII/SIRI and death outcomes in individuals with CKM syndrome using outcomes from the National Health and Nutrition Examination Survey (NHANES, 1999–2018). Methods This cross-sectional investigation comprised 18,452 individuals (≥ 20 years) with CKM syndrome, utilizing outcomes from ten cycles of NHANES (1999–2018). …”
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Comparative cardiovascular outcomes of aripiprazole vs. risperidone in patients with type 2 diabetes and schizophrenia: a retrospective cohort study by Yi-Ting Yeh, Shih-Chang Lo, Chien-Ning Huang, Chien-Ning Huang, Chien-Ning Huang, Yi-Sun Yang, Yi-Sun Yang, Pei-Lun Liao, Edy Kornelius, Edy Kornelius

“…We aimed to compare major adverse cardiovascular events (MACEs) in patients with co-occurring T2DM and schizophrenia treated with aripiprazole versus risperidone.MethodsWe conducted a multi-center retrospective cohort study within the TriNetX US Collaborative Network (2014–2024). …”
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4-D ERT monitoring of oil spill contamination dynamics and remediation planning in southern Nigeria by Stanley Uchechukwu Eze, Difference Odeyovwi Ogagarue, Juyeon Jeong, Myung Jin Nam, Omafume M. Orji, Williams N. Ofuyah

“…The results obtained from the geophysical and geochemical methods showed a strong correlation and have been validated as efficacious tools for environmental monitoring and pollution assessment at contaminated sites. …”
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Remnant cholesterol inflammatory index, calculated from residual cholesterol to C-reactive protein ratio, and stroke outcomes: a retrospective study using the National institutes o... by Yanmei Yu, Yiming Zhang, Chunyan Zhu, Tingting Duan, Zichen Rao

“…This research sought to examine the predictive value of RCII and RC in estimating extent of neurological impairment, assessed using the National Institutes of Health Stroke Scale (NIHSS), and functional recovery, evaluated using the three-month modified Rankin Scale (mRS), among individuals diagnosed with AIS. Methods The study enrolled 775 individuals diagnosed with AIS. …”
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