RNA mis‐splicing in children with congenital myotonic dystrophy is associated with physical function by Julia M. Hartman, Kobe Ikegami, Marina Provenzano, Kameron Bates, Amanda Butler, Aileen S. Jones, Kiera N. Berggren, Jeanne Dekdebrun, Marnee J. McKay, Jennifer N. Baldwin, Kayla M. D. Cornett, Joshua Burns, Michael Kiefer, Nicholas E. Johnson, Melissa A. Hale, the DMCRN Consortium

“…However, the association between RNA mis‐splicing and physical function in children with the most severe form of disease, congenital myotonic dystrophy (CDM), is unknown. Methods Eighty‐two participants (42 adults with DM1 and 40 children with CDM) with muscle biopsies and measures of myotonia, motor function, and strength were combined from five observational studies. …”
Get full text

Like mother like daughter, the role of low human capital in intergenerational cycles of disadvantage: the Pune Maternal Nutrition Study by Akanksha A. Marphatia, Akanksha A. Marphatia, Jonathan C. K. Wells, Alice M. Reid, Aboli Bhalerao, Chittaranjan S. Yajnik

“…Few studies have evaluated whether maternal human and socio-economic capital at conception are independently associated with maternal and offspring outcomes.MethodsUsing data on 651 mother-child dyads from the prospective Pune Maternal Nutrition Study in rural India, composite markers were generated of “maternal human capital” using maternal marriage age and maternal and husband's education, and 'socio-economic capital' using household wealth and caste. …”
Get full text

Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the... by Jing Cheng, Qi Cheng, Yingting Wu, Jiashun Yin, Fei He

“…We aimed to evaluate associations between TyG-BMI and all-cause mortality at multiple time points in this high-risk cohort. Methods This retrospective cohort study analyzed 4,523 elderly patients (aged >65 years) with severe HF and T2DM from the MIMIC-IV database. …”
Get full text

Drivers of onward HIV transmission risk among adolescent boys growing up with HIV: a longitudinal cohort study by Avy Violari, Xiaoyue Zhang, Rachel Kidman, Janan Janine Dietrich, Stefanie Vermaak, Candice W Ramsammy, Phumla Madi, Given Leshabane

“…Associations between baseline factors and high transmission risk (a composite of detectable viral load and any reported non-condom use) were analysed using logistic regression models. …”
Get full text

Brain working memory network indices as landmarks of intelligence by Mohammadreza Khodaei, Paul J. Laurienti, Dale Dagenbach, Sean L. Simpson

“…However, most network studies of intelligence have used univariate methods to investigate topological network measures, with their focus limited to a few measures. …”
Get full text

Variation in Venous Thromboembolism Outcomes Based on Primary Cancer Site by Javier Trujillo-Santos, MD, PhD, Cihan Ay, MD, PhD, Behnood Bikdeli, MD, MS, David Jiménez, MD, PhD, Aurora Villalobos, MD, PhD, Luciano López-Jiménez, MD, Montserrat Pérez-Pinar, MD, Javier Pagán-Escribano, MD, PhD, Maurizio Ciammaichella, MD, Manuel Monreal, MD, PhD

“…Methods: We analyzed 18,660 patients with active cancer and VTE and 88,162 without cancer in the RIETE (Registro Informatizado de la Enfermedad Tromboembólica) registry. …”
Get full text

Socioeconomic factors and test preparation strategies are related to success on the USMLE Step 2 clinical knowledge (CK) exam: a single-institution study by Hila Ghersin, Michelle C. Gulfo, Bailey A. Frohlich, Scott M. Wilson, Ashley A. Berlot, Janice S. Zhang, Rohan Kankaria, Ashley Radparvar, Juan Lin, Michelle A. Blackmore, Amanda C. Raff

“…In this study, we investigated predictors of Step 2 CK success across two years at one institution. Methods A survey regarding Step 2 CK exam preparation and demographic factors was administered to two student cohorts at a New York medical school in 2022 and 2023. …”
Get full text

Nutritional status and systemic inflammation in COPD: prognostic value of the advanced lung cancer inflammation index by Jun Yao, Peng Wu, Zhishu Li, Lingyan Zhao, Ziqiao Fu, Ping Shi, Xiaomin Xiong, Xuping Chen, Bin Yu, Yan He, Tong Feng, Jia Zeng, Ran Duan, Ran Duan

“…The Advanced Lung Cancer Inflammation Index (ALI), which integrates nutritional status and systemic inflammation, may offer potential prognostic value in COPD management.ObjectivesThis study aimed to evaluate the relationship between ALI and mortality outcomes in COPD patients, with a specific focus on the interplay between nutrition, inflammation, and their non-linear associations with all-cause and cardiovascular mortality.MethodsData were derived from the NHANES (1999–2018) cohort, comprising 47,880 participants, including 1,960 COPD patients. …”
Get full text

Predicting Transvaginal Surgical Mesh Exposure Outcomes Using an Integrated Dataset of Blood Cytokine Levels and Medical Record Data: Machine Learning Approach by Mihyun Lim Waugh, Tyler Mills, Nicholas Boltin, Lauren Wolf, Patti Parker, Ronnie Horner, Thomas L Wheeler II, Richard L Goodwin, Melissa A Moss

“…ConclusionsSupervised machine learning models demonstrated improved prediction accuracy when trained using a composite dataset that combined patient medical record data and biomaterial-induced blood cytokine levels, surpassing the performance of models trained with either dataset in isolation. …”
Get full text

Interplay between worsening kidney function and cardiovascular events in patients with type 2 diabetes: an analysis from the ACCORD trial by João Pedro Ferreira, Patrick Rossignol, Faiez Zannad, Abhinav Sharma, Diana Ferrao, Francisco Vasques-Novoa, Adelino Leite-Moreira

“…We have used a large population of patients with T2D and a high cardiovascular risk enrolled in the Action to Control Cardiovascular Risk in Diabetes Study.Research design and methods Time-updated, joint, and multistate modeling were used. …”
Get full text

Relationship between kidney function and healthy life expectancy: A historical cohort study by Hisayuki Ogura, Tadashi Toyama, Hikaru Samuta, Kohei Hirako, Tomoya Itatani, Shiori Nakagawa, Megumi Oshima, Shinji Kitajima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Tomoyuki Takura, Takashi Wada, Yasunori Iwata

“…The primary endpoint was a composite of becoming a care level ≥ 2 or death. Multivariable Cox proportional hazards models were used to calculate the risk regarding time to the primary endpoint. …”
Get full text

Associations of frailty and cognitive impairment with all-cause and cardiovascular mortality in older adults: a prospective cohort study from NHANES 2011–2014 by An-Bang Liu, Yan-Xia Lin, Guan-Ying Li, Ting-Ting Meng, Peng Tian, Jian-Lin Chen, Xin-He Zhang, Wei-Hong Xu, Yu Zhang, Dan Zhang, Yan Zheng

“…This study aims to explore how frailty and psychometric mild cognitive impairment (pMCI) jointly affect all-cause and cardiovascular disease (CVD) mortality. Methods The cohort study we examined 2,442 participants aged ≥ 60, is the secondary analysis from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. …”
Get full text

Reduced sensitivity to thyroid hormones is associated with differentiated thyroid cancer in the euthyroid thyroidectomy population by Huaijin Xu, Huaijin Xu, Hongzhou Liu, Xiaodong Hu, Xiaomeng Jia, Zhe Xue, Anning Wang, Shaoyang Kang, Shaoyang Kang, Zhaohui Lyu, Zhaohui Lyu

“…BackgroundThe inconclusive associations between thyroid-related hormones and differentiated thyroid cancer (DTC) suggest complex pathophysiologic processes, for which thyroid hormone sensitivity may provide new insights.MethodsWe retrospectively analyzed preoperative clinical data and postoperative pathological data of 9,515 euthyroid adults who underwent thyroidectomy for thyroid nodules pathologically confirmed as benign nodules or DTC. …”
Get full text

Intraoperative hemodynamics in prediction of postoperative kidney injury after type a aortic dissection surgery: a retrospective cohort study by Lihai Chen, Yi Cheng, Xinyi Bu, Chen Zhang, Jie Sun, Xuesheng Liu, Siyu Kong, Yali Ge, Hongwei Shi, Jifang Zhou

“…This study investigated whether intraoperative hypotension and venous congestion are important predictors of postoperative kidney injury and major adverse events.Methods We retrospectively analyzed 543 adults undergoing TAAD surgery (2016–2023). …”
Get full text

Physical activity and mortality in the general population with and without major depression by Vagner Deuel de O. Tavares, Jeanne V. A. Williams, Vandad Sharifi, Andrew Bulloch, Gina Dimitropoulos, Nicole Leite Galvão-Coelho, Scott Patten

“…The aim of this study was to estimate the association of PA with mortality in major depressive disorder (MDD). Methods: We used data from the Canadian Community Health Survey—Mental Health and Well-Being (CCHS 2002), conducted in 2002 (n = 31,200), and the Canadian Community Health Survey—Mental Health (CCHS-MH 2012), conducted in 2012 (n = 20,935), for this analysis. …”
Get full text

A comprehensive review of silicon anodes for high-energy lithium-ion batteries: Challenges, latest developments, and perspectives by Ebrahim Feyzi, Anil Kumar M R, Xia Li, Sixu Deng, Jagjit Nanda, Karim Zaghib

“…Furthermore, the review discusses innovative solutions to address these challenges, such as utilizing novel binders, electrolyte additives, structural, interfacial, composite engineering techniques, and prelithiation methods. …”
Get full text

Healthy lifestyle factors and combined macrovascular and microvascular events in diabetes patients with high cardiovascular risk: results from ADVANCE by Shoujiang You, Danni Zheng, Yanan Wang, Qiang Li, Tu N. Nguyen, Ruth Peters, Xiaoying Chen, Xia Wang, Yongjun Cao, Diederick E. Grobbee, Stephen Harrap, Giuseppe Mancia, Bryan Williams, Neil R. Poulter, Liu Lisheng, Michel Marre, Pavel Hamet, Craig S. Anderson, Mark Woodward, John Chalmers, Katie Harris

“…Multivariable Cox models were used to determine associations of 0, 1, 2, and ≥ 3 HLFs with vascular events and all-cause mortality. …”
Get full text

The temporal onset of associations of cortical proteins with cognitive resilience vary during late life by Andrea R. Zammit, Tianhao Wang, Lei Yu, Shahram Oveisgharan, Vladislav A. Petyuk, Philip L. De Jager, Julie A. Schneider, David A. Bennett, Aron S. Buchman

“…Cognition was assessed using a composite derived from 19 tests. We first used linear mixed-effects models to identify cortical proteins associated with cognitive resilience. …”
Get full text

Land use change has profoundly altered the process of bacterial community assembly in the northeastern black soil zone by Ning Sun, Xu Zhao, Xu Zhao, Fangyuan Liu, Fangyuan Liu, Ge Song, Mengmeng Zhang, Fuqiang Song

“…This study aims to investigate the effects of these practices on soil bacterial communities in the Northeast China Black Soil Region.MethodsWe utilized high-throughput sequencing to compare soil bacterial community characteristics between undisturbed grasslands (CK) and reclaimed croplands (F). …”
Get full text

Sex Differences in the Association Between Lipoprotein(a) and Cardiovascular Outcomes: The MGB Lp(a) Registry by Gurleen Kaur, Adam N. Berman, David W. Biery, Stephanie A. Besser, Wanda Y. Wu, Brittany Weber, Michael C. Honigberg, Khurram Nasir, Martha Gulati, Marcelo F. Di Carli, Leslee J. Shaw, Deepak L. Bhatt, Ron Blankstein

“…Background Sex‐based differences in the association of lipoprotein(a) with cardiovascular outcomes have not been well established for those without prior atherosclerotic cardiovascular disease. Methods and Results Patients with no baseline atherosclerotic cardiovascular disease were identified in the MGB (Mass General Brigham) Lp(a) Registry, a retrospective cohort of patients who had lipoprotein(a) measured from 2000 to 2019. …”
Get full text