Acceptability of a 250 mg levofloxacin formulation in children receiving TB preventive treatment by S.E. Purchase, J. Brigden, J.A. Seddon, N.A. Martinson, L. Fairlie, S. Staples, A. Poswa, T. Duong, H.S. Schaaf, A.C. Hesseling

“…Despite the need for pediatric formulations, the 250 mg adult LFX formulation is affordable and widely used for TB treatment and prevention in children. METHODS: TB-CHAMP (Tuberculosis Child Multidrug-resistant Preventive Therapy ISRCTN92634082) was a trial of MDR-TB preventive treatment, comparing levofloxacin to placebo in children with MDR-TB exposure. …”
Get full text

From fragmented to integrated: Advancing surface water quality assessment through WQPI in the upper Medjerda River, Northeastern Algeria by Benacherine Mostefa, Lyazid Mohamed Nadjib, Allaoua Noua, Soualah Alila Hana, Satour Abd El Latif, Chouiter Norhane, Debassi Bouchra, Zineb Chetouh, Md Galal Uddin

“…In this study, we evaluated the surface water quality of the upper Medjerda River in northeastern Algeria by integrating traditional indices, the Organic Pollution Index (OPI) and the Weighted Arithmetic Water Quality Index (WA_WQI), with advanced multivariate analyses including Principal Component Analysis (PCA) and Generalized Linear Models (GLMs). To overcome the limitations of conventional methods, we developed a new composite metric, the Water Quality Pollution Index (WQPI), synthesizing both general physicochemical conditions and organic pollution. …”
Get full text

Tocilizumab modulates the activity of the classical and alternative complement pathways in rheumatoid arthritis patients by Iván Ferraz-Amaro, Iván Ferraz-Amaro, Sergio Santos-Concepción, Javier Castro-Hernández, Maria Vanesa Hernández-Hernández, Beatriz Tejera Segura, Cristina Luna, Esmeralda Delgado-Frias, Federico Díaz-González, Federico Díaz-González, Federico Díaz-González

“…The complement system has been implicated in the etiopathogenesis of RA.ObjectiveTo evaluate the effect of systemic IL-6 inhibition on complement pathways functional activity in RA patients treated with TCZ.DesingProspective non-interventional study.MethodsTwenty-seven RA patients included in the TOCRIVAR study who received TCZ (8mg/kg IV/q4w) were evaluated at baseline and at weeks 12, 24 and 52 of treatment. …”
Get full text

Social Vulnerability and Long‐Term Cardiovascular Outcomes After COVID‐19 Hospitalization: An Analysis of the American Heart Association COVID‐19 Registry Linked With Medicare Clai... by Reza Fakhraei, Yang Song, Dhruv S. Kazi, Rishi K. Wadhera, James A. de Lemos, Sandeep R. Das, David A. Morrow, Issa J. Dahabreh, Christine M. Rutan, Kathie Thomas, Robert W. Yeh

“…We evaluated the association between social vulnerability and a composite of myocardial infarction, stroke, heart failure, venous thromboembolism, cardiogenic shock, cardiac arrest, and death, following discharge, using Cox regression models. …”
Get full text

Prognostic Value of Biomarkers in Cancer Patients Treated With Immune Checkpoint Inhibitor Therapy by Christopher Mann, MD, Ulrike Pailer, MSc, Andreas Spannbauer, MD, Fardin Hamidi, MD, Aliza Veronika Braser, Martin Hülsmann, MD, Christian Gerges, MD, PhD, Michael Gottsauner-Wolf, MD, Mariann Gyöngyösi, MD, Markus Raderer, MD, Martin Riesenhuber, MD, PhD, Christian Hengstenberg, MD, Jutta Bergler-Klein, MD, Thomas A. Zelniker, MD, MSc

“…The primary outcome of interest was the composite of acute cardiovascular hospitalization heart failure or death. …”
Get full text

Burden of Coronary Artery Disease as a Predictor of New Vascular Events and Mortality in Patients With Ischemic Stroke: Insights From the Norwegian Stroke in the Young Study by Khuluud Abdi Jibril, Kier Jan Kuiper, Beenish Nawaz, Halvor Naess, Annette Fromm, Halvor Øygarden, Kristin Modalsli Sand, Rudy Meijer, Abukar Mohamed Ali, Terje H. Larsen, Øyvind Bleie, Elisabeth Skaar, Ulrike Waje‐Andreassen, Sahrai Saeed

“…In the multivariable Cox regression models, CAD was a strong and independent predictor of all‐cause mortality (hazard ratio [HR], 2.20 [95% CI, 1.05–4.60]; P=0.037) and the composite end point of death or recurrent ischemic stroke (HR, 3.24 [95% CI, 1.46–7.20]; P=0.004). …”
Get full text

TreatmENT of AnastomotiC LeakagE after colon cancer resection: the TENTACLE – Colon study by Jobbe M. G. Lemmens, Sander Ubels, Nynke G. Greijdanus, Kiedo Wienholts, Marleen M. H. J. van Gelder, Albert Wolthuis, Jérémie H. Lefevre, Kilian Brown, Matteo Frasson, Nicolas Rotholtz, Quentin Denost, Rodrigo O. Perez, Tsuyoshi Konishi, Martin Rutegård, Susan L. Gearhart, Thomas Pinkney, Muhammed Elhadi, Roel Hompes, Pieter J. Tanis, Johannes H. W. de Wilt

“…Methods The TENTACLE – Colon is an international multicentre retrospective cohort study. …”
Get full text

Heterogeneous Effects of Intensive Glycemic and Blood Pressure on Cardiovascular Events Among Diabetes by Living Arrangements by Kanta Kiyohara, Naoki Kondo, Taku Iwami, Yuichiro Yano, Akira Nishiyama, Koichi Node, Nobuya Inagaki, O. Kenrik Duru, Kosuke Inoue

“…Cox proportional hazard models were used to estimate the joint effect of intensive glycemic and BP control on the composite cardiovascular outcome according to living arrangements. …”
Get full text

Eco-friendly synthesis of ZnO, CuO, and ZnO/CuO nanoparticles using extract of spent Pleurotus ostreatus substrate, and their antioxidant and anticancer activities by Simangele Ngwenya, Nkanyiso J. Sithole, Khosi Ramachela, Doctor M. N. Mthiyane, Mulunda Mwanza, Moganavelli Singh, Damian C. Onwudiwe

Get full text

Pro-C-Type Natriuretic Peptide in Women With Angina Pectoris and No Obstructive Coronary Artery Disease by Peter D. Mark, MD, PhD, Jakob Schroder, MD, Andreas K. Jensen, MD, Timothy C.R. Prickett, PhD, Eva Prescott, MD, DMSc, Jens P. Goetze, MD, DMSc

“…Follow-up analyses included all-cause death and a composite endpoint of cardiovascular events, where we calculated HR estimates from crude and adjusted (age, creatinine) Cox proportional hazards models. …”
Get full text

Sex-stratified analysis of marketing exposure and current e-cigarette use among Saudi adolescents by Najim Z. Alshahrani, Abdullah M. Alarifi, Mohammed R. Algethami, Mohammed A. Aljunaid, Ahmed K. Shukri, Mohannad A. Alzain

“…This study examined the association between exposure to e-cigarette marketing and current use among Saudi adolescents using nationally representative data.MethodsWe analysed cross-sectional data from the 2022 Global Youth Tobacco Survey (GYTS) in Saudi Arabia, a nationally representative, school-based survey of adolescents aged 13–15 years. …”
Get full text

Gut microbiome predictors of advanced therapy response in Crohn’s disease: protocol for the OPTIMIST prospective, longitudinal, observational pilot study in Canada by Greg Rosenfeld, Susanna Meade, Yvette Leung, Astrid-Jane Williams, Gurpreet Kaur, Brian Bressler, Cristian Aldo Massaro, Fanny Laure Lemarié, Genelle Lunken

“…The aim of the Optimising IBD Patient Treatment with Integrated Microbiome Investigation for Specialised Therapeutics (OPTIMIST) study is to evaluate microbiome profiles across various sample types in a Canadian CD cohort starting or already on advanced therapy, with the goal of developing predictive models for personalised therapeutics.Methods and analysis This study is a two-phase, longitudinal, prospective observational pilot study conducted in British Columbia, Canada, involving both CD patients and non-IBD controls. …”
Get full text

Agreement between CES-D and CIDI-SF scales of depression among older adults: a cross-sectional comparative study based on the longitudinal aging study in India, 2017-19 by T. Muhammad, Soomi Lee, Manish Kumar, T. V. Sekher, Mathew Varghese

“…Methods Data came from the first wave of the Longitudinal Aging Study in India (LASI) which was conducted during 2017-19. …”
Get full text

Fibrinogen-to-Albumin Ratio as a Novel Predictor of Intracerebral Hemorrhage in Maintenance Hemodialysis Patients by He X, Wang Y, Wang Y, Li X

“…The fibrinogen-to-albumin ratio (FAR), a composite inflammatory and nutritional marker, may offer predictive value for ICH in this high-risk population.Methods: This retrospective study analyzed a total of 536 MHD patients (ICH group: n=207; non-ICH group: n=329) from June 2019 to June 2024. …”
Get full text

Association between cardiometabolic index and coronary artery calcification in young and middle-aged adults with coronary heart disease by Xi Wu, Mingxing Wu, Haobo Huang, Zhe Liu, He Huang, Lei Wang

“…Nevertheless, the relationship between CMI and CAC in young and middle-aged individuals diagnosed with coronary heart disease (CHD) remains insufficiently explored. Methods This retrospective analysis included CHD patients aged 18–59 years who were admitted to the hospital and underwent coronary computed tomography angiography (CTA) between January 2018 and August 2022. …”
Get full text

Investigation of the effects of different denture base fabrication techniques and hard relining resin materials on the fixation of immediate provisional hybrid prosthesis to titani... by Burcu Kanat-Ertürk, Cansu Akarsu, Önjen Tak

“…Then, titanium cylinders (Opus Implant) were fixed to the specimens using five hard relining resin materials: acrylic resin-based (Ufi Gel Hard)(UGH), heat-polymerized acrylic resin (Futura Basic Hot)(FBH), autopolymerizing composite resin (Quick Up)(QP), autopolymerizing denture repair resin based on diacrylate (Qu-resin)(QR), and autopolymerizing low shrinkage modelling acrylic resin (Pattern resin LS)(PR) (n = 7). …”
Get full text

Interplay of education and community norms in justifying intimate partner violence among ever-married women aged 15–49 years in Bangladesh: a cross-sectional study by Mohammad Hridoy Patwary, Sumaiya Nusrat Esha

“…This study examines the interplay between education and community norms in shaping the attitudes toward IPV among ever-married women aged 15 to 49 in Bangladesh. Methods This study utilized data from the 2022 Bangladesh Demographic and Health Survey (BDHS). …”
Get full text

Impact of Pulmonary Hypertension and Patent Ductus Arteriosus in Preterm Infants with Presumed Pulmonary Hypoplasia by Sol Kim, Yumi Seo, Moon-Yeon Oh, Min Soo Kim, Sook Kyung Yum

“…The aim of this study is to evaluate whether the two factors representing pulmonary circulation provide different contributions to respiratory outcomes in preterm infants with and without pulmonary hypoplasia. <b>Methods</b>: The medical records of preterm very low birth weight (VLBW) infants admitted to our unit during the study period from January 2013 to December 2020 were retrospectively reviewed. …”
Get full text

Risk of complications in the late vs early days of the 42nd week of pregnancy: A nationwide cohort study by Charlotte Brix Andersson, Jesper Padkaer Petersen, Søren Paaske Johnsen, Martin Jensen, Ulrik Schiøler Kesmodel

“…To address this issue, this study aimed to compare the risk of neonatal morbidity and pregnancy‐ and birth‐related complications between gestational age (GA) 41+4–42+0 and GA 41+0–41+3 weeks. Material and methods This nationwide registry‐based cohort study included singleton births without major congenital malformations, with registered GA, and with intended vaginal delivery at GA 41+0– 42+0 weeks between 2009 and 2018 in Denmark. …”
Get full text

Combined healthy lifestyles and overactive bladder: a cross-sectional study of NHANES 2007–2020 by Tianjie Li, Tianjie Li, Jian Hou, Bo Xiao, Jianxing Li, Xiaodong Liu

“…This study aimed to investigate the association between a composite healthy lifestyle score and risk of OAB in a nationally representative sample of adults.MethodsThis cross-sectional study utilized data from 20,195 non-pregnant adults aged 20–79 years in the National Health and Nutrition Examination Survey (NHANES) 2007–2020. …”
Get full text