Oxidative balance score and mortality: mediating role of insulin resistance across age strata in the NHANES cohort by Lin Zhang, Lin Zhang, Heming Zhang, Heming Zhang, Hongxia Xiang, Jiachen Zhang, Wei Gong, Junjie Xv, Xue Yu

“…BackgroundThis study examined the association between oxidative balance score (OBS), a composite measure of oxidative/antioxidative factors, and mortality, while investigating insulin resistance (IR) indices as potential mediators using a nationally representative cohort.MethodsA cohort of 11,849 U. …”
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Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome by Worawan B. Limpitikul, Michael G. Silverman, Nedyalka Valkov, Jeong-Gun Park, Ashish Yeri, Fernando Camacho Garcia, Guoping Li, Priyanka Gokulnath, Marta Garcia-Contreras, Eric Alsop, Elizabeth Hutchins, Michail Spanos, Claire Lin, Kriti Bomb, Anthony Rosenzweig, Raymond Kwong, Kendall van-Keuren Jensen, James L. Januzzi, Jr., Ravi Shah, David A. Morrow, Marc S. Sabatine, Saumya Das

“…Associations between each miRNA and the composite endpoint of hospitalization for HF or cardiovascular death (HHF/CVD) were estimated in Cox proportional hazards models. …”
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Clinical and demographic factors modify the association between plasma phosphorylated tau‐181 and cognition by Corey J. Bolton, Marilyn Steinbach, Omair A. Khan, Dandan Liu, Julia O'Malley, Logan Dumitrescu, Amalia Peterson, Angela L. Jefferson, Timothy J. Hohman, Henrik Zetterberg, Katherine A. Gifford, for the Alzheimer's Disease Neuroimaging Initiative

“…Linear regression models related plasma p‐tau181 to neuropsychological composite and SCD scores with follow‐up models examining plasma p‐tau181 interactions with cognitive diagnosis, apolipoprotein E (APOE) ε4 carrier status, age, and sex on cognitive outcomes. …”
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Associations of Sarcopenia and Its Components With Cardiovascular Risk: Five‐Year Longitudinal Evidence From China Health and Retirement Longitudinal Study by Yang Chen, Ziyi Zhong, Konstantinos Prokopidis, Ying Gue, Garry McDowell, Yang Liu, Coleen Ditchfield, Muath Alobaida, Bi Huang, Gregory Y. H. Lip

“…The primary outcome was composite CVD, comprising heart disease and stroke. …”
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Continuation vs Withdrawal of Beta-Blockers and Outcomes After Myocardial Infarction With Preserved Left Ventricular Function by Michael H. Chiu, MD, MSc, Yuan Dong, MSc, Nowell Fine, MD, SM, Finlay A. McAlister, MD, MSc, Tolulope Sajobi, MSc, PhD, Danielle A. Southern, MSc, Erik Youngson, MMath, Sean van Diepen, MD, MSc, Matthew T. James, MD, PhD, Stephen B. Wilton, MD, MSc

“…Secondary outcomes were each of the components of the composite. Cox proportional hazard models were used to evaluate the association between early BB discontinuation and outcomes. …”
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Applying evidence-based cross-disciplinary concepts helps to explain the heterogeneity in pain, function, and biological measures in individuals with knee pain with/at risk of oste... by Angela M. Mickle, Jared J. Tanner, Udell Holmes, III, Ahmed Rashid, Olivier Barolette, Brittany Addison, Nicola Sambuco, Cynthia Garvan, Song Lai, Christoph Seubert, Siegfried Schmidt, Roland Staud, Jeffrey C. Edberg, David Redden, Burel R. Goodin, Catherine C. Price, Roger B. Fillingim, Kimberly T. Sibille

“…We investigate group differences based on dispositional traits and poverty status, specific to (1) pain intensity and functional limitations and (2) biological measures, a clinical composite and brain age. Methods:. Adults aged 45 to 85 years with knee pain associated with chronic musculoskeletal pain provided information on demographics, socioeconomic and psychosocial factors, pain, and physical function. …”
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Effects of proinflammatory cytokines and programmed cell death on cognitive domains in older age patients with bipolar disorder by Pei-Ying Lee, Chih Chiang Chiu, Po-Hsiu Kuo, Cho-Yin Huang, Shang-Ying Tsai, Chian-Jue Kuo, Wen-Yin Chen

“…Aim of this study is to investigate proinflammatory cytokines and the PD pathway in OABD, for their correlation with clinical features and neuroaxonal integrity, and the impact on cognitive domains. Methods Eighty-seven euthymic OABD patients were assessed using the Brief Assessment of Cognition in Affective Disorders. …”
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Metabolic Signatures of Blood Pressure and Risk of Cardiovascular Diseases by Maria Manou, Christos Papagiannopoulos, Christos V. Chalitsios, Alexandros‐Georgios Asimakopoulos, Georgios Markozannes, Monica Bulló, Konstantinos K. Tsilidis, Christopher Papandreou, Ioanna Tzoulaki

“…We further assessed the associations between BP metabolic signatures and incident composite CVD (N=6742), myocardial infarction (N=4192), and stroke (N=2757) in the UK Biobank, using multivariable Cox regression models. …”
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Prognostic Implications of Guideline-Directed Medical Therapy for Heart Failure in Functional Mitral Regurgitation: A Systematic Review and Meta-Analysis by Vasileios Anastasiou, Andreas S. Papazoglou, Stylianos Daios, Dimitrios V. Moysidis, Eirinaios Tsiartas, Matthaios Didagelos, Kyriakos Dimitriadis, Theodoros Karamitsos, George Giannakoulas, Konstantinos Tsioufis, Antonios Ziakas, Vasileios Kamperidis

“…The use of RASi and BB was associated with a significantly lower risk of all-cause mortality (HR 0.52 [0.39–0.68]; <i>p</i> < 0.00001, I² = 62% and HR 0.62 [0.49–0.77]; <i>p</i> < 0.0001, I² = 44%, respectively) and the composite outcome (HR 0.54 [0.44–0.67]; <i>p</i> < 0.00001, I² = 33% and HR 0.62 [0.52–0.75], <i>p</i> < 0.00001, I² = 35%, respectively) in unadjusted models. …”
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Early childhood undernutrition, preadolescent physical growth, and cognitive achievement in India: A population-based cohort study. by Apurv Soni, Nisha Fahey, Zulfiqar A Bhutta, Wenjun Li, Jean A Frazier, Tiffany Moore Simas, Somashekhar M Nimbalkar, Jeroan J Allison

“…Primary exposure was assessed using the Composite Index of Anthropometric Failure (CIAF) based on 2004 to 2005 survey. …”
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Retrospective cohort study of the association between maternal employment precarity and infant low birth weight in women in the USA by Anjum Hajat, Divya Patil, Daniel A Enquobahrie, Trevor Peckham, Noah Seixas

“…Objectives To investigate the association between maternal employment precarity and infant low birth weight (LBW), and to assess if this association differs by race/ethnicity.Methods Data were collected from 2871 women enrolled in the National Longitudinal Survey of Youth 1979 and the National Longitudinal Survey of Youth 1979 Children and Young Adult Cohort. …”
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Socioeconomic and racial-ethnic disparities in flame retardant exposure and executive function skills in preschool children by Alexis Merculief, Megan McClelland, Stephanie Foster, John Geldhof, Shannon Lipscomb, Kim Anderson, Molly L. Kile

“…The present study examined independent and joint effects of income and race/ethnicity on flame retardant exposure in early childhood and investigated associations between flame retardant exposure and children’s EF. Methods This cross-sectional study used data from 349 preschool children recruited in Oregon. …”
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Evaluation of the marginal fit and fracture resistance of interim restorations fabricated using different techniques: an in vitro study by Mostafa Elashkar, Yehia Aboushady, Merna Ihab, Mohamed T. El Halawani

“…Aim The aim of this in vitro study was to investigate the marginal fit and fracture resistance of manually fabricated, computer-aided design and computer-aided manufacturing (CAD/CAM) milled, and CAD/CAM three-dimensionally (3D) printed 3-unit interim fixed dental prostheses (FDPs). Materials and methods Sixty-four 3-unit interim FDPs were fabricated on epoxy resin models using different fabrication techniques: manual fabrication with poly methyl methacrylate (PMMA) (n = 16), manual fabrication with Bis-acrylic composite resin (n = 16), CAD/CAM milling (n = 16), and CAD/CAM 3D-printing with a digital light processing (DLP) printer (n = 16). …”
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The association of systemic immune-inflammation index with incident breast cancer and all-cause mortality: evidence from a large population-based study by Yu Li, Yu Li, Meng Yu, Ming Yang, Jingqi Yang

“…However, its predictive value in a nationwide representative population, particularly for breast cancer incidence and mortality, is not well-established.MethodsThis study aimed to assess the association of SII and the risk of breast cancer incidence and all-cause mortality in breast cancer patients within the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. …”
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Device measured physical activity before pregnancy and the risk of adverse pregnancy outcomes in the HUNT study: a population-based cohort study by Laura Vatn Slapgaard, Signe Nilssen Stafne, Vegar Rangul, Ingrid Aanesland Dahle, Julie Horn

“…We aimed to examine the association between objectively measured physical activity before pregnancy and risk of APOs. Methods The study population consisted of women with one or more singleton births registered in the Medical Birth Registry of Norway (MBRN) after participating in the fourth survey of the Trøndelag Health Study (HUNT4, 2017–2019). …”
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Validation of Risk Scoring Systems in Predicting Adverse Cardiac Outcomes in Pregnant Women With Valvular Heart Disease by Malini Sukayogula, Tarakeswari Surapaneni, Anish Keepanasseril, Jue Li, Yang Pan

“…To validate and compare the performance of four risk stratification tools—the DEVI (Adverse Cardiac Events in Valvular Rheumatic Heart Disease in Pregnancy) score, Zwangerschap bij Aangeboren Hartafwijking (ZAHARA) score, Cardiac Disease in Pregnancy II (CARPREG II), and modified WHO (mWHO) classification—in predicting adverse cardiac events during pregnancy in women with valvular heart disease (VHD). Methods:. This retrospective cohort study was conducted at Fernandez Hospital, a tertiary care referral center in Hyderabad, India, utilizing clinical data from pregnancies managed between January 2011 and December 2023. …”
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J-shaped association between serum glucose potassium ratio and prognosis in heart failure with preserved ejection fraction with stronger predictive value in non-diabetic patients by Liang Shan, Keyang Zheng, Wenlong Dai, Peng Hao, Yintang Wang

“…Abstract Background: The relationship between serum glucose/potassium ratio (GPR) and the adverse outcomes in patients with heart failure with preserved ejection fraction (HFpEF) has not been completely clarified. Methods: Patients were included from the American cohort of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial. …”
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Clinical and Molecular Insights Into Anti-MDA5 Antibody-Positive Dermatomyositis: A Single-Center Retrospective and Transcriptomic Study by Ren Y, Wu T, Shi W

“…Future multicenter prospective studies are essential to validate these biomarker findings and develop composite prognostic models incorporating clinical, radiographic, and molecular parameters.Keywords: Anti-MDA5 dermatomyositis, rapidly progressive interstitial lung disease, prognostic biomarkers, KL-6, transcriptomics, immunopathogenesis…”
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Ante-mortem cognitive trajectories associated with Aβ and tau biomarker profiles in older adults with cerebrovascular disease: a longitudinal cohort study by Emily Rosenich, Yen Ying Lim, on behalf of the National Alzheimer’s Coordinating Center

“…Participants were classified into four groups (A − T−, A + T−, A − T+, A + T+) based on semiquantitative Consortium to Establish a Registry for Alzheimer’s Disease neuritic plaque staging and Braak staging. Linear mixed models assessed rate of change in Preclinical Alzheimer’s Cognitive Composite scores, episodic memory, and executive function. …”
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Determinants of improvement trends in health workers' compliance with outpatient malaria case-management guidelines at health facilities with available "test and treat" commodities... by Beatrice Amboko, Kasia Stepniewska, Lucas Malla, Beatrice Machini, Philip Bejon, Robert W Snow, Dejan Zurovac

“…This study examined the factors associated with the improvements.<h4>Methods</h4>Data from 11 national, cross-sectional health facility surveys undertaken from 2010-2016 were analysed. …”
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