Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in miceResearch in context by Farooq Syed, Olivia Ballew, Chih-Chun Lee, Jyoti Rana, Preethi Krishnan, Angela Castela, Staci A. Weaver, Namratha Shivani Chalasani, Sofia F. Thomaidou, Stephane Demine, Garrick Chang, Alexandra Coomans de Brachène, Maria Ines Alvelos, Eugenia Martin Vazquez, Lorella Marselli, Kara Orr, Jamie L. Felton, Jing Liu, John S. Kaddis, Piero Marchetti, Arnaud Zaldumbide, Donalyn Scheuner, Decio L. Eizirik, Carmella Evans-Molina

“…TYK2 missense mutations protect against type 1 diabetes (T1D), and inhibition of TYK2 shows promise in other autoimmune conditions. Methods: We evaluated the effects of specific TYK2 inhibitors (TYK2is) in pre-clinical models of T1D, including human β cells, cadaveric islets, iPSC-derived islets, and mouse models. …”
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Multifunctional Z‐scheme NaGdF4:Yb,Tm@ZnO/Ag3PO4 nanoheterojunction photocatalysts for water purification and antibacterial wound healing by Ran Yi, Changyuan Zhang, Dan Shan, Mengyu Di, Chen Li, Yu Wang, Yang Wu, Jing Zheng, Wenqi Liu, Baiqi Wang

“…Herein, NaGdF4:Yb,Tm@ZnO/Ag3PO4 (UZA) nanoheterojunction photocatalysts were synthesized via hydrothermal, sol–gel, and in situ deposition methods. The UZA photocatalyst demonstrated exceptional efficiency in generating reactive oxygen species (ROS), crucial for organic pollutant degradation. …”
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Impacts of Community Parks on Residents’ Health Benefits and Enhancement Strategies Thereof from the Perspective of Micro-Renewal: A Case Study of Nanjing by Tianyuan SHOU, Mingjuan ZHANG, Jiaxing WEI

“…Therefore, integrating vegetation coverage, hard-surfaced space, and animal species perception to evaluate the multidimensional characteristics of community parks and their non-linear impacts on residents’ health benefits has both theoretical value and practical support for community park design oriented at health benefits.MethodsThis research employs a comprehensive approach to investigate 34 community parks in Nanjing, China. …”
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Limited distribution of cratonic strike-slip faults in Sichuan basin and their genesis mechanisms by Zijing Liu, Zijing Liu, Nan Su, Nan Su, Shaobo Liu, Shaobo Liu, Zhuxin Chen, Zhuxin Chen, Pengcheng Tang, Saijun Wu, Lining Wang, Lining Wang, Rong Ren, Rong Ren, Cuiguo Hao, Zhengshuo Miao

“…IntroductionThe genesis mechanism of cratonic strike-slip faults in the Sichuan basin is not yet fully resolved, largely due to the lack of comprehensive characterization of fault distribution, which constrains the understanding of the relationship between fault development and tectonic events.MethodIn this study, we supplement extensive three-dimensional seismic data from areas beyond central Sichuan to delineate fault distribution across the entire basin. …”
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impHFrEF trial: study protocol for an open-label, multicentre study of improvement the outcome of patients with heart failure in China using a mobile hEalth-supported platForm by Xinxin Zhang, Fangfang Wang, Bing Xu, Qin Shen, Junhong Wang, Xiaoyu Dong, Yu Zou, Fuzhong Chen, Guangjuan Li, Wensen Chen

“…Therefore, effective management and monitoring of patients with HF to ensure they receive GDMT is crucial for improving the prognosis.Design and methods This is a multicentre, open-label, randomised, parallel-group study involving patients with CHF across five centres. …”
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Diagnostic sensitivity of immune-inflammatory cell proportion in early diagnosis of endometrial cancer by Li Sun, Shujie Zhai, Guojia Wu, Jie Gu, Yiran Huang, Dandan Hong, Jianmei Wang, Yongmei Li

“…The model was validated in an additional cohort. Result: In the single-indicator ROC analysis, the baseline AUC for NLR was 0.724, with a significance level of p ​< ​0.05, indicating good predictive power. …”
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Risk of cardiovascular events in patients with metabolic syndrome: Results of a population-based prospective cohort study (PURE Turkey) by Aytekin Oğuz, Mustafa Kılıçkap, Sadi Güleç, Yüksel Altuntaş, Kubilay Karşıdağ, Ahmet Temizhan, Burcu Çalık Tümerdem, Miraç Vural Keskinler, Sumathy Rangarajan, Salim Yusuf

“…This study aimed to assess CV risk of MetS, contribution of its components to the risk, and whether MetS provides additional risk beyond its components. Methods: The Prospective Urban Rural Epidemiology (PURE) Turkey cohort included 3933 individuals aged between 35 and 70 years, with a median follow-up of 8.9 years. …”
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Psychometric properties of the pain anxiety symptom scale among postoperative patients in Amol, Iran by Hamid Sharif-Nia, Hamid Sharif-Nia, Erika Sivarajan Froelicher, Erika Sivarajan Froelicher, João Marôco, Esmaeil Hoseinzadeh, Sima Hejazi, Sima Hejazi, Reza Fatehi, Poorya Nowrozi, Bita Mohammadi

“…Also, after necessary modifications during confirmatory factor analysis, the final model was approved. As for reliability, the Cronbach’s alpha, composite reliability, and MaxR for all constructs were greater than 0.7, demonstrating good internal consistency and construct reliability.ConclusionAccording to the results, the Persian version of the Pain Anxiety Symptom Scale has a valid structure and acceptable reliability. …”
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A Deep Learning-Based Probabilistic Approach for Non-Destructive Testing of Aircraft Components Using Laser Ultrasonic Data by Adriano Liso, Cosimo Patruno, Angelo Cardellicchio, Pierfrancesco Ardino, Nicola Gallo, Giuseppe del Prete, Valerio Dentico, Veronica Vespini, Sara Coppola, Pietro Ferraro, Vito Reno

“…Here, we present a deep learning-based method for the non-destructive detection of defects in composite samples based on a laser ultrasonic system (LUT). …”
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Subtle changes on electrocardiogram in severe patients with COVID-19 may be predictors of treatment outcome by Illya Chaikovsky, Illya Chaikovsky, Dmytro Dziuba, Olga Kryvova, Katerina Marushko, Julia Vakulenko, Kyrylo Malakhov, Оleg Loskutov, Оleg Loskutov

“…The study aimed to investigate the value of a new electrocardiographic metric for detecting minor myocardial injury in patients during COVID-19 treatment.MethodsThe study was conducted in 2021. A group of 26 patients with verified COVID-19 diagnosis admitted to the intensive care unit for infectious diseases was examined. …”
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Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study by Olivier D. Steen, Martje Bos, Sonja L. van Ockenburg, Yiling Zhou, Ilja M. Nolte, Harold Snieder, Kenneth Kendler, Judith G. M. Rosmalen, Hanna M. van Loo

“…We investigated whether functional and internalizing disorders co-aggregate with these diseases in families to gain insight into the aetiology of functional and internalizing disorders.  Methods We included 166,774 subjects (aged 3–94), from the population-based Lifelines Cohort Study, a Dutch general population cohort. …”
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Cultural Humility: A Collaborative Approach to Recruiting Patients with Deliberate Self-Harm into a Multi-Hospital Randomized Controlled Trial by Suzanne H. Brownhill, Garry J. Stevens, Trent E. Hammond, Richard Baldacchino, Rose Maposa, Bonyface Makoni, Aviva Sheb'a, Jagadeesh Andepalli, Anita Kotak, Olav D'Souza, Azadeh Atashnama, Anish Thayil, Alison Jones

“…The findings of this multidisciplinary consultation informed a composite model of knowledge exchange and the development of educational briefing/ orientation modules that make explicit team members’ roles and responsibilities to foster group member participation and enhance patient recruitment. …”
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Association of triglyceride-glucose index and its combinations with sarcopenia among community-dwelling older adults: based on the Chongqing Aging and Sarcopenia Evaluation (CHASE)... by Xinyu Yu, Siqi Jiang, Zhiyu Chen, Keke Ren, Shan Li, Yetao Luo, Deqing Chen, Qinghua Zhao, Huanhuan Huang

“…The relationship between the TyG index and its combined indicators and sarcopenia remains insufficiently explored.AimTo investigate the association between the TyG index and its combined parameters and sarcopenia.MethodsThis cross-sectional study encompassed 792 community-dwelling older adults from the Chongqing Aging and Sarcopenia Evaluation (CHASE) cohort. …”
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Association Between Caregiver Strain and Self‐Care Among Caregivers With Hypertension: Findings From the REGARDS Study by Asia Gobourne, Joanna Bryan Ringel, Alexandra King, Monika Safford, Catherine Riffin, Ronal Adelman, Adam Bress, Tracy K. Paul, Raegan W. Durant, David L. Roth, Madeline R. Sterling

“…We examined the association between caregiver strain and hypertension self‐care among caregivers with hypertension. Methods and Results We included participants of the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study who identified as caregivers and had hypertension. …”
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The independent and joint role of socioeconomic status and family relationships on mortality risk in China: cultural differences and health inequalities in the context of intergene... by Zhixi Zhu, Yiying Wang, Xin Wang, Fuyan Zhang, Lisha Yu, Tao Liu

“…This study investigates the independent and combined effects of SES and family relationships on all-cause mortality in China. Methods A baseline survey was conducted in 2010 involving 9280 adult permanent residents from 12 counties (districts) in Guizhou Province, using stratified cluster random sampling. …”
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Inflammation and nutritional status in relation to mortality risk from cardio-cerebrovascular events: evidence from NHANES by Chengzhi Hou, Xuanchun Huang, Jie Wang, Cong Chen, Chao Liu, Shuyuan Liu, Shuyuan Liu, Hongping Li

“…This study aims to evaluate the relationship between inflammation and nutritional indices and mortality among, identifying the most predictive indices.MethodsThis study included cohort data of the survivors of major adverse cardiovascular and cerebrovascular events (MACCE) from the National Health and Nutrition Examination Survey (NHANES) in 1999–2010. …”
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Atherothrombotic Outcomes After Sodium‐Glucose Cotransporter 2 Inhibitors Versus Dipeptidyl Peptidase‐4 Inhibitors in Patients With Type 2 Diabetes: A Territory‐Wide Retrospective... by Pauline Yeung Ng, Andrew Kei‐Yan Ng, April Ip, Wai Ching Sin, Kai‐Hang Yiu

“…Background This study compared the risks of atherothrombotic major adverse cardiovascular events in patients with type 2 diabetes taking SGLT2 (sodium‐glucose cotransporter 2) inhibitors to those taking DPP‐4 (dipeptidyl peptidase‐4) inhibitors. Methods and Results All adult patients (≥18 years of age) with type 2 diabetes and newly prescribed with SGLT2 inhibitors or DPP‐4 inhibitors across all public hospitals in Hong Kong between January 2015 and December 2019 were included. …”
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Insights into the Prognostic Efficacy of the Geriatric Nutritional Risk Index for Nasopharyngeal Carcinoma in the Era of Volumetric Modulated Arc Therapy: A Nomogram for Predicting... by Xiang Lin, Wei Wang, Jianming Ding, Zhaodong Fei, Chuanben Chen

“…Background: The geriatric nutritional risk index (GNRI), a composite metric of serum albumin and body weight, has emerged as a prognostic tool in various cancers. …”
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Development and psychometric evaluation of the CO-PARTNER tool for collaboration and parent participation in neonatal care. by Nicole R van Veenendaal, Jennifer N Auxier, Sophie R D van der Schoor, Linda S Franck, Mireille A Stelwagen, Femke de Groof, Johannes B van Goudoever, Iris E Eekhout, Henrica C W de Vet, Anna Axelin, Anne A M W van Kempen

“…A tool is needed to support parents and to study the effects and implementation of parent-partnered models of neonatal care.<h4>Methods</h4>We developed and psychometrically evaluated a tool measuring active parent participation and collaboration in neonatal care within six domains: Daily Care, Medical Care, Acquiring Information, Parent Advocacy, Time Spent with Infant and Closeness and Comforting the Infant. …”
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595 Is PHASTR faster? A target trial emulation case study in the N3C by Steve Johnson, Carolyn Bramante, Til Stürmer, John Buse, Talia Wiggen, Jared Huling, Andrew Toler

“…We quickly delivered an answer due to productive technical and collaboration support in the N3C. Methods/Study Population: Our analytic plan was updated based on helpful feedback from the PHASTR program. …”
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