Abstract 074: Early Versus Late Anticoagulation In AF‐related Ischemic Stroke: A Systematic Review and Meta‐analysis of RCTs by Hesham Kelani

“…We aim to investigate safety and efficacy of early versus late anticoagulation in AF patients with AIS. Methods This meta‐analysis followed the Preferred Reporting Items for Systematic reviews and Meta‐Analysis (PRISMA) guidelines. …”
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Topical Steroids and Antibiotics for Adult Blepharokeratoconjunctivitis (BKC): A Meta-Analysis of Randomized Clinical Trials by Lu Zhao, Ya-jie Sun, Zhi-qiang Pan

“…A meta-analysis was conducted to evaluate the efficacy and safety of topical treatments (including steroids and antibiotics) for adults with blepharokeratoconjunctivitis (BKC). Methods. The following databases were searched for relevant randomised controlled trials (RCTs): China National Knowledge Infrastructure (CNKI), Web of Science, MEDLINE, PubMed, Embase, and Cochrane Central Register of Controlled Trials database (CENTRAL). …”
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Translation, validity and reliability of the Malay version of the adult carer quality of life questionnaire (AC-QOL) in informal caregivers of stroke survivors in Kelantan, Malaysi... by Erwan Ershad Ahmad Khan, Wan Nor Arifin, Kamarul Imran Musa

“…The Adult Carer Quality of Life Questionnaire (AC-QoL) methodically evaluates caregivers’ well-being across diverse dimensions. …”
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Assessing the use of remotely sensed surface water flux to estimate net groundwater storage change in an aquifer predominantly used for irrigation by Cindy Viviers, Michael van der Laan

“…A Random Forest classifier, trained on seasonal Sentinel-2 composites to capture crop phenological changes, was used to identify cultivated areas in monthly composites. …”
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Curcumin and Papain-Loaded Liposomal Natural Latex Dressings with Phototherapy: A Synergistic Approach to Diabetic Wound Healing by Franciéle M. Silva, Jaqueline R. Silva, Wellington Rodrigues, Breno A. S. M. Sousa, Thamis F. S. Gomes, Mario F. F. Rosa, Suélia S. R. F. Rosa, Marcella L. B. Carneiro

“…The therapeutic efficacy of these composite dressings, in combination with red light-emitting diode (LED) phototherapy, was evaluated in a diabetic rat model. …”
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Advances in high-pressure materials discovery enabled by machine learning by Zhenyu Wang, Xiaoshan Luo, Qingchang Wang, Heng Ge, Pengyue Gao, Wei Zhang, Jian Lv, Yanchao Wang

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ZEB1 transcription factor promotes immune escape in melanoma by Christophe Caux, Stephane Dalle, Arnaud de la Fouchardière, Laurie Tonon, Maud Plaschka, Valentin Benboubker, Maxime Grimont, Justine Berthet, Jonathan Lopez, Myrtille Le-Bouar, Brigitte Balme, Garance Tondeur, Lionel Larue, Alain Puisieux, Yenkel Grinberg-Bleyer, Nathalie Bendriss-Vermare, Bertrand Dubois, Julie Caramel

“…We thus wondered whether ZEB1 signaling in melanoma cells may promote immune evasion and resistance to immunotherapy.Methods We evaluated the putative correlation between ZEB1 expression in melanoma cells and the composition of the immune infiltrate in a cohort of 60 human melanoma samples by combining transcriptomic (RNA-sequencing) and seven-color spatial multi-immunofluorescence analyses. …”
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Deciphering cholangiocarcinoma heterogeneity and specific progenitor cell niche of extrahepatic cholangiocarcinoma at single-cell resolution by Chunliang Liu, Xiang Wang, Erdong Liu, Yali Zong, Wenlong Yu, Youhai Jiang, Jianan Chen, Mingye Gu, Zhengyuan Meng, Jingfeng Li, Yang Liu, Yongjie Zhang, Jing Tang, Hongyang Wang, Jing Fu

“…Findings were validated using external multi-omics datasets, tissue microarray cohort, spatial RNA in situ sequencing, CCA patient-derived organoids (PDOs), and mouse models. Results iCCAs and eCCAs exhibited distinct tumor ecosystems, with notable differences in cellular composition, diversity, and abundance across various cell types. …”
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MAFLD mediates the association between CHR and gallstones in the U.S. adults: evidence from NHANES 2021–2023 by Xin Feng, Xiangyu Song, Xi’an Yang, Fuxiang Luan, Yufei Gu, Fengyu Zheng, Huahu Guo, Shishi Qiao

“…Methods This cross-sectional analysis utilized data from the National Health and Nutrition Examination Survey (NHANES, 2021–2023) to assess the correlation between the CHR and gallstone prevalence through weighted logistic regression. …”
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Novel application of CHUANG BI FU biologic protein sponge in promoting peripheral nerve injury repair by regulating vascular regeneration by Yunhao Cai, Jiahao Liu, Renwei Han, Zizhao Ma, Kaihang Yu, Ping Wu, Xiaokun Li, Zhouguang Wang, Jian Wang

“…Methods This study used a 3.5-mm nerve defect model in mice, and wrap CHUANG BI FU around the nerve defect site, connecting the distal and proximal ends of the damaged nerve without suturing the nerve. …”
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Examining the impact of early life adversity on adolescent sleep health: Findings from the ABCD study by Ethan T. Hunt, Keith Brazendale, Augusto César Ferreira De Moraes, Marcus Vinicius Nascimento-Ferreira, Christopher D. Pfledderer, Sarah Sampaio Izabel, Erin E. Dooley, Baojiang Chen, Alejandra Fernandez, Micah E. Johnson, Hugh Garavan, Alexandra S. Potter, Sarajane L. Dube, Nicholas Allgaier, Deanna M. Hoelscher, Susan F. Tapert

“…Methods: Social jetlag and weekly sleep loss were assessed using the Munich Chronotype Questionnaire at 2-year and 3-year follow-ups. …”
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Investigation of the relationship between lead exposure in heavy metals mixtures and the prevalence of stroke: a cross-sectional study by Jiarong He, Wen Zhang, Fang Zhao, Ming Wang, Zhuo Wang, Chen Liang, Jing Pan, Jiaoying Jia, Mingming Zhang

“…However, the specific influence of heavy metal exposure on stroke prevalence remains underexplored. Methods This study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018 to investigate the association between blood metal concentrations and the incidence of stroke. …”
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Integrating adipsin with novel cardiometabolic and inflammatory indices for enhanced early prediction of gestational diabetes mellitus: a prospective cohort study by Meizhi Cai, Xuan Jiang, Xinyi Xu, Sidi Zhao, Yue Sun, Yushuo Yang, Ping Yang, Chen Fang, Yifan Huang

“…Increased CMI and SIRI, as well as reduced adipsin levels, were independently associated with a higher risk of GDM in both unadjusted and adjusted models (all P < 0.05). The composite model incorporating all three biomarkers achieved a higher area under the curve (AUC) of 0.918 compared with the individual models for CMI (AUC = 0.825), SIRI (AUC = 0.802), and adipsin (AUC = 0.724). …”
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Risk adjusted 30‐day mortality and serious adverse event rates among a large, multi‐center cohort of emergency department patients with acute heart failure by Dana R. Sax, Dustin G. Mark, Jamal S. Rana, Sean P. Collins, Jie Huang, Mary E. Reed, CREST Network

“…Use of a risk stratification tool could improve disposition decision making by identifying low‐risk patients who may be safe for outpatient management. Methods We performed a secondary analysis of a retrospective, multi‐center cohort of 26,189 ED patients treated for AHF from January 1, 2017 to December 31, 2018. …”
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Association between visceral adiposity index and endometriosis: a population-based study by Jiajia Zhang, Qian Zhang, Tianyu Chu, Xian Chen, Hui Zhou, Dewu Xu, Chunlin Dong, Yibo Wu

“…The objective of our research was to investigate the association between VAI and endometriosis.MethodsThis is a cross-sectional study. The investigation utilized information from the NHANES (1999–2006), focusing on participants aged ≥20 years. …”
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The effect of gamification on brand co-creation in app-based businesses: investigating the mediating role of consumer engagement and the moderating role of hedonic and innovativene... by Rayhane Rezagholizade, Zahra Sadeqi-Arani, Esmail Mazroui

“…The extensive nature of the target population, combined with restricted access to the entire community, necessitated the use of this accessible sampling method. To collect data, standard and researcher-made questionnaires were used. …”
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A Computational Study on Renal Artery Anatomy in Patients Treated with Fenestrated or Branched Endovascular Aneurysm Repair by Yuzhu Wang, Yuna Sang, Wendong Li, Minjie Zhou, Yushun Zhao, Xiaodong He, Chao Wang, Xiaoqiang Li, Zhao Liu

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Area Deprivation and Clinical Biomarkers of Inflammation in Cancer Survivors of the National Institutes of Health All of Us Research Program by Cecily A. Byrne, Vanessa M. Oddo, Evgenia Karayeva, Greg Kopetsky, Sage Kim

“…The area deprivation index (ADI) is a composite measure of income, education, employment, and housing, which quantifies neighborhood deprivation. …”
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Retrospective evaluation of novel serum inflammatory biomarkers in first-episode psychiatric disorders: diagnostic potential and immune dysregulation by Min Qiu, Chenkai Zhang, Haiqing Zhang, Hao Chen, Yingjia Lei, Ping Li, Shaochuan Zhang

“…The area under the curve (AUC) value of the NHR + MHR + NLR composite index model for the SCZ group was 0.846 (p &lt; 0.001). …”
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Association Between the Non-High-Density Lipoprotein Cholesterol-to-High-Density Lipoprotein Cholesterol Ratio (NHHR) and Mortality in Patients with COPD: Evidence From the NHANES... by Zhong Y, Zhou K, Li S, Zhang R, Wang D

“…Yuhua Zhong,1 Kesi Zhou,2 Sheng Li,1 Renzi Zhang,1 Daoxin Wang1 1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Anesthesiology, Sichuan Second Hospital of T.C.M, Chengdu, People’s Republic of ChinaCorrespondence: Renzi Zhang; Daoxin Wang, Email zhangrenzi@stu.cqmu.edu.cn; wangdaoxin@hospital.cqmu.edu.cnPurpose: The non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) is a new composite blood lipid index. We aimed to investigate the relationships of the NHHR with mortality from all-causes, cardiovascular disease (CVD), and chronic lower respiratory disease (CLRD) in US patients with COPD.Methods: We assessed the association between the NHHR and mortality via weighted multivariate Cox proportional hazards regression models with restricted cubic splines (RCSs). …”
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