Novel anthropometric indices are superior adiposity indexes to portend visual impairment in middle-aged and older Chinese population by Qing Chen, Yanan Hou, Yifan Zhou, Jianfeng Luo, KaiweiSa Abuduxukuer, Chuchu Wang, Jialong Dong, Yiting Wang, Wenming Shi, Fei Shi, Qing Peng

“…Objective To investigate differential associations of traditional and novel adiposity indices with visual impairment (VI) in the middle-aged and older Chinese population.Methods and analysis Based on the China Health and Retirement Longitudinal Study, 7750 Chinese older adults aged over 45 were included at baseline 2011, and 4133 participants who accomplished all three interviews from 2011 to 2015 were adapted for longitudinal analyses. …”
Get full text

Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review by Ielmina Domilescu, Bogdan Miutescu, Florin George Horhat, Alina Popescu, Camelia Nica, Ana Maria Ghiuchici, Eyad Gadour, Ioan Sîrbu, Delia Hutanu

“…Methods: MEDLINE, Embase and PubMed were searched from inception to 30 April 2025. …”
Get full text

The GD3 ganglioside promotes cell growth, plasticity and chemotherapy resistance of human glioblastoma cancer stem cells by Victoria Hein, Nathalie Baeza-Kallee, Raphaël Bergès, Nora Essakhi, Aurélie Soubéran, Carole Colin, Philippe Morando, Romain Appay, Thomas Graillon, Aurélie Tchoghandjian, Dominique Figarella-Branger, Emeline Tabouret

“…Here, we aimed to demonstrate that the GD3 ganglioside was a relevant marker and actionable target for glioblastoma cancer stem-like cells. Methods To this end, we used commercial glioblastoma cell lines, human glioblastoma samples, organotypic culture and xenografted mouse models to study GD3 antigen expression and consequences of its downregulation through a shRNA strategy targeting the ST8SIA1 mRNA which encodes the key enzyme for GD3 synthesis. …”
Get full text

Psychometric properties of the Chinese version of the SF-36v2 in patients with severe mental illnesses in China: factor structure, reliability, and validity by Yang Wang, Xia Zhang, Jiajia Dong, Jianwen Zhu, Jie Fu, Sizhe Wang, Jinxin Li, Yue Zhang, Jianxiao Zheng, Lu Wen, Dianjiang Li, Hong Fan

“…This study aimed to evaluate the psychometric characteristics of SF-36v2 among Chinese SMIs patients to determine its suitability for assessing their QOL. Methods We conducted a cross-sectional study involving 924 randomly selected SMIs patients from 23 community health centers in Nanjing, China. …”
Get full text

Potential activity of Ferula macrecolea essential oil for treating Giardia lamblia infection through modulating electrolytes and suppressing NF-κB p65 pathway by Iraj Salimikia, Seyed Ehsan Yaghoubi, Amal Khudair Khalaf, Leila Masoori, Javad Ghasemian Yadegari, Hossein Mahmoudvand, Hossein Mahmoudvand

“…In light of the previously discussed information and the recognized antimicrobial properties of Ferula macrecolea, this study aims to investigate both the in vitro and in vivo anti-giardial effects of F. macrecolea essential oil (FME) on G. lamblia infection.MethodsGas chromatography-mass spectrometry (GC-MS) was utilized to analyze the chemical composition of the prepared FME. …”
Get full text

Modulation of the Plasma Lipidomic Profile in Piglets Fed Polar Lipid-Rich Diets by Rayllana Larsen, Salma Chakroun, Marie-Pierre Létourneau-Montminy, Janie Levesque, Dimas Estrasulas de Oliveira, Jorge Eduardo Rico, Daniel E. Rico

“…Their health benefits need to be further characterized in other models of stress and inflammation.…”
Get full text

Abstract 229: Recanalization Rate in Mechanical Thrombectomy in Patients With Elevated LDL‐C Levels by Xiaoyi Gao, Kara Christopher, Wilson Rodriguez, Weston Gordon, Guillermo Linares

“…We also aim to investigate whether LDL‐C levels affect MT recanalization rate. Methods We reviewed the records of 223 patients who received MT at our institution from 2018‐2023. …”
Get full text

Research on the correlation between gut microbiota and brain cognitive function under chronic hypoxia at high altitude by Feng Zeng, Hanxue Li, Yan Ma, Yan Ma, Shuang Ma, Shuang Ma

“…This study investigated the contribution of gut microbiota to cognitive dysfunction induced by chronic hypoxia.MethodsC57BL/6 J mice were assigned to four groups: control group (NC), control pseudo-germ-free group (CA), hypoxic group (HC), and hypoxic pseudo-germ-free group (HA). …”
Get full text

Gut microbiota dysbiosis in patients with Alzheimer’s disease and correlation with multiple cognitive domains by Qionglei Chen, Jiayu Shi, Gaojie Yu, Huijia Xie, Shicheng Yu, Jin Xu, Jiaming Liu, Jing Sun

“…The aim of this study was to explore microbial signatures associated with global cognition and specific cognitive domains in AD patients and to determine their predictive value as biomarkers.MethodsA total of 64 subjects (18 mild AD, 23 severe AD and 23 healthy control) were recruited in the study. 16 s rDNA sequencing was performed for the gut bacteria composition, followed by liquid chromatography electrospray ionization tandem mass spectrometry (LC/MS/MS) analysis of short-chain fatty acids (SCFAs). …”
Get full text

Cropland restricts occurrence and alters spatial ecology near the mule deer geographical range limit by Levi J. Heffelfinger, David G. Hewitt, Joshua P. Vasquez, Timothy E. Fulbright, Randy W. DeYoung, Louis A. Harveson, Warren C. Conway, Shawn S. Gray

“…Cropland can benefit wildlife nutritionally but may result in habitat loss because of changes in landscape composition and human disturbance. Methods We quantified the influence of cropland presence and coverage on mule deer spatial ecology in the southern Great Plains. …”
Get full text

The effect of prenatal balanced energy and protein supplementation on gestational weight gain: An individual participant data meta-analysis in low- and middle-income countries. by Dongqing Wang, Uttara Partap, Enju Liu, Janaína Calu Costa, Ilana R Cliffer, Molin Wang, Sudeer Kumar Nookala, Vishak Subramoney, Brittany Briggs, Imran Ahmed, Alemayehu Argaw, Shabina Ariff, Nita Bhandari, Ranadip Chowdhury, Daniel Erchick, Armando García-Guerra, Masoumah Ghaffarpour, Giles Hanley-Cook, Lieven Huybregts, Fyezah Jehan, Fatemeh Kaseb, Nancy F Krebs, Carl Lachat, Tsering Pema Lama, Dharma S Manandhar, Elizabeth M McClure, Sophie E Moore, Ameer Muhammad, Lynnette M Neufeld, Andrew M Prentice, Amado D Quezada-Sánchez, Dominique Roberfroid, Naomi M Saville, Yasir Shafiq, Bhim P Shrestha, Bakary Sonko, Sajid Soofi, Sunita Taneja, James M Tielsch, Laéticia Céline Toe, Naser Valaei, Wafaie W Fawzi

“…<h4>Methods and findings</h4>Individual participant data from 11 randomized controlled trials of prenatal BEP supplements (N = 12,549, with 5,693 in the BEP arm and 6,856 in the comparison arm) in low- and middle-income countries were used. …”
Get full text

ABSOLUTIVE VERBS AS A SUBSTRATE OF FORMAL-GRAMMATICAL AND SEMANTIC SYNTACTICAL STRUCTURES OF UNEXTENDED SENTENCES by Liudmyla V. Suprun, Volodymуr M. Suprun

“…In research we use the methods of linguistic analysis, they are descriptive (in considering the phenomena of one level), comparative (analyzing the components of different levels to identify interlevel relationships), statistical calculations and quantitative characteristics, interpretive analysis (interpretation of semantics of certain syntactic units), transformation (transformation of a certain syntactic structure in order to characterize it). …”
Get full text

<i>Syzygium aromaticum</i> Phytoconstituents Target SARS-CoV-2: Integrating Molecular Docking, Dynamics, Pharmacokinetics, and <i>miR-21 rs1292037</i> Genotyping by Mustafa Ahmed Muhmood, Faiza Safi, Mohammed Mukhles Ahmed, Safaa Abed Latef Almeani

“…Secondly, GC-MS was used to characterize the composition of clove extract. Thirdly, pharmacokinetic profiles were predicted using in silico models. …”
Get full text

Targeting HVEM-GPT2 axis: a novel approach to T cell activation and metabolic reprogramming in non-small cell lung cancer therapy by Yuanshan Yao, Chunji Chen, Bin Li, Wen Gao

“…This study aims to explore the role of HVEM in non-small cell lung cancer (NSCLC) microenvironment. Methods The lung cancer datasets for this study were directly downloaded from The Cancer Genome Atlas (TCGA). …”
Get full text

Weight-adjusted waist circumference index and chronic diseases as predictors of depression risk in U.S. adults: a cross-sectional study with mediation analysis by Yali Guo, Meilin Song, Cuixiao Wang, Cuixiao Wang

“…ObjectiveThis study aimed to examine the association between the weight-adjusted waist circumference index (WWI) and the risk of depression in U.S. adults, as well as the potential mediating roles of chronic diseases (hypertension, diabetes, stroke, and coronary heart disease) in this relationship.MethodsData from 7,709 adults aged 20–80 years in the 2017–2023 National Health and Nutrition Examination Survey (NHANES) were analyzed. …”
Get full text

INTERGENERATIONAL DIALOGUE IN THE NOVEL “BONJOUR TRISTESSE” BY FRANҪOISE SAGAN by Olga A. Bigun, Nataliia Ya. Yatskiv

“…Historical, cultural, comparative historical and typological methods are used to study the embodiment of age-related aspects, as well as to establish thematic, figurative, and compositional features of the functioning of intergenerational dialogue in a literary text. …”
Get full text

Evaluation of Clavulanic Acid Adsorption in MgAl-Layered Double Hydroxides: Kinetic, Equilibrium and Thermodynamic Studies by Marcus Bruno Soares Forte, Élen Cristina Luna Elias, Heloise O. Pastore, Francisco Maugeri Filho, Maria Isabel Rodrigues

“…A model was obtained to predict the degradation constant. …”
Get full text

Prognostic Value of Epicardial Adipose Tissue in Heart Failure With Mid‐Range and Preserved Ejection Fraction: A Multicenter Study by Wenxian Wang, Yan Gao, Jian Wang, Congshan Ji, Hui Gu, Xianshun Yuan, Shifeng Yang, Ximing Wang

“…Addition of EAT volume to the baseline multivariable model significantly improved model performance (C statistic improvement: 0.711–0.760; P<0.001). …”
Get full text

Influence of cognitive, neuropsychiatric, and diagnostic factors on financial capacity: A longitudinal analysis of the ADNI cohort by Milap A. Nowrangi, Jeannie Marie Leoutsakos, Haijuan Yan, Arnold Bakker, Kevin J. Manning, George W. Rebok, Paul B. Rosenberg, Vidyulata Kamath

“…To investigate the relationship between FC, cognitive domains, neuropsychiatric symptoms, and transitions from normal cognition (cognitive normal [CN]) to mild cognitive impairment (MCI) or Alzheimer's disease (AD), we conducted a secondary analysis of the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort using the Financial Capacity Instrument short form (FCI‐SF). Methods To examine these longitudinal relationships, we fit two models, a random effects (random intercept) “time‐averaged” model and a “time since previous visit” model, where we regressed each of the five component financial scores on each of the cognitive composite scores. …”
Get full text

Experimental Study on the Uplift Bearing Capacity of Pre-Drilled Planted Piles in Isolated Stone Strata Based on Transparent Soil Technology by Wenli Liao, Qipeng Cai, Xiangyu Guo, Hao Lin, Jiajin Zhou, Shizhuo Su

“…This paper combines pile-planting technology with isolated stones to incorporate them into the load-bearing system, resulting in a new type of pre-drilled composite pile suitable for isolated stone sites. A visualization testing system for pile-soil deformation is developed using Particle Image Velocimetry (PIV) technology and transparent soil, conducting non-intrusive model tests on pile-planting and boulder-capped piles under different uplift load conditions, and comparing the results with a discrete-continuous coupled three-dimensional numerical model analysis. …”
Get full text