Butyrate-producing bacteria in pregnancy maintenance: mitigating dysbiosis-induced preterm birth by Azusa Uchida, Kenji Imai, Rika Miki, Tomonari Hamaguchi, Hiroshi Nishiwaki, Mikako Ito, Jun Ueyama, Satomi Hattori, Sho Tano, Kazuya Fuma, Seiko Matsuo, Takafumi Ushida, Kinji Ohno, Hiroaki Kajiyama, Tomomi Kotani

“…We hypothesized that dysbiosis disrupts immune tolerance and promotes PTB, and that butyrate (short-chain fatty acid produced by specific gut bacteria) may counteract this effect by enhancing regulatory T cell (Treg)-mediated immune regulation. Methods We established a dysbiosis-induced PTB mouse model using vancomycin treatment combined with subclinical immune activation via anti-CD3ε antibody. …”
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Investigating the Role and Underlying Mechanisms of 18β-Glycyrrhetinic Acid in the Therapy of Ulcerative Colitis Through Modulation of the PPAR-γ/NF-κB... by Zhu A, Qiu Q, Xu Z, Zhang Q, Sun F, Liu Y, Chen Z, Zhang Y, Yao J

“…Aijing Zhu,1,* Qingqing Qiu,1,* Zhengguang Xu,1,* Qilian Zhang,2 Fang Sun,1,3 Yanzhan Liu,1 Zeang Chen,1 Yanan Zhang,4 Jing Yao1,3 1School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China; 2People’s Hospital Affiliated to Shandong First Medical University, Jinan, 271100, People’s Republic of China; 3Jining Key Laboratory of Pharmacology, Jining Medical University, Jining, 272067, People’s Republic of China; 4Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing Yao, Jining Medical University, School of Basic Medicine, Jining Medical University, Jining, 272067, People’s Republic of China, Tel +86 537-3616269, Email yjing_87@163.com Yanan Zhang, Affiliated Hospital of Jining Medical University, Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining, Shandong, 272029, People’s Republic of China, Tel +86 15153705143, Email yanan1202@163.comBackground: 18β-glycyrrhetinic acid (18β-GA), a triterpenoid saponin naturally occurring in Glycyrrhizae uralensis, has potent anti-inflammatory and antioxidant properties, but the therapeutic efficacy and precise mechanism of 18β-GA in ulcerative colitis (UC) remain unclear.Methods: To determine the therapeutic potential of 18β-GA, we constructed a dextran sodium sulfate (DSS)-induced UC model on a cohort of thirty-two female BALB/c mice and used mouse peritoneal macrophages to establish a co-culture system for in vitro experiments. …”
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New framework for the development of clinical guidelines in Russia by D. V. Blinov, E. S. Akarachkova, A. S. Orlova, E. V. Kryukov, D. I. Korabelnikov

“…Aim - based on the existing regulations and recent documents from the regulatory bodies, determine the methodology for the development of clinical guidelines (CG) that meet the requirements of the legislation in the Russian Federation.Materials and methods. We analyzed a number of regulatory and subordinate acts confirming the concept and status of the CG, in particular, the Federal Law № 323-ФЗ “On the principles of health care for citizens of the Russian Federation”, Federal Law № 489-ФЗ “On the amendments to article 40 of the Federal Law “On compulsory medical insurance in the Russian Federation” and the Federal Law “On the principles of health care for citizens of the Russian Federation” concerning clinical guidelines, Order № 102н of the Ministry of Health of the Russian Federation dated 28 Feb 2019 “Regulations on the scientific and practical council of the Ministry of Health of Russia” and Order № 103н of the Ministry of Health of the Russian Federation of 28 Feb 2019 “On Approval of the procedure and terms for the development of clinical guidelines and their revision, the model format of clinical guidelines and requirements to their structure, contents and scientific validity of the information included in the clinical guidelines”. …”
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Comparison of the Changes in Visceral Adipose Tissue After Lobectomy and Segmentectomy for Patients With Early‐Stage Lung Cancer by Tetsuya Isaka, Takuya Nagashima, Kota Washimi, Haruhiro Saito, Hiroto Narimatsu, Shunsuke Shigefuku, Chiaki Kanno, Ryotaro Matsuyama, Naoko Shigeta, Yui Sueishi, Hiroyuki Ito

“…ABSTRACT Background The impact of lobectomy versus segmentectomy on body composition changes, particularly adipose tissue, in patients with early‐stage lung cancer remains unclear. …”
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The mechanism of SAP overexpression in alleviating periodontitis in mice by HUANG Yinyin, LIANG Dongliang, ZOU Yaokun, HAN Jingru, GE Qing, LIU Xueyan, GUO Yadong, HUANG Xinli, YANG Lan

“…Objective To investigate the mechanism by which serum amyloid P component (SAP) alleviates periodontitis in mice, providing an experimental basis to establish SAP as a novel therapeutic agent for periodontitis. Methods Ethical approval was obtained from the Institutional Animal Ethics Committee. …”
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Therapeutic efficacy of a galactoglucan from Pleurotus citrinopileatus in constipation: modulation of aquaporin signaling and intestinal barrier by Yi Gao, Yi Gao, Lan Deng, Lan Deng, Yuanyuan Chen, Yuanyuan Chen, Peiyou Qin, Yuanyuan Zhao, Xiaoyan Zhao, Wei Liu, Dan Wang, Shuang Zhao

“…This study investigated the therapeutic potential of Pleurotus citrinopileatus polysaccharide (PCP-g), a novel galactoglucan, against sucralfate-induced constipation murine model, focusing on intestinal motility, fecal parameters, aquaporin signaling, and gut microbiota modulation.MethodsPCP-g was purified from P. citrinopileatus and its physicochemical properties were characterized. …”
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Chemical and isotopic signatures of hot springs from east-central Sonora State, Mexico: a new prospection survey of promissory low-to-medium temperature geothermal systems by Erika Almirudis, Edgar R. Santoyo-Gutiérrez, Mirna Guevara, Francisco Paz-Moreno, Enrique Portugal

“…The collected samples were analysed by chemical and isotopic methods for determining their chemical (major and trace elements) and isotopic (18O/16O and D/H) compositions. …”
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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation by Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen

“…However, it remains unknown whether and how FPHA affects the immune microenvironment of the bone defects. Methods FPHA was synthesized and its composition and structural properties were confirmed. …”
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Aloe vera-derived extracellular vesicle-like particles suppress pancreatic carcinoma progression through triggering pyroptosis via ROS-GSDMD/E signaling pathway by Jieyu Shen, Tianfu Wei, Mingchen Li, Yuankuan Jiang, Jiahui Zhang, Yueyi Qi, Cai Chen, Xiaojie Li, Peng Huang, Jialin Qu

“…Aloe Vera is a tender and juicy plant with anti-tumor properties, while whether Aloe Vera-derived EVLP (AV-EVLP) can inhibit PC and what the underlying mechanism is still unclear. Methods Two kinds of AV-EVLPs (EV-U and EV-P) were isolated from Aloe vera using comparative purification techniques. …”
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Inonotus obliquus (chaga) ameliorates folic acid-induced renal fibrosis in mice: the crosstalk analysis among PT cells, macrophages and T cells based on single-cell sequencing by Yueling Peng, Yaling Zhang, Yaling Zhang, Rui Wang, Xinyu Wang, Xingwei Liu, Hui Liao, Rongshan Li

“…Inonotus obliquus (Chaga), a traditional medicinal mushroom, has shown promising effects in chronic kidney disease (CKD), yet its cellular and molecular mechanisms remain largely unexplored.MethodsWe analysed the chemical composition of Chaga using UPLC-MS and predicted its biological targets using PubChem and Swiss Target Prediction. …”
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The Circular Kitchen by Bas Jansen

“…Design decisions can be based on the feasibility of total costs, and designs can apply production methods, business models, and supply chains that differ from the current industry standard. …”
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Finite time trajectory tracking control of underwater salvage robot under full-state constraints by Xue Bai, Yan Zhang, Wenyi Tan, Yang Liu, Baihui Jiang, Jiawei Wang

“…The scheme uses the super-twisting algorithm to design the observer to accurately estimate the composite disturbance composed of model uncertainty and unknown complex time-varying disturbance in the system. …”
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Adsorptive removal of methylene blue dye by a ternary magnetic rGO/AK/Fe3O4 nanocomposite: Studying adsorption isotherms, kinetics, and thermodynamics by Hayat Mulaw Ahmed, Worku Lakew Kebede, Abrha Berhe Yaebyo, Amogne Wendu Digisu, Sleshi Fentie Tadesse

“…Magnetite nanoparticles (Fe3O4) were coated on reduced graphene oxide (rGO) nanosheets and AK surface by chemical co-precipitation method supported by ultrasonication. It is characterized by X-ray diffraction (XRD), Scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy to investigate the crystal structure, morphology, and functional groups present in rGO/AK/Fe3O4 composites, respectively. …”
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Psychometric evaluation of the Farsi version of the electroconvulsive therapy related anxiety questionnaire by Seyedmohammad Mirhosseini, Hamid Sharif-Nia, Mohamad Gharehbaghi, Somaye Minaei-Moghadam, Jasmien Obbels, Fateme Imani Parsa, Mahboobeh Khajeh, Hossein Ebrahimi

“…Confirmatory factor analysis demonstrated a good fit for the proposed model. All composite reliability, maximum reliability, and heterotrait-monotrait ratios supported the convergent and discriminant validity of the ERAQ. …”
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The impact of gradient variable temperature fermentation on the quality of cigar tobacco leaves by Qianying Zhang, Qianying Zhang, Yang Huang, Yang Huang, Hongyue An, Hongyue An, Shuanghong Yang, Shuanghong Yang, Jinshan Lei, Jinshan Lei, Yue Wang, Yue Wang, Pinhe Li, Pinhe Li, Hongfei Zhang, Wen Cai, Wen Cai, Wen Cai, Yun Jia, Yun Jia, Yongqiang Pang, Dongliang Li, Dongliang Li

“…IntroductionIn order to enhance the quality of cigar tobacco leaves (CTLs), a gradient variable temperature fermentation approach was employed.MethodsThe temperature gradient demonstrated a gradual increase from low temperature (35 ± 2°C) to moderate temperature (45 ± 2°C), and then to high temperature (55 ± 2°C). …”
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Design and Technological Aspects of Integrating Multi-Blade Machining and Surface Hardening on a Single Machine Base by Vadim Skeeba, Vladimir Ivancivsky, Aleksey Chernikov, Nikita Martyushev, Nikita Vakhrushev, Kristina Titova

“…Theoretical studies were carried out using the basic provisions of system analysis, geometric theory of surface formation, design of metalworking machines, methods of finite elements, and mathematical and computer modeling. …”
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Enhanced automated art curation using supervised modified CNN for art style classification by Weiwei Li

“…To address these challenges, we developed a Modified CNN model capable of distinguishing art styles and movements using features such as color patterns, textures, and compositions. …”
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Prediction of the long-term risk of adverse cardiovascular events after an episode of acute coronary syndrome in patients with type 2 diabetes by E. A. Nikitina, I. S. Meletev, O. V. Soloviev, E. N. Chicherina

“…To determine independent predictors of adverse cardiovascular events (ACE) and to develop a long-term (12 months) prognostic model after an episode of acute coronary syndrome (ACS) in patients with type 2 diabetes (T2D).Material and methods. …”
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Adhesive contact between two-dimensional anisotropic elastic bodies by Nguyen Dinh Duc, Nguyen Van Thuong

“…The full-field solutions and the relation for the contact region and applied force are developed using the Stroh complex variable formalism, the analytical continuation method, and concepts of the JKR adhesive model. We will show that the frictionless contact of two anisotropic elastic materials is just a special case of the present contact problem, and its solutions can be obtained by setting the work of adhesion equal to zero. …”
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Optimization of PES-based Hollow fiber membranes incorporating MgO-modified activated carbon via response surface methodology for enhanced pure water permeability by Farkhonde Arabloo, Sirus Javadpour

“…The results of experimental tests conducted under the optimal conditions obtained using the RSM method for particle concentration and process parameters were in close agreement with the model predictions, confirming the model’s accuracy. …”
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