Houttuynia cordata-Derived Exosome-Like Nanoparticles Mitigate Colitis in Mice via Inhibition of the NLRP3 Signaling Pathway and Modulation of the Gut Microbiota by Li JH, Xu J, Huang C, Hu JX, Xu HM, Guo X, Zhang Y, Xu JK, Peng Y, Zhang Y, Zhu MZ, Zhou YL, Nie YQ

“…This study aims to evaluate the efficacy of HELNs in treating colitis in mice and investigate its potential mechanisms.Methods: HELNs were isolated from H. cordata for characterization, and their safety and stability were evaluated. …”
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Comparison of the Blood–Brain Barrier Penetration Ability and Anti-Neuroinflammatory Activity of Chromones in Two Types of Agarwood by Mengyuan Yang, Yanan Yuan, Jingfan Wei, Yifei Pei, Yuanfei Niu, Yifan Zhao, Xiangying Kong, Zhijie Zhang

“…It further investigated the absorption and brain distribution characteristics of these components in rats and their neuroprotective effects mediated through anti-neuroinflammatory pathways. <b>Methods</b>: This study confirmed, through ITS2 barcoding and chloroplast genome analysis, that both the ordinary and Qi-Nan agarwood are derived from <i>Aquilaria sinensis</i>. …”
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Analysis of the spatiotemporal evolution and driving factors of land use change in Jinan springs area of the Northern Karst region, China from 1986 to 2022 by Shenting Gang, Xiaoyun Kong, Tao Jia, Minghui Lv, Lixia Li

“…To explore the land-use change characteristics and their driving mechanisms, six periods of Landsat series land-use data were collected for the years 1986, 1995, 2000, 2009, 2016 and 2022. A Random Forest model was employed for classifying the remote sensing data, while the land use dynamic and land use transfer matrix were used to analyse the scale, composition, morphology, pattern and spatial and temporal characteristics of land use changes from 1986 to 2022. …”
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Ginsenoside Reshapes Intestinal Microecology to Alleviate Microgravity Stress by Wang Y, Chen T, Shi Z, Dong L, Li M, Peng B, Li Q, Pan R, Xiao S, Yang Q, Jiang N, Liu X, Hu Q, Chen Y

“…This study focused on the regulation of GTSs in intestinal homeostasis imbalance caused by microgravity.Methods: A hindlimb suspension (HLS) rat model was established to evaluate the intestinal protective effects of GTSs. …”
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Adjuvanticity of Tannic Acid-Modified Nanoparticles Improves Effectiveness of the Antiviral Response by Janicka M, Chodkowski M, Osinska A, Bylinska K, Obuch-Woszczatyńska O, Patrycy M, Chodaczek G, Ranoszek-Soliwoda K, Tomaszewska E, Celichowski G, Grobelny J, Cymerys J, Krzyżowska M

“…HSV-1 also invades the nervous system where it establishes a lifelong latency-making infection poorly treatable We previously showed that both tannic acid-modified silver and gold nanoparticles (TA-Ag/AuNPs) inhibit HSV-1 infection in vitro.Methods: We used an in vitro and in vivo model of HSV-1 infection to study how metal type, size and tannic acid modification of nanoparticles can influence development of the early innate response and the mounting of specific anti-HSV-1 response upon treatment of the nasal mucosa.Results: We found that tannic acid is necessary for binding with HSV-1, with smaller sizes independent of the NPs composition, whereas for larger NPs, only TA-AgNPs can inhibit HSV-1 infection. …”
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Small intestinal bacterial overgrowth and metabolic dysfunction-associated steatotic liver disease by Ziteng Wang, Ziteng Wang, Wentao Tan, Jiali Huang, Qian Li, Jing Wang, Hui Su, Chunmei Guo, Hong Liu

“…After stratifying by the diagnostic methods for SIBO and MASLD, the meta-analysis results suggest a reduction in inter-group heterogeneity. …”
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Protective Effects of Frankincense Oil on Wound Healing: Downregulating Caspase-3 Expression to Facilitate the Transition from the Inflammatory to Proliferative Phase by Krishnaraju Venkatesan, Durgaramani Sivadasan, Moufida Abderrahmen Al Weslati, Mohammed Gayasuddin Mouid, Manoj Goyal, Monika Bansal, Mohamed EL-Dosoky Mohamed Salama, Syed Azizullah Ghori, Fazil Ahmad

“…<b>Methods:</b> The chemical composition of FEO was analyzed using gas chromatography-mass spectrometry (GC-MS). …”
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Sex-Dependent Effects of Body Fat on Cardiac Function and Outcomes in Community-Dwelling Older Adults by Haowen Jiang, MBBS, Jie Jun Wong, MBBS, Glades H.M. Tan, BEng, Louis L.Y. Teo, MBBS, See Hooi Ewe, MBBS, PhD, Ru-San Tan, MBBS, Fei Gao, PhD, Angela S. Koh, MBBS, MPH, PhD

“…Methods: Community-dwelling older adults without cardiovascular disease underwent prospective baseline same-day anthropometry for body fat mass (BFM), percentage body fat (PBF), and waist hip ratio (WHR) quantification by bioimpedance and transthoracic Doppler echocardiography, with measurements repeated at 5 years. …”
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Skeletal Muscle‐Specific Deletion of E3 Ligase Asb2 Enhances Muscle Mass and Strength by Hye Rim Jang, Shi‐Young Park, Yeonmi Lee, Dongjin Lee, Jongjun Lee, Yoonil Cho, Cheol Soo Choi, Hui‐Young Lee

“…Methods Asb2 MKO mice were generated using Acta1‐Cre recombinase. …”
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Prevalence and Associated Factors of Sarcopenic Obesity Among Nursing Home Residents: A Cross‐Sectional Multi‐Centre Study by Doris Eglseer, Hristo Hristov, Sanja Krušič, Nadan Gregorič, Irena Hren, Igor Pravst, Živa Lavriša

“…The aims of the present study were to assess the prevalence of sarcopenic obesity, to evaluate the co‐occurence of sarcopenia, obesity and malnutrition (risk) and to assess the association between specific characteristics and sarcopenic obesity/probable sarcopenic obesity in nursing home residents. Methods Three hundred eighty‐seven nursing home residents with low to moderate care requirements from 20 nursing homes in Slovenia participated in the cross‐sectional NutriCare study. …”
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Limosilactobacillus reuteri prevents progression of ankylosing spondylitis in mice by restoring gut microbiota-metabolism homeostasis by Lianjun Yang, Ke You, Kun Wang, Bin Liu, Tao Chen, Zhifei Cui, Dawei Zhang, Zhihai Su, Xiang Liu, Hai Lu

“…Recent studies suggest that gut microbiota plays a crucial role in the pathogenesis of AS. Methods This study investigated the therapeutic effects of Limosilactobacillus reuteri (L. reuteri) on AS progression and its underlying mechanisms using a proteoglycan (PG)-induced mouse model. …”
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Effects of ketogenic diets on polycystic ovary syndrome: a systematic review and meta-analysis by Rossella Cannarella, Michele Rubulotta, Alessia Leonardi, Andrea Crafa, Antonio Calvo, Federica Barbagallo, Sandro La Vignera, Aldo E. Calogero

“…Abstract Background This systematic review and meta-analysis aimed to evaluate the effects of ketogenic diet (KD) and very-low-energy ketogenic therapy (VLEKT) protocols on various health outcomes in patients with polycystic ovary syndrome (PCOS) and increased body weight. Methods A systematic search was conducted across Scopus, PubMed, Cochrane, and Embase databases from their inception through January 2025, using a predefined search strategy. …”
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Biological maturation determines the beneficial effects of high-intensity functional training on cardiorespiratory fitness in male adolescents by Jarosław Domaradzki, Cristian Alvarez, Rafał Szafraniec, Dawid Koźlenia

“…Background During adolescence, between 15–18 years of age, biological maturation is associated with changes in body composition, blood pressure (BP), and cardiorespiratory fitness (CRF). …”
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Number of blood neutrophil granulocytes is associated with diffuse coronary involvement in patients with increased lipoprotein (a) by A. Yu. Filatova, E. A. Larina, O. I. Afanasieva, L. N. Ilina, N. V. Radukhina, M. I. Afanasieva, E. A. Klesareva, A. A. Shiryaev, S. K. Kurbanov, E. E. Vlasova, V. P. Vasiliev, Sergey N. Pokrovsky, Tatiana I. Arefieva

“…To assess the level of lipoprotein (a) (Lp(a)) and other lipid profile parameters, the composition of blood leukocytes in patients with focal and diffuse coronary atherosclerosis who underwent coronary artery bypass surgery (CABG), as well as to study the effect of Lp(a) on the activation of leukocytes in vitro.Material and methods. …”
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Testing and assessment procedure for evaluating the competencies of students (on the example of highly qualified personnel training) by Tatyana Nikolaevna Poddubnaya, Anna Andreevna Yurchenko

“…Methods of analysis, synthesis, analogy, generalization, modeling have been used in the research. …”
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Multi-omics data integration reveals metabolome as the top predictor of the cervicovaginal microenvironment. by Nicholas A Bokulich, Paweł Łaniewski, Anja Adamov, Dana M Chase, J Gregory Caporaso, Melissa M Herbst-Kralovetz

“…Multi-omics integration methods, including neural networks (mmvec) and Random Forest supervised learning, were utilized to explore potential interactions and develop predictive models. …”
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Plasma Fatty Acid Profiling and Mathematical Estimation of the Omega-3 Index: Toward Diagnostic Tools in Atherosclerosis and Statin Therapy Monitoring by Nikolay Eroshchenko, Elena Danilova, Anastasiia Lomonosova, Alexey Antonik, Svetlana Lebedeva, Daria Gognieva, Dmitry Shchekochikhin, Tatiana Demura, Marina Krot, Nana Gogiberidze, Abram Syrkin, Philipp Kopylov

“…<b>Methods:</b> In this case–control study, plasma and carotid plaques of 52 patients undergoing carotid endarterectomy were analyzed. …”
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Initiating Empagliflozin and Sacubitril/Valsartan Early After Acute Myocardial Infarction: Mechanistic Study by Daina Martínez‐Falguera, Júlia Aranyó, Gemma Ferrer‐Curriu, Albert Teis, Elena Revuelta‐Lopez, Idoia Diaz‐Güemes, Marta Monguió‐Tortajada, Edgar Fadeuilhe, Oriol Rodríguez‐Leor, Francesc Poblador, Borja Montejo, Santiago Roura, Roger Villuendas, Axel Sarrias, Victor Bazan, Esther Jorge, Victoria Delgado, Francisco Rafael Jimenez‐Trinidad, Montserrat Rigol, Neus Martinez‐Micaelo, Núria Amigó, Antoni Bayes‐Genis, Felipe Bisbal, Carolina Gálvez‐Montón

“…This study evaluated early empagliflozin initiation, with or without sacubitril/valsartan, on post‐MI inflammation, oxidative stress, metabolism, fibrosis, cardiac function, and ventricular tachycardia (VT) risk in a pig model. Methods A total of 24 of 30 pigs survived the MI procedure and were subsequently randomized to receive beta‐blocker treatment alone (control‐MI), beta‐blocker+empagliflozin, or beta‐blocker+empagliflozin+sacubitril/valsartan. …”
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Petrology and mineral chemistry of the Hamaneh granitoid, West of Yazd (Central Iran zone) by Javad Ghanei Ardakani, Maryam Ahankoub

“…Amphiboles, Biotite, plagioclase, and chlorite are minerals whose chemical composition show the temperature and pressure conditions of magma. …”
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Cost-Based Optimal Allocation of Shunt Capacitors in Radial Distribution Networks Considering Load Types Using Crow Search Algorithm by Stephen W. Mathenge, Edwell. T. Mharakurwa, Lucas Mogaka

“…Power flow analysis was conducted via the Backward/Forward Sweep (BFS) method on the IEEE 33-bus system, incorporating four load models: Constant impedance (CZ), constant current (CI), constant power (CP), and composite ZIP. …”
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