The Single Nucleotide Polymorphism PPARG2 Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients by Ana Paula dos Santos Rodrigues, Lorena Pereira Souza Rosa, Hugo Delleon da Silva, Elisângela de Paula Silveira-Lacerda, Erika Aparecida Silveira

“…Methods. 150 severely obese patients (body mass index (BMI) ≥ 35 kg/m2) from Central Brazil were recruited. …”
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Molecular endotypes in sepsis: integration of multicohort transcriptomics based on RNA sequencing by Kengo Mekata, Michihito Kyo, Modong Tan, Nobuaki Shime, Nobuyuki Hirohashi

“…We hypothesized that integrating RNA-seq data from patients with sepsis would reveal molecular endotypes with distinct biological and clinical signatures. Methods In this meta-analysis, we systematically searched for publicly available RNA-seq datasets of sepsis. …”
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Patterns of Immune Infiltration in Breast Cancer and Their Clinical Implications: A Gene-Expression-Based Retrospective Study. by H Raza Ali, Leon Chlon, Paul D P Pharoah, Florian Markowetz, Carlos Caldas

“…<h4>Methods and findings</h4>We applied an established computational approach (CIBERSORT) to bulk gene expression profiles of almost 11,000 tumours to infer the proportions of 22 subsets of immune cells. …”
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Associations of MIND and DI-GM dietary scores with depression, anxiety, and gut microbiota in patients with colon cancer: a cross-sectional study by Yaqin Meng, Jing Tian, Xiu Xiu Li, Zhou Xu

“…BackgroundDietary patterns influence psychological health, systemic inflammation, and gut microbiota composition in colon cancer patients. This study evaluates the associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) score and the Dietary Index for Gut Microbiota (DI-GM) with psychological outcomes, inflammatory markers, gut microbiota diversity (Shannon index) and composition (Firmicutes/Bacteroidetes ratio), and tumor biomarkers in colon cancer patients.MethodsA cross-sectional study was conducted on 630 colon Cancer patients. …”
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Characterization of vaginal microbiota across female reproductive phases by Qingzhi Zhai, Yuan Gao, Mingyang Wang, Li Li, Lian Li, Jianghua Li, Ying Ma, Ke Niu, Mingxia Ye

“…This study aimed to investigate the dynamic variations in vaginal microbial communities corresponding to different hormonal states throughout the female reproductive phase.MethodsVaginal samples were collected from 150 healthy women across five reproductive phases: follicular phase, luteal phase, early pregnancy, lactation, and menopause (30 samples per group). 16S rRNA sequencing was used to analyze the microbial composition. …”
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The prevalence and prognostic significance of Sarcopenia and Adipopenia in Pleural Mesothelioma by Andrew C. Kidd, Gordon W. Cowell, Geoffrey A. Martin, Jenny Ferguson, Dean A. Fennell, Matt Evison, Kevin G. Blyth

“…Introduction: Altered body composition is associated with adverse survival in multiple cancers. …”
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Study on the improvement of cognitive deficits in APP/PS1 mice by danggui shaoyao san and its disassembled prescriptions through modulation of the gut microbiota by Xingduo Liu, Chaoqun Sun, Yuqiong Dai, Feifei Duan, Tianzhen He, Menglu Zhen, Enxi Liang, Shuting Zhang, Yun Xia, Nianchun Hu, Ruoting Zhan, Ruoting Zhan, Dong Deng, Sijun Liu

“…This study investigated whether Danggui Shaoyao San and its disassembled prescriptions could improve cognitive deficits in APP/PS1 mice by modulating the structure of the gut microbiota, thereby providing a theoretical basis for AD treatment and the further development and application of Danggui Shaoyao San.MethodsForty APP/PS1 and eight C57BL/6 mice were divided into six groups: DSS (6.4 g/kg/d), QDW (4.6 g/kg/d), DW (1.8 g/kg/d), GV971 (positive control, 40 mg/kg/d), model (saline), and control (saline). …”
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Combination of Sodium Butyrate and Immunotherapy in Glioma: regulation of immunologically hot and cold tumors via gut microbiota and metabolites by Sui Li, Sui Li, Li Wang, MingYu Han, Huali Fan, Hailin Tang, Huile Gao, Guobo Li, Zheng Xu, Zhaokai Zhou, JunRong Du, Cheng Peng, Fu Peng, Fu Peng

“…The gut microbiota, particularly its bacterial composition, plays a crucial role in the development and function of the immune system. …”
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A novel measure for characterizing ultrasound device use and wear by Hamid Shokoohi, Andrew Goldsmith, Kay Negishi, Jeffrey R. Herrala, Eden Diamond, Sigmund Kharasch, Michael Blaivas, Andrew S. Liteplo

“…We propose the ULTrA model as a method to identify underperforming devices which could be upgraded or eliminated, and to compare relative performance amongst a group of departmental ultrasound machines. …”
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Cyclostratigraphy of the Miocene Nakayama Formation on Sado Island in central Japan and paleoceanographic implications by Jumpei Yoshioka, Junichiro Kuroda, Kenji M. Matsuzaki

“…Our new cyclostratigraphic age model and method are expected to promote using the Miocene siliceous sediments for paleoceanographic and paleoclimatologic studies. …”
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Kirjeldamisest lavastamiseni. Loovuurimuslik vaade / From Describing to Staging: A Practice-as-Research Look by Karl Saks, Hedi-Liis Toome, Anu Sööt, Ele Viskus

“…It is also recommended to use the model again in a similar learning process. …”
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Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice by Yun-kai Lin, Yu-fei Pan, Tian-yi Jiang, Yi-bin Chen, Tai-yu Shang, Meng-you Xu, Hui-bo Feng, Yun-han Ma, Ye-xiong Tan, Hong-yang Wang, Li-wei Dong

“…Methods In this work, we utilized lipidomics and microRNA (miRNA) sequencing to elucidate the lipid and miRNA profiles of AT-Exos in a diet-induced obesity model. …”
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End-to-End Intelligent Fault Diagnosis of Transmission Bearings in Electric Vehicles Based on CNN by Yong Chen, Guangxin Li, Anhe Li, Bolin He

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Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction evaluated by new angiography-derived index of microvascular resistance by Benoit Caullery, Laurent Riou, Stephanie Marliere, Estelle Vautrin, Nicolas Piliero, Olivier Ormerzzano, Helene Bouvaist, Gerald Vanzetto, Gilles Barone-Rochette

“…Background: Several methods for measuring IMR derived from angiography have been developed. …”
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Zero-Shot Remote Sensing Scene Classification Based on Automatic Knowledge Graph and Dual-Branch Semantic Correlation Supervision by Chao Wang, Jiajun Yang, Tanvir Ahmed, Yang Zhao, Tong Zhang, Bing Sun, Tao Xie, Jie Wang, Tianyu Chen

“…To address these limitations, this article proposes the &#x201C;zero-shot remote sensing scene classification via automatic knowledge graph and dual-branch semantic correlation supervision (AKG-DBSS).&#x201D; This method starts with the scenes and automates the construction of a knowledge graph, &#x201C;scene-landscape-ground objects&#x201D; (ASLG-KG), by analyzing the composition and spatial distribution of ground objects in local regions. …”
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Parameter optimization for multistage horizontal well fracturing based on multi-cluster perforation for deep coal measure gas: A case study of the Jurassic Baijiahai area in the Ju... by Bo WANG, Chenghong JIN, Jiang LIU, Zhiwei WANG, Shenjian LI, Mao SHENG

“…As a result, existing fracturing experience cannot be directly applied, highlighting the investigation of fracturing parameter optimization tailored for deep CMG production.MethodsFocusing on deep CMG reservoirs in the Baijiahai area within the Junggar Basin, this study constructed a model of multistage horizontal well fracturing based on multi-cluster perforation for a composite geological structure composed of a roof, a floor, gangue, and coals. …”
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Prediction of Unconfined Compressive Strength of Expansive Soil Amended with Bagasse Ash and Lime Using Artificial Neural Network by D.R. Goutham, A.J. Krishnaiah

“…Due to the complexities of this composite material, determining the UCS of stabilized ES using traditional methods such as empirical approaches and experimental methods is challenging. …”
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Theoretical and Experimental Study of the Effects of Impact Drilling Parameters on the Properties of Surrounding Rock Damage by Zhi Liu, Wanrong Wu, Qianhua Hao, Peng Sun, Yuangen Ding

“…. × 200 mm) containing central axial holes formed either by impact or nonimpact drilling methods were tested in uniaxial compression to failure on an Instron 1346 universal testing machine to investigate their mechanics and damage properties. …”
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Understanding normal and restricted normal products in soft directed graphs by Jinta Jose, Bobin George, Rajesh K. Thumbakara, Sijo P. George

“…Building on Molodtsov’s foundational work in developing soft set theory to address uncertainty in data, this study presents new methods for modeling and understanding complex systems where uncertainty plays a significant role. …”
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A Powerful Approach in Visualization: Creating Photorealistic Landscapes with AI by Gusztáv Jakab, Enikő Magyari, Benedek Jakab, Gábor Timár

“…The article, which primarily presents a methodological description, does not contain numerical results. To test the method, we applied a procedure: we ran the algorithm on a current topographic map of a sample area and compared the resulting image with the view model provided by Google Earth.…”
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