Mixture Containing 5% Polysaccharide Extract of <i>Cerioporus squamosus</i> (Huds.) Quélet, 5% Dexpanthenol, and 0.2% Hyaluronic Acid Shows In Vitro and In Vivo Wound Healing Prope... by Jovana D. Petrović, Tamara A. Carević Milićević, Jasmina M. Glamočlija, Jelena B. Kulaš, Ivana I. Mirkov

“…<b>Background:</b> This study explores wound healing and the antimicrobial potential of a natural formulation containing a polysaccharide extract from <i>Cerioporus squamosus</i>, hyaluronic acid, and dexpanthenol. <b>Methods:</b> Wound healing effects were assessed using HaCaT keratinocytes, while antimicrobial activity was evaluated against human skin pathogens using a microdilution assay. …”
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Whole genome comparisons reveal gut-to-lung translocation of Escherichia coli and Burkholderia cenocepacia in two cases of ventilator-associated pneumonia in ICU patients by Huihui Gao, Lei Xu, Yixin Liu, Xiaolong Wang, Siyuan Zhu, Huai Lin, Yuting Gao, Daqing Mao, Xing Lu, Yi Luo

“…However, the scarcity of reported cases with confirmed sources limits the ability to evaluate and manage VAP, which remains a major challenge for healthcare systems globally. Methods Pathogens were isolated from endotracheal aspirate (ETA) samples of VAP patients using conventional culture techniques. …”
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Single-cell RNA-sequencing uncovers the dynamic changes of tumour immune microenvironment in advanced lung adenocarcinoma by Lei Cheng, Tianqing Chu, Haijiao Lu, Jialin Qian, Yinchen Shen, Chaoxian Zhao

“…Background The heterogeneity of lung adenocarcinoma (LUAD) plays a vital role in determining the development of cancer and therapeutic sensitivity and significantly hinders the clinical treatment of LUAD.Objective To elucidate the cellular composition and reveal previously uncharacterised tumour microenvironment in LUAD using single-cell RNA-sequencing (scRNA-seq).Methods Two scRNA-seq datasets with 106 829 high-quality cells from 34 patients including 11 normal, 9 early (stage I and II) and 14 advanced (stage III and IV) LUAD were integrated and clustered to explore diagnostic and therapeutic cell populations and their biomarkers for diverse stages of LUAD. …”
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General principles of expanding the speed range of operation of autonomous power supply systems for passenger cars by S. L. Samoshkin, S. S. Mironov, O. S. Samoshkin, M. V. Khodenkov, A. S. Sarikov

“…It is solved by forcing the excitation of the generators.Analysis of modern systems of autonomous power supply of passenger cars showed that the expansion of the speed range of its operation can be achieved in three ways:•             raising the gear ratio of the gearbox to ensure it is switched on to the nominal mode at a carriage speed of 15 - 20 km/h without changing the parameters of the generator and the entire system of autonomous power supply;•             modernization of the electrical equipment complex for passenger cars to ensure the operation of the main power consumers and charge the battery while driving at low speeds (over 18 km/h) without changing the mechanical parameters and composition of the serial generator-drive unit;•             modernization of the generator in order to reduce its turnon revolutions to the power required to provide the main power consumers without changing the mechanical parameters of the drive.All three methods have its advantages and disadvantages, the choice of any of them is determined by the technical requirements for a specific car model.…”
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Anti-Obesity Properties of a <i>Latilactobacillus sakei</i> Strain in <i>C. elegans</i> and Diet-Induced Obese Rats by Ignacio Goyache, Paula Aranaz, Raquel Virto, Lorena Valdés, Miguel López-Yoldi, Ana Romo-Hualde, Fermin I. Milagro

“…Objective: we aim to characterize the effects of a novel probiotic strain of <i>Latilactobacillus sakei</i> (<i>L. sakei</i>) in two different animal models with adiposity excess. Methods: <i>Caenorhabditis elegans</i> was used as a starting in vivo model to analyse how the probiotics affect fat accumulation, oxidative stress, senescence, and lifespan when exposed to high-glucose conditions. …”
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Assessment of polyvinylpyrrolidone vinyl acetate effect on quercetin properties in binary solid dispersion prepared by hot melt extrussion by A. A. Danilova, K. A. Gusev, N. O. Arkhipova, L. G. Danilov, E. V. Vishnyakov, D. N. Maimistov, E. V. Flisyuk

“…Assessment of PVP/VA effect on quercetin solubility properties in binary solid dispersion prepared by HME.Materials and methods. Quercetin substance with purity 98 % was purchased from Molekula Limited, United Kingdom. …”
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Effect of melatonin on gut microbiome and metabolomics in diabetic cognitive impairment by Ming Gao, Ming Gao, Jie Li, Jie Li, Xu Han, Beiyao Zhang, Jinting Chen, Jiadong Lang, Qiangqiang Zhang

“…MEL has been shown to modulate gut microbiota composition in diabetic model. However, the underlying mechanism through which the gut microbiome contributes to DCI remains unclear. …”
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High-Risk Consult Multidisciplinary Team in a Tertiary Maternity Unit: Changing Prevalence of Cases by Ng YHG, Wright A, Ng YYV, Kavalloor NV, Tan LK, Quek BH, Tan KH

“…The High-Risk Consult (HRC) brings together a multidisciplinary team of specialists, including maternal–fetal medicine specialists, neonatologists, anaesthesiologists, and relevant subspecialities to provide comprehensive, individualized care for these complex pregnancies. While this model of care delivery is increasingly adopted worldwide, data on the prevalence and patterns within such multidisciplinary services remains limited.Objective: To describe the types of high-risk antenatal cases managed by an HRC and compare the prevalence of these conditions across two distinct time periods.Methods: This retrospective observational study analyzed all cases discussed at the HRC of a single tertiary center, KK Women’s and Children’s Hospital (KKH), in Singapore. …”
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Innovative Resource-Saving Equipment for Safflower Processing to Improve Oil Quality by Maigul Mursalykova, Gulnara Kokayeva, Mukhtarbek Kakimov, Bożena Gajdzik, Radosław Wolniak, Damian Dzienniak, Michał Bembenek

“…A comparative analysis of the physicochemical and fatty acid profiles of safflower oil produced using traditional and combined grinding-pressing methods confirmed the superiority of the new approach. …”
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Biostimulant-Based Molecular Priming Improves Crop Quality and Enhances Yield of Raspberry and Strawberry Fruits by Petar Kazakov, Saleh Alseekh, Valentina Ivanova, Tsanko Gechev

“…Methods: Metabolome analysis was performed by liquid chromatography–mass spectrometry analysis (LC-MS), and essential elements analysis was performed by inductively coupled plasma-mass spectrometry (ICP-MS). …”
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A randomized controlled trial utilizing an interactive accelerometer linked to a smartphone application for enhancing physical activity and health among military employees by Emilia Pietiläinen, Emilia Pietiläinen, Heikki Kyröläinen, Heikki Kyröläinen, Kai Parkkola, Kai Parkkola, Tiina Luukkaala, Tiina Luukkaala, Tommi Vasankari, Tommi Vasankari

“…IntroductionThe primary objectives of the present individualized randomized controlled trial were to increase physical activity (PA) and improve physical fitness.Materials and methods260 military employees around Finland participated. …”
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Perivascular Lymphocyte Clusters Induced by Gastric Subserous Layer Vaccination Mediate Optimal Immunity against Helicobacter through Facilitating Immune Cell Infiltration and Loca... by Chupeng Hu, Wei Liu, Ningyin Xu, An Huang, Zhiqin Zeng, Shuanghui Luo, Zhenxing Zhang, Menghui Fan, Feng Ye, Tao Xi, Yingying Xing

“…TRM cells have received increasing attention; however, the role of new vessels in protective response is still unknown. Materials and Methods. We performed the laparotomy to access the stomach and injected alum-based vaccine into the gastric subserous layer (GSL). …”
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Actions of annatto-extracted tocotrienol supplementation on obese postmenopausal women: study protocol for a double-blinded, placebo-controlled, randomised trial by Rui Wang, JaeHoon Lee, Amir Aryaie, Grant Tinsley, Bruce A Watkins, Lane Moore, Adel Alhaj-Saleh, Kartik Shankar, Sarah R Wood, Chwan-Li Shen

“…Cellular studies and high-fat-diet-induced obese mouse model mimicking obesity show the antiobesity effect of annatto-extracted tocotrienols (TT) with antioxidant capability. …”
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Mobile-Based Platform With a Low-Calorie Dietary Intervention Involving Prepackaged Food for Weight Loss for People With Overweight and Obesity in China: Half-Year Follow-Up Result... by Xi Wang, Suyuan Wang, Lingyu Zhong, Chenghui Zhang, Yanhong Guo, Mingxia Li, Li Zhao, Shuming Ji, Junjie Pan, Yunhong Wu

“…Dual-energy x-ray absorptiometry and quantitative computed tomography were used to assess body fat. A multilevel model for repeated measurements was used to compare differences between the 2 groups. …”
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Time Course of Changes in Extravascular Water of the Lung After Pneumonectomy According to the Data of Transpulmonal Thermodilution by V. V. Kuzkov, Ye. V. Suborov, V. N. Kuklin, M. Sobkhez, M. Yu. Kirov, L. Ya. Bjertnes

“…Objective: to study the accuracy of pulmonary extravascular water (PEVW) measurement by thermochromodilution (TCD) and isolated thermodilution (ITD) on a model of pneumonectomy and subsequent ventilator-induced lung lesion (VILL) in sheep.Materials and methods: the study was conducted at the Research Laboratory of University of Tromse. …”
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Lipid accumulation inhibition strategies alleviate Fusobacterium nucleatum-infected colorectal cancer by Zhongkun Zhou, Yuqing Niu, Yunhao Ma, Dekui Zhang, Yiqing Wang, Rui Ji, Jianfang Zhao, Chi Ma, Hongmei Zhu, Yingqian Liu, Lixue Tu, Juan Lu, Baizhuo Zhang, Hua Zhang, Xin Ma, Peng Chen

“…The development of treatment strategies for F. nucleatum-infected CRC is of great importance. Methods Shotgun metagenomic and metabolomic analyses of human feces, as well as metabolomic analysis of human blood, were performed to reveal the dysbiosis and metabolic dysregulation in CRC. …”
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Spectrum of γ-Secretase dysfunction as a unifying predictor of ADAD age at onset across PSEN1, PSEN2 and APP causal genes by Sara Gutiérrez Fernández, Cristina Gan Oria, Dieter Petit, Wim Annaert, John M. Ringman, Nick C. Fox, Natalie S. Ryan, Lucía Chávez-Gutiérrez

“…Methods We performed biochemical assessment of γ-secretase dysfunction on 28 PSEN2 and 19 APP mutations, including disease-associated, unclear and benign variants. …”
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The impact of <i>LEP</i> gene polymorphisms located at exon 2 (<i>LEP</i>-<i>Hin</i>fI) and intron 2 (<i>LEP-Sau</i>3AI) on growth and reproductive traits in Saanen goats by N. Senturk, T. N. Selvi, M. Demir, H. Ustuner, H. Samli, S. Ardicli

“…Population genetic analysis included the number of effective alleles, heterozygosity, polymorphism information content, and compatibility with the Hardy–Weinberg equilibrium. The general linear model procedure's least-squares methods were used for the statistical analysis. …”
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Strategies for upgrading the training of personnel at the Shanghai Municipal and district Centers for Disease Control and Prevention by HE Yongchao, SUI Mengyun, LI Yugang

“…ObjectiveTo investigate the current status of personnel training, barriers and bottlenecks at Shanghai Municipal and district Centers for Disease Control and Prevention (hereinafter referred to as" CDC"), so as to provide a reference basis for the formulation of training policies that are consistent with the CDC’s staff development path, characteristics of the era, and features of Shanghai mega⁃city.MethodsQuestionnaire survey and qualitative interview were used to collect the data, covering the basic information of the research subjects, as well as training status, needs, barriers and problems. …”
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Identifying functional groups among the diverse, recombining antigenic var genes of the malaria parasite Plasmodium falciparum from a local community in Ghana. by Mary M Rorick, Edward B Baskerville, Thomas S Rask, Karen P Day, Mercedes Pascual

“…This method for functional classification does not rely on an inferred phylogenetic history, nor does it rely on inferring function based on conserved sequence features. …”
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