Development of <i>Salvia officinalis</i>–Based Self-Emulsifying Systems for Dermal Application: Antioxidant, Anti-Inflammatory, and Skin Penetration Enhancement by Krisztina Bodnár, Boglárka Papp, Dávid Sinka, Pálma Fehér, Zoltán Ujhelyi, István Lekli, Richárd Kajtár, Fruzsina Nacsa, Ildikó Bácskay, Liza Józsa

“…The aim of our experimental work was to improve the solubility and thus bioavailability of the active ingredient by developing self-nano/microemulsifying drug delivery systems (SN/MEDDSs) with the help of Labrasol and Labrafil M as the nonionic surfactants, Transcutol HP as the co-surfactant, and isopropyl myristate as the oily phase. Methods: The formulations were characterized for droplet size, zeta potential, polydispersity index (PDI), encapsulation efficacy, and stability. …”
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Optimization of Protein Extraction from Rapeseed Oil Cake by Dephenolization Process for Scale-Up Application Using Artificial Neural Networks by Branislava Đermanovć, Jelena Vujetić, Tea Sedlar, Danka Dragojlović, Ljiljana Popović, Predrag Kojić, Pavle Jovanov, Bojana Šarić

“…To overcome these obstacles, various extraction and modification techniques, including enzymatic and ultrasound-assisted methods, were used to enhance protein functionality and improve both nutritional and sensory properties. …”
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Characterization of T-Cell Receptor Profiles Predicts Survival Situation in Patients with Hepatocellular Carcinoma by Fengyan Wang MD, Li Deng MD, Ziqiang Li MD, Qiwei Cao MD, Runze Jiang PhD, Changqing Xu MD, Jing Yang MD

“…Results The TCR composition in HCC long-survivors was found to be less diverse than in the short-survivors. …”
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Sodium butyrate alleviates DSS-induced inflammatory bowel disease by inhibiting ferroptosis and modulating ERK/STAT3 signaling and intestinal flora by Yingyin Liu, Nachuan Chen, Huaxing He, Lulin Liu, Suxia Sun

“…However, the precise mechanism linking NaB, IBD, and ferroptosis is not clear.Objective This study aimed to demonstrate that NaB suppresses ferroptosis, thereby alleviating inflammatory bowel disease (IBD) through modulation of the extracellular regulated protein kinases/signal transducer and activator of transcription 3 (ERK/STAT3) signaling pathway and intestinal flora.Methods An IBD model was established using 2.5% (w/v) dextran sulfate sodium (DSS). …”
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Effects of Breccias and Round Gravels on Steep Cut Slope Runoff and Sediment Yield Under Simulated Rainfall by Luo Jing, Pei Xiangjun, Li Junhao, Cao Longxi, Shan Shihan, Huang Yingping

“…[Methods] Based on the shape and material composition of a steep cut slope and on climatic characteristics along the Pai-Mo road, the cut slope runoff and sediment yield process was observed by using indoor simulated rainfall experiments. …”
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Overweight and obesity combined with low physical function and non-communicable diseases among older adults in nursing homes represent a group with nutritional risk, malnutrition,... by Tenna Christoffersen, Inge Tetens, Anja Weirsøe Dynesen, Margit Dall Aaslyng, Janne Kunchel Lorenzen, Anne Marie Beck

“…Methods: This cross-sectional pilot study included residents from six nursing homes in a rural Danish municipality. …”
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Evaluating the effects of time-restricted eating on overweight and obese women with polycystic ovary syndrome: A randomized controlled trial study protocol. by Hui Liu, Fuliang Shangguan, Fen Liu, Yu Guo, Huixi Yu, Hanbing Li, Yinhua Su, Zhongyu Li

“…Statistical analysis will include the Anderson-Darling test for normality, T-test/Wilcoxon test based on distribution, mixed-effects models for assessing time/group effects, Cox model for time-to-event analysis, repeated ANOVA for change analysis, and sensitivity analysis. …”
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Dynamics of subpopulations of CD15⁺CD66b⁺ and CD62L⁺CD63⁺ circulating neutrophils in patients with benign neoplasms and progression of k... by I. R. Myagdieva, T. V. Abakumova, D. R. Dolgova, O. Yu. Gorshkov, T. P. Gening, R. Sh. Zaineeva, S. A. Timofeeva

“…To assess the dynamics of CD15+CD66b+ and CD62L+CD6+ circulating neutrophil subpopulations in patients with benign neoplasms and during the progression of kidney cancer.Materials and methods. The study focused on circulating neutrophils from patients with benign neoplasms and kidney cancer. …”
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Neuroprotective Effects of Qi Jing Wan and Its Active Ingredient Diosgenin Against Cognitive Impairment in Plateau Hypoxia by Tiantian Xia, Ziqiao Yan, Pan Shen, Mingyang Chang, Nan Zhang, Yunan Zhang, Qi Chen, Rui Wang, Li Tong, Wei Zhou, Zhexin Ni, Yue Gao

“…However, its effects on cognitive dysfunction in plateau hypoxic environments remain unclear. <b>Methods</b>: In this study, acute and chronic plateau cognitive impairment mouse models were constructed to investigate the preventive and therapeutic effects of QJW and its significant active ingredient, diosgenin (Dio). …”
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Structural and optical tuning of BiVO₄ via cerium doping for enhanced dye degradation performance by Debapriya Pradhan, Susanta Kumar Biswal, Rasmirekha Pattanaik, Rishabh kamal, Suresh Kumar Dash, Prafulla kumar Panda, Nibedita Nayak

“…Abstract Nanomaterials with advanced functionalities offer immense potential for environmental remediation by accelerating pollutant degradation and promoting sustainable purification methods. This study presents the synthesis of lanthanide cerium (Ce)-doped BiVO₄ via a cost-effective co-precipitation approach, followed by a comprehensive evaluation of its structural, morphological, and optical characteristics. …”
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Obesity reprograms the normal pancreas and pancreatic cancer microbiome in mice and humans by Raquel Santana da Cruz, Shravanthy Suguru, Sara P. C. Paiva, Ijeoma Nwugwo, Bhaskar Kallakury, Benjamin A. Weinberg, Katherine L. Cook, Sonia de Assis

“…Yet, it is not understood whether patient’s characteristics impact this relationship.MethodsWe examined the influence of obesity (defined by body weight in mice or body mass index [BMI] in humans) on the normal and cancerous pancreas microbiome in mice and humans using 16S sequencing.ResultsOverall, we observed that diet-induced obesity accelerated PDAC progression in the KC mouse model of PDAC. …”
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Effect of benralizumab treatment on the airway microbiome in COPD by Koirobi Haldar, Vijay Mistry, Mathew Richardson, Corinne Hamblet, Maria Jison, Michael R. Barer, Christopher McCrae, Christopher E. Brightling

“…No significant changes in the composition or diversity of the sputum microbiome were observed. …”
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Association of weight-adjusted-waist index with all-cause and cardiovascular mortality in hypertension: a prospective cohort study by Youmian Lan, Qiongbing Zheng, Chujia Lin, Kun Lin, Yongsong Chen

“…This study aims to explore the association between WWI and all-cause and cardiovascular mortality in hypertensive patients. Methods Adult participants with hypertension were included from the National Health and Nutrition Examination Survey (2003–2016). …”
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Identification and bioinformatics analysis of cilia-associated gene families in Euplotes amieti (Ciliophora, Hypotrichia) by Liheng Shen, Xiaobing Xiong, Zixiang Xu, Yingli Liu, Yan Sheng, Xin Sheng

“…IntroductionCiliates serve as pivotal model organisms for investigating the protein composition and regulatory mechanisms underlying cellular processes. …”
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Development and Validation of the Questionnaire “Types of Role Self-Efficacy” by V.V. Enin

“…To date, there are no diagnostic methods that allow us to study the manifestation of role self-efficacy and its types. …”
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Fine ash from the Campanian Ignimbrite super-eruption, ~ 40 ka, southern Italy: implications for dispersal mechanisms and health hazard by Flaminia Gianchiglia, Paolo Ballirano, Biagio Giaccio, Andreas Koutsodendris, Sebastien Nomade, Alessandro Pacella, Danilo M. Palladino, Jörg Pross, Daniel Veres, Gianluca Sottili

“…Current atmospheric dispersal models rely on empirical drag equations calibrated with geometric shape descriptors. …”
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Mediating effect of physical activity on the association between body fat distribution, dysmobility syndrome, and cognitive impairment in older women in the community by Minjun Kim, Inhwan Lee

“…Purpose: To examine the association between body fat distribution, dysmobility syndrome, and cognitive impairment in 181 community-dwelling older women and assess physical activity’s mediating role. Methods: Body composition was assessed using dual-energy X-ray absorptiometry, and the android-to-gynoid (A/G) fat ratio was calculated as the android fat proportion divided by the gynoid fat proportion. …”
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Elevated serum adiponectin, elevated tumor necrosis factor-α and decreased transthyretin in Japanese elderly women with low grip strength and preserved insulin sensitivity by Satomi Minato, Kaori Kitaoka, Mika Takeuchi, Ayaka Tsuboi, Miki Kurata, Tsutomu Kazumi, Keisuke Fukuo, Megumu Yano

“…Objective To determine if serum adiponectin levels are associated with low grip strength and/or low muscle mass in the elderly independently of insulin resistance and inflammation.Research design and methods Cross-sectional associations were analyzed by logistic regression between low grip strength and/or low muscle mass and body composition, elevated serum adiponectin (≥20 mg/L), and biomarkers of nutrition status, insulin resistance and inflammation in 176 community-living Japanese elderly women. …”
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Distribution of different plant life forms on tropical islands: patterns and underlying mechanisms by Chengfeng Yang, Jingyan Zhao, Shengzhuo Huang, Shurong Zhou, Yikang Cheng

“…The structural equation model (SEM) revealed that island area, isolation, and climatic factors directly affect the richness and abundance of trees but not shrubs. …”
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Schisandrin B alleviates metabolic associated fatty liver disease by regulating the PPARγ signaling pathway and gut microbiota in mice by Jiuchen Wan, Chenjian Lang, Meng Gao, Feilong Liu, Xiyuan Feng, He Li, Chunmei Wang, Jinghui Sun

“…ObjectiveThe aim of this study was to investigate the improving effect of Schisandrin B (Sch B) on metabolic associated fatty liver disease (MAFLD) by regulating the PPARγ signaling pathway and gut microbiota, and its mechanism in mice.MethodsMale C57BL/6 mice were fed with a high-fat diet (HFD) continuously for 16 weeks to establish a MAFLD model. …”
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