Predictive value of self-prioritized mobility factors on gait speed and life space in older nigerians: A cross-sectional study by Divine Esohe Eghomwanre, Freeman Ojeikere Ahonsi, Isreal Adandom, Tyler Sun, Daniel Rayner, Francis Kolawole, Henrietta Fawole, Soroush Shirazi, Michael Kalu

“…The gait speed model indicates that an increase in executive function, pain, respiratory system, body composition, fatigue, social factors, racial characteristics, marital status, social network, and fear of reinjury explain about 74 % of variation in gait speed. …”
Get full text

116 Acute inorganic arsenic exposure and antibiotic perturbation of the murine gut microbiome induce interindividual susceptibility to a sepsis-like disease by Trenton Wolfe, Barbara A. Roggenbeck, Qian Wang, Lu Wang, Emma Dardenne-Ankringa, Andreina Rodoni, Nick V. Pinkham, Reece Erickson, Seth T. Walk

“…Here, we aim to understand how baseline microbiomes from various mouse vendors impact these outcomes and characterize the observed disease. Methods/Study Population: We developed a novel mouse model where mice are exposed to an antibiotic (cefoperazone) for 2 days, followed by co-exposure to the antibiotic and 100 ppm arsenate. …”
Get full text

Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration by Graham Hagger, Sarah Guest, Stephen Birchall, Alys Bradley, Charlie Brindley, David Corbett, Paul J. Cummings, Cristina Freire, James Harris, Andrew Wise, Melanie Wood, Lloyd G. Czaplewski

“…Here, we describe the development and preclinical characterization of a formulation of linezolid, a suspension of 50 mg/mL micronized powder, for intradiscal administration. Methods Micronization, particle size analysis, Franz cell diffusion assays, ex vivo bioassay, and estimates of gelling temperature were used to optimize the composition and properties of the formulation. …”
Get full text

Potential mechanisms of action of Jiao'ai decoction in the treatment of premature ovarian failure: Integrated molecular pathway, gut flora, and untargeted metabolism by Da Zhang, Xiaoqing Zhang, Dongsheng Wei, Ning Wang, Piwen Zhao

“…Specifically, we evaluated the receptor for advanced glycation end (RAGE) products pathway, metabolic disorders, and intestinal flora dysbiosis. Methods: Forty female rats with normal estrous cycles were randomly divided into five groups: control, model, estradiol, low-dose JAD, and high-dose JAD, with 8 rats in each. …”
Get full text

Studying the possibilities of pharmacological correction of hypoxia-induced pulmonary hypertension using a phenolic compound with a laboratory cypher KUD975 by L. V. Korokina

“…The aim of our work was to study a pharmacological activity of a selective arginase-2 and thrombin inhibitor from a phenolic compounds group with a laboratory cypher KUD975 on a model of arterial pulmonary hypertension induced by hypoxia.Materials and methods. …”
Get full text

Brake rigging dynamic simulation under braking on a track section with irregularities (the case of a passenger car) by I. A. Yaitskov, V. V. Kosarevskii

“…The simulated modeling of the brake rigging system of a passenger car with KVZ-TsNII type II trolleys equipped with shoe brakes is carried out.Results. …”
Get full text

Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation by Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler, Fang Xiao

“…Methods Bile acids in fecal samples from patients with IBD and DSS-induced colitis mice, with and without antibiotic treatment, were analyzed using ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). …”
Get full text

Heavy grazing intensifies antagonistic effects of nitrogen and phosphorus addition on the water use efficiency of grasslands in Inner Mongolia by Xuebao Xu, Shiming Tang, Yanlong Li, Guangyi Lv, Tongrui Zhang, Bin Zhang, Zhaokai Sun, Zhenpeng Liu, Xinning Wang, Hongyun Yao, Cuiping Gao, Xinya Wang, Chongzhi Sun, Fengqin Yuan, Lei Zhang, Chengjie Wang

“…However, the regulatory effects of grazing intensity on plant WUE under nitrogen (N) and phosphorus (P) addition remain unclear. Methods This study employed stable carbon isotope techniques in a typical steppe ecosystem in Inner Mongolia, China, to investigate the effects of grazing, N and P addition, and their interactions on the foliar δ13C values of four dominant plant species. …”
Get full text

Multi-Objective Optimization Design of Ship Propulsion Shafting Based on Response Surface Methodology and Genetic Algorithm by ZHANG Cong, SHU Bingnan, ZHANG Jiangtao, JIN Yong

“…In order to reduce the power loss of the transmission equipment, enhance the transmission efficiency of the propulsion shafting, and improve the vibration performance of the shafting, a multi-objective optimization design of a ship shafting experimental platform is performed based on the response surface model and genetic algorithm. The central composite design (CCD) method is used to select appropriate experimental points in the optimized design space, and the response surface model is developed with minimum total power consumption and vibration response amplitude. …”
Get full text

COMPLEXITY OF SELLING PRODUCTS AND SERVICES FOR CRYPTOCURRENCIES by Tetiana Yarotska, Oleksandr Yakushenko

“…Using the Group Method of Data Handling (GMDH), we identified a connection between Bitcoin’s value fluctuations and market indicators that differ in terms of technological orientation (Nasdaq Composite) and investment risk (silver). …”
Get full text

Metagenomics and Non‐Targeted Metabolomics Reveal the Role of Gut Microbiota and Its Metabolites in Brain Metastasis of Non‐Small Cell Lung Cancer by Chen‐Guang Liu, Mei‐Xi Lin, Yu Xin, Man Sun, Jia Cui, Dan Liu, Dan Zang, Jun Chen

“…Gut microbiota composition and metabolite profiles were detected and analyzed, and statistical methods, including machine learning models, were applied to identify differences and potential biomarkers. …”
Get full text

Expression of the TIGIT axis and the CD39/CD73 purinergic pathway in bone metastasis-derived immune cells by Elias Brauneck, Leon-Gordian Leonhardt, Anne Marie Assemissen, Yagana Wahid, Moritz Kruppa, Niklas Kruppa, Julius Krüger, Stephan Menzel, Friedrich Koch-Nolte, Julian Kylies, Katja Weisel, Carsten Bokemeyer, Jasmin Wellbrock, Walter Fiedler, Lennart Viezens, Franziska Brauneck

“…The study aimed to compare the composition of immune cell infiltration from aspirates of different BM prior to systemic therapy. …”
Get full text

Reaction Pathways of Oxidative Transformation of the Radioprotector Quercetin by V. V. Olicheva, A. D. Titova, I. R. Ilyasov, V. N. Fateenkov, A. V. Braun

“…The influence of the solvent composition on the oxidation products during the autoxidation of quercetin was revealed, while the radical and electrochemical models of oxidation differ in the presence of polymer adducts. …”
Get full text

Research on evaluation of basic railway safety management capability based on combination weighting – TOPSIS by Yankun Qi, Xiaoyu Li, Jinghui Liu, Hanqiu Li, Chen Yang

“…Game theory combination weighting is utilized to integrate subjective and objective weight values derived using AHP and CRITIC methods and further combined using the TOPSIS method in order to construct a comprehensive basic railway safety management capability evaluation model. …”
Get full text

Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats by Baocang Yin, Baocang Yin, Mingzhen Yang, Mingzhen Yang, Bowen Wang, Bowen Wang, Yun Zhang, Yun Zhang, Ningli Li, Ningli Li, Qin Li, Yingying Li, Cory J. Xian, Tiejun Li, Tiejun Li, Yuankun Zhai, Yuankun Zhai

“…Modern pharmacological research has proved that E. ulmoides could prohibit the occurrence of osteoporosis and arthritis.AimTo investigate the effect and action mechanism of total flavonoids isolated from the leaves of E. ulmoides (TFEL) on bone loss in ovariectomized (OVX) rats, and to study its effect on intestinal flora.Materials and methodsThe 3-month-old female rats were randomly divided into six groups: sham operation group, OVX model group, estradiol group, TFEL low (TFEL-L) (50), mid (-M) (100) and high (-H) (200 mg/kg/d) dose groups. …”
Get full text

Evaluation of the Effect of κ-casein Gene Polymorphism in Milk Powder on the Technological Properties of Acid-Induced Milk Gels by Alexandr G. Kruchinin, Svetlana N. Turovskaya, Elena E. Illarionova, Alana V. Bigaeva

“…The experiment involved standard methods, optical methods, dynamic viscometry, and PCR-RFLP. …”
Get full text

A Handheld IoT Vis/NIR Spectroscopic System to Assess the Soluble Solids Content of Wine Grapes by Xu Zhang, Ziquan Qin, Ruijie Zhao, Zhuojun Xie, Xuebing Bai

“…The results indicate that spectral data optimization methods are effective and essential for improving the performance of SSC prediction models. …”
Get full text

Comprehensive Analysis of the Influence of Technical and Biological Variations on De Novo Assembly of RNA-Seq Datasets by Gonzalez Sergio Alberto, Rivarola Maximo, Ribone Andres, Lew Sergio, Paniego Norma

“…One problem to overcome is the research gap regarding the best method to use in each study to obtain high-quality de novo assembly. …”
Get full text

Genetic structure of the European hedgehog (Erinaceus europaeus) in Denmark. by Sophie Lund Rasmussen, Jeppe Lund Nielsen, Owen R Jones, Thomas B Berg, Cino Pertoldi

“…We used a Bayesian clustering method to subdivide individuals into genetically distinct populations. …”
Get full text

Influence of wet and dry commercial diets on the oral microbiota of Yorkshire terriers by Corrin Wallis, Zack Ellerby, Gregory Amos, Lucy J. Holcombe

“…Exploratory factor analysis, a statistical method for dimensionality reduction of multivariate data, was used to identify groups of covarying bacterial species. …”
Get full text