In vitro and in vivo investigations of selected varieties of Areca catechu L - Phytochemical analysis, antiulcer, and wound healing activity by R. Deveswaran, D.J. Madhu Kumar, V. Madhavan, Soma Chaki, Misbah Khan, Govind R. Kadambi, B.V. Basavaraj, J. Anbu

“…Background: This study investigated the phytochemical composition and potential medicinal properties of arecanut grown in various regions of Karnataka. …”
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NT2-derived astrocyte–neuron co-culture reflects physiological relevance and offers research validity by Sylwia Kedracka-Krok, Ewelina Fic, Zuzanna Cepil, Piotr Rybczyński, Agata Szlaga, Radosław Cacała, Sławomir Lasota, Anna Blasiak, Marta Dziedzicka-Wasylewska

“…Ntera-2 cells and NT2 cells are used interchangeably in this publication. Methods Using an advanced proteomic approach, we assessed the protein composition and abundance of neuron and astrocyte co-cultures and discovered that the astrocytic protein profile in co-culture with neurons was more representative compared with that in pure astrocyte cultures. …”
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Chitosan/Sodium Tripolyphosphate/Sodium Alginate/miRNA-34c-5p Antagomir Scaffolds Promote the Functionality of Rabbit Cranial Parietal Repair by Lin C, Bai X, Zhang L

“…Subsequently, the in vivo efficacy of miR-34c-5p Agomir/Antagomir in regulating bone repair was evaluated in the rabbit cranial bone defect model, with micro-CT scanning and histological analysis conducted at 4, 8, and 12 weeks.Results: CTS scaffolds with a composition ratio of 1:0.2:0.1 were successfully synthesized, exhibiting a mean particle size of 360.1 nm. …”
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Multi-omics insights into beagle dog fed with a sucking-rewarded automatic feeding device by Yang Jiao, Xin Wang, Aizhen Yu, Li Wu, Hongping Li

“…The present study is designed to investigate the impacts of this innovative device, utilizing a multi-omics profiling approach, on beagle dogs as a surrogate model.MethodsThis study involved seven-day-old male newborn beagle puppies, carefully selected and matched in terms of body weights. …”
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Qing-Re-Hua-Shi Decoction ameliorates DSS-induced colitis by modulating multiple signaling pathways and remodeling the gut microbiota and metabolite profile by Wei Chen, Lin Xu, Long Wang, Yu-nan Shan, Yan Li, Jin-shui Zhu

“…However, its molecular mechanisms remain unclear.PurposeThis study investigates the effects of QRHSD on DSS-induced colitis in mice, employing multi-omics analyses, including RNA-seq transcriptomics, 16S rRNA microbiomics, non-targeted metabolomics, and network pharmacology analysis.MethodsThe chemical composition of QRHSD was analyzed using quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). …”
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Gegen Qinlian Decoction Ameliorated DSS-Induced Colitis by Attenuating Inflammation, Restoring Intestinal Mucosal Barrier and Modulating Gut Microbiota by Wang Y, Yan R, Ye L, Tang C, Zhou H, Zhao G

“…However, the specific mechanisms by which GQD exerts its effects remain poorly understood, limiting its application in UC treatment.Purpose: In this study, we utilized a dextran sodium sulfate-induced colitis model in mice to evaluate the efficacy of GQD and to elucidate its underlying mechanisms.Methods: Network pharmacology was employed to explore the potential targets and signaling pathways of GQD, which were subsequently validated using Western blot. …”
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A myostatin inhibitory antibody combined with insulin, partially rescues the musculoskeletal phenotype of female insulin-deficient diabetic mice by R. Clay Bunn, Reuben Adatorwovor, Philip D. Ray, Alexander R. Keeble, Christopher S. Fry, Sasidhar Uppuganti, Jeffry S. Nyman, John L. Fowlkes, Evangelia Kalaitzoglou

“…Inhibition of myostatin, a negative regulator of muscle mass, was explored as a druggable target to improve the musculoskeletal phenotype associated with insulin-deficient diabetes in female mice.MethodsWe investigated whether administration of an inhibitory myostatin antibody (MyoAb) in streptozotocin-induced diabetes in female mice is protective for skeletal muscle and bone. …”
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Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis by Hongming Wei, Lu Zhan, Xinhuang Lv, Yan Lin, Jie Zheng, Wenwen Yang, Jiaming Liu, Jing Sun, Songfang Chen

“…Recent studies have highlighted the important role of gut microbiota in both hyperuricemia and AIS, but there is little available data on the relationship between gut microbiota and the pathogenesis of AIS with hyperuricemia (HAS). Methods Here we profiled the gut microbiota composition in 63 HAS patients and 269 non-HAS patients through 16s rRNA sequencing. …”
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Effect of Iron Content on the Thermal Conductivity and Thermal Diffusivity of Orthopyroxene by Xinzhuan Guo, Bo Feng, Baohua Zhang, Shuangmeng Zhai, Weihong Xue, Yunke Song, Yuping Song, Xinxin Yan

“…With increasing Fe content, the two parameters both quickly decrease from the beginning and then slack off. We further modeled the thermal evolution of S‐type asteroids, which strongly depends on the composition model and the dimension of the planet. …”
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Sequence characterization and evolutionary analysis of S-RNase gene among five genera Pomoideae by LIANG Wenjie, XIE Zhiliang, Wuyun Tana

“…The Find Best DNA/Protein Models program of MEGA11 software was used to find out the optimal model suitable for the sequence of 5 genera of Pyridae S-RNase gene, and the corresponding model and algorithm were used to calculate the differentiation between the sequences. …”
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Lateral Spacing of TiO₂ Nanotube Coatings Modulates In Vivo Early New Bone Formation by Andreea Mariana Negrescu, Iuliana Ionascu, Madalina Georgiana Necula, Niculae Tudor, Maksim Kamaleev, Otilia Zarnescu, Anca Mazare, Patrik Schmuki, Anisoara Cimpean

“…The in vivo new bone formation was histologically evaluated (haematoxylin and eosin—HE staining) at 6 and 30 days post-implantation in a rat model. Mechanical characterisation revealed that the two morphologies presented a similar chemical composition and mechanical strength, but, in terms of surface roughness, the spTNTs exhibited a higher average roughness. …”
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LIGHTWEIGHT DESIGN FOR OVERHAUL TOOLING SUPPORT SEAT BASED ON TOPOLOGY OPTIMIZATION AND SIX SIGMA ROBUSTNESS by WANG ZiNing, WU JianJun, XIANG JianMing, WANG BaiSong, JIN YingQi

“…Support seat’s topology structures was extracted based on topology optimization with variable density method. The response surface model was established based on the central composite design method and the finite element numerical simulation technique. …”
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Effect of Subsurface Drip Irrigation on Soil Desalination and Soil Fungal Communities in Saline–Alkaline Sunflower Fields by Jiapeng Zhang, Dongmei Qiao, Dongliang Zhang, Zhaonan Chi, Xueqin Fan, Lixia Cao, Weiping Li

“…Structural equation modeling quantified the relationships between soil physicochemical properties, with an SMC of 0.94, indicating a model fit within an acceptable range. …”
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The Relationship Between Cover Crop Species and Soil Fungal Communities in Irrigated Vineyards in the Okanagan Valley, Canada by Erika Y. Lin, Daniel Rosa, Mehdi Sharifi, Michael J. Noonan, Miranda Hart

“…Groundcover vegetation can be employed as a natural method for increasing soil health and perennial plant performance; however, cover crop species may differ in the plant–soil feedback effects that modulate the rhizosphere. …”
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Refined Monitoring of Water Bodies in Built-Up Areas and Analysis and Evaluation of Water Color Characteristics in Complex Urban Backgrounds by Bin Li, Yong Xie, Zui Tao, Wen Shao, Gan Qin

“…Comparison with measured data reveals a root mean square error of 3.9° and an average absolute percentage error of 1.5%, validating the proposed method’s accuracy. Industrial location, population density, soil erosion, and other factors significantly affect water color, particularly as industrial activities and soil erosion alter water composition and suspended solids, directly impacting water color. …”
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Unbalanced long-chain fatty acid beta-oxidation in newborns with cystic fibrosis and congenital hypothyroidism by Catherina T. Pinnaro, Kelli K. Ryckman, Aliye Uc, Andrew W. Norris

“…Lipid catabolism is downregulated in hypothyroidism. Methods: We analyzed acylcarnitine data in newborn screening blood spot samples from infants with cystic fibrosis, with congenital hypothyroidism, or without congenital disorders. …”
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Optimizing polyphenol extraction and UPLC-MS/MS analysis from red clover (Trifolium pratense L.) species using response surface methodology by Emily P. Verhulst, Carlos Álvarez, Nigel P. Brunton, Dilip K. Rai

“…The combined factors of ethanol concentration (60–80%), extraction time (15–45 min) and extraction temperature (40–80°C) were evaluated. Central composite design software was used to conduct Response Surface Methodology (RSM) modelling and optimize the polyphenol yield from the red clover. …”
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Identifying and ranking the effective financial factors on rural entrepreneurial small businesses by Khosro Farahi, Parvaneh Gelard, Hamid Tohidi

“…Data analysis and validation of financial factors on rural entrepreneurship in both service and agriculture sectors were performed using the fitting of a time-series regression model. The results indicate a positive and significant effect of rural population ratio, financing through financial institutions, economic growth, openness rate in business space, gender composition, and inflation rate in agriculture sectors, as well as a significant reverse effect of official employment rate, job-seeking population ratio, exchange rate uncertainty, government employment rate and graduation ratio on entrepreneurship in both service and agriculture sectors. …”
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Microfluidics study on immiscible displacement mechanisms of oil by hybrid low salinity water and polymer in fractured porous media by Masoumeh Amiri, Mobeen Fatemi

“…Abstract Application of hybrid low salinity water and polymer flooding (LSPF) as an enhanced oil recovery (EOR) method takes advantage from the wettability alteration by low salinity water and enhancement of mobility ratio by addition of polymer. …”
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Muzyka i horror. "Lśnienie" Stanleya Kubricka by Krzysztof Kozłowski

“…The study shall employ Carl Dahlhaus’ (1971) model of “method of interpretative analysis” used in respect to Richard Wagner as well as the notion of Wagners Konzeption des musikalischen Dramas. …”
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