Chemical Diversity of UK-Grown Tea Explored Using Metabolomics and Machine Learning by Amanda J. Lloyd, Alina Warren-Walker, Jasen Finch, Jo Harper, Kathryn Bennet, Alison Watson, Laura Lyons, Pilar Martinez Martin, Thomas Wilson, Manfred Beckmann

“…The intraclass variability in leaf composition was similar between the varieties. We explored the metabolic changes over the day in one variant (<i>Camellia assamica</i> Masters), yielding a model with a significant R² value of 0.617 (<i>p</i> < 0.01, 3000 permutations). …”
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The impact of Alpinia galanga rhizome fortification on the nutritional profile, antioxidant capacity and sensory characteristics of White Lacy Pancake (appam) by Debopriya Mandal, Sarita Roy, Runu Chakraborty

“…This study investigates the use of galangal rhizome (Alpinia galanga) to enhance appam’s sensory attributes and nutritional profile. Methods In the preliminary experiment, galangal rhizome was dried at various microwave powers, such as 360 W, 720 W, and 900 W, to get maximum TPC, TFC, and FRAP values. …”
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Specific soil factors drive the differed stochastic assembly of rhizosphere and root endosphere fungal communities in pear trees across different habitats by Yunfeng Liu, Yunfeng Liu, Zhenzhou Wang, Xiang Sun, Xueli He, Yuxing Zhang

“…However, the mechanisms underlying the assembly of these symbiotic fungal communities in the roots of P. betulifolia across different habitats remain poorly understood.MethodsPyrus betulifolia of 30-year-old were selected from five sites in northern China to investigate the assembly of fungal communities in the rhizosphere and root endosphere. …”
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Clinical and Hemodynamic Effects of CPAP-Therapy in Patients with Cardiogenic Pulmonary Edema by M. V. Gorbunova, A. R. Tatarsky, S. L. Babak, L. A. Golubev, A. G. Chuchalin

“…Central hemodynamic parameters were measured before and 60 and 180 minutes after the initiation of CPAP-therapy, by using a Swan-Ganz thermodilution cathether (HANDS OFF, model AH-05000-H, ARROW, USA). Arterial and mixed venous blood gas composition was rapidly determined on an automatic gas analyzer (Rapidlab 348, Bayer, USA).Results. …”
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The alleviating effects and mechanisms of Enterococcus faecium Kimate-X and Lactobacillus plantarum Kimate-F combination on canine inflammatory bowel disease by Rui Zhang, Wanjin Hu, Saiwei Zhong, Weiyang Chen, Shuang Xie, Meiru Chen, Qinghua Yu

“…In vivo efficacy was evaluated in dextran sulfate sodium (DSS)-induced colitis models in mice and dogs. Metagenomic sequencing was performed on canine fecal samples to analyze microbiota composition and functional pathways. …”
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Protective Effect of Obeticholic Acid on Sepsis-Induced Liver Dysfunction via Regulating Bile Acid Homeostasis by Jiahui Wang, Li Ma, Yuan An, Yan Ge, Dan Xu, Enqiang Mao

“…This study aims to explore the protective effect and mechanism of the FXR agonist obeticholic acid (OCA) on liver dysfunction when sepsis occurs. <b>Methods:</b> A rat model of sepsis was induced by cecal ligation and puncture (CLP) for 24 h. …”
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Irisin mitigates osteoporotic-associated bone loss and gut dysbiosis in ovariectomized mice by modulating microbiota, metabolites, and intestinal barrier integrity by Yiran Wang, Huimin Deng, Zhihui Zhang, Hongbo Wu, Xiaofeng Wang, Zhiwen Zhang

“…This study aimed to investigate the role of irisin in mitigating osteoporotic bone defects by examining its effects on gut microbiota, related metabolites, and intestinal barrier integrity. Methods An osteoporosis model was created using ovariectomized (OVX) mice. …”
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The Effects of Different Types of Exercise on Pulmonary Inflammation and Fibrosis in Mice with Type 2 Diabetes Mellitus by Haoyang Gao, Xiaotong Ma, Ze Wang, Danlin Zhu, Yifan Guo, Linlin Zhao, Weihua Xiao

“…This study aimed to investigate the impact of different exercise types (swimming, resistance training, and high-intensity interval training [HIIT]) on pulmonary inflammation and fibrosis in T2DM mice, and to explore underlying molecular mechanisms. <b>Methods:</b> A T2DM mouse model was established by a high-fat diet (HFD) combined with streptozotocin (STZ) induction. …”
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Heart Failure Impairs Bone Marrow Hematopoietic Stem Cell Function and Responses to Injury by Tina B. Marvasti, Faisal J. Alibhai, Grace J. Yang, Shu‐Hong Li, Jun Wu, Terrence Yau, Ren‐Ke Li

“…Patients with HF exhibited more circulating blood myeloid cells, and analysis of patient BM revealed significant differences in cell composition and colony formation potential. Human CD34+ cell reconstitution potential was also assessed using the NOD‐SCID‐IL2rγnull mouse xenotransplant model. …”
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Synthesis and properties of some pyrazole derivatives of 1,2,4-triazole-3-thiol by A. S. Hotsulia, S. M. Kulish

“…The aim of the research was to examine the conditions for obtaining S-alkylderivatives of 5-(5-methylpyrazole)-4-ethyl-1,2,4-triazole-3-thiol and to investigate these compounds’ properties. Materials and methods. The first phase of the research involved the use of diethyloxalate, acetone and sodium methylate as starting substances for the synthesis of the intermediate. …”
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Synthesis and properties of 2-(4-phenyl-5-(((5-phenylamino-1,3,4-thiadiazole-2-yl)thio)methyl)-1,2,4-triazole-3-yl)thio)ethanoic acid and its salts by A. S. Hotsulia, S. O. Fedotov

“…Estimation of the biological potential of the obtained compounds by molecular modeling method. Materials and methods. 4-Phenyl-5-(((5-phenylamino-1,3,4-thiadiazole-2-yl)thio)methyl)-1,2,4-triazole-3-thiol, which was synthesized by the classical method described in earlier works, was used as a key intermediate. …”
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A Comprehensive Study Employing Computational Analysis and Mendelian Randomization Has Revealed the Impact of Key Genes on Liver Cancer by Size Li, Wenying Qi, Junzheng Wu, Chunhua Luo, Shihao Zheng, Xu Cao, Wei Wang, Qiyao Liu, Hongbo Du, Xiaoke Li, Xiaobin Zao, Yongan Ye

“…We also used the CIBERSORT deconvolution method to evaluate immune cell composition in HCC tissues, followed by correlation studies examining relationships between our key genes of interest and various immune cell populations. …”
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Investigating male factors and their relationships with reproductive health outcomes: a case-control study protocol for Towards Optimal Fertility, Fathering, and Fatherhood studY (... by Fabian Yap, See Ling Loy, Yin Bun Cheung, Jerry Kok Yen Chan, Keith Godfrey, Chee Wai Ku, Jun Wei Pek, Melissa D/O Tharmalingam Durgahshree, Melinda Chan, Yie Hou Lee

“…Predictive male factors will be identified using the least absolute shrinkage and selection operator method, accounting for female factors. We will construct a logistic regression model incorporating both male and female factors to derive a fertility index, which will be evaluated using cross-validation on subsets of the study population. …”
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Non-Invasive Multiclass Diabetes Classification Using Breath Biomarkers and Machine Learning with Explainable AI by Alberto Gudiño-Ochoa, Julio Alberto García-Rodríguez, Raquel Ochoa-Ornelas, Eduardo Ruiz-Velazquez, Sofia Uribe-Toscano, Jorge Ivan Cuevas-Chávez, Daniel Alejandro Sánchez-Arias

“…This study presents a breath-based multiclass diabetes classification system leveraging only three gas sensors (CO, alcohol, and acetone) to analyze exhaled breath composition. <b>Methods</b>: Breath samples were collected from 58 participants (22 healthy, 7 prediabetic, and 29 diabetic), with blood glucose levels serving as the reference metric. …”
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Simulation and optimization of heat transfer in underground in-situ shale upgrading by LI Yuan, ZHONG Anhai, QIAN Qin, YU Denglang, ZHANG Yuzhe, ZHONG Yanlei, WANG Dan

“…A three-dimensional fracture-network heat transfer model was established. Combined with the finite element fluid simulation technology， the heat transfer law of the fracture-network was systematically simulated and analyzed， and the influence law of fracturing， gas injection volume， gas injection temperature， rock layer heating methods， and insulation on the heating effect of in-situ upgrading was explored. …”
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Artificial intelligence–based diabetes risk prediction from longitudinal DXA bone measurements by Sulaiman Khan, Zubair Shah

“…To handle class imbalance, we augmented our data using Synthetic Minority Over-sampling Technique (SMOTE) and SMOTEENN (SMOTE with Edited Nearest Neighbors), and to further investigated the association between bones data features and diabetes status, we employed ANOVA analytical method. For diabetes onset prediction, we employed both conventional and deep learning (DL) models to predict risk factors associated with diabetes in Qatari adults. …”
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Atmospheric Cold Plasma Technology Enabling Scalable Surface‐Independent Protein Immobilization for Biosensing Applications by Lieze Dankers, Bernard Nisol, Derick Yongabi, Tom Van der Donck, Jesús Gándara Loe, Patrick Wagner, Jin Won Seo, Rob Ameloot, Karen Leirs, Jeroen Lammertyn

“…Consistent performance across polymethylmethacrylate (PMMA), cyclic olefin copolymer (COC), polyvinyl chloride (PVC), and glass proves the method’s universal applicability. Hence, this technology enables versatile, scalable, cost‐effective biosensor fabrication with high‐performance bioreceptor layers on various surfaces.…”
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Impact of amber powdered waste on the processability and properties of PCL-based materials by Cláudia A.B. dos Santos, Bartłomiej Kryszak, Michał Grzymajło, Łukasz J. Wilk, Patrycja Szymczyk-Ziółkowska, Adam Junka, Aleksandra Ujćič, Konrad Szustakiewicz

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The relation between the gut microbiome and osteoarthritis: A systematic review of literature. by Emanuele Chisari, Marjan Wouthuyzen-Bakker, Alex W Friedrich, Javad Parvizi

“…<h4>Methods</h4>An extensive review of the current literature was performed using three different databases. …”
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Fatty acids of erythrocyte membranes and blood serum as biomarkers for early detection of colorectal cancer by M. V. Kruchinina, V. N. Kruchinin, A. A. Gromov, M. V. Shashkov, A. S. Sokolova, I. N. Yakovina, A. A. Shestov

“…The aim of the study was to identify fatty acids (FA) of erythrocyte membranes and blood serum, which can serve as potential biomarkers for early detection of colorectal cancer.Material and methods. the study involved 65 patients with stage I-II CRC (mean age 63,3 ± 9,6 years (30 men, 35 women) and 35 people in the comparison group, matched by age and sex. the composition of fatty acids of erythrocyte membranes and blood serum was studied using a gc/ms system based on three agilent 7000B quadrupoles (USA). methods of the MATLAB software (R2019a, MathWorks) and the R programming language were used for statistical processing: t-test, unsupervised principal component analysis (PCA), Fold change, Volcano plot, machine learning method (Random Forest), Roc analysis, Heatmaps.Results. patients with stage I-II CRC showed a decrease in the level of saturated, individual monounsaturated fatty acids and a highly significant increase in the most of the polyunsaturated fatty acids with a predominance of omega-3. …”
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