Therapeutic effects of medicinal and food-based traditional herbal couples on type 2 diabetes mellitus based on pharmacodynamics and pharmacokinetics by Yuhang Xu, Jing Li, Mengyao Cui, Xiaoliang Li, Hongyan Zhai, Deling Wu, Deling Wu, Deling Wu, Xiaoqin Chu, Xiaoqin Chu, Xiaoqin Chu, Xiaoqin Chu

“…However the mechanism of action of CR-PLR on T2DM has not yet been fully elucidated.MethodsThe decoction of CR-PLR was prepared by aqueous extraction method and the composition of it was analyzed using UPLC-Q-TOF-MS and HPLC. …”
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Land Use/Land Cover Change Impact on Hydrological Process in the Upper Baro Basin, Ethiopia by Tewodros Getu Engida, Tewodros Assefa Nigussie, Abreham Berta Aneseyee, John Barnabas

“…The Soil Water Assessment Tool (SWAT) model was used for the simulation of the streamflow. …”
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Palmitic acid and eicosapentaenoic acid supplementation in 3T3 adipocytes: impact on lipid storage and oxidative stress by Edina Bakondi, Tobias Jung, Susanna Marg, Vanessa Schnell, Daniela Weber, Tim J. Schulz, Tilman Grune, Annika Höhn

“…Adipocytes, with a key role in regulating metabolic homeostasis, respond to increased calorie intake and altered fatty acid composition with hypertrophy or hyperplasia. Of particular interest are saturated fatty acids such as palmitic acid and omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA), which have differential effects on adipocyte function and inflammation.Methods Using 3T3-L1 cells as a model for adipocytes, we evaluated the effects of PA and EPA on lipid accumulation, droplet size, and oxidative stress markers.Results We were able to show that EPA supplementation in 3T3 adipocytes does not lead to excessive lipid accumulation, but rather reduces the size of lipid droplets and also induces redox changes due to the unsaturated nature of EPA.Discussion These results emphasize the contrasting roles of PA and EPA and the importance of fatty acid composition in the regulation of adipocyte function.…”
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Features and relationships of metabolic syndrome components in men with androgen deficiency. Part 2. Disorders of carbohydrate and purine metabolism. Retrospective study data by Z. Sh. Pavlova, V. Yu. Grevina

“…Currently, few epidemiological data on a relation between impaired purine and carbohydrate metabolism and testosterone deficiency in overweight men due to adipose tissue and metabolic syndrome (MS) are available.Aim: to study relationships between disturbances in carbohydrate and purine metabolism and testosterone level in men with adipose tissue excess and MS.Materials and Methods. There were enrolled 64 overweight men to the study. …”
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Regulation of lipid metabolism by 1,2,4-trioxolanes and betulin under hypoxia and immobilization stress in rats by N. B. Melnikova, D. S. Malygina, P. V. Yastrebov, I. V. Spitskaya, A. G. Soloveva, A. E. Fayans, A. L. Esipovich

“…Lipid metabolism disorders, caused by both excessive physical and psycho-emotional stress, and physical hypoxia, are important problems in the prevention and treatment of a number of diseases.The objective was to study the effect of 1,2,4-trioxolanes and betulin in fish oil on lipid and energy metabolism in an experiment on rats under hypoxia and immobilization stress (IS).Methods and materials. The studies were carried out using 75 male Wistar rats (intact and experimental animals) on a model of hypoxia and immobilization stress for 10 days. …”
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Decoding hippocampal subfield and glial responses in ischemia using single-cell transcriptomics by Donghee Kwak, Ji Hyun Park, Yun Hak Kim, Hong Il Yoo

“…Understanding the cellular and molecular alterations in these regions before and after ischemic insult can provide insights into stroke pathology and recovery mechanisms. Methods We conducted single-cell RNA sequencing on Sprague–Dawley rats subjected to four-vessel occlusion (4-VO) surgery, a model of transient global cerebral ischemia, and compared them with normal control rats. …”
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The correlation between insulin resistance and blood lipids in children by Jiang Li, Xu Lulian, Lu Yang, Xu Xu

“…Background: This work focused on the correlation between insulin resistance (IR) and blood lipids (BL) in children with simple obesity, as well as the intervention effects of high-intensity interval training (HIIT) in weight loss in children. Methods: 80 children aged 6 to 17 years with simple obesity were selected from our hospital and randomly grouped into two groups. …”
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附加非线性阻尼夹层的间隙弹性机构减振分析 by 王国庆, 左建昌, 王帑, 刘宏昭

“…It is presented to realize the low cost vibration control that method of adhering nonlinear damping alloy constraint layer partly to the component of mechanism with clearance joints.The nonlinear spring damping contact model is adopted to describe the contact force of the clearance joint elements,based on it,the dynamic model of the crank rocker mechanism with clearance joints is established.By using curve fitting describe the rule of the dissipation factor of damping alloy changing with stress and taking account of the sheared,the nonlinear constitutive relation was given depending on the stress and strain base on the equivalent viscous damping theory,then deduced a type of composite element model with two nodes and ten degrees of freedom,which had the characteristics of nonlinear damping and structural damping,established the dynamic model of the elastic mechanism partly adhering nonlinear damping alloy constraint layer.The methods presented are feasible by numerical simulation.…”
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From design to 3D printing: A proof-of-concept study for multiple unit particle systems (MUPS) printed by dual extrusion fused filament fabrication by Lee Roy Oldfield, Aaron Felix Christofer Mentrup, Stefan Klinken-Uth, Tobias Auel, Anne Seidlitz

“…Control of release can be achieved by adapting the particle composition. Despite the advantages of MUPS, only a limited number of preparations are available on the market. 3D printing could be a new advantageous method to produce MUPS tablets compared to the conventional production via tableting. …”
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Sorption Equilibria of Heavy Metals on Polysiloxane with Grafted 2-aminoethylpyridine Functional Groups by A. S. Zasuhin, L. K. Neudachina, Yu. G. Yatluk, V. A. Osipova, Yu. S. Moskaleva, E. F. Muzipova, M. V. Morozova, V. A. Starcev

“…A new silica-based organic-inorganic hybrid material with grafted 2-aminoethylpyridine functional groups (SiAEP) has been synthesized by sol-gel method. Methods of the elemental analysis, 13С and 1H NMR spectroscopy have been used in order to find substance composition; surface-structural characteristics of the SiAEP have been defined by method of nitrogen adsorption–desorption isotherms. …”
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Fecal occult blood affects intestinal microbial community structure in colorectal cancer by Wu Guodong, Wu Yinhang, Wu Xinyue, Shen Hong, Chu Jian, Qu Zhanbo, Han Shuwen

“…Subsequently, FOBT was included as a characteristic element in the model construction, and the prediction accuracy of the model was all increased. …”
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Expert panel as reference standard procedure in diagnostic accuracy studies: a systematic scoping review and methodological guidance by Bas E. Kellerhuis, Kevin Jenniskens, Mike P. T. Kusters, Ewoud Schuit, Lotty Hooft, Karel G. M. Moons, Johannes B. Reitsma

“…This review maps the current landscape of expert panels used as reference standard in diagnostic accuracy or model studies. Methods PubMed was systematically searched for eligible studies published between June 1, 2012, and October 1, 2022. …”
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C-Reactive Protein-to-Serum Chloride Ratio: A Novel Marker of All-Cause Mortality in Maintenance Haemodialysis Patients by Francisco Valga, Tania Monzón, José C. De la Flor, Angelo Santana-del-Pino, Nicanor Vega-Díaz, Ana Yurena Sanchez-Santana, Gloria Antón-Pérez, Sergio Ruiz-Santana, José C. Rodríguez-Pérez, Patricia Perez-Borges

“…Survival time was collected for all patients and analysed using the Kaplan–Meier method. A Cox proportional hazards regression model was used to evaluate survival probabilities. …”
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Comparison of In Vitro Biotransformation of Olive Polyphenols Between Healthy Young and Elderly by Stef Lauwers, Anne-Sophie Weyns, Annelies Breynaert, Tim Van Rillaer, Valerie Van Huynegem, Erik Fransen, Wout Bittremieux, Sarah Lebeer, Emmy Tuenter, Nina Hermans

“…Therefore, it can be hypothesised that differences in the gut microbiome between young and elderly individuals may impact the biotransformation rate and the type and amount of metabolites formed. Methods: An in vitro biotransformation model was used to mimic the conditions in the stomach, small intestine and colon of two age groups of healthy participants (20–30 years old, ≥65 years old), using oleuropein as a single compound and an olive leaf extract as test compounds. …”
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Associations of Individual and Neighborhood Factors with Disparities in COVID-19 Incidence and Outcomes by Margaret E. Samuels-Kalow, Rebecca E. Cash, Kori S. Zachrison, Auriole Corel Rodney Fassinou, Norman Harris II, Carlos A. Camargo Jr.

“…Many studies have used neighborhood racial/ethnic composition to study such disparities, but less is known about the interplay between individual race/ethnicity and neighborhood racial composition. …”
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Computed tomography-derived quantitative imaging biomarkers enable the prediction of disease manifestations and survival in patients with systemic sclerosis by Gabriela Riemekasten, Felix Nensa, Hanna Grasshoff, René Hosch, Malte Maria Sieren, Lennart Berkel, Jörg Barkhausen, Roman Kloeckner, Franz Wegner

“…Despite its known impact on body composition (BC), clinical decision-making has yet to incorporate these biomarkers. …”
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Focusing on scRNA-seq-Derived T Cell-Associated Genes to Identify Prognostic Signature and Immune Microenvironment Status in Low-Grade Glioma by Jiayu Wen, Qiaoyi Huang, Jiuxiu Yao, Wei Wei, Zehui Li, Huiqin Zhang, Surui Chang, Hui Pei, Yu Cao, Hao Li

“…The clinical outcomes of low-grade glioma (LGG) are associated with T cell infiltration, but the specific contribution of heterogeneous T cell types remains unclear. Method. To study the different functions of T cells in LGG, we mapped the single-cell RNA sequencing results of 10 LGG samples to obtain T cell marker genes. …”
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Study of Technological Parameters and Pharmacological Activity of the Gel with Strawberry (<i>Fragaria ananassa</i>) Leaves with Dry Extract by O. V. Yaborоva, I. V. Alekseeva, V. D. Belonogova, O. A. Oleshko

“…Based on technological, biopharmaceutical and pharmacological research methods, the composition of a gel from strawberry leaves with dry extract, which has antimicrobial and anti-inflammatory effects, was proposed and substantiated for the first time. …”
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UV Hyperspectral Imaging and Chemometrics for Honeydew Detection: Enhancing Cotton Fiber Quality by Mohammad Al Ktash, Mona Knoblich, Frank Wackenhut, Marc Brecht

“…Reference cotton samples were sprayed multiple times with honey solutions to replicate the natural composition of honeydew. Comparisons were made with an alternative method where samples were soaked in sugar solutions of varying concentrations. …”
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Experimental studies of natural material-based coatings for thermal protection of metallic surfaces by Alexander A. Genbach, David Yu. Bondartsev, Natalia A. Genbach, Ekaterina A. Genbach

“…The thermodynamic characteristics of thermal tools have been established in the model and experimentally; the granulometric composition of materials has been obtained; the hydrodynamic operating modes of the burners have been selected (fuel combustion method, jet length, jet angle). …”
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