A comparative review of Haute Autorité de Santé and National Institute for Health and Care Excellence health technology assessments of Ikervis® to treat severe keratitis in adult p... by Yasmina Iffet Eroglu

“…Objective: To review the dry eye disease environment, its challenges and available treatment options, and compare the NICE and HAS assessments to question HAS’ decision to maintain full reimbursement of compounded CsA formulations in the absence of evidence, while reimbursing the EMA-approved drug at 15%. Method: extensive search on PubMED. Results: Comparator selection, composite score assessment and use of CE model are key differentiators. …”
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A Data-Driven Approach to Link GC-MS and LC-MS with Sensory Attributes of Chicken Bouillon with Added Yeast-Derived Flavor Products in a Combined Prediction Model by Simon Leygeber, Carmen Diez-Simon, Justus L. Großmann, Anne-Charlotte Dubbelman, Amy C. Harms, Johan A. Westerhuis, Doris M. Jacobs, Peter W. Lindenburg, Margriet M. W. B. Hendriks, Brenda C. H. Ammerlaan, Marco A. van den Berg, Rudi van Doorn, Roland Mumm, Age K. Smilde, Robert D. Hall, Thomas Hankemeier

“…This study describes a straightforward data-driven approach for studying foods with added YPs to identify flavor-impacting correlations between molecular composition and sensory perception. It also highlights limitations and preconditions for good prediction models. …”
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Snake Venom Peptide Fractions from <i>Bothrops jararaca</i> and <i>Daboia siamensis</i> Exhibit Differential Neuroprotective Effects in Oxidative Stress-Induced Zebrafish Models by Felipe Assumpção da Cunha e Silva, Brenda Rufino da Silva, Leticia Ribeiro de Barros, Emidio Beraldo-Neto, Adolfo Luis Almeida Maleski, Carlos Alberto-Silva

“…While the peptide fraction (<10 kDa) from <i>Bothrops jararaca</i> venom has shown in vitro neuroprotection, analogous fractions from related species remain unexplored in vivo. <b>Methods:</b> This study comparatively evaluated the neuroprotective effects of two peptide fractions (pf) from <i>Daboia siamensis</i> (pf-<i>Ds</i>) and <i>B. jararaca</i> (pf-<i>Bj</i>) against H₂O₂-induced oxidative stress using in vitro (PC12 cells) and in vivo (zebrafish, <i>Danio rerio</i>) models. …”
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Integrating data from unmanned aerial vehicles and Sentinel-2 with PROSAIL-5D-driven machine learning for fuel moisture content estimation in agroecosystems by Jinlong Liu, Jia Jin, Jing Huang, Mengjuan Wu, Shaozheng Hao, Haoyi Jia, Tengda Qin, Yuqing Huang, Dan Chen, Nathsuda Pumijumnong

“…The results indicate: (1) The AWT fusion method effectively integrates UAV and Sentinel-2 data, improving spatial and spectral consistency with field measurements. (2) Calibration of the PROSAIL-5D model significantly improves the retrieval accuracy of equivalent water thickness (Cw, R2 = 0.847) and dry matter content (Cm, R2 = 0.735), both key parameters for FMC calculation. (3) Incorporating 70 % of the measured spectral data (UAV and fused Sentinel-2) into the PROSAIL-5D simulated dataset enhanced FMC estimation accuracy (R2 = 0.765), representing a 133.94 % improvement compared with using UAV data alone. …”
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Biomod2 for evaluating the changes in the spatiotemporal distribution of Locusta migratoria tibetensis Chen in the Qinghai-Tibet Plateau under climate change by Rulin Wang, Nier Wu, Zhaopeng Shi, Chao Li, Na Jiang, Chun Fu, Mingtian Wang

“…[Objective] The present study endeavors to elucidate the impact of climate change on the distribution of Locusta migratoria tibetensis Chen and to furnish theoretical underpinnings for the forecasting and management of this pest. [Method] Utilizing 68 geographical distribution points of L. migratoria tibetensis, in conjunction with 6 environmental variables, a composite model was developed employing the Biomod2 software package to simulate potential shifts in the spatial distribution of L. migratoria tibetensis under future climate scenarios. …”
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Assessing Digital Performance of Public Services in the EU: E-Governance and Technology Integration by Oana Ramona Lobonț, Cristina Criste, Alexandra Ioana Vintilă, Andreea Florentina Crăciun, Nicoleta Claudia Moldovan

“…To evaluate the digital performance of the European Union regions, the analysis employs the following methods: (i) Principal Component Analysis to construct a composite Institutional Quality Index based on governance indicators, (ii) Gaussian graphical models to assess the relationships between digital intensity, institutional quality, and e-government highlighting the interconnections between variables, (iii) Data Envelopment Analysis to measure the relative efficiency of public service delivery, and (iv) cluster dendrograms to identify the clusters of countries with similar performance levels and challenges. …”
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Analysis of Three-Dimensional Micro-Contact Morphology of Contact Groups Based on Superpixel AMR Morphological Features and Fractal Theory by Jiahang Shen, Defeng Cui, Wenhua Li, Peidong Zhao, Xianchun Meng, Jiyuan Cai, Zheng Han, Haitao Wang

“…To fully obtain multimodal data such as the three-dimensional micro-morphological features and chemical composition distribution of contact surfaces, this paper proposes a contact surface feature-matching method based on entropy rate superpixel seed point adaptive morphological reconstruction. …”
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Developments in gastrointestinal organoid cultures to recapitulate tissue environments by Madeline R. Kuhn, Madeline R. Kuhn, Emma A. Wolcott, Emma A. Wolcott, Ellen M. Langer, Ellen M. Langer, Ellen M. Langer

“…Organoids provide a manipulable platform to investigate organ development and function as well as to model patient-specific phenotypes. This mini review examines various methods used for culturing organoids to model normal and disease conditions in gastrointestinal tissues. …”
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Monitoring Spatial-Temporal Variability of Vegetation Coverage and Its Influencing Factors in the Yellow River Source Region from 2000 to 2020 by Boyang Wang, Jianhua Si, Bing Jia, Xiaohui He, Dongmeng Zhou, Xinglin Zhu, Zijin Liu, Boniface Ndayambaza, Xue Bai

“…We investigated spatial-temporal changes in vegetation coverage by combining the maximum value composite (MVC), the dimidiate pixel model (DPM), the Theil–Sen median slope, and the Mann–Kendall test. …”
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Digital culture of a modern teacher as a professional activity resource in the conditions of educational space digital transformation by Alexandra Vladimirovna Leontyeva, Saida Aslanovna Bibalova, Fatima Ramazanovna Khatit

“…This goal was achieved through the use of the following research methods: literature analysis, classification, modeling, description, ways of visualizing data in the form of figures and tables.The results of the research: 1) the analysis of scientific sources has made it possible to determine the conceptual approaches to considering the problem of the digital culture of a teacher, which made it possible to accumulate information and develop a map of the component composition of a teacher’s digital culture; 2) the basic components of a teacher’s digital culture have been theoretically substantiated: digital literacy and motivational-value attitude; 3) a procedure for assessing the level of formation of a teacher’s digital culture has been proposed.Key conclusions: 1) the map of the component composition of the digital culture of a teacher is an integrative information about the essence and composition of the digital culture of a teacher and includes the types of digital competence, their corresponding competencies, indicators and digital skills; 2) the basic components of a teacher’s digital culture are digital literacy and a motivationalvalue attitude, each of which is represented by indicators and digital skills corresponding to it; 3) the methodology for assessing the formation of a teacher’s digital culture includes a level scale and the calculation of an individual index of digital competence. …”
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Prediction cardiovascular deterioration in a paediatric intensive care unit (PicEWS): a machine learning modelling study of routinely collected health-care dataResearch in context by Dan Fredman Stein, Michael J. Carter, John Booth, Mark J. Peters, Samiran Ray, Neil J. Sebire, Payam Barnaghi, Mario Cortina-Borja

“…We compared model compositions, including without trend, variability, and frequency of input to smaller models. …”
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In silico study of hyposalivation and sugar exposure on biofilm dysbiosisWhy Is This Important? by David Head, PhD, Philip D. Marsh, PhD, Deirde Devine, PhD, Livia M.A. Tenuta, DDS, MS, PhD

“…Maintaining dental biofilm symbiosis (health) under hyposalivation requires knowledge of the impact of acid inhibition under given dietary regimens. Methods: An individual-based mathematical model was used to predict biofilm dysbiosis under normal or hyposalivatory conditions by regulating the frequency of sugar intake and inhibiting microbial glycolysis, reducing the acid challenge to the tooth mineral. …”
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Cartilage defect repair in a rat model via a nanocomposite hydrogel loaded with melatonin-loaded gelatin nanofibers and menstrual blood stem cells: an in vitro and in vivo study by Libo Yuan, Ling Yao, Xianzhen Ren, Xusheng Chen, Xu Li, Yongqing Xu, Tao Jin

“…In this study, we developed a composite hydrogel system for the delivery of melatonin and menstrual blood stem cells (MenSCs) to treat a rat model of cartilage defect. …”
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A MATHEMATICAL APPROACH TO INVESTMENT WITH CHARGE ON BALANCE AND VOLUNTARY CONTRIBUTIONS UNDER WEIBULL MORTALITY FORCE FUNCTION by Edikan Edem Akpanibah, Peter Benneth, Ase Matthias Esabai

“…Furthermore, an optimization problem is established from the extended Hamilton Jacobi Bellman (EHJB) equation using variational method. By applying the variable separation technique and mean variance utility, the optimal control strategy (OCS) and the efficient frontier are obtained. …”
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Evaluation of the current status and risks of aquatic ecology in the Jialing River Basin based on the characteristics and succession trends of phytoplankton communities by Maojin Huang, Fei Xu, Jia Xia, Xue Yang, Fubin Zhang, Siyao Liu, Tuo Zhang

“…Morphological identification methods, random forest, neutral community model, and modified stochasticity ratio were used to analyze phytoplankton composition, environmental drivers, and community assembly mechanisms. …”
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New Approaches to Studying Prevalence Gallstone Disease by N. A. Khokhlacheva, T. S. Kosareva, A. P. Lukashevich

“…The study applied statistical forecasting methods. Models were built in the Microsoft Excel 2010 program in a polynomial trend.Results. …”
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Quality by Design and In Silico Approach in SNEDDS Development: A Comprehensive Formulation Framework by Sani Ega Priani, Taufik Muhammad Fakih, Gofarana Wilar, Anis Yohana Chaerunisaa, Iyan Sopyan

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Longitudinal Reciprocal Effects of Physical Exercise, Executive Function, and Subjective Well-Being: A Three-Wave Random-Intercept Cross-Lagged Panel Model in Chinese Minority Coll... by Xueyan Bai, Lin Yang

“…Data were analyzed using a random-intercept cross-lagged panel model (RI-CLPM), and multigroup analysis (MGA) was used to examine the moderating effects of gender, family ethnic composition, and residential area. …”
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A scoring model integrating CXCL9, GDF15, FGF21, and NfL, predicts long-term mortality in type 2 diabetes: a retrospective study by Matilde Sbriscia, Sara Caccese, Francesca Marchegiani, Rina Recchioni, Giulia Matacchione, Chiara Giordani, Emanuele Francini, Stefano Salvioli, Maria Conte, Matteo Landolfo, Anna Rita Bonfigli, Federica Turchi, Jacopo Sabbatinelli, Fabiola Olivieri, Angelica Giuliani

“…A biomarker-based scoring model was developed by integrating independent predictors of mortality. …”
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The crustal structure of Onega-Kandalaksha paleorift identified by complex analysis of the anomalous magnetic field of the White Sea by A. S. Baluev, Yu. V. Brusilovsky, A. N. Ivanenko

“…The parameters of the magnetically active layer are estimated by the independent complementary methods of quantitative interpretation developed by the Laboratory of Geophysical Fields, P.P. …”
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