Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study by Yilin Hou, Yilin Hou, Peipei Tian, Peipei Tian, Guangyao Song, Guangyao Song, Guangyao Song, An Song, Dandan Liu, Dandan Liu, Zhimin Wang, Zhimin Wang, Yihe Shi, Yihe Shi, Yale Tang, Yale Tang, Xiaoyu Wang, Xiaoyu Wang, Luxuan Li, Luxuan Li, Luping Ren, Luping Ren, Luping Ren

“…This study explores the oral fat tolerance test (OFTT) for its predictive value in CAS, using postprandial TRL levels as a diagnostic biomarker.MethodsA total of 107 volunteers with normal fasting lipid profiles and no CAS at baseline were included. …”
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ISG15 as a Potent Immune Adjuvant in MVA-Based Vaccines Against Zika Virus and SARS-CoV-2 by Juan García-Arriaza, Michela Falqui, Patricia Pérez, Rocío Coloma, Beatriz Perdiguero, Enrique Álvarez, Laura Marcos-Villar, David Astorgano, Irene Campaña-Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Carmen Elena Gómez, Susana Guerra

“…Finally, we evaluated the magnitude and functional quality of the elicited antigen-specific cellular immune responses in vivo. <b>Results:</b> Analysis of early innate responses revealed both platform- and variant-specific effects. …”
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Evaluating Cardiac Impairment From Abnormal Respiratory Patterns: Insights From a Wireless Radar and Deep Learning Study by Chun-Chih Chiu, Wen-Te Liu, Jiunn-Horng Kang, Chun-Chao Chen, Yu-Hsuan Ho, Yu-Wen Huang, Zong-Lin Tsai, Rachel Chien, Ying-Ying Chen, Yen-Ling Chen, Nai-Wen Chang, Hung-Wen Lu, Kang-Yun Lee, Arnab Majumdar, Shu-Han Liao, Ju-Chi Liu, Cheng-Yu Tsai

“…Thus, this study analyzed respiratory patterns from a wireless radar framework to explore their associations with echocardiographic (2D-echo) measurements. Methods: Background details, 2D-echo parameters, and biochemical data were collected from patients in a cardiology ward in northern Taiwan. …”
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Universal Fab-Fc masked cytokine prodrug platform: αPD-L1/IL-15 prodrug activates CD44+ CD8+ T cells in tumor-draining lymph nodes to enhance antitumor immunity by Wei Li, Ying Qin, Zejian Wang, Luyao Song, Gen Qi, Wenqiang Shi, Qiongya Zeng, Zilan Song, Ao Zhang, Huili Lu

“…Antitumor efficacy of P-T was assessed in two murine cold tumor models. A comprehensive immune correlate analysis was conducted in the tumor and tumor-draining lymph node (TDLN) to identify key effector cells responsible for overcoming resistance, followed by further confirmation with egression of T cell blockade, surgical excision of TDLN, and adoptive transfer experiments. …”
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Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients by Ahmad A Tarhini, Zhihua Chen, Dongliang Du, Joshua Davis, Justin C Boucher, Katarzyna A Rejniak, Jose A Guevara-Patino, Timothy I Shaw, Alyssa Obermayer, Mate Z Nagy, Lourdes B Plaza-Rojas, Elena Kostenko, Anna L Austin, Awino Maureiq E Ojwang'

“…As T cell-based therapies often fail to work in solid tumors, this study aims to investigate the effects of hypoxia on T cell topo-distribution in the TME, gene expression association with T cell states, and clinical responses in melanoma.Methods To generate detailed information on tumor oxygenation and T cell accessibility, we used mathematical modeling of human melanoma tissue microarrays that incorporate oxygen supply from vessels, intratumoral diffusion, and cellular uptake. …”
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Long-term associations of PM1 versus PM2.5 and PM10 with asthma and asthma-related respiratory symptoms in the middle-aged and elderly population by Xue-yan Zheng, Shu-jun Guo, Jian-xiong Hu, Rui-lin Meng, Yan-jun Xu, Yun-hong Lv, Ye Wang, Ni Xiao, Chuan Li, Xiao-jun Xu, De-jian Zhao, Hong-ye Zhou, Jia-hui He, Xiao-min Tan, Jing Wei, Li-feng Lin, Wei-jie Guan

“…Using logistic regression models, we presented the associations as odds ratios and 95% confidence intervals, for each interquartile range (IQR) increase in PM1/PM2.5/PM10 concentration. …”
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Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas by Jin Xu, Andrew Knight, Jonathan Nguyen, Hong Wang, Walter J Storkus, Cindy Sander, John M Kirkwood, Jiqiang Yao, Xiaofei Song, Jane Messina, James J Mulé, Lilit Karapetyan, Carlos Moran-Segura, Aofei Li, Marion Joy, Sabrina Bruno, Hassan M Abushukair, Danielle Vargas De Stefano, Ayah N Al-Bzour, Caroline Layding

“…In this study, we examined characteristics and the prognostic utility of LA and TLS status in histological samples from patients with melanoma.Methods We assessed The Cancer Genomic Atlas-skin cutaneous melanoma digital slides and melanoma specimens from the University of Pittsburgh for the presence of LA and TLS using H&amp;E staining, multiplex immunofluorescence (mIF) and transcriptomic analyses. …”
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Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients With Type 2 Diabetes: A National Prospective Cohort Study by Lei Xi, Li Li, Songbo Fu, Yuancheng Dai, Juan Shi, Yanmei Yu, Ying Peng, Hongmei Qiu, Jinsong Kuang, Hongyun Lu, Huige Shao, Chunlei Yuan, Xiaohu Wang, Ping Zhang, Sheli Li, Yanhui Pan, Ling Hu, Zhigang Zhao, Yunxia Chen, Jian Kuang, Yi Shu, Jinhua Qian, Qibin Mao, Jieji Zhang, Yan Liu, Hong Yang, Zhaoli Yan, Weici Xie, Qian Zhang, Ping Zhang, Hongji Wu, Ling Gao, Yongjun Jin, Ning Xu, Chaoyang Xu, Xiaohui Sun, Zhimin Feng, Qing Zhang, Lin Li, Guang Ning, Yifei Zhang, Yanan Cao, Weiqing Wang

“…Furthermore, mediation models were constructed to figure out the mediating role of metabolic factors (blood pressure, UACR, and HbA1c). …”
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History and actual problems of organ donation by G.I. Kovtun, B.M. Todurov, O.A. Kanyura

“…The review is devoted to the history of the development of organ transplantation and the analysis of models of organ transplantation in countries that are leaders in the field of transplantation. …”
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Minimax Bayesian Neural Networks by Junping Hong, Ercan Engin Kuruoglu

“…Robustness is an important issue in deep learning, and Bayesian neural networks (BNNs) provide means of robustness analysis, while the minimax method is a conservative choice in the classical Bayesian field. …”
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Influence of Memorable Culinary Experience on Revisit Intention Mediated by Place Identity in Semarang by Laela Kodriyah, Harmanda Berima Putra

“…The data collection technique in this research is a questionnaire in the form of a Google Form. data analysis using Structural Equation Modeling Smart PLS. …”
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V-notch tip subjected to in-plane mixed mode loading: overview of recent results and possible future outcomes by F. Berto

“…Finally, for comparison, the support factor is determined on a purely numerical basis by iterative analysis of FE models.…”
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Multiple Imputation Based on Conditional Quantile Estimation by Matteo Bottai, Huiling Zhen

“…The method does not require modeling a likelihood and has desirable features that may be useful in some practical settings. …”
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VECTOR DATA DIFFERENCES IDENTIFICATION IN THE THEMATIC PROCESSING OF SPACE IMAGES by A. A. Zalatoi, A. V. Urbanovich

“…This method allows you to automate the process and reduce the time of thematic analysis of cosmic information, obtained from remote sensing of the Earth for topographic mapping and monitoring areas.…”
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hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…C2C12 myotube nutrition-deprivation and mice tail suspension models were established. Subsequently, the diameter of C2C12 myotubes, Soleus mass, cross-sectional area (CSA) of muscle fibers, and grip strength in mice were assessed to investigate the impact of hBMSC-EVs on muscle atrophy. …”
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Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SI... by Charles Hillman, Talha Syed, Dominika M Pindus, Tomasz S Ligeza, Jin Kuang, Scott Paluska, Joseph So, Miroslaw Wyczesany, Jesus Sarol, Flor B Quiroz, Ramiya Shanmugam, Maciej Kos, Naiman Khan, Art Kramer

“…The study will address three aims: (1) to assess feasibility, acceptability, fidelity and safety of HIIT breaks to improve neurocognitive function in middle-aged and older adults; (2) to quantify the differences between conditions in the change in the amplitude and latency of the P3b component of event-related potentials (a marker for frontoparietal function) and (3) to explore the differences between conditions in attentional control, episodic memory and FC of the FPN and DMN in middle-aged and older adults.Methods and analysis 54 healthy adults, aged 40–75 years, will be recruited from the local community and randomly assigned to a condition sequence (HIIT, LIIT vs LIIT and HIIT). …”
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Associations of adverse childhood and adulthood experiences with depressive and anxiety symptoms among rural left-behind women: A cross-sectional study in China by Shiyi Shan, Yuanfei Liu, Leying Hou, Denan Jiang, Chenhao Zhang, Jing Wu, Zeyu Luo, Jiayao Ying, Wen Liu, Peige Song

“…Multivariable log-binomial models with stabilized inverse probability of treatment weights (IPTW) were applied to analyze the associations of ACEs and AAEs with depressive and anxiety symptoms. …”
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Associations of reallocating sedentary leisure-time to alternative discretionary movement behaviours with incident cardiometabolic diseases in 0.5 million Chinese adultsResearch in... by Paul J. Collings, Mengyao Wang, Harrison Hin Sheung Ho, Shiu Lun Au Yeung, Parco M. Siu, Benjamin J. Cowling, Stephen J. Sharp, Søren Brage, Nicholas J. Wareham, Huaidong Du, Derrick A. Bennett, Youngwon Kim

“…Isotemporal substitution Cox regression models were used to estimate the associations of reallocating self-reported sedentary leisure-time to the same amount of sleep, housework, Taichi, or conventional exercise (e.g., walking, jogging, ball games, swimming) with the risk of incident diabetes, stroke, and myocardial infarction (MI). …”
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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Following a prespecified analysis plan, rwOS by TMB level was assessed using Cox PH models adjusted for Eastern Cooperative Oncology Group performance status, prior treatment, microsatellite instability, sex, age, opioid rx pretherapy, and socioeconomic assessment.Results 8440 patients met inclusion criteria. …”
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Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice by Yan Liu, Yi Zhou, Xiaodong Li, Ming Niu, Rongjuan Chen, Jinman Shao, Lanlan Si, Dan Luo, Yayun Lin, Le Li, Kai Zhang, Xiaohe Xiao, Zhihui Xu, Min Liu, Mengji Lu, Fabien Zoulim, Dongping Xu

“…This study aimed to clarify whether rtL180M+A181C+M204V mutations may contribute to HBV ETV resistance.Methods: Serum samples were collected from 22,009 patients who underwent resistance testing in Beijing 302 Hospital from 2007 to 2016. …”
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