Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension by Gufeng Gao, Gufeng Gao, Gufeng Gao, Gufeng Gao, Gufeng Gao, Ai Chen, Ai Chen, Ai Chen, Ai Chen, Ai Chen, Yan Yan, Yan Yan, Yan Yan, Yan Yan, Yan Yan, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Weijun Lin, Weijun Lin, Weijun Lin, Weijun Lin, Weijun Lin, Huakan Lin, Huakan Lin, Huakan Lin, Huakan Lin, Huakan Lin, Guili Lian, Guili Lian, Guili Lian, Guili Lian, Guili Lian, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Li Luo, Li Luo, Li Luo, Li Luo, Li Luo

“…The objective of this research was to explore the role of the protein kinase C (PKC)/IRS-1/ERK signaling pathway in the progression of PAH and its influence on the proliferation and migration of PASMCs.MethodsTo establish the PAH model, low-dose Monocrotaline (MCT) was intraperitoneally administered to male SD rats twice a week. …”
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Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)Research in context by Podjanee Jittamala, Simon Boyd, William H.K. Schilling, James A. Watson, Thundon Ngamprasertchai, Tanaya Siripoon, Viravarn Luvira, Elizabeth M. Batty, Phrutsamon Wongnak, Lisia M. Esper, Pedro J. Almeida, Cintia Cruz, Fernando R. Ascencao, Renato S. Aguiar, Najia K. Ghanchi, James J. Callery, Shivani Singh, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Wanassanan Madmanee, Kanokon Suwannasin, Amornrat Promsongsil, Borimas Hanboonkunupakarn, Kittiyod Poovorawan, Manus Potaporn, Attasit Srisubat, Bootsakorn Loharjun, Walter R.J. Taylor, Farah Qamar, Abdul Momin Kazi, M. Asim Beg, Danoy Chommanam, Sisouphanh Vidhamaly, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Arjen M. Dondorp, Nicholas P.J. Day, Mauro M. Teixeira, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J. White

“…However, these SSRIs have not been recommended in therapeutic guidelines and their antiviral activity in vivo has not been characterised. Methods: PLATCOV is an open-label, multicentre, phase 2, randomised, controlled, adaptive pharmacometric platform trial running in Thailand, Brazil, Pakistan, and Laos. …”
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Lipoprotein(a) as an early marker of cardiovascular events in high-risk subjects: insights from the Moli-sani cohort study by Francesco Gianfagna, Simone Poli, Simona Costanzo, Simona Costanzo, Augusto Di Castelnuovo, Teresa Panzera, Amalia De Curtis, Sara Magnacca, Mariarosaria Persichillo, Lorenzo De Santi, Claudia Cristofani, Daniele Loffredo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Licia Iacoviello, the Moli-sani Study Investigators, Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati, Chiara Cerletti, Marialaura Bonaccio, Americo Bonanni, Simona Costanzo, Amalia De Curtis, Augusto Di Castelnuovo, Alessandro Gialluisi, Francesco Gianfagna, Mariarosaria Persichillo, Jos Vermylen, Renzo Pegoraro, Antonio G. Spagnolo, Deodato Assanelli, Livia Rago, Simona Costanzo, Sabatino Orlandi, Teresa Panzera, Augusto Di Castelnuovo, Marialaura Bonaccio, Francesca Bracone, Simona Costanzo, Giuseppe Di Costanzo, Simona Esposito, Alessandro Gialluisi, Anwal Ghulam, Francesco Gianfagna, Martina Morelli, Maria Loreto Muñoz Venegas, Antonietta Pepe, Emilia Ruggiero, Amalia De Curtis, Concetta Civitillo, Alisia Cretella, Sara Magnacca, Mariarosaria Persichillo, Francesca Bracone, Giuseppe Di Costanzo, Martina Morelli, Americo Bonanni

“…We analyzed the association between Lp(a) and the risk of a major cardiovascular event in subjects with previous CVD.MethodsThe analysis was conducted on the Moli-sani study population (24,325 individuals aged ≥35 years, recruitment from 2005 to 2010), focusing on subjects with prior CVD. …”
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Clinicopathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer over two decades: A population-based study. by Sandeep Samuel, Sarbajit Mukherjee, Nischala Ammannagari, Venkata K Pokuri, Boris Kuvshinoff, Adrienne Groman, Charles M LeVea, Renuka Iyer

“…The effect of clinicopathological variables on overall survival (OS) and disease specific survival (DSS) were analyzed using univariate and multivariate proportional hazards modeling. All associations were considered statistically significant at an alpha error of 0.01.…”
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The Interactive Effects of Fruit Intake Frequency and Serum miR-484 Levels as Biomarkers for Incident Type 2 Diabetes in a Prospective Cohort of the Spanish Adult Population: The D... by Ana Lago-Sampedro, Wasima Oualla-Bachiri, Cristina Maldonado-Araque, Sergio Valdés, Inmaculada González-Molero, Viyey Doulatram-Gamgaram, Elias Delgado, Felipe J. Chaves, Luis Castaño, Alfonso Calle-Pascual, Josep Franch-Nadal, Gemma Rojo-Martínez, Sara García-Serrano, Eva García-Escobar

“…Association analyses were performed using logistic regression models adjusted for potential confounders. Interaction effects were evaluated on the multiplicative and additive scales. …”
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The relationship between exercise and the occurrence of abdominal wall complications in patients on peritoneal dialysis by Xinqiu Li, Tiantian Ma, Jiayu Hao, Di Song, Hongyan Wang, Tianjiao Liu, Xiao Xu, Jie Dong

“…This study aims to investigate the association between exercise and abdominal wall complications in the PD population. Methods A retrospective data analysis of a prospective cohort. …”
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Peak systolic blood pressure during preparticipation exercise testing in 12,083 athletes: age, sex, and workload-indexed values and predictors by Petra Pesova, Petra Pesova, Bogna Jiravska Godula, Bogna Jiravska Godula, Otakar Jiravsky, Otakar Jiravsky, Libor Jelinek, Marketa Sovova, Katarina Moravcova, Jaromir Ozana, Ivan Ranic, Ivan Ranic, Radek Neuwirth, Radek Neuwirth, Radek Neuwirth, Roman Miklik, Matej Pekar, Matej Pekar, Libor Sknouril, Libor Sknouril, Vladimir Tuka, Eliska Sovova

“…In future studies, these findings may inform the development of personalised training strategies and risk stratification models in athletic populations.…”
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Effect of levothyroxine on major adverse cardiovascular events in patients with hypothyroidism and cardiovascular disease by Lijia Liu, Lijia Liu, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang, Xiaowei Chen, Xiaowei Chen, Zuoxiang Liu, Zuoxiang Liu, Houyu Zhao, Shizhan Ma, Shizhan Ma, Shizhan Ma, Meng Zhao, Meng Zhao, Meng Zhao, Peng Shen, Yexiang Sun, Hongbo Lin, Siyan Zhan, Siyan Zhan, Siyan Zhan, Jiajun Zhao, Jiajun Zhao, Jiajun Zhao, Feng Sun, Feng Sun

“…The analysis included patients newly diagnosed with hypothyroidism between July 2006 and December 2021 who also had pre-existing CVD at the time when they received the first hypothyroidism diagnosis. …”
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British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV by Joel Singer, Melanie Lee, Angela Kaida, Neora Pick, Valerie Nicholson, Rebecca Gormley, Shayda A Swann, Jason Brophy, Amber R Campbell, Allison Carter, Chelsea Elwood, Tsion Gebremedhen, Elizabeth M King, Vonnie Lee, Evelyn J Maan, Patience Magagula, Sheila Nyman, Davi Pang, Tetiana Povshedna, Jerilynn C Prior, Shelly Tognazzini, Melanie C M Murray, Helene C F Cote

“…This interdisciplinary cohort study aims to understand how biological, clinical and sociostructural determinants of health interact to modulate healthy ageing in WLWH.Methods and analysis The British Columbia Children and Women: AntiRetroviral therapy and Markers of Aging-Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CARMA-CHIWOS) Collaboration (BCC3) study will enrol WLWH (n=350) and sociodemographically matched HIV-negative women (n=350) living in British Columbia. …”
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Multimorbidity patterns and premature mortality in a prospective cohort: effect modifications by socioeconomic status and healthy lifestyles by Qingping Xue, Shanshan Zhang, Xue Yang, Yan-Bo Zhang, Yidan Dong, Fan Li, Shuo Li, Nianwei Wu, Tong Yan, Ying Wen, Chun-Xia Yang, Jason HY Wu, An Pan, Yunhaonan Yang, Xiong-Fei Pan

“…The latent class analysis was used to establish multimorbidity patterns based on 11 chronic conditions. …”
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Characterisation of the respiratory syncytial virus seasonality and its environmental factors in the Americas—a multi-country observational study using routine surveillance network... by Paula Couto, Harry Campbell, You Li, Marc Rondy, Juliana Leite, Angel Rodriguez, Andrea Vicari, Harish Nair, Andrea Pontoriero, Carlos Maria Giovacchini, Julio Sabido, Mellissa Diaz Musa, Jorge Polanco, Marcelo Ferreira da Costa Gomes, Felipe Cotrim de Carvalho, Liza Lee, Rodrigo A. Fasce, Natalia Alejandra Vergara Mallegas, Paula Camila Rodriguez Ferrari, Paula Rodríguez-Romero, Angélica María Rico Turca, Elias Guilarte García, Ronald Skewes-Ramn, Ruth Gómez Carrera, Ana Del Carmen Sanchez de Molina, Laura Lissette Arévalo Avila, Maria del Mar Ordoñez, Selene Gonzales, Robert Camargo Ángeles, Laura Adriana Flores Cisneros, Irma López Martínez, Catherine Lissette Castillo Castillo, Danilo Franco, Katia Peralta, Cynthia Vazquez de Lopez Moreira, Lidia Redondo Bravo, Priscila Born, Jorge Jara, Paula Couto, Harry Campbell, You Li, Marc Rondy, Angel Rodriguez, Juliana Leite, Andrea Vicari, Harish Nair

“…Time-series analysis identified temporal patterns and trends. Negative binomial, Moving Epidemics Method, and WHO Moving Averages Models were compared to assess seasonality. …”
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Changes in the estimated glucose disposal rate and incident cardiovascular disease: two large prospective cohorts in Europe and Asia by Xiaowei Zheng, Wenyang Han, Yiqun Li, Minglan Jiang, Xiao Ren, Pinni Yang, Yiming Jia, Lulu Sun, Ruirui Wang, Mengyao Shi, Zhengbao Zhu, Yonghong Zhang

“…Cox proportional hazard models were used to calculate the hazard ratio (HR) and 95% confidence interval (95% CI) after adjusting for potential confounders. …”
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Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkins... by Dang Wei, Anna Freydenzon, Octave Guinebretiere, Karim Zaidi, Fen Yang, Weimin Ye, Niklas Hammar, Karin Modig, Naomi R. Wray, Maria Feychting, Nadine Hamieh, Bruno Ventelou, Beranger Lekens, Laurene Gantzer, Stanley Durrleman, Allan McRae, Baptiste Couvy-Duchesne, Fang Fang, Thomas Nedelec, Stanley Durrleman, Bruno Ventelou, Thomas Nedelec, Octave Guinebretiere, Karim Zaidi, Fang Fang, Dang Wei, Fen Yang, Allan McRae, Naomi Wray, Baptiste Couvy-Duchesne, Anna Freydenzon, Lydie Tran, Evans Cheruiyot

“…Conditional logistic regression models and meta-analysis were applied to assess the associations between these factors and the risk of receiving a diagnosis of AD, PD, or ALS. …”
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Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…SOD1 had the highest importance score in ML-based LP predictive models. Additionally, advanced age may be associated with higher mortality in LP. …”
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Assessment and Enhancement of Coastal Community Resilience Strategies: A Case Study of Wuyuan Bay in Xiamen by Xu Mengjie, Liu Xingzhao, Xie Huili, Zhang Yang, Dai Hongxia, Zhou Yanhai, Huang Faming

“…By integrating 16 subjective and objective indicators, including the rescue facility coverage rate and residents' disaster preparedness literacy, we employed the AHP-CRITIC combined weighting method to determine indicator weights and quantify community resilience levels using TOPSIS analysis. …”
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Association of surrogate adiposity markers with prevalence, all-cause mortality and long-term survival of heart failure: a retrospective study from NHANES database by Fan-Shun Guo, Fan-Shun Guo, Chen Guo, Chen Guo, Jia-Hao Dou, Jia-Hao Dou, Jun-Xiang Wang, Rui-Yun Wu, Rui-Yun Wu, Shou-Fang Song, Shou-Fang Song, Xue-Lu Sun, Xue-Lu Sun, Yi-Wei Hu, Yi-Wei Hu, Jin Wei, Jin Wei

“…Cox proportional hazards models and restricted cubic spline (RCS) analysis were employed to assess the association between surrogate adiposity markers and all-cause mortality in HF patients. …”
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Effects of Carnosine Supplementation on Cognitive Outcomes in Prediabetes and Well-Controlled Type 2 Diabetes: A Randomised Placebo-Controlled Clinical Trial by Rohit Hariharan, Aya Mousa, Kirthi Menon, Jack Feehan, Barbara Ukropcová, Jozef Ukropec, Martin Schön, Arshad Majid, Giancarlo Aldini, Maximilian de Courten, James Cameron, Simon M. Bell, Barbora de Courten

“…The aim of this study is to assess the effects of carnosine on cognitive function in individuals with prediabetes or well-controlled T2DM. <b>Methods:</b> This is a secondary analysis of a double-blind randomised controlled trial (RCT), whereby 49 adults with prediabetes or early-stage well-controlled T2DM were randomised to receive 2 g of carnosine or identical placebo daily for 14 weeks. …”
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Global Burden of Oral Diseases in Adolescents and Young Adults Aged 10–24 Years by Wei Lu, Bing Wang, Mi Du, Shaohua Ge

“…Objectives: This study aims to analyse global trends in the burden of oral diseases, including dental caries and noncarious oral diseases (NCODs), in individuals aged 10 to 24 from 1990 to 2021 and project future trends up to 2050. Methods: Using data from the Global Burden of Disease Study (GBD) 2021, this trend analysis examines the number, age-standardised rates (ASRs), and average annual percentage changes (AAPCs) in prevalence, incidence, and disability-adjusted life years for oral diseases across different age groups, sexes, social-development index (SDI) levels, regions, and nations. …”
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C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation by Veronica Veschi, Francesco Verona, Sebastiano Di Bella, Alice Turdo, Miriam Gaggianesi, Simone Di Franco, Laura Rosa Mangiapane, Chiara Modica, Melania Lo Iacono, Paola Bianca, Ornella Roberta Brancato, Caterina D’Accardo, Gaetana Porcelli, Vincenzo Luca Lentini, Isabella Sperduti, Elisabetta Sciacca, Peter Fitzgerald, David Lopez-Perez, Pierre Martine, Kate Brown, Giuseppe Giannini, Ettore Appella, Giorgio Stassi, Matilde Todaro

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Meta-analyses of IL1A polymorphisms and the risk of several autoimmune diseases published in databases. by Hang Su, Na Rei, Lei Zhang, Jiaxiang Cheng

“…<h4>Background</h4>Based on published data, we aimed to quantitatively elucidate the possible genetic influence of rs17561 G/T and rs1800587 C/T polymorphisms of the IL1A (interleukin 1 alpha) gene in the susceptibility to several autoimmune diseases.<h4>Methods</h4>A series of meta-analyses were carried out. …”
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