Modified Saengmaeksan, an herbal formula containing six herbs, improves hypertension through RhoA/Rho kinase-mediated vasorelaxation by Young Mi Seok, Hye-Lin Kim, Hyo In Kim, Hobin Moon, Yohan Han, Eun Sang Cho, Hyun Hee Leem, Hyo Jung Kim, Sujin Shin, Se-Jin Kim, Jin Ki Jung, Wei Huang, Kyung Oh Jung, Doo Suk Lee, Sung Giu Jin, Hyunwoo Kim, Changsop Yang, Kyungjin Lee, Jinbong Park

“…The molecular mechanisms were explored through Western blot analysis and GTP-RhoA assays. Results: mSMS significantly reduced systolic and diastolic blood pressure in both hypertensive models, with the ethanol extract demonstrating superior efficacy. mSMS inhibited the RhoA/Rho kinase pathway, leading to reduced phosphorylation of MYPT1 and CPI17, and improved vascular relaxation. …”
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Comparative adverse event profiles of triplet therapy versus docetaxel-based therapy in patients with metastatic prostate cancer: a multicenter retrospective study by Fumihiko Urabe, Hirokazu Kagawa, Takafumi Yanagisawa, Hidetsugu Takahashi, Masaki Hashimoto, Shuhei Hara, Wataru Fukuokaya, Yu Imai, Kosuke Iwatani, Taro Igarashi, Mahito Atsuta, Kojiro Tashiro, Masaya Murakami, Shunsuke Tsuzuki, Brendan A. Yanada, Toshihiro Yamamoto, Kenichi Hata, Hiroki Yamada, Jun Miki, Takahiro Kimura

“…Conclusion: This study represents the first real-world analysis comparing the adverse event profiles of triplet therapy and docetaxel-based therapy in Japanese patients with mCSPC, as well as docetaxel-based therapy in those with mCRPC. …”
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Context-Specific Impact Of Antimicrobial Stewardship On Antibiotic Use And Antibiotic Resistance In Hospitals In A Lower-Middle Income Country - Results From Implementation Study W... by Trang Quynh Le, Dung Tien Viet Vu, Quang Minh Le, Huyen Thi Thu Nguyen, Vinh Hai Vu, Duc Minh Chau, Em Thi Hoang Dung Vo, Tu Thi Cam Nguyen, Quan Anh Truong, Khanh Hong Nguyen, Hoa Nguyen Minh Le, Thomas Kesteman, Elizabeth Dodds Ashley, Deverick J. Anderson, Hugo C. Turner, Thach Ngoc Pham, Ben S. Cooper, Choisy Marc, H Rogier Van Doorn, Huong Thi Lan Vu

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RECOVID: Retrospective Observational Study of Renal Outcomes and Long-Term Mortality in Patients With COVID-19-Associated AKI, A Comparison Between Vaccinated and Unvaccinated Pati... by Niloofar Nobakht, Charley Jang, Tristan Grogan, Peter Fahim, Ira Kurtz, Joanna Schaenman, James Wilson, Mohammad Kamgar

“…Multivariable cox, logistic, and linear regression models were used for mortality, RRT status at discharge, and length of stay, respectively. …”
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Médiation du cinéma documentaire et pratiques des abonnés cinéphiles de Tënk by Samuel GANTIER

“…The analysis shows the appropriation of an editorial line that hybridizes subscription (SVOD) and pay-per-view (VOD) economic models. …”
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Influence of the Neural Network Hyperparameters on its Numerical Conditioning by S. V. Sholtanyuk

“…Formulas for assessment of condition numbers of individual components of the forecasting perceptron and of the neural network itself have been proposed. Comparative analysis of results of training the forecasting perceptron with various hyperparameters on modeled time series has been performed. …”
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Fuzzy Difference Operators for Spatial Change Detection in 2D Spatial Scene by Nadeem Salamat, El-hadi Zahzah

“…Fuzzy difference operators are used in different fields of decision making processes, image analysis and computer vision applications. Change detection in a spatial scene is the basic issue in modeling relative motion between object pair. …”
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A Spatiotemporal Dataset of Soil Properties in Northeast China Based on Soil Sampling and Interpolation From 2009 to 2020 by Shuzhen Li, Jieyong Wang, Xu Lin, Yaqun Liu

“…Geodetector analysis revealed significant spatial variability in soil properties (q > 0.8, p < 0.001). …”
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STING regulates NETs formation by activating GSDMD in influenza viral pneumonia by Rongrong Huang, Rongrong Huang, Rongrong Huang, Ranran Chen, Ranran Chen, Ranran Chen, Lijuan Xing, Lijuan Xing, Lijuan Xing, Lianhao Wu, Lianhao Wu, Lianhao Wu, Wenwen Zhu, Junsong Jing, Junsong Jing, Junsong Jing, Ting Zhou, Yueguo Wu, Sheng Zhang, Zhenqiang You, Zhenqiang You, Zhenqiang You

“…To elucidate the mechanisms of viral pneumonia progression and potential targets for its treatment.MethodsViral pneumonia models were induced by the PR8 virus strain in wild-type (WT) and STING knockout (STING-KO) mice. …”
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Rethinking Radiation Therapy for Perineural Invasion in Oral Cancer: Does More Coverage Improve Outcomes? by Sarbani Ghosh Laskar, Anuj Kumar, Ashwini Adhau, Shwetabh Sinha, Samarpita Mohanty, Munita Bal, Neha Mittal, Swapnil Rane, Asawari Patil, Ashwini Budrukkar, Monali Swain, Pallavi Rane, Gouri Pantvaidya, Sudhir Nair, Deepa Nair, Anuja Deshmukh, Shivakumar Thiagarajan, Richa Vaish, Vidisha Tuljapurkar, Chandrashekhar Dravid, Poonam Joshi, Rathan Shetty, Arjun Singh, Pankaj Chaturvedi

“…Survival outcomes, including overall survival (OS) and disease‐free survival (DFS), were assessed using the Kaplan–Meier method, and prognostic factors were analysed using univariate and multivariate models. …”
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Association of Circulating Phenylacetylglutamine With Multi‐Vessel Coronary Disease Severity and Outcomes in ST‐Segment–Elevation Myocardial Infarction by Peng Zhao, Nana Dong, Yan Wang, Suhong Zhao, Yanan Tian, Zhifeng Qin, Xiaofang Ban, Feiyuan Han, Li Meng, Fan Yang, Yidan Wang, Yunfei Wu, Zhongzhi Yu, Qinglu Xu, Xinyue Li, Shuo Li, Huibin Liu, Shaohong Fang, Wanqing Xie, Bo Yu, Xinxin Liu, Jinwei Tian

“…Quantitative coronary angiography analysis was performed using the QAngio XA 7.3 system. …”
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Frailty, Pitavastatin, and Major Adverse Cardiovascular Events Among People With HIV by Kristine M. Erlandson, MD, MS, Ariela R. Orkaby, MD, Triin Umbleja, MSc, Heather J. Ribaudo, PhD, Todd T. Brown, MD, PhD, Markella V. Zanni, MD, Marissa R. Diggs, AB, Sarah M. Chu, MSN, Kathleen V. Fitch, MSN, Carl J. Fichtenbaum, MD, Carlos Malvestutto, MD, MPH, Judith A. Aberg, MD, Gerald S. Bloomfield, MD, MPH, Judith S. Currier, MD, Karen T. Tashima, MD, Marcus Vinícius Guimarães de Lacerda, MD, PhD, Sonya L. Heath, MD, Michael T. Lu, MD, MPH, Alan Landay, PhD, George A. Kuchel, MD, Pamela S. Douglas, MD, Steven K. Grinspoon, MD

“…Objectives: The purpose of this study was to evaluate whether frailty is associated with MACE and whether pitavastatin prevents MACE regardless of frailty. Methods: We conducted a post hoc analysis of the REPRIEVE trial, a randomized, blinded trial of pitavastatin 4 mg vs placebo. …”
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Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape by Andrea Rodríguez-Agustín, Andrea Rodríguez-Agustín, Rubén Ayala-Suárez, Francisco Díez-Fuertes, Francisco Díez-Fuertes, María José Maleno, Izar de Villasante, Angelika Merkel, Mayte Coiras, Mayte Coiras, Víctor Casanova, Víctor Casanova, José Alcamí, José Alcamí, José Alcamí, José Alcamí, Núria Climent, Núria Climent, Núria Climent

“…The observed differentially methylated and expressed genes were involved in inflammatory responses, lipid antigen presentation, and apoptosis.DiscussionTat expression in HIV infection may constitute a key epigenetic modelling actor that contributes to HIV pathogenesis and chronic inflammation. …”
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Gene-expression signature predicts autoimmune toxicity in metastatic melanoma by Michael Bailey, Andrew White, Francesca Sparano, Alessandra Cesano, Mariaelena Capone, Corrado Caracò, Ester Simeone, Lucia Festino, Alfredo Budillon, Sarah Warren, Domenico Mallardo, Paolo A Ascierto, Vito Vanella, Ernesta Cavalcanti, Claudia Trojaniello, Maria Grazia Vitale, Margaret Ottaviano, Paolo Chiodini, Mario Fordellone, Bianca Arianna Facchini, Maria Ingenito, Caterina Costa, Rosaria De Filippi

“…Gene-expression signatures were identified and validated using cross-validated sparse partial least squares modeling and principal component analysis, then correlated with toxicity occurrence.Results A total of 223 and 186 irAEs were observed in the AT and FLT groups, respectively, including arthralgia, colitis, and headache. …”
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The role of environmental access to exercise opportunities in cardiovascular mortality: evidence from a nationwide study by Xiaowen Wang, Yongshi Gu, Ying Wang, Yuqing Qiu, Tianling Chen, Philip K. Hopke, Kai Zhang, Shao Lin, Yanji Qu, Ziqiang Lin, Xinlei Deng, Jie Sun, Shuming Zhu, Xueqing Deng, Sizhe Li, Xian Lin, Zhicheng Du, Yuantao Hao, Wangjian Zhang

“…We explored the associations between county-level access to exercise opportunities and cardiovascular disease (CVD) mortality across US counties. Methods We conducted an ecological analysis using aggregated data from two primary sources: the County Health Rankings and Roadmaps data and CDC WONDER mortality data. …”
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Association Between Long Term Exposure to PM_2.5 and Its Components on Severe Obesity in Chinese Children and Adolescents: A National Study in China by Tongjun Guo, Tianjiao Chen, Li Chen, Jieyu Liu, Xinli Song, Yi Zhang, Ruolin Wang, Jianuo Jiang, Yang Qin, Ziqi Dong, Dengcheng Zhang, Zhiying Song, Wen Yuan, Yanhui Dong, Yi Song, Jun Ma

“…Results: A total of 160,205 children were included in the analysis. Long-term exposure to PM_2.5 may increase the odds of severe childhood obesity, with this effect being more pronounced in girls. …”
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Positive rate and influencing factors of adolescent idiopathic scoliosis among school children aged 9 to 18 years in Xiamen, China by Zhongrui Peng, Yuanchao Li, Hong Yang, Yanfang Jiang, Yuqing Li, Mengyang Gao, Yangjingling Hua, Guimei Liu, Manqi Zhou, Tianmu Chen, Huarong Hong, Lei Li

“…Multivariable logistic regression models demonstrated age and sex (AOR: 5.00, 95% CI: 4.33–5.76) were associated with AIS. …”
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Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer by Xiaojun Wang, Qiqiao Du, Qiuwen Mai, Qiaojian Zou, Shuyi Wang, Xiaoying Lin, Qianrun Chen, Mengxun Wei, Chudan Chi, Zhangqing Peng, Karima Abdugheni, Liu Du, Yili Chen, Shuzhong Yao, Junxiu Liu

“…Results: Fatty acid synthase (FASN) was identified as a key driver of cisplatin resistance in CC through transcriptome sequencing and Gene Expression Omnibus (GEO) data analysis. The clinically safe FASN inhibitor TVB-2640 was found to restore cisplatin sensitivity, resulting in synergistic tumor growth attenuation in xenograft models. …”
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Future of Agrivoltaic projects: A review from the technological forecasting perspective by Leticia Pekk, Petar Sabev Varbanov, Ting Pan, Zoltan Weltsch, Bernadett Radli-Burjan, Andras Hary, Xue-Chao Wang

“…These include global development, current applications, and technological progress. The analysis reveals growing attention to system design, performance optimisation, and crop compatibility. …”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…On the other hand, innovation ecosystems have gained increasing importance in the last decade, and so far, numerous studies and models of innovation ecosystems have been presented in different industries and sectors. …”
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