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Metabolomic profiles differentiate between porto-sinusoidal vascular disorder, cirrhosis, and healthy individuals
Published 2024-12-01“…Artificial neural network and support vector machine models were developed to classify PSVD against cirrhosis or HV metabolomic profiles. …”
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69763
Meet-in-the-middle meets multi-omics identifying molecular signatures of environmental drivers of childhood overweight
Published 2025-08-01“…Exposome and multi-omics features were integrated into latent factors by Multi-omics Factor Analysis, based on which structural equation modelling was used to assess whether multi-omics mediated associations between exposome and child body mass index (BMI). …”
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69764
Impact of Apolipoprotein A-I Infusions on Cardiovascular Events Post-MI by Neutrophil-Lymphocyte Ratio and LDL-Cholesterol Levels
Published 2025-05-01“…Cox proportional hazards models evaluated risk by dichotomized baseline NLR (>median vs ≤median). …”
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69765
Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosisResearch in context
Published 2025-06-01“…The role of the Signal Transducer and Activator of Transcription 3 (Stat3) in AKI remains controversial, and its complex regulatory mechanisms must be further explored. Methods: We generated renal tubular epithelial cells Stat3 conditional knockout (cKO) mice and used them in cecal ligation and puncture (CLP) and ischaemia-reperfusion (I/R) induced AKI models. …”
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69766
A Novel Definition and Grading Diagnostic Criteria for Tumour‐Type‐Specific Comprehensive Cachexia Risk
Published 2025-04-01“…Risk factors for cachexia, including tumour characteristics and nutritional parameters, were examined to develop diagnostic scales using Cox proportional hazards models and Kaplan–Meier analysis. Results Ten nutrition items (body mass index, weight loss, intake reduction, physical activity function, fatigue, handgrip strength, anorexia, albumin level, albumin/globulin ratio and neutrophil/lymphocyte ratio) with different weighted scores were identified to construct a nutrition‐weighted scoring scale (NWSS) for nutrition risk. …”
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69767
تقييم تأثير وسائل الاعلام والدعاية على إدراک المستخدمين للعمارة والعمران "دراسة حالة مشروعات الاسکان في مصر"...
Published 2019-03-01“….- Evaluating the role played by mass media, in terms of positivity and negativity, through running an analysis of the messages conveyed by media and advertising, whichare often influenced by the vision of the investing developers, in quest for marketing their housing products.- Detecting the criteria upon which the mass media rely in order to market an architectural product, to see if such mass media adopt honesty in presenting the characteristicsof the product, and to see whether such presentation provides the user with the informed knowledge of what he/she is going to possess or not.- Outline controls system to regulate the methods of promotion and marketing, in connection with the information to be provided by the mass media about the architecturalproducts available at the housing market, to enable residence seekers to select the most suitable product, among the available residential models, in accordance wi th theirdiverse and versatile characteristics and needs.…”
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69768
Differential Effects of Gynecological and Chronological Age on Low Birth Weight and Small for Gestational Age
Published 2025-07-01“…Adjusted odds ratios were calculated using binary logistic regression models. The outcome variables were low birth weight and small for gestational age. …”
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69769
Racial/ethnic disparities in the association of maternal diabetes and obesity with risk of preterm birth among 17 million mother-infant pairs in the United States: a population-bas...
Published 2025-03-01“…We further categorized preterm birth into three subtypes: extremely (< 28 weeks), very (28–31 weeks), and moderately (32–36 weeks) preterm birth. Logistic regression models were used for association analyses in this study. …”
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69770
Diagnostic Criteria for Cancer‐Associated Cachexia: Insights from a Multicentre Cohort Study
Published 2025-02-01“…We also examined which diagnostic criteria are more feasible and appropriate for cancer‐associated cachexia in clinical practice. Methods A multicentre cohort study was conducted, which involved 5769 participants with cancer. …”
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69771
EPOCHS. XI. The Structure and Morphology of Galaxies in the Epoch of Reionization to z ∼ 12.5
Published 2025-01-01“…We use standard software to fit single Sérsic models to each galaxy in the rest-frame optical and extract their parametric structural parameters (Sérsic index, half-light radius, and axis ratio) and Morfometryka to measure their nonparametric concentration and asymmetry parameters. …”
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EPOCHS. I. The Discovery and Star-forming Properties of Galaxies in the Epoch of Reionization at 6.5 < z < 18 with PEARLS and Public JWST Data
Published 2025-01-01“…Finally, we note a significant observed excess of galaxies compared to models at z > 12, revealing a tension between predictions and our observations.…”
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Longitudinal Body Composition Identifies Hepatocellular Carcinoma With Cachexia Following Combined Immunotherapy and Target Therapy (CHANCE2213)
Published 2024-12-01“…Multiple Cox proportional hazards models were used to calculate adjusted hazard ratios (HRs) for survival. …”
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Emotional literacy programme in special schools for children with a learning disability in England: the ZF-SEND feasibility RCT
Published 2024-12-01“…To inform a future trial, effect sizes and 95% CIs were estimated around the between-group comparisons of clinical measures (secondary outcomes) collected as part of the study. This analysis was based on the intention-to-treat principle and controlled for the clustered nature of children within schools using two-level mixed models. …”
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Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum diso...
Published 2025-04-01“…Time to disability milestones was estimated through Kaplan-Meier analysis and Cox proportional hazard regression models adjusted for sex, year of onset, immunotherapy exposure and antibody status. …”
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Myo-inositol affects the health, metabolome, and lactation performance of peripartum dairy cows
Published 2025-06-01“…Therefore, this study explored the effects of myo-inositol on the health, metabolome, and lactation performance of peripartum dairy cows using both in vitro and in vivo models.MethodsThe ANKOM RFS gas production system was used for the in vitro experiment; Twenty four healthy Holstein cows were assigned to CON group (n = 4; no supplementation of YC or myo-inositol), YC group (n = 10; 2 g/kg YC), and IN65 group (n = 10; 2 g/kg YC + 16 mg/kg myo-inositol) for in vivo experiment.ResultsThe concentrations of five volatile fatty acids (acetic acid, butyric acid, isobutyric acid, valeric acid, and isovaleric acid), and total volatile fatty acids were significantly higher in the IN65 group compared to the CON group at 6 h in vitro (P < 0.01). …”
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CArdiovasculaR Outcomes Based Upon EjectIon Systolic TimE in Patients With ST Elevation Myocardial Infarction (ARISE-STEMI) Study
Published 2025-04-01“…Univariable and multivariable Cox regression analysis were used to identify risk predictors. The primary outcome was mortality at 30 days. …”
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Metabolic obesity phenotypes and the risk of cancer: a prospective study of the Kailuan cohort
Published 2024-10-01“…This study aimed to investigate the relationship between metabolic health status combined with obesity phenotypes and the risk of cancer.MethodsData from 91,834 participants in the Kailuan cohort were analyzed, excluding individuals with a body mass index (BMI) < 18.5 kg/m² and those with a history of cancer. …”
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Same data, different analysts: variation in effect sizes due to analytical decisions in ecology and evolutionary biology
Published 2025-02-01“…We expanded the scope of this prior work by implementing a large-scale empirical exploration of the variation in effect sizes and model predictions generated by the analytical decisions of different researchers in ecology and evolutionary biology. …”
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ECM1 expression in chronic liver disease: Regulation by EGF/STAT1 and IFNγ/NRF2 signalling
Published 2025-08-01“…We investigated the mechanism of ECM1 regulation in hepatocytes under pathophysiological conditions. Methods: We used promoter analysis to predict Ecm1 transcriptional regulators and assessed the expression of Ecm1-related genes by single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq. …”
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