Associations of serum and bronchoalveolar immunoglobulins with lung microbiota diversity, B-cell memory phenotypes, and COPD morbidity and exacerbations by Vickram Tejwani, Nirupama Putcha, Han Woo, Chen Liu, David Lafon, Neil E. Alexis, Antoine Azar, R. Graham Barr, Igor Barjaktarevic, Russell P. Bowler, Alejandro Comellas, David J. Couper, Ashraf Fawzy, MeiLan K. Han, Nadia N. Hansel, Robert J. Kaner, Jerry A. Krishnan, Nathaniel Marchetti, Fernando J. Martinez, Jill Ohar, Wanda O’Neal, Victor E. Ortega, Robert Paine III, Tess D. Pottinger, Martin Stämpfli, Lisa Ruvuna, Prescott G. Woodruff, Christine M. Freeman, Yvonne J. Huang, Jeffrey L. Curtis

“…Here, we examined associations of lower respiratory tract bacterial diversity to Ig levels in serum and bronchoalveolar lavage (BAL) and to the memory phenotypes of blood and BAL B cells. Methods We analyzed data from phase I of SPIROMICS, an observational cohort study of smoking-related COPD. …”
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Antibiotic stewardship in hematological patients with Escherichia coli and Klebsiella pneumoniae bloodstream infections: evaluating short-course and carbapenem-sparing strategies by Yuqing Cui, Xiaomeng Feng, Ling Pan, Qingsong Lin, Jieru Wang, Sisi Zhen, Yuping Fan, Xin Chen, Yizhou Zheng, Yingchang Mi, Fengkui Zhang, Xiaofan Zhu, Zhijian Xiao, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng

“…Abstract Background To address the overuse of antibiotics, this study examined the clinical characteristics and outcomes associated with antibiotic duration and carbapenem-sparing regimens in hematological patients with Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) bloodstream infections (BSI). Methods We conducted a retrospective analysis of hematological patients with E. coli or K. pneumoniae BSI from 2017 to 2023. …”
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Association between a large change between the minimum and maximum monthly values of solar insolation and a history of suicide attempts in bipolar I disorder by Philipp Ritter, Tasha Glenn, Eric D. Achtyes, Martin Alda, Esen Agaoglu, Kürsat Altınbaş, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Ceylan Balaban, Claudia Becerra-Palars, Aniruddh P. Behere, Prakash B. Behere, Habte Belete, Tilahun Belete, Gabriel Okawa Belizario, Frank Bellivier, Robert H. Belmaker, Francesco Benedetti, Michael Berk, Yuly Bersudsky, Şule Bicakci, Harriet Birabwa-Oketcho, Thomas D. Bjella, Conan Brady, Jorge Cabrera, Marco Cappucciati, Angela Marianne Paredes Castro, Wei-Ling Chen, Eric Y. W. Cheung, Silvia Chiesa, Margarita Chanopoulou, Marie Crowe, Alessandro Cuomo, Sara Dallaspezia, Pratikkumar Desai, Seetal Dodd, Bruno Etain, Andrea Fagiolini, Frederike T. Fellendorf, Ewa Ferensztajn-Rochowiak, Jess G. Fiedorowicz, Kostas N. Fountoulakis, Mark A. Frye, Pierre A. Geoffroy, Michael J. Gitlin, Ana Gonzalez-Pinto, John F. Gottlieb, Paul Grof, Bartholomeus C. M. Haarman, Hirohiko Harima, Mathias Hasse-Sousa, Chantal Henry, Lone Hoffding, Josselin Houenou, Massimiliano Imbesi, Erkki T. Isometsä, Maja Ivkovic, Sven Janno, Simon Johnsen, Flávio Kapczinski, Grigorios N. Karakatsoulis, Mathias Kardell, Lars Vedel Kessing, Seong Jae Kim, Barbara König, Timur L. Kot, Michael Koval, Mauricio Kunz, Beny Lafer, Mikael Landén, Erik R. Larsen, Rasmus W. Licht, Vera M. Ludwig, Carlos Lopez-Jaramillo, Alan MacKenzie, Helle Østergaard Madsen, Simone Alberte Kongstad A. Madsen, Jayant Mahadevan, Agustine Mahardika, Mirko Manchia, Wendy Marsh, Monica Martinez-Cengotitabengoa, Julia Martini, Klaus Martiny, Yuki Mashima, Declan M. McLoughlin, Alie N. R. Meesters, Ybe Meesters, Ingrid Melle, Fátima Meza-Urzúa, Elisabeth Michaelis, Pavol Mikolas, Yee Ming Mok, Scott Monteith, Muthukumaran Moorthy, Gunnar Morken, Enrica Mosca, Anton A. Mozzhegorov, Rodrigo Munoz, Starlin V. Mythri, Fethi Nacef, Ravi K. Nadella, Takako Nakanotani, René Ernst Nielsen, Claire O’Donovan, Adel Omrani, Yamima Osher, Uta Ouali, Maja Pantovic-Stefanovic, Pornjira Pariwatcharakul, Joanne Petite, Johannes Petzold, Andrea Pfennig, Maximilian Pilhatsch, Yolanda Pica Ruiz, Marco Pinna, Maurizio Pompili, Richard Porter, Danilo Quiroz, Francisco Diego Rabelo-da-Ponte, Raj Ramesar, Natalie Rasgon, Woraphat Ratta-apha, Maria Redahan, M. S. Reddy, Andreas Reif, Eva Z. Reininghaus, Jenny Gringer Richards, Janusz K. Rybakowski, Leela Sathyaputri, Angela M. Scippa, Christian Simhandl, Daniel Smith, José Smith, Paul W. Stackhouse, Dan J. Stein, Kellen Stilwell, Sergio Strejilevich, Kuan-Pin Su, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Andi J. Tanra, Yoshitaka Tatebayashi, Wen Lin Teh, Leonardo Tondo, Carla Torrent, Daniel Tuinstra, Takahito Uchida, Arne E. Vaaler, Eduard Vieta, Biju Viswanath, Carlo Volf, Kai-Jie Yang, Maria Yoldi-Negrete, Oguz Kaan Yalcinkaya, Allan H. Young, Yosra Zgueb, Peter C. Whybrow, Michael Bauer

“…A large change in solar insolation between the minimum and maximum monthly values was associated with a history of suicide attempts in patients with bipolar I disorder, a replication of our prior analysis. The estimated model also associated state sponsored religion in the onset country, female gender, a history of alcohol or substance abuse, and being part of a younger birth cohort with a history of suicide attempts. …”
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CO Isotopologue-derived Molecular Gas Conditions and CO-to-H2 Conversion Factors in M51 by Jakob den Brok, María J. Jiménez-Donaire, Adam Leroy, Eva Schinnerer, Frank Bigiel, Jérôme Pety, Glen Petitpas, Antonio Usero, Yu-Hsuan Teng, Pedro Humire, Eric W. Koch, Erik Rosolowsky, Karin Sandstrom, Daizhong Liu, Qizhou Zhang, Sophia Stuber, Mélanie Chevance, Daniel A. Dale, Cosima Eibensteiner, Ina Galić, Simon C. O. Glover, Hsi-An Pan, Miguel Querejeta, Rowan J. Smith, Thomas G. Williams, David J. Wilner, Valencia Zhang

“…All observations are convolved in this analysis to an angular resolution of 4″, corresponding to a physical scale of 170 pc. …”
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Trends in Global Burden and Socioeconomic Profiles of Atrial Fibrillation and Atrial Flutter: Insights from the Global Burden of Disease Study 2021 by Samuel Chin Wei Tan, MD, Mae-Ling Tang, MD, Hongyuan Chu, MD, Yun-Tao Zhao, MD, Cuilian Weng, MD

“…This study quantifies the burden and identifies key risk factors for AF/AFL across 204 countries and territories from 1990 to 2021. Methods: Using data from the Global Burden of Disease (GBD) study 2021, we employed average annual percentage change (AAPC) and Bayesian Age Period Cohort (BAPC) modelling to assess trends and future projections, with a focus on disparities across Socio-Demographic Index (SDI) levels. …”
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Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study. by Vijay R Varma, Youjin Wang, Yang An, Sudhir Varma, Murat Bilgel, Jimit Doshi, Cristina Legido-Quigley, João C Delgado, Anup M Oommen, Jackson A Roberts, Dean F Wong, Christos Davatzikos, Susan M Resnick, Juan C Troncoso, Olga Pletnikova, Richard O'Brien, Eelko Hak, Brenda N Baak, Ruth Pfeiffer, Priyanka Baloni, Siamak Mohmoudiandehkordi, Kwangsik Nho, Rima Kaddurah-Daouk, David A Bennett, Shahinaz M Gadalla, Madhav Thambisetty

“…Step 1: We assayed serum concentrations CA, CDCA, and 7α-OHC and used linear regression and mixed effects models to test their associations with brain amyloid accumulation (N = 141), WMLs, and brain atrophy (N = 134) in the Baltimore Longitudinal Study of Aging (BLSA). …”
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WTAP/YTHDF1-mediated m6A modification amplifies IFN-γ-induced immunosuppressive properties of human MSCs by Quan Chen, Luoquan Ao, Qing Zhao, Lu Tang, Yanli Xiong, Yuchuan Yuan, Xiaofeng Wu, Wei Xing, Zhan Li, Wei Guo, Huaping Liang, Song Guo Zheng, Qizhou Lian, Di Lu, Weijun Wan, Xiang Xu

“…Objectives: To elucidate the regulation mechanism and biological functions of N6-methyladenosine (m6A) modification in the immunosuppressive functions by the IFN-γ-licensing MSCs. Methods: Epitranscriptomic microarray analysis and MeRIP-qPCR assay were performed to identify the regulatory effect of WTAP in the IFN-γ-licensing MSCs. …”
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Sex differences in risk factors for unsuccessful tuberculosis treatment outcomes in Eastern Europe from 2020 to 2022: a multi-country retrospective cohort studyResearch in context by Ole Skouvig Pedersen, Tetiana Butova, Valerii Miasoiedov, Yurii Feshchenko, Mykhailo Kuzhko, Stefan Niemann, Alex Rosenthal, Alina Grinev, Gabriel Rosenfeld, Michael Drew Hoppes, Julia Kilmnick, Valeriu Crudu, Nelly Ciobanu, Alexandru Codreanu, Bekzat Toxanbayeva, Lyailya Chingissova, Kateryna Yurko, Valerii Kucheriavchenko, Vitalii Vekshyn, Sergo Vashakidze, Natalia Shubladze, Zaza Avaliani, Abdullaat Kadyrov, Gulmira Kalmambetova, Merbubu Sydykova, Eugenia Ghita, Victor Ionel Grecu, Alina Marinela Miulescu, Christian Morberg Wejse, Andreas Fløe, Victor Naestholt Dahl, Dmytro Butov

“…Uni- and multivariable logistic regression models were used to assess the association between sex and unsuccessful outcomes (‘treatment failure’, ‘lost to follow-up’, ‘died’, or any of these). …”
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Reperfusion failure after successful thrombectomy of large vessel occlusion stroke: clinical and imaging evidence by M. Barbagallo, M. Barbagallo, M. Zahn, M. Zahn, J. Zimmermann, J. Zimmermann, R. Klövekorn, R. Klövekorn, J. Held, J. Held, B. Nemeth, B. Nemeth, B. Reolon, B. Reolon, J. Bellomo, J. Bellomo, A. Schwarz, J. M. Veerbeek, C. H. B. Van Niftrik, C. H. B. Van Niftrik, M. Sebök, M. Sebök, M. Piccirelli, M. Piccirelli, L. Michels, L. Michels, A. R. Luft, A. R. Luft, A. R. Luft, Z. Kulcsar, Z. Kulcsar, L. Regli, L. Regli, G. Esposito, G. Esposito, J. Fierstra, J. Fierstra, P. Thurner, P. Thurner, T. Schubert, T. Schubert, S. Wegener, S. Wegener

“…Our current understanding of the underlying pathomechanisms is limited and mostly based on rodent models. The goal of this study was to further characterize RF by applying advanced multimodal hemodynamic imaging in stroke patients.MethodsPatients from the IMPreST study with LVO stroke and successful recanalization [corresponding to thrombolysis in cerebral ischemia grade (TICI) 2b-3] were included. …”
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Efficacy and safety of autologous adipose tissue-derived stromal vascular fraction in patients with premature ovarian insufficiency: protocol for a single-centre randomised control... by Jie Qiao, Hui Liu, Rong Li, Tian Tian, Yang Yu, Chen Zhang, Ping Liu, Lin Zeng, Rui Yang, Jia Li, Shuo Yang, Jialin Li, Qing Guo, Hongxia Zhang, Caihong Ma, Xiaojuan Liu, Xiumei Zhen, Yaodong Zhang, Yanru Lou, Chenhong Liu, Wan Yang, Huiyu Xu, Hongsen Bi

“…Although SVF has shown therapeutic effects in animal models of POI, there is insufficient evidence demonstrating the efficacy and safety of autologous SVF in women with POI.Methods and analysis This study is a single-centre randomised controlled trial designed to explore the efficacy and safety of using autologous SVF in improving pregnancy outcomes in patients with infertility diagnosed with POI. …”
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Health program for prEvention of cardiovascuLar disEases based on a risk screeNing strategy with Ankle-brachial index: HELENA study protocol by Gina Domínguez-Armengol, Gina Domínguez-Armengol, Francesc Ribas-Aulinas, Francesc Ribas-Aulinas, Elisabet Balló, Maite Alzamora-Sas, Maite Alzamora-Sas, Mar Serrat-Costa, Anna Ruiz-Comellas, Anna Ruiz-Comellas, Anna Ruiz-Comellas, Maria Jose Forcadell-Peris, Maria Jose Forcadell-Peris, Pere Toran, Ruth Martí-Lluch, Ruth Martí-Lluch, Ruth Martí-Lluch, Anna Ponjoan, Anna Ponjoan, Anna Ponjoan, Jordi Blanch, Lia Alves-Cabratosa, Lluís Zacarías-Pons, Lluís Zacarías-Pons, Eric Tornabell-Noguera, Eric Tornabell-Noguera, Álvaro Sánchez-Pérez, Álvaro Sánchez-Pérez, Anna Berenguera-Ossó, Anna Berenguera-Ossó, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, Rafel Ramos, The HELENA Study Group

“…Secondary outcomes include CHD (a composite of angina and hard CHD), cerebrovascular disease, and adverse effects from lipid-lowering medication. Survival analysis will estimate the effectiveness of adding the ABI screening strategy, with Cox models (intention-to-treat) and marginal structural models controlling for confounding variables.Results and discussionDirect health improvements in the intervened population are expected, including a reduction in CHD incidence and its risk factors. …”
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Efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis: a protocol for a multicentre, randomised, parallel... by José Antonio Pinto, Alex Fonollosa, Ester Carreño, Maria Isabel Rodriguez, David Diaz-Valle, Diana Peiteado, Luis Rodriguez-Rodriguez, Miguel Cordero-Coma, Marta Tejera Santana, Lidia Cocho, Ana Belen Rivas, Amanda Lopez-Picado, Valentina Calamia, Felix M Francisco Hernandez, Angel Garcia-Aparicio, Javier Garcia-Gonzalez, Jose Juan Mondejar, Leticia Lojo-Oliveira, Llucí Martínez-Costa, Santiago Munoz, Beatriz Rodriguez-Lozano, Esperanza Pato, Elena Molina, Luis Alberto Tebar, Mara Albert Fort, Mayte Ariño Gutierrez, Pedro Arriola Villalobos, Joseba Artaraz Beobide, Antonio Atanes Sandoval, Jose Manuel Sanchez, Francisco Blázquez, Pablo Borges Deniz, Lara Borrego Sanz, Gabriela Bustamante Sanchez-Arnedo, Bruno Casco Silva, Ricardo Cuiña Sardiña, Almudena De Pablo Cabrera, Maria Del Mar Esteban Ortega, Patricia Fernandez Puente, Dalifer Dayanira Nuñez, Javier Garcia Bella, Sara Garcia Carazo, Luis Garcia Onrubia, Jose Maria Morales, Jose Antonio Fernandez, Vanesa Hernandez Hernandez, Inés Hernanz Rodriguez, Jose Maria Cantalapiedra, Ventura Hidalgo Barrero, Maria De Jovani Casano, Sara López Sierra, Virginia Lozano Lopez, Alfredo Madrid Garcia, Rosalia Mendez Fernandez, Pilar Nozal Aranda, Eugenio Perez Blazquez, Chamaida Plasencia Rodriguez, Sheila Recuero Diaz, Ignacio Robles Barrena, Esther Rodriguez Almaraz, Fayna Maria Gonzalez, Guadalupe Rodriguez Martinez, Fredeswinda Isabel Bueno, Ioana Ruiz Arruza, Beatriz Sanchez Marugan, Olga Sanchez Pernaute, Armelle Schlinker Giraud, Alvaro Seijas Lopez, Patricia Simon Alonso, Elia Valls Pascual

“…However, a direct comparison between these two treatment strategies has not been carried out yet.Methods and analysis The Combination THerapy with mEthotrexate and adalImumAb for uveitis (CoTHEIA) study is a phase III, multicentre, prospective, randomised, single-blinded with masked outcome assessment, parallel three arms with 1:1:1 allocation, active-controlled, superiority study design, comparing the efficacy, safety and cost-effectiveness of methotrexate, adalimumab or their combination in non-infectious non-anterior uveitis. …”
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Renewable Energy Sources and the New Paradigm in Energy Engineering by Eden Mamut

“…But, in a document of the European Commission [1] developed based on a comprehensive analysis of a large volume of scientific publications, it is mentioned that <em>“Mostly due to current methods of capture and data malpractice, approximately 50% of all research data and experiments is considered not reproducible, and the vast majority (likely over 80%) of data never makes it to a trusted and sustainable repository.”…”
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RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer by Shumei Huang, Dongni Shi, Shuqin Dai, Xingyu Jiang, Rui Wang, Muwen Yang, Boyu Chen, Xuwei Chen, Lingzhi Kong, Lixin He, Pinwei Deng, Xiangfu Chen, Chuyong Lin, Yue Li, Jun Li, Libing Song, Yawei Shi, Weidong Wei

“…The synergistic effects of an RNF31 inhibitor plus paclitaxel on TNBC were evaluated. Cox regression models were adopted to assess the prognostic role of RNF31 in TNBC. …”
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Early bevacizumab dose and time modifications may affect efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma treatment by F. Rossari, D. Lavacchi, E. Alimenti, C. Soldà, F. Salani, L. Esposito, S. Foti, S. Camera, M. Persano, F. Lo Prinzi, F. Vitiello, E. Pellegrini, M. Bruccoleri, M.D. Rizzato, M. Caccese, I.G. Rapposelli, A. Guidolin, A. De Rosa, L. Antonuzzo, G. Masi, M.A. Iavarone, S. Lonardi, M. Rimini, A. Casadei-Gardini

“…Additionally, early bevacizumab dose/time modifications (eBEVmod) may negatively impact outcome. Materials and methods: Data from AtezBev-treated aHCC patients (n = 100) in five Italian institutions were retrospectively analyzed. …”
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Adherence to Life’s Essential 8 enhances gut microbiota diversity and cognitive performance by Yannick N. Wadop, Jazmyn Muhammad, Rebecca Bernal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Claudia L. Satizabal, Alexa Beiser, Alexa Beiser, Alexa Beiser, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramachandran S. Vasan, Ramnik Xavier, Ramnik Xavier, Ramnik Xavier, Tiffany Kautz, Tiffany Kautz, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Sudha Seshadri, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Jayandra Jung Himali, Bernard Fongang, Bernard Fongang, Bernard Fongang

“…Multivariable linear regression models and mediation analysis were used to investigate this relationship.ResultsParticipants with greater adherence to LE8 demonstrated significantly increased gut microbial diversity (α-diversity: Chao1, p = 0.0014; Shannon, p = 0.0071) and distinct microbial compositions (β-diversity: PERMANOVA p = 1e-4). …”
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CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells by Miaomiao Chen, Wenjian Chen, Shiwen Sun, Yanli Lu, Guoxiu Wu, Hongyu Xu, Huiru Yang, Chong Li, Weizhi He, Mingyang Xu, Xiuhua Li, Dong Jiang, Yongchao Cai, Changcheng Liu, Wencheng Zhang, Zhiying He

“…Objectives: This study was designed to investigate whether senescence induction of hTICs in the precancerous stage inhibit HCC initiation. Methods and Results: HCC models developed from chronic liver injury (CLI) were established by using Fah-/- mice and N-Ras + AKT mice. …”
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The relationship between prenatal perfluorine and polyfluoroalkyl substances (PFAS) exposure and infant neurodevelopment: Modifying effects of DHA revised by Ting-ting Jiang, Lian-man Lei, Xia-yu Zhang, Ya-ling Li, Lu-ming Yan, Zi-shun Lu, Zi-yi Liu, Bo-lin Liu, Lian-jie Dou, An-hui Zhang, Min Yu, Min Zhu, Fei Li, Ji-an Xie, Chao Zhang, Jia-hu Hao

“…Infant neurodevelopment was assessed at 6 and 12 months using the Ages and Stages Questionnaire (ASQ-3) score. Generalised linear models (GLMs) and Bayesian kernel machine regression (BKMR) were used to evaluate the associations between single or mixed PFAS exposure and infant neurodevelopment. …”
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Cost-effectiveness of sodium zirconium cyclosilicate for the treatment of hyperkalemia in patients with chronic kidney disease or heart failure in Spain by Roberto Alcázar-Arroyo, María G Crespo-Leiro, Jordi Bover, Juan Oliva, Miren Sequera-Mutiozabal, Simona Gradari, Anisia Martínez-López, Blanca López-Chicheri, Neus Vidal-Vilar, Susana Aceituno, Marta Cobo

“…Materials and methods: Two microsimulation models reflecting the natural history of CKD and HF were used. …”
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Screening for breast cancer: a systematic review update to inform the Canadian Task Force on Preventive Health Care guideline by Alexandria Bennett, Nicole Shaver, Niyati Vyas, Faris Almoli, Robert Pap, Andrea Douglas, Taddele Kibret, Becky Skidmore, Martin Yaffe, Anna Wilkinson, Jean M. Seely, Julian Little, David Moher

“…When deemed appropriate, studies were pooled via random-effects models. The overall certainty of the evidence was assessed following GRADE guidance. …”
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