High levels of serum uric acid are associated with microvascular complications in patients with long-term diabetes by Hanying Wang, Liping Gu, Yuhang Ma, Xindan Xing, Yuan Qu, Xin Shi, Xinyi Liu, Hancong Wan, Qian Zhu, Yingchen Shen, Chong Chen, Li Su, Yufan Wang, Kun Liu

“…Abstract Aims To assess the association between serum uric acid (SUA) level and the prevalence of diabetic retinopathy (DR) and chronic kidney disease (CKD) in patients with long-term diabetes. Methods A cross-sectional analysis was conducted involving diabetic patients from Shanghai General hospital during October 2018 and October 2021. …”
Get full text

Using Implementation Science to Evaluate the Implementation of Patient-Reported Outcome Measures (PROMs) in a Clinical Heart Failure Care Setting by Sarah V.C. Lawrason, MSc, PhD, Heather Ross, MSc, MD, Michael McDonald, MD, Juan Duero Posada, MD, Samantha Engbers, BAH, Anne Simard, MHSc

“…The purpose of this study was to use implementation science frameworks to systematically evaluate the uptake and integration of PROMs into clinical HF care. Methods: The Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework guided this mixed-methods, 1-year quality-improvement project. …”
Get full text

Study protocol for the Bio-HEAT study: Investigating the Biological pathways from HEAT exposure to preterm birth and other adverse maternal and child health outcomes in South Afric... by Lebohang Radebe, Nicholas B. Brink, Clive Gray, Marié Landsberg, Robyn Hetem, G Justus Hofmeyr, Phelelani T. Mpangase, Sibusisiwe Makhanya, Michael Urban, Shane Norris, Amy Wise, Valerie Vannevel, Karl-Gunter Technau, Matthew F. Chersich, Renate Strehlau, Ijeoma Solarin, Kimberly Mc Alpine, Darshnika Pemi Lakhoo, Admire Chikandiwa, Howard Chang, Margaret M. Brennan

“…Conceptual frameworks and graphical causal models will be developed to delineate pathways of vulnerability and protective mechanisms.…”
Get full text

Grip Strength and Age-Related Ocular Diseases: Insights from Observational, Mendelian Randomization, and Mediation Analyses by Chao Chen, Dongling Guo, Jiaqi Meng, MD, Jiao Qi, MD, Keke Zhang, MD, Wenwen He, MD, Yih Chung Tham, PhD, Xiangjia Zhu, PhD

“…Subjects: A total of 307 796 UK Biobank participants with grip strength and covariates data available. Methods: Logistic regression models were used to evaluate the associations between grip strength and age-related ocular diseases. …”
Get full text

COL4A5-p.Gly624Asp is the Predominant Variant in Europe Associated With a Mild Alport Syndrome Phenotype by Bastian M. Krüger, Annika Jens, Anna Neuhaus, Jasmina Ćomić, Riccardo Berutti, Jonathan de Fallois, Friederike Petzold, Johannes Münch, Jan Kowald, Tom H. Lindner, Klemens Budde, Klara K. Brüning, Julia Thumfart, Jacob Haas, Carolin B. Brigl, Kerstin Amann, Velibor Tasic, Nora Abazi-Emini, Valbona Nushi-Stavileci, Jovana Putnik, Nataša Stajić, Evelyn Seelow, Charlotte Hammett, Kai-Uwe Eckardt, Korbinian M. Riedhammer, Eva V. Schrezenmeier, Julia Hoefele, Jan Halbritter

“…Allelic and gene dosage effects drive phenotypic differences and should be incorporated into future risk models.…”
Get full text

Leveraging data science to understand and address multimorbidity in sub-Saharan Africa: the MADIVA protocol by Kobus Herbst, Stephen Tollman, Kathleen Kahn, Francesc Xavier Gómez-Olivé, Jaya George, Catherine Kyobutungi, Karen Hofman, Gershim Asiki, Michèle Ramsay, Daniel Ohene-Kwofie, Chodziwadziwa W Kabudula, Helen Robertson, Isaac Kisiangani, Palwende Boua, Eric Maimela, Damazo T Kadengye, Michelle Kamp, Daniel Maina Nderitu, Phelelani Thokozani Mpangase, Kayode Adetunji, Samuel Iddi, Skyler Speakman, Scott Hazelhurst, Kerry Glover, Tabitha Osler, Tanya Akumu, Diana Awuor, Victoria Bronstein, Joan Byamugisha, Jacques D Du Toit, Barry Dwolatzky, Paul A Harris, Celeste Holden, Nhlamulo Khoza, Faith Kimongo, Dekuwin E Kogda, Michael Klipin, Stephen P Levitt, Dylan Maghini, Karabo Maila, Ndivhuwo Makondo, Molulaqhooa Linda Maoyi, Reineilwe Given Mashaba, Nkosinathi Gabriel Masilela, Theophilous Mathema, Daphine T Nyachowe, Evelyn Thsehla, Siphiwe A Thwala, Roy Zent, Patrick Opiyo Owili

“…These datasets will be harmonised, linked and curated, and then used to develop MM risk prediction models, novel data science methods and interactive dashboards for research and clinical use. …”
Get full text

Facies changes, sedimentary environments and sequence stratigraphy of the lower Carboniferous deposits in the Kalmard area, Central Iran, Member D of Gachal formation by Mohammadnabi Gorgij, Somayyeh Shahraki Mirzaei

“…With respect to complete Unit D in the southern part of Kalmard area and a necessary of the study of sequence stratigraphy of Tournaisian–Visean strata in this part of Central Iran, this stratigraphic section has been selected. Materials & MethodsFor identification of microfacies characters and analysis, environmental conditions, and sequence stratigraphy of unit D of Gachal formation, the Godar-e-Gachal section has been selected that has 50.4 m thickness. …”
Get full text

The absolute lactate levels versus clearance for prognostication of post‐cardiotomy patients on veno‐arterial ECMO by Mohamed Laimoud, Patricia Machado, Michelle Gretchen Lo, Mary Jane Maghirang, Emad Hakami, Rehan Qureshi

“…This work aimed to analyse the impact of changes in blood lactate levels on the survival of patients on post‐cardiotomy ECMO (PC‐ECMO) and whether lactate clearance (LC) performs better than absolute lactate levels. Methods and Results We retrospectively analysed the data of adult patients who received PC‐ECMO at our centre between 2016 and 2022. …”
Get full text

Associations of metabolic status with all-cause mortality among individuals with osteoarthritis: A prospective cohort study by Hao Yang, Muhui Zeng, Tianxiang Fan, Haowei Chen, Xiaofeng Fang, Zhong Alan Li, Xiaoshuai Wang, David J. Hunter, Changhai Ding, Zhaohua Zhu

“…Moreover, the association between metabolic status and risk of mortality among OA patients remains unclear. Methods: The analysis included baseline populations with OA from the UK Biobank (UKBB) study and the National Health and Nutrition Examination Survey (NHANES) 1999–2018. …”
Get full text

Adaptación, validación e invarianza factorial de una escala para evaluar la calidad de los cursos virtuales desarrollados para estudiantes peruanos de ciencias de la salud durante... by Claudio Intimayta-Escalante, Rubí Plasencia-Dueñas, Janeth N. Nuñez-Lupaca, Kevin Flores-Lovon, Nancy Ramirez-Bernuy, Giancarlo Pares-Ballasco, Natalia Barrientos-Odias, Ronald Castillo-Blanco

“…Factor invariance was considered adequate when the ΔCFI≤0.010 and the ΔRMSEA≤0.015 between models at different levels. Reliability was assessed with the alpha and omega index. …”
Get full text

Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted... by Manuel Recio-Rufián, Teresa López-Viñau, Víctor Gálvez-Soto, Ángela Cano, Rafael Ruiz-Montero, Belén Gutiérrez-Gutiérrez, Irene Gracia-Ahufinger, Germán Peñalva, Juan Antonio Marín-Sanz, Miriam Marín-Sanz, David Segorbe, Juan Jesús Pineda-Capitán, Montserrat Muñoz-Rosa, Cristina Riazzo, Federico Giovagnorio, Elisa Ruiz-Arabi, José David Torres-Peña, Juan José Castón, Isabel Machuca, Inmaculada Salcedo-Leal, Luis Martínez-Martínez, Elena Pérez-Nadales, Julián Torre-Cisneros, KLEBMAN study group

“…Interrupted time series and ARIMA models assessed ASP and IPC impacts on incidence density (ID). …”
Get full text

PDK2-enhanced glycolysis aggravates fibrosis via IL11 signaling pathway in Graves’ orbitopathy by Zhiyu Peng, Zhiyu Peng, Zhiyu Peng, Zhiyu Peng, Rui Huang, Rui Huang, Rui Huang, Lu Gan, Lu Gan, Lu Gan, Jinghan Wang, Jinghan Wang, Jinghan Wang, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Jie Ding, Jie Ding, Jie Ding, Yinan Han, Yinan Han, Yinan Han, Jihong Wu, Jihong Wu, Jihong Wu, Kang Xue, Kang Xue, Kang Xue, Jie Guo, Jie Guo, Jie Guo, Rui Zhang, Jiang Qian, Ruiqi Ma, Ruiqi Ma, Ruiqi Ma

“…Lactate production was measured to assess glycolysis status. Animal models were assessed by T2-weighted magnetic resonance (MR) scan. …”
Get full text

Impact of enteral nutrition initiated within 24 h of ECMO on nutritional status and inflammatory response in children by Ye Ren, Ye Ren, Ye Ren, Siwei Lu, Siwei Lu, Siwei Lu, Yingfu Chen, Yingfu Chen, Yingfu Chen, Yuelin Sun, Yuelin Sun, Yuelin Sun, Yueqiang Fu, Yueqiang Fu, Yueqiang Fu, Chengjun Liu, Chengjun Liu, Chengjun Liu, Jing Li, Jing Li, Jing Li, Hongxing Dang, Hongxing Dang, Hongxing Dang

“…Linear mixed-effects models (LME) were applied to assess the effect of EEN on changes in CRP and CHE levels over time during ECMO.ResultsA total of 47 children were included in this study, with 24 patients (51.1%) successfully receiving EEN. …”
Get full text

Bronchoalveolar lavage cell percentages as diagnostic markers of immune checkpoint inhibitor pneumonitis by Mahnoor Mir, Felipe Soto, Pedro Antonio Amezcua Gomez, Rodrigo Del Rio Arroyo, Adarsh Suresh, Amber Su, Qiong Gan, John Stewart, Roberto Adachi, Diwakar D. Balachandran, Lara Bashoura, Roberto F. Casal, Burton F. Dickey, George A. Eapen, Scott E. Evans, Horiana Grosu, Carlos A. Jimenez, Julie Lin, David E. Ost, Bruce F. Sabath, Vickie R. Shannon, Aung Naing, Jianjun Gao, Jia Wu, Karthik Suresh, Saadia A. Faiz, Mehmet Altan, Ajay Sheshadri

“…We constructed logistic regression models to assess the relationship between BAL lymphocyte, eosinophil, and neutrophil percentages and the diagnosis of pneumonitis, and the area under the receiver-operator curves (AUROC) was used to assess their discriminatory function. …”
Get full text

Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway by Kyonghwan Choe, Muhammad Ali, Roy Lardenoije, Renzo J.M. Riemens, Ehsan Pishva, Horst Bickel, Siegfried Weyerer, Per Hoffmann, Michael Pentzek, Steffi Riedel-Heller, Birgitt Wiese, Martin Scherer, Michael Wagner, Diego Mastroeni, Paul D. Coleman, Alfredo Ramirez, Inez H.G.B. Ramakers, Frans R.J. Verhey, Bart P.F. Rutten, Gunter Kenis, Daniel L.A. van den Hove

“…Functional interactions between genes and identification of common phenotype-specific positive and negative elementary circuits were conducted using computational modeling, i.e. gene regulatory network (GRN) and network perturbational analysis. …”
Get full text

Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy by Amélie Taschereau, Frédérique White, Catherine Allard, Andrea G. Edlow, François Aguet, Kristin G. Ardlie, Jose C. Florez, Jose C. Florez, Jose C. Florez, Jose C. Florez, Pierre-Étienne Jacques, Pierre-Étienne Jacques, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe, Camille E. Powe, Camille E. Powe, Camille E. Powe, Luigi Bouchard, Luigi Bouchard, Luigi Bouchard, Marie-France Hivert, Marie-France Hivert, Marie-France Hivert

Get full text

Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Functional analyses revealed that LINC00339 dysregulation exhibited an inverse correlation with osteogenic differentiation capacity across multiple osteoblast cell models. Subcellular localization analysis via FISH confirmed the predominant cytoplasmic distribution of LINC00339 in bone cells. …”
Get full text

Recurrence of autoimmune hepatitis cholestatic variant syndromes after liver transplantation affects graft and patient survival by Vincenzo Ronca, Alessandro Parente, Ellina Lytvyak, Bettina E. Hansen, Gideon Hirschfield, Alan Bonder, Maryam Ebadi, Saleh Elwir, Mohamad Alsaed, Piotr Milkiewicz, Maciej K. Janik, Hanns-Ulrich Marschall, Maria Antonella Burza, Cumali Efe, Ali Rıza Calışkan, Murat Harputluoglu, Gökhan Kabaçam, Débora Terrabuio, Fernanda de Quadros Onofrio, Nazia Selzner, Albert Parés, Laura Llovet, Murat Akyıldız, Cigdem Arikan, Mihael P. Manns, Richard Taubert, Anna-Lena Weber, Thomas D. Schiano, Brandy Haydel, Piotr Czubkowski, Piotr Socha, Natalia Ołdak, Nobuhisa Akamatsu, Atsushi Tanaka, Cynthia Levy, Eric F. Martin, Aparna Goel, Mai Sedki, Irena Jankowska, Toru Ikegami, Maria Rodriguez, Martina Sterneck, Marcial Sebode, Christoph Schramm, Maria Francesca Donato, Francesca Colapietro, Ansgar Lohse, Raul J. Andrade, Vilas R. Patwardhan, Bart van Hoek, Maaike Biewenga, Andreas E. Kremer, Yoshihide Ueda, Mark Deneau, Mark Pedersen, Marlyn J. Mayo, Annarosa Floreani, Patrizia Burra, Maria Francesca Secchi, Benedetta Terziroli Beretta-Piccoli, Marco Sciveres, Giuseppe Maggiore, Syed-Mohammed Jafri, Dominique Debray, Muriel Girard, Florence Lacaille, Michael Heneghan, Andrew L. Mason, Ye Oo, Aldo J. Montano-Loza

“…Cumulative probabilities of graft and overall survival after LT were calculated using a semi-Markov model. Results: The autoimmune pattern of recurrence resembled the original VS in 19 cases (61%). …”
Get full text

Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4Summary by Yue Zhao, Hong-Yu Nie, Shan Jiang, Meng-Fei Zhao, Peng Sun, Jing-Zi Zhang, Xiao-Chen Wang, Yi-Ping Tang, Ming-jie Zou, Xian-Wen Yuan, Xi-Tai Sun, Xiao-Dong Shan, Jian He, Jiang-Huai Liu, Yan Bi, Lei Fang, Xiao Han, Chao-Jun Li

“…This study aimed to identify the key regulator responsible for MUO. Methods: Metabolomics analysis was conducted to compare hepatic metabolite profiles between individuals with MUO and MHO and mice. …”
Get full text

Maternal asthma and newborn DNA methylation by Casper-Emil Tingskov Pedersen, Thanh T. Hoang, Jianping Jin, Anna Starnawska, Raquel Granell, Hannah R. Elliott, Anke Huels, Heather J. Zar, Dan J. Stein, Yining Zhang, Herman T. den Dekker, Liesbeth Duijts, Janine F. Felix, Júlia Sangüesa, Mariona Bustamante, Maribel Casas, Martine Vrijheid, Latha Kadalayil, Faisal I. Rezwan, Hasan Arshad, John W. Holloway, Stefan Röder, Ana C. Zenclussen, Gunda Herberth, Nicklas Heine Staunstrup, Henriette Thisted Horsdal, Jonathan Mill, Eilis Hannon, iPSYCH-MINERvA Group, Isabella Annesi-Maesano, Giancarlo Pesce, Nour Baïz, Barbara Heude, Sahra Hosseinian-Mohazzab, Carrie V. Breton, Sophia Harlid, Justin Harbs, Magnus Domellof, Christina West, Edwina Yeung, Xuehuo Zeng, Wenche Nystad, Siri E. Håberg, Maria C. Magnus, Diana Schendel, Stephanie J. London, Klaus Bønnelykke

“…Paternal asthma was analyzed for comparison. Models were adjusted for covariates and cell-type composition. …”
Get full text