Self‐Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study by Göran Bergström, Eva Hagberg, Elias Björnson, Martin Adiels, Carl Bonander, Ulf Strömberg, Jonas Andersson, Mattias Brunström, Carl‐Johan Carlhäll, Gunnar Engström, David Erlinge, Isabel Goncalves, Anders Gummesson, Emil Hagström, Ola Hjelmgren, Stefan James, Magnus Janzon, Lena Jonasson, Lars Lind, Martin Magnusson, Viktor Oskarsson, Johan Sundström, Per Svensson, Stefan Söderberg, Raquel Themudo, Carl Johan Östgren, Tomas Jernberg

“…For comparison, we also developed a tool using variables from laboratory tests, physical examinations, and self‐report (clinical tool) and evaluated both models using receiver operating characteristic curve analysis, external validation, and benchmarked against factors in the pooled cohort equation. …”
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HiSNAP trial—a multicentre, randomised, open-label, blinded end point, safety and efficacy trial of conventional (300 mg/kg) versus higher doses of acetylcysteine (450 mg/kg and 60... by Alasdair Gray, David M Wood, Jacqueline James, Keith Boath, Rajendra Raman, Matt Reed, Rachel O’Brien, Alison Grant, Sharon Tuck, Liza Keating, Craig Davidson, Christopher J Weir, Jonathan Carter, Stephen Lynch, James W Dear, Michael Eddleston, Lyle Moncur, Julia Grahamslaw, Katherine Oatey, Marianne Gillings, Lynsey Milne, Natalie Homer, Caroline Blackstock, Philippa Wright, Christopher Humphries, Alan Timmins, Laura Muir, Ruben Thanacoody, Ellise Clarke, Heather Robertson, Anna Miell, Chloe Haigh, Luisa Padovani, Karen Gray, Sandra Pirie, Christina Coventry, Amy Armstrong, Sian Irvine, Oliver Carlill, Donna Clark, Fraser Craig, Angela Crawford, Carlyn Davie, Judith Flemming, Marie-Claire Harris, Katy Letham, Malgorzata Litwin, Fiona McCurrach, Shona McDonald, Fraser McFadyen, Hazel Milligan, Victoria Minnis, Gillian Pickering, Rebecca Rielly, Emma-Beth Wilson, Lisa-Marie Butt, Kathleen Scullion, Claire Cheyne, Angela McGeough, Nikki McLaughlin, Fern Purdie, Sandee Beattie, Anna Borkowska, Katie Hamilton, Keith Jacques, Jeronimo Martin Ramirez, Vasilika Ntoko, Surinder Pandhor, Janine Ramsey, Maria Simpson

“…Basic pharmacology, mathematical modelling and observational studies suggest that this dose may be insufficient in some patients (particularly those taking a large overdose).Methods and analysis A multicentre trial, taking place across several hospitals in Scotland, UK, within Emergency Departments and Acute Medical Units. …”
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Regional adipose distribution and metabolically unhealthy phenotype in Chinese adults: evidence from China National Health Survey by Binbin Lin, Yaoda Hu, Huijing He, Xingming Chen, Qiong Ou, Yawen Liu, Tan Xu, Ji Tu, Ang Li, Qihang Liu, Tianshu Xi, Zhiming Lu, Weihao Wang, Haibo Huang, Da Xu, Zhili Chen, Zichao Wang, Guangliang Shan

“…Odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated by logistic regression models. All analyses were performed separately by sex. …”
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Micronutrient dose response (MiNDR) study among women of reproductive age and pregnant women in rural Bangladesh: study protocol for double-blind, randomised, controlled trials by Tahmeed Ahmed, Hasmot Ali, Michael Rosenblum, Daniel J Erchick, Towfida Jahan Siddiqua, Rezwanul Haque, Parul Christian, Sarah Baker, Eleonor Zavala, Kerry J Schulze, SM Tafsir Hasan, Khalid Bin Ahsan, Sulagna Bandyopadhyay, Hasan Mahmud Sujan, Md. Hafizur Rahman, Katherine K Stephenson, Ximing Ge, Ethan K Gough, Brooke Langevin, Lee Shu Fune Wu, Brian Dyer, Anjan Kumar Roy, Mohammad Jubair, Amena Al Nishan, Mathangi Gopalakrishnan, Klaus Kraemer

“…A bioefficacy study to determine amounts required to attain nutrient adequacy among women of reproductive age (WRA) and pregnant women (PW) aims to address this gap.Methods and analysis Two, four-arm, dose-response trials (n=240 participants/trial) with a double-blind, individually randomised, controlled design are underway in 18–35 year-old WRA and PW in rural northern Bangladesh. …”
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Vitamin K‐dependent gamma‐carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGF... by Zheng Wu, Qing Ye, Shan Zhang, Li‐Peng Hu, Xiao‐Qi Wang, Lin‐Li Yao, Lei Zhu, Shu‐Yu Xiao, Zong‐Hao Duan, Xue‐Li Zhang, Shu‐Heng Jiang, Zhi‐Gang Zhang, De‐Jun Liu, Dong‐Xue Li, Xiao‐Mei Yang

“…The molecular function of transmembrane proline‐rich Gla proteins (PRRGs) remains unexplored. Methods Analysis of pancreatic ductal adenocarcinoma (PDAC) datasets, including transcription profiles, clinical data, and tissue microarrays, was conducted to evaluate PRRG1 expression and its clinical relevance. …”
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Efficacy, cost-utility and physiological effects of Acceptance and Commitment Therapy (ACT) and Behavioural Activation Treatment for Depression (BATD) in patients with chronic low... by Antonio I Cuesta-Vargas, Azucena García-Palacios, Juan P Sanabria-Mazo, Carlos G Forero, Paula Cristobal-Narváez, Ariadna Colomer-Carbonell, Adrián Pérez-Aranda, Laura Andrés-Rodríguez, Lance M McCracken, Francesco D'Amico, Pere Estivill-Rodríguez, Bernat Carreras-Marcos, Antonio Montes-Pérez, Olga Comps-Vicente, Montserrat Esteve, Mar Grasa, Araceli Rosa, Michael Maes, Xavier Borràs, Silvia Edo, Antoni Sanz, Albert Feliu-Soler, Juan R Castaño-Asins, Juan V Luciano

“…The objectives of this 12 month, multicentre, randomised, controlled trial (RCT) are (i) to examine the efficacy and cost-utility of adding a group-based form of ACT or BATD to treatment-as-usual (TAU) for patients with CLBP and moderate to severe levels of depressive symptoms; (ii) identify pre–post differences in levels of some physiological variables and (iii) analyse the role of polymorphisms in the FKBP5 gene, psychological process measures and physiological variables as mediators or moderators of long-term clinical changes.Methods and analysis Participants will be 225 patients with CLBP and moderate to severe depression symptoms recruited at Parc Sanitari Sant Joan de Déu (St. …”
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Clinical and cost-effectiveness of individualised exercises and foot orthoses in the treatment of plantar heel pain: protocol for the TREADON randomised multi-arm multi-stage adapt... by Thomas Jaki, Melaine A Holden, Anne-Maree Keenan, Royes Joseph, Christian D Mallen, Hylton B Menz, Jesse Kigozi, Edward Roddy, Pavel Mozgunov, Martin J Thomas, Kendra Cooke, Jo Smith, Gemma Hughes, Emma Marshall, Martyn Lewis, Stephanie Butler-Walley, Simon Wathall, Laura Bowyer, June Brammar, Sarah A Lawton, Chris Drake, Thomas Burnett, Gordon J Hendry, Nadine E Foster

“…Objectives To determine the clinical and cost-effectiveness of individualised exercises and/or prefabricated foot orthoses plus self-management advice (SMA) compared to SMA alone in adults with PHP. Methods A multi-centre four-arm two-stage adaptive parallel-group RCT with internal pilot. …”
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The Association of Heart Failure and Liver T1 Mapping in Cardiac Magnetic Resonance Imaging by Adrian T. Huber, Joanna Bartkowiak, Robin Seitz, Benedikt Bernhard, Martina Boscolo Berto, Giancarlo Spano, Benedikt Wagner, Verena C. Obmann, Lukas Ebner, Inga A. S. Todorski, Michael P. Brönnimann, Kady Fischer, Dominik P. Guensch, Andreas Christe, Annalisa Berzigotti, Lorenz Räber, Tobias Reichlin, Thomas Pilgrim, Fabien Praz, Christoph Gräni, Nicholas Brugger, Alan A. Peters

“…<b>Background/Objectives:</b> The objective of this study was to investigate the association between congestive heart failure (CHF) and T1 mapping in both liver lobes using cardiac MRI. <b>Methods:</b> This retrospective study included patients who underwent cardiac MRI with T1 mapping sequences on a 1.5 T scanner. …”
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Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

“…We also evaluated the therapeutic potential of an innovative inhibitor targeting these epigenetic effectors. Methods Immunohistochemical analysis of DNMT1, G9a, and UHRF1 expression was conducted in human PDAC tissue samples. …”
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Post-treatment duration of positivity for standard and ultra-sensitive Plasmodium falciparum antigen-based rapid diagnostic tests, a cohort study from a low-endemic setting in Nami... by Henry Ntuku, Brooke Whittemore, Lucille Dausab, Ihn Kyung Jang, Allison Golden, William Sheahan, Xue Wu, Hannah Slater, Gonzalo J. Domingo, Smita Das, Elias Duarte, Lydia Eloff, Teun Bousema, Kjerstin Lanke, Cara Smith Gueye, Lisa M. Prach, Jaishree Raman, Petrina Uusiku, Stark Katokele, Roly Gosling, Bryan Greenhouse, Davis Mumbengegwi, Michelle S. Hsiang

“…The duration of test positivity has not previously been studied in a low transmission setting. Methods: We conducted a longitudinal cohort study in a low transmission setting in Namibia. …”
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The metabolic effect of combined liraglutide treatment and lifestyle modification on obese adolescents in a tertiary center, Riyadh by Amir Babiker, Amir Babiker, Amir Babiker, Haifa Alfaraidi, Haifa Alfaraidi, Haifa Alfaraidi, Gadah Aljarallah, Joud Albaraki, Reem Alharbi, Nouf Alsomali, Abeer Alkhalaf, Nagarajkumar Yenugadhati, Nagarajkumar Yenugadhati, Fahad Al Juraibah, Fahad Al Juraibah, Fahad Al Juraibah, Ibrahim Al Alwan, Ibrahim Al Alwan, Ibrahim Al Alwan

“…Comparisons of two repeated measures obtained at T1 (baseline) and T2 (6-9 months) or T3 (9-12 months), including changes in body mass index (BMI), glycated hemoglobin (HbA1c) and other metabolic markers, were performed in the two matched groups using paired t-tests. Regression analysis using linear mixed models (SAS 9.4) were used to assess the effect of treatment status over time (P-value ≤ 0.05).ResultsData collected from 138 patients (n=69 in each group) with mean BMI and HbA1c of 35.78 kg/m2 and 5.85%, respectively. …”
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Association of Dipeptidyl Peptidase-4 Inhibitors with Glaucoma Risk in Patients with Type 2 Diabetes: A Nationwide Cohort Study by Yi-An Lu, MD, Peng-Tai Tien, MD, PhD, Yih-Dih Cheng, PhD, Yow-Wen Hsieh, PhD, Der-Yang Cho, MD, Shang-Feng Tsai, MD, PhD, Chien-Hsiang Weng, MD, MPH, Heng-Jun Lin, Hui-Ju Lin, MD, PhD, I-Jong Wang, MD, PhD, Chien-Chih Chou, MD, PhD

“…Cox proportional hazards models were applied to estimate hazard ratios for POAG and NTG, adjusting for age, sex, comorbidities, and concurrent antidiabetic medications. …”
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Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival by Wenjia Yuan, Hedong Zhang, Longkai Peng, Chao Chen, Chen Feng, Zhouqi Tang, Pengcheng Cui, Yaguang Li, Tengfang Li, Xia Qiu, Yan Cui, Yinqi Zeng, Jiadi Luo, Xubiao Xie, Yong Guo, Xin Jiang, Helong Dai, Sihan Zhou, Xiuyuan Hao

“…Interferon regulatory factor 4 (IRF4) has been shown to play a pivotal role in inducing T cell dysfunction. Methods:. A novel ultra-low-dose combination of Trametinib and Rapamycin, targeting IRF4 inhibition, was employed to investigate T cell proliferation, apoptosis, cytokine secretion, expression of T-cell dysfunction-associated molecules, effects of mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways, and allograft survival in both in vitro and BALB/c to C57BL/6 mouse cardiac transplantation models. …”
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Survival after radical cystectomy for bladder cancer: Multicenter comparison between minimally invasive and open approaches by Weibin Xie, Junming Bi, Qiang Wei, Ping Han, Dongkui Song, Lei Shi, Dingwei Ye, Yijun Shen, Xin Gou, Weiyang He, Shaogang Wang, Zheng Liu, Jinhai Fan, Kaijie Wu, Zhiwen Chen, Xiaozhou Zhou, Chuize Kong, Yang Liu, Chunxiao Liu, Abai Xu, Baiye Jin, Guanghou Fu, Wei Xue, Haige Chen, Tiejun Pan, Zhong Tu, Tianxin Lin, Jian Huang

“…Multivariable Cox proportional hazard models were used to evaluate the association among OS, CSS and risk factors of interest. …”
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X-chromosome-linked miR-542-5p as a key regulator of sex disparity in rats with adjuvant-induced arthritis by promoting Th17 differentiation by Jiu Jie Yang, Zhi Li, Lin Na Wang, Bai Xiong Huang, Jerome P. L. Ng, Xiong Fei Xu, Yu Ping Wang, David Wei Zhang, Bo Qin, Ding Qi Zhang, Chang Liu, Wei Dan Luo, Betty Yuen Kwan Law, Hui Miao Wang, Meng Han Liu, Xiao Yun Yun, Joyce Tsz Wai Chan, Wan Yu Wu, Yi Ting Li, Peter Kam Fai Cheung, Man Chon Pou, Kat Sang Ha, Wang Fai Ao Ieong, Chi Hou Leong, Kit Ieng Leong, Chan Wang Lei, Lek Hang Cheang, Vincent Kam Wai Wong

“…This study aims to investigate the possible role of X-linked miR-542-5p in RA pathogenesis and gender differences. Methods We investigated the impact of miR-542-5p on RA pathogenesis and gender differences by manipulating its expression in various rat models. …”
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Jab1 regulates HRR mRNA stability to modulate PARP inhibitor sensitivity in triple-negative breast cancer by Xin Peng, Yingying Wang, Zixiang Yu, Shengfan Huang, Shaolu Zhang, Zhenxing Zhong, Yongzhe Wang, Shanshan Liu, Kailin Wang, Christophe Nicot, Francois X. Claret, Dexin Kong

“…This study investigates the role of Jab1 in regulating the stability of homologous recombination repair (HRR)-related RNAs and evaluates its potential as a therapeutic target to enhance PARPi sensitivity in TNBC. Methods RNA-Seq analysis revealed that shRNA-mediated Jab1 knockdown profoundly affected HRR and DNA replication processes in TNBC cells. …”
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Real-world effectiveness of Ad26.COV2.S or BNT162b2 booster vaccines against severe COVID-19 in adults who received a primary dose of Ad26.COV2.S in South Africa during the Delta p... by L Fairall, N Yende-Zuma, Tarylee Reddy, N Garrett, A Goga, S Bennet, N Folb, I Seocharan, S Mametja, M Semenya, S R N Simelane, L-G, G E Gray

“…Time‐varying Cox regression models were used to assess the effectiveness of boosting with either Ad26.COV2.S or BNT162b2 v. not boosting against severe COVID‐19 outcomes associated with emerging variants, adjusting for various demographic and clinical factors. …”
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Blockade of colon cancer metastasis via single and double silencing of PCSK7/PCSK9: enhanced T cells cytotoxicity in mouse and human by Delia Susan-Resiga, Nabil G Seidah, Nathalie Labrecque, Jean-Sebastien Delisle, Leila Jafarzadeh, Chloé Porcheron, Mailys Le Devehat, Anna Roubtsova, Hadi Bayat, Alexandra Evagelidis, Vatsal Sachan, Alexie Fonta Holder, Rachid Essalmani, Gabrielle Boudreau, Annik Prat, Rebecca Cusseddu, Jean-François Côté, Abdel-Majid Khatib

“…The present study presents a novel role in immunity for proprotein convertase subtilisin-kexin 7 (PCSK7), the seventh proprotein convertase of the 9-membered secretory proprotein convertase subtilisin-kexin (PCSK)-family.Methods We analyzed cell surface levels of various immune checkpoint proteins in human and mouse cell models in the presence or absence of PCSK7 expression. …”
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Regional lymph node invasion in pediatric non-rhabdomyosarcoma soft tissue sarcoma: an international cohort study from the International Soft Tissue Sarcoma ConsortiumResearch in c... by Daniel Orbach, Matthieu Carton, Amadeus T. Heinz, Lise Borgwardt, J Herve Brisse, Carlo Morosi, Erin R. Rudzinski, Akmal Safwat, Monika Sparber-Sauer, Stephanie Terezakis, Andrea Ferrari, Aaron R. Weiss, William H. Meyer, David O. Walterhouse, Timothy B. Lautz

“…Descriptive statistics, logistic regressions, and Cox proportional hazards models were used to analyze the data and assess prognostic factors. …”
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Clinicopathologic and genomic features associated with brain metastasis after resection of lung adenocarcinomaCentral MessagePerspective by Elizabeth G. Dunne, MD, Cameron N. Fick, MD, Brooke Mastrogiacomo, MS, Kay See Tan, PhD, Nicolas Toumbacaris, MSPH, Stijn Vanstraelen, MD, Gaetano Rocco, MD, Jaime E. Chaft, MD, Puneeth Iyengar, MD, Daniel Gomez, MD, Prasad S. Adusumilli, MD, Bernard J. Park, MD, James M. Isbell, MD, Matthew J. Bott, MD, Smita Sihag, MD, Daniela Molena, MD, James Huang, MD, David R. Jones, MD

“…Objective: To identify clinicopathologic and genomic features associated with brain metastasis after resection of lung adenocarcinoma (LUAD) and to evaluate survival after brain metastasis. Methods: Patients who underwent complete resection of stage I-IIIA LUAD between 2011 and 2020 were included. …”
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