Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease by Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Le Liu, Ye Chen, Ye Chen

“…Current precision medicine approaches lack robust molecular tools integrating transcriptomic signatures with immune dynamics for personalized treatment guidance.MethodsWe performed multi-omics analyses of GEO datasets using machine learning algorithms (LASSO/Random Forest) to derive a four-gene signature. …”
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Relationship between maternal gingival bleeding during pregnancy and neurodevelopmental delay in their one-year-old children by Xiayu ZHANG, Lianman LEI, Lianjie DOU, Min YU, Min ZHU, Chao ZHANG, Jiahu HAO

“…Multivariable unconditional logistic regression models were used to analyze the relationship between maternal gingival bleeding symptoms during pregnancy and neurodevelopmental delay in their one-year-old children. …”
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Development and validation of scales measuring self-efficacy and behavioral capability in managing common medical emergencies in dental clinics by Yasmine N. Alawaji, Hussam M. Alqahtani, Abdulmohsen Alfadley, Aram Alshehri, Ali Aboalela, Sahr H. Altuwaijri, Farraj Albalawi, Sara A. Kalagi, Abdulrhman Alghamdi, Abdullah Alshibani, Meshal Alharbi, Meshary Binhotan, Nesrin A. Alharthy

“…., knowing what and how to do a behavior) in handling common medical emergencies in dental clinics and to identify factors influencing these outcomes. Methods Two newly created 13-item self-efficacy and 19-item behavioral capability were validated for their construct validity and psychometric properties. …”
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Fit for School Study protocol: early child growth, health behaviours, nutrition, cardiometabolic risk and developmental determinants of a child’s school readiness, a prospective co... by Peter Szatmari, Mark S Tremblay, Peter Jüni, Christopher Allen, Julia Thompson, Kevin Thorpe, Douglas Campbell, Andreas Laupacis, Elise Mok, Catherine S Birken, Jessica A Omand, Kim M Nurse, Cornelia M Borkhoff, Jonathon L Maguire, Muhammad Mamdani, Patricia C Parkin, Janis Randall Simpson, Eric Duku, Caroline Reid-Westoby, Magdalena Janus, Catherine S. Birken, Jonathon L. Maguire, Ronald Cohn, Cornelia M. Borkhoff, Charles Keown-Stoneman, Christine Kowal, Dalah Mason, Jillian Baker, Denis Leduc, Patricia Li, Navindra Persaud, Susan Shepherd, Carolyn Taylor, Farnaz Bazeghi, Imaan Bayoumi, Sarah Carsley, Patricia Raso, Amanda Offord

“…This paper presents the Fit for School Study protocol.Methods and analysis This is an ongoing prospective cohort study. …”
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P4HA1 mediates YAP hydroxylation and accelerates collagen synthesis in temozolomide-resistant glioblastoma by Xueru Li, Gangfeng Yu, Xiao Zhong, Jiacheng Zhong, Xiangyu Chen, Qinglong Chen, Jinjiang Xue, Xi Yang, Xinchun Zhang, Yao Ling, Yun Xiu, Yaqi Deng, Hongda Li, Wei Mo, Yong Zhu, Ting Zhang, Liangjun Qiao, Song Chen, Fanghui Lu, Xuehong Zhang

“…This study aimed to investigate the mechanism of TMZ chemoresistance by GBM cells reprogramming collagens. Methods:. Key extracellular matrix components, including collagens, were examined in paired primary and recurrent GBM samples as well as in TMZ-treated spontaneous and grafted GBM murine models. …”
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Exploring the impact of chronic urticaria profile as a key predictor of alexithymia: A cross‐sectional study by Ivan Cherrez‐Ojeda, Simon Francis Thomsen, Ana M. Gimenez‐Arnau, Jennifer Astrup Sørensen, Hermenio Lima, Kiran Godse, Carole Guillet, Luis Escalante, Astrid Maldonado, Gonzalo Federico Chorzepa, Blanca Morfin‐Maciel, Jose Ignacio Larco Sousa, Erika deArruda‐Chaves, Abhishek De, Daria Fomina, Anant Patil, Roberta Jardim Criado, Luis Felipe Ensina, Solange O. R. Valle, Rosana Câmara Agondi, Herberto Chong Neto, Nelson Rosario, German Dario Ramon, Marco Faytong‐Haro, Isabel Ogueta, Ivan Tinoco Moran, Jennifer Donnelly, Emek Kocatürk, Anna Zalewska‐Janowska, Karla Robles‐Velasco

“…Regression models were used to investigate the relationship between clinical and demographic factors of patients with CU as key predictors of alexithymia. …”
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AGN STORM 2. II. Ultraviolet Observations of Mrk 817 with the Cosmic Origins Spectrograph on the Hubble Space Telescope by Y. Homayouni, Gisella De Rosa, Rachel Plesha, Gerard A. Kriss, Aaron J. Barth, Edward M. Cackett, Keith Horne, Erin A. Kara, Hermine Landt, Nahum Arav, Benjamin D. Boizelle, Misty C. Bentz, Thomas G. Brink, Michael S. Brotherton, Doron Chelouche, Elena Dalla Bontà, Maryam Dehghanian, Pu Du, Gary J. Ferland, Laura Ferrarese, Carina Fian, Alexei V. Filippenko, Travis Fischer, Ryan J. Foley, Jonathan Gelbord, Michael R. Goad, Diego H. González Buitrago, Varoujan Gorjian, Catherine J. Grier, Patrick B. Hall, Juan V. Hernández Santisteban, Chen Hu, Dragana Ilić, Michael D. Joner, Jelle Kaastra, Shai Kaspi, Christopher S. Kochanek, Kirk T. Korista, Andjelka B. Kovačević, Daniel Kynoch, Yan-Rong Li, Ian M. McHardy, Jacob N. McLane, Missagh Mehdipour, Jake A. Miller, Jake Mitchell, John Montano, Hagai Netzer, Christos Panagiotou, Ethan Partington, Richard W. Pogge, Luka Č. Popović, Daniel Proga, Daniele Rogantini, Thaisa Storchi-Bergmann, David Sanmartim, Matthew R. Siebert, Tommaso Treu, Marianne Vestergaard, Jian-Min Wang, Martin J. Ward, Tim Waters, Peter R. Williams, Fatima Zaidouni, Ying Zu

“…Using the cross-correlation lag analysis method, we find significant correlated variations in the continuum and emission-line light curves. …”
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Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis by Dr Katharine Stott, Mr Jason Mohabir, Miss Kate Bowers, Assistant Professor Jennifer Tenor, Associate Professor Dena Tofaletti, Dr Jennifer Unsworth, Ms Ana Jimenez-Valverde, Mr Ajisa Ahmadu, Dr Melanie Moyo, Mrs Ebbie Gondwe, Mrs Wezi Chimang'anga, Mr Madalitso Chasweka, Dr David Lawrence, Professor Joseph Jarvis, Professor Tom Harrison, Professor William Hope, Professor David Lalloo, Professor Henry Mwandumba, Professor John Perfect, Professor Christina Cuomo

“…An intensive pharmacokinetic study was undertaken, and population pharmacokinetic models were constructed for fluconazole, flucytosine, amphotericin B deoxycholate and liposomal amphotericin B. …”
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Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner by Oliver Thews, Thomas Schmid, Alexander Kluttig, Andreas Wienke, Melanie Zinkhan, Wolfgang Ahrens, Till Bärnighausen, Hermann Brenner, Stefanie Castell, Berit Lange, Wolfgang Lieb, Karin Halina Greiser, Marcus Dörr, Lilian Krist, Stefan N. Willich, Volker Harth, Nadia Obi, Michael Leitzmann, Annette Peters, Börge Schmidt, Matthias B. Schulze, Henry Völzke, Matthias Nauck, Stephanie Zylla, Anke Hannemann, Tobias Pischon, Ilais Moreno Velásquez, Matthias Girndt, Claudia Grossmann, Michael Gekle

“…In multivariable linear regression models, we observed an association of uric acid (mmol/l) with PWV (m/s) of β = 1.12 (95% confidence interval (CI): 0.78; 1.45) in males and β = 1.35 (1.05; 1.66) in females, independent of other factors known to affect vascular stiffness. …”
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Triglyceride glucose-weight-adjusted waist index as a cardiovascular mortality predictor: incremental value beyond the establishment of TyG-related indices by Jiajun Qiu, Jin’e Li, Shan Xu, Jingqi Yang, Haixia Zeng, Yuying Zhang, Shiqi Yang, Lixuan Fang, Jiadian Huang, Hongtao Zhou, Jiaying Feng, Yujie Zan, Jia Zhan, Jianping Liu

“…Weighted Cox proportional hazards models were used to assess the associations between TyG-related indices and cardiovascular mortality. …”
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FirstCPR: A pragmatic community organisation-based cluster randomised trial to increase community training and preparedness to respond to out-of-hospital cardiac arrest by Sonali Munot, Julie Redfern, Janet E Bray, Blake Angell, Andrew Coggins, Alan Robert Denniss, Garry Jennings, Sarah Khanlari, Pramesh Kovoor, Saurabh Kumar, Kevin Lai, Simone Marschner, Paul M. Middleton, Ian Oppermann, Zoe Rock, Christopher Semsarian, Matthew Vukasovic, Adrian Bauman, Clara K. Chow

“…Outcomes were assessed via surveys at 12 months and pre-specified analysis involved hierarchical mixed-models. Results: Of 165 randomised clusters (82 intervention), 58% were sports and 42% were social/faith-based. …”
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GPATCH3, a splicing regulator that facilitates tumor immune evasion via the modulation of ATPase activity of DHX15 by Tingrong Ren, Gaigai Wei, Gaigai Wei, Jingjing Yi, Jingjing Yi, Yuqi Zhang, Haiping Zhao, Nana Wu, Huiling Zhang, Zhihan Guo, Yihan Wang, Jiating Kuang, Zhaoying Sheng, Duanwu Zhang

“…In vitro and in vivo models, including GPATCH3-depleted cell lines and mouse xenografts, were used to assess its roles in tumor progression. …”
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SARS-CoV-2 seroprevalence among learners in grades 1–7, their parents and teachers in KwaZulu-Natal, South Africa: a cross-sectional study by Reshmi Dassaye, Terusha Chetty, Terusha Chetty, Brodie Daniels, Trisha Ramraj, Zakir Gaffoor, Elizabeth Spooner, Ncengani Mthethwa, Duduzile Faith Nsibande, Vuyolwethu Magasana, Khanya Mohlabi, Isaac Singini, Nomonde Gwebushe, Kubashni Woeber, Kubashni Woeber, Ameena Goga, Ameena Goga

“…All participants provided informed consent, completed a questionnaire and provided a fingerprick of blood for SARS-CoV-2 antibody testing using the COVID-19 IgG/IgM Rapid Test. Statistical methods included descriptive analysis, jackknife-estimated seroprevalence and incidence (unadjusted and sensitivity-adjusted), and logistic regression using generalized linear models.ResultsA total of 645 participants (i.e., 456 learners, 147 parents and 42 teachers) were enrolled into the survey. …”
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Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases by Jia-Hao Wang, Shan-Shan Dong, Wei Huang, Hao-An Wang, Shao-Shan Liu, Xiaoyi Ma, Ren-Jie Zhu, Wei Shi, Hao Wu, Ke Yu, Tian-Pei Zhang, Cong-Ru Wang, Yan Guo, Hanzhong Xue, Tie-Lin Yang

“…We also utilized these proteins to construct disease diagnostic models, and notably, models for 14 out of 18 diseases achieved an area under the curve (AUC) exceeding 0.8, indicating promising diagnostic potential. …”
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Patterns of Postablation Recurrence and Adverse Cardiovascular Outcomes in Patients With Atrial Fibrillation by Sitong Li, Jingrui Zhang, Song Zuo, Jue Wang, Yiwei Lai, Mingxiao Li, Zejun Yang, Zixu Zhao, Manlin Zhao, Lan Ren, Zhen Wang, Chao Jiang, Liu He, Xueyuan Guo, Xiaoxia Liu, Ribo Tang, Ning Zhou, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Changsheng Ma

“…Cardiovascular outcomes included cardiovascular death, thromboembolism, and cardiovascular hospitalization. Cox proportional models with landmark analysis were used to assess the relationship between recurrence patterns and outcomes. …”
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Fumarprotocetraric acid and geraniin were identified as novel inhibitors of human respiratory syncytial virus infection in vitro by Chao Wang, Chao Wang, Yi-Man Huang, Yi-Man Huang, Jun Zhao, Jun Zhao, Yi-Ming Bai, Yi-Ming Bai, Cai-Qin Yan, Cai-Qin Yan, Guan-Hua Du, Guan-Hua Du, Li-Shu Zheng, Li-Shu Zheng, Ai-Lin Liu, Ai-Lin Liu

“…In this study, natural products were screened to identify novel anti-RSV inhibitors.MethodsThe antiviral effect of 320 compounds on RSV in HEp-2 cells was tested using a Cytopathic effect (CPE) inhibition assay. …”
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Systematic Review of the Effects of Iron on Cardiovascular, Kidney, and Safety Outcomes in Patients With CKD by Bernard Chan, Amanda Varghese, Sunil V. Badve, Roberto Pecoits-Filho, Murilo Guedes, Clare Arnott, Rebecca Kozor, Emma O’Lone, Min Jun, Sradha Kotwal, Geoffrey A. Block, Glenn M. Chertow, Scott D. Solomon, Muthiah Vaduganathan, Vlado Perkovic, Brendon L. Neuen

“…We evaluated the effects of iron versus usual care or placebo on the clinical outcomes in patients with CKD. Methods: We conducted a systematic review and meta-analysis of randomized trials on i.v. or oral iron in patients with CKD (PROSPERO CRD42023453468). …”
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Multicenter validation of an RNA-based assay to predict anti-PD-1 disease control in patients with recurrent or metastatic head and neck squamous cell carcinoma: the PREDAPT study by Howard L McLeod, A Dimitrios Colevas, Georges Azzi, Kevin C Flanagan, Douglas Adkins, Jessica Ley, Ezra E W Cohen, James Wade, Jon Earls, Jeffrey Hiken, Rachel L Wellinghoff, Michelle M Ponder, William H Westra, Vera Vavinskaya, Leisa Sutton, Ida Deichaite, Orlan K Macdonald, Karim Welaya, Andrew W Pippas, Jennifer Slim, Bruce Bank, Xingwei Sui, Steven E Kossman, Todd D Shenkenberg, Warren L Alexander, Katharine A Price, David N Messina, Jarret I Glasscock, Eric J Duncavage

“…There is a critical clinical need to identify patients who benefit from these antiprogrammed cell death protein 1 (anti-PD-1) immune checkpoint inhibitors.Methods Here, we report findings from a multicenter observational study, PREDicting immunotherapy efficacy from Analysis of Pre-treatment Tumor biopsies (PREDAPT), conducted across 17 US healthcare systems. …”
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Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood by Kothandaraman Narasimhan, Mya Thway Tint, Li Chen, Sartaj Ahmad Mir, Suresh Anand Sadananthan, Navin Michael, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Priti Mishra, Anne K. Bendt, Kok Hian Tan, David Cameron-Smith, Yap Seng Chong, Peter D. Gluckman, Peter J. Meikle, Melvin Khee Shing Leow, Fabian Yap, Yung Seng Lee, Chan Shiao Yng, Johan G. Eriksson, S Sendhil Velan, Neerja Karnani, Markus R. Wenk

“…Understanding these relationships could provide insights into early sex-specific differences in lipid metabolism. Methods We conducted lipidomics of umbilical cord blood plasma samples (350 (46.6%) girls and 401 (53.4%) boys) from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort. …”
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Clonal divergence and genomic meltdown in prostatic pleomorphic giant cell adenocarcinoma by Xiaoshi Ma, Xiaoshi Ma, Kun Chen, Kun Chen, Jing Zhang, Liming Liu, Liming Liu, Jiping Luo, Kaipeng Huang, Hongying Zhang, Danni Liu, Jizhou Gou, Changyin Feng, Xia Zhao, Wanying Li, Lipeng Chen, Li Yin, Li Yin, Li Yin, Xianlin Meng, Zhiqiang Cheng, Zhiqiang Cheng

“…This study presents the first integrative clinicogenomic profiling of PGCA, revealing a novel prognostic gene signature with direct implications for diagnosis and treatment.MethodsWe conducted comprehensive clinicopathological and genomic analyses of a treatment-refractory PGCA case using histology, immunohistochemistry (IHC), whole-exome sequencing (WES), clonal evolution modeling, and multicohort validation. …”
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