Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice by Yan Liu, Yi Zhou, Xiaodong Li, Ming Niu, Rongjuan Chen, Jinman Shao, Lanlan Si, Dan Luo, Yayun Lin, Le Li, Kai Zhang, Xiaohe Xiao, Zhihui Xu, Min Liu, Mengji Lu, Fabien Zoulim, Dongping Xu

“…This study aimed to clarify whether rtL180M+A181C+M204V mutations may contribute to HBV ETV resistance.Methods: Serum samples were collected from 22,009 patients who underwent resistance testing in Beijing 302 Hospital from 2007 to 2016. …”
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Providing continuity of care for people living with noncommunicable diseases in humanitarian settings: A qualitative study of health actors' experiences in Lebanon by C. Akik, Z. El Dirani, R. Willis, C. Truppa, C. Zmeter, S. Aebischer Perone, J. Roswall, R. Hamadeh, K. Blanchet, B. Roberts, M.F. Fouad, P. Perel, É. Ansbro

“…Thematic analysis, combining inductive and deductive approaches, was guided by a conceptual framework for NCD models of care in humanitarian settings. …”
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A polytherapy approach demonstrates therapeutic efficacy for the treatment of SOD1 associated amyotrophic lateral sclerosisResearch in context by Jeremy S. Lum, Mikayla L. Brown, Natalie E. Farrawell, Rachael Bartlett, Christen G. Chisholm, Jody Gorman, Anthony Dosseto, Florian Dux, Lachlan E. McInnes, Heath Ecroyd, Luke McAlary, Peter J. Crouch, Paul S. Donnelly, Justin J. Yerbury

“…The small molecule, CuATSM, has repeatedly shown in mouse models to be a promising therapeutic treatment for SOD1-associated ALS and is currently in Phase II/III clinical trials for the treatment of ALS. …”
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Use of Z-codes related to social determinants of health among adult inpatients in France: a nationwide study from 2014 to 2022 by Sara Fernandes, Vanessa Pauly, Sophie Klay, Veronica Orleans, Yann Brousse, Bach Tran, Masoud Rahmati, Dong Keon Yon, Lee Smith, Guillaume Fond, Coralie Lemoine, Francois Antonini, Bastien Boussat, Geoffray Agard, Laurent Boyer

“…Univariable and multivariable mixed-effects models were used to identify characteristics of hospital stays associated with SDOH codes for the year 2022. …”
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The effects of a brand-specific, hemp-derived cannabidiol product on physiological, biochemical, and psychometric outcomes in healthy adults: a double-blind, randomized clinical tr... by Gianna F. Mastrofini, Bridget A. McFadden, Alexa J. Chandler, Blaine S. Lints, Harry P. Cintineo, Nathaniel D. Rhoades, Caroline S. Vincenty, Sten O. Stray-Gundersen, Abbi D. Lane, Shawn M. Arent

“…Change from baseline was calculated for each measure, and mixed effects models were used to determine differences between groups over time while adjusting for baseline values (α = 0.05). …”
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SPECIFICS OF THE GRAND MOTHER IMAGE TRANSFORMATION IN THE SHORT STORY “THE LOVELY LADY” BY D.H. LAWRENCE by Lyudmyla M. Kulakevych

“…The study has been conducted using elements of motive-based, receptive-interpretive, psychoanalytic, and comparative methods of analysis. In the short story “The Lovely Lady” D.H. …”
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Effect of low-dose primaquine treatment on Plasmodium vivax recurrence and transmission-blocking activity in southwest Ethiopia: a longitudinal cohort study by Hallelujah Getachew, Kassahun Habtamu, Ashenafi Abossie, Assalif Demissew, Arega Tsegaye, Teshome Degefa, Daibin Zhong, Xiaoming Wang, Guofa Zhou, MingChieh Lee, James W. Kazura, Christopher L. King, Delenasaw Yewhalaw, Guiyun Yan

“…Based on polymerase chain reaction (PCR) positivity, the time to the first recurrence was estimated using Kaplan–Meier survival analysis. Cox regression models were employed to assess risk factors for recurrence. …”
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Association of Alzheimer's Disease Blood Biomarkers With Sarcopenia Incidence and Progression: A 12‐Year Population‐Based Study by Chiara Ceolin, Caterina Gregorio, Alice Margherita Ornago, Giulia Grande, Martina Valletta, Caterina Trevisan, Adrián Carballo Casla, Giuseppe Sergi, Amaia Calderón‐Larrañaga, Davide Liborio Vetrano

“…Baseline data on AD biomarkers were collected. Latent class mixed models identified two sarcopenia trajectories: one with early progression accelerating around age 70 years and another with later progression accelerating after age 80 years, observed in both sexes. …”
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An eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Predisposition in Patients With Metastatic Cancers: Protocol for a Randomized Trial by Kimberley T Lee, Briana McLeod, Brian Egleston, Sarah Brown, Sarah Howe, Dominique Fetzer, Lauren Gutstein, Cara Cacioppo, Dana Clark, Susan M Domchek, Jessica Ebrahimzadeh, Dana Falcone, Demetrios Ofidis, Hannah Griffin, Rajia Mim, Santina Hernandez, Linda Fleisher, Kelsey Karpink, Enida Selmani, Aysha Tahsin, Lynne Wagner, Michelle Weinberg, Kuang Yi-Wen, Elisabeth Wood, Angela R Bradbury

“…ResultsAs of January 2025, we have completed enrollment of 229 participants. Data analysis is ongoing, and we expect the results to be published in 2025. …”
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Paradoxical Effect of Myosteatosis on the Immune Checkpoint Inhibitor Response in Metastatic Renal Cell Carcinoma by Jiwoong Yu, Hyeonju Ahn, Kyung Yeon Han, Wan Song, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Se Hoon Park, Woong‐Yang Park, Ji Hyun Lee, Minyong Kang

“…This study investigated the prognostic implications of pretreatment low skeletal muscle mass (LSMM) and myosteatosis in patients with mRCC undergoing first‐line ICI‐based therapies, comparing outcomes between PD‐1 inhibitor + CTLA‐4 inhibitor and PD‐1 inhibitor + TKI, incorporating single‐cell RNA sequencing. Methods A retrospective analysis was performed on 90 patients with mRCC treated with ICI‐based therapies between November 2019 and March 2023. …”
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The effect of malaria prevention and control interventions on malaria morbidity among children under 5 years and pregnant women in Kintampo North Municipality, Ghana by Christopher Tamal, Chrysantus Kubio, Delia Akosua Bandoh, Maurice Owiny, Ernest Kenu, Edwin Andrew Afari, Samuel Oko Sackey, Donne Kofi Ameme, Priscillia Nortey, Timothy Letsa, Alice Vorleto, Charles Gyamfi, Isaac Addisi

“…We performed correlation analysis between malaria interventions and malaria morbidity. …”
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Differential expression of plasma extracellular vesicles microRNAs and exploration of their association with bone metabolism in childhood trauma participants treated in a psychosom... by Yangyang He, Yangyang He, Karin Wuertz-Kozak, Karin Wuertz-Kozak, Petra Cazzanelli, Sanne Houtenbos, Sanne Houtenbos, Francisco Garcia-Carrizo, Francisco Garcia-Carrizo, Tim J. Schulz, Tim J. Schulz, Tim J. Schulz, Pia-Maria Wippert, Pia-Maria Wippert

“…Secondly, general linear regression models were employed to investigate the associations between specific EV miRNAs and circulating bone turnover markers (procollagen type 1 amino-terminal propeptide (P1NP), osteocalcin, and β-CrossLaps (CTx)), adjusting for depression as a potential confounder. …”
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Targeted Delivery of Exosome-Derived miRNA-185-5p Inhibitor via Liposomes Alleviates Apoptosis and Cuproptosis in Dilated Cardiomyopathy by Xu S, Zeng Y, Tan X, Zhang G, Xu A, Fan H, Yu F, Qin Z, Song Y, Jiang Y, Wang X, Zhang D, Nong Y, Lian D, Tang J, Zhou Y

“…This system was used in both in vitro and in vivo models of DCM induced by doxorubicin (DOX). We evaluated the effects of this treatment on cardiac function, apoptosis, cuproptosis, oxidative stress, and fibrosis using echocardiography, histological analysis, Western blotting, and biochemical assays.Results: In vitro experiments demonstrated that the Lipo@miR-185-5p inhibitor markedly attenuated apoptosis and cuproptosis in H9C2 cells and iPSC-derived cardiomyocytes, with a 42.6% reduction in apoptotic cell rates and over 50% downregulation of cuproptosis-related markers (both P < 0.01). …”
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Relationship between time-varying achieved HbA1c and risk of coronary artery disease events among common haptoglobin phenotype groups with type 2 diabetes: the ADVANCE study by Giuseppe Mancia, Mark Woodward, John Chalmers, Neil Poulter, Eric Rimm, Elizabeth Selvin, Michel Marre, Michelle Samuel, Stephen Harrap, Katie Harris, John Sapp, Leah E Cahill, Rachel A Warren, Samantha K Lavallée, Andrew P Levy, Allie S Carew

“…Introduction This study sought to determine whether the association between attaining specific glycated hemoglobin (HbA1c) targets (<7.0% (<53 mmol/mol) and ≥8.0% (≥64 mmol/mol) compared with 7.0%–7.9%) over time and risk of incident coronary artery disease (CAD) was dependent on haptoglobin (Hp) phenotype in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) study.Research design and methods Prospectively collected HbA1c data from the ADVANCE biomarker case-cohort study, updated at 6 months and every 12 months thereafter over a median of 5.0 (IQR 4.5–5.3) years, were analyzed in relation to incident CAD in the Hp2-2 (n=1323) and non-Hp2-2 (n=2069) phenotypes separately using weighted multivariable-adjusted Cox regression models. …”
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Multimodal imaging biomarkers for progression from intermediate to advanced age-related macular degeneration (AMD): a 10-year prospective longitudinal cohort study from the Univers... by Alan Palestine, Anne M Lynch, Naresh Mandava, Ramya Gnanaraj, Andres Lisker-Cervantes, Jennifer Patnaik, Vivian Rajeswaren, Nihaal Mehta, William Gange, Marc Mathias, Niranjan Manoharan, Talisa E de Carlo Forest

“…Objective To evaluate multimodal imaging (MMI) biomarkers for predicting progression from intermediate to advanced age-related macular degeneration (AMD).Methods and analysis This prospective longitudinal cohort study included patients with intermediate AMD (iAMD) enrolled in the University of Colorado AMD registry between July 2014 and August 2023, with follow-up through February 2024. …”
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Impact of rapid temperature fluctuations on acute stroke risk: a nationwide case-crossover study from 2001 to 2020Research in context by Miku Kono, Wei-Te Wu, Chuan-Pin Lee, Yu-Yin Chang, Yao-Hsu Yang, Ching-Chun Lin, Pau-Chung Chen

“…This study aimed to explore the link between ambient temperature, sudden day-to-day temperature changes, and stroke onset in Taiwan, taking air pollutants into consideration. Methods: We conducted a time-stratified case-crossover study from 2001 to 2020 using Distributed Lag Nonlinear Models (DLNM) within conditional logistic regression to examine lagged associations between temperature parameters and stroke risk. …”
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Computer-simulated mirror osteotomy in the treatment of post-traumatic cubitus varus deformity in children by WenQiang Xu, YongFei Fan, XiuLin Ma, JianQiang Zhang, WenZhi Bi, ChaoYu Liu, Wei Wang

“…Abstract Purpose To explore the feasibility and early clinical efficacy of computer-based mirroring technology in simulating osteotomy for the treatment of post-traumatic cubitus varus deformity in children. Methods A retrospective analysis was conducted on the data of 26 patients with cubitus varus deformity who were admitted between June 2019 and June 2024. …”
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Current Landscape and Multidimensional Determinants of Spiritual Coping Mechanisms Among Tuberculosis Patients in Zhejiang, China: A Population-Based Cross-Sectional Investigation by Lu L, Zheng L, Zhu Q, Qiu Q, Zhou T, Fu J, Pan X, Zheng G, Xu Y

“…Multivariate linear regression analysis indicated that PMS (2.852, P=0.005), APGAR (3.740, P< 0.0001), BRS (3.457, P=0.001), and gender (3.343, P=0.001) significantly affected the PSC level in TB patients. …”
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Weighted Family History Density of Substance Use: Influence on Participant Substance Use Onset, Duration, and Escalation by Litteral CA, Martel MM, Mattingly DT, Moore JX

“…Substance preference concordance and sex-specific links between affected family members and participants were also assessed.Methods: A cross-sectional analysis of the National Epidemiological Survey on Alcohol and Related Conditions III (NESARC-III) included 36,309 adults. …”
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Evaluating the Effectiveness of Spousal Testing Among Syphilis-Infected Pregnant Women in the Context of Mother-to-Child Transmission Elimination: A Multicenter Study in Southeaste... by Xue X, Huang X, Liu G, Jiang X, Lin W, Chen Y, Huang C

“…Univariate and multivariate unconditional logistic regression models were used to analyze the factors associated with the testing status of spouses of pregnant women with syphilis.Results: A total of 4,875 spouses were tested for syphilis. …”
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