Retrospective study of definitive therapy for head and neck mucosal melanoma: The RESUME study by Motoo Nomura, Naomi Kiyota, Yasushi Shimizu, Atsushi Motegi, Tetsuo Akimoto, Takashi Mukaigawa, Takashi Fujii, Nayuta Tsushima, Kiyoto Shiga, Taiji Koyama, Daisuke Kawakita, Akira Ohkoshi, Mitsuhiko Nakahira, Nobuhiro Hanai, Shigeyuki Murono, Tsutomu Ueda, Hiroki Mitani, Mutsukazu Kitano, Junichiro Ohori, Yuki Saito, Nobuhiko Oridate, Naoki Nishio, Hisayuki Kato, Kenji Okami, Takenori Ogawa, Yasushi Fujimoto, Mioko Matsuo, Kiyoaki Tsukahara, Morimasa Kitamura, Satoshi To, Shujiro Minami, Yosuke Ariizumi, Soichi Fumita, Akihiro Homma

“…Progression-free survival (PFS) and overall survival (OS) were compared between the S and RT cohorts and between those with and without ICI using propensity score-adjusted models. Results: A total of 304 patients were enrolled: 152 in the S cohort and 152 in the RT cohort. …”
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Applying machine learning to assist in the morphometric assessment of brain arteriolosclerosis through automation by Jerry J. Lou, Peter Chang, Kiana D. Nava, Chanon Chantaduly, Hsin-Pei Wang, William H. Yong, Viharkumar Patel, Ajinkya J. Chaudhari, La Rissa Vasquez, Edwin Monuki, Elizabeth Head, Harry V. Vinters, Shino Magaki, Danielle J. Harvey, Chen-Nee Chuah, Charles S. DeCarli, Christopher K. Williams, Michael Keiser, Brittany N. Dugger

“… Objective quantification of brain arteriolosclerosis remains an area of ongoing refinement in neuropathology, with current methods primarily utilizing semi-quantitative scales completed through manual histological examination. …”
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Effect of sodium-glucose cotransporter 2 inhibitors on ventricular function in systemic right ventricular failure by Lorna Swan, Gruschen R Veldtman, Hubert W Vliegen, Philippine Kiès, Filip Zemrak, Amanda Hunter, Anastasia D Egorova, Monique RM Jongbloed, J Wouter Jukema, Simon T MacDonald, Niki L Walker, Ali N Zaidi, Madelien V Regeer, Bart JA Mertens, Ralph ML Neijenhuis, Ari M Cedars

“…This study investigated the changes in ventricular function in sRV failure patients in the first year after starting SGLT2i.Methods Adult sRV patients from the international, real-world ACHIEVE-SGLT2i registry were included if they had a clinical diagnosis of sRV failure, a transthoracic echocardiogram before starting SGLT2i, and at least one in the first year after starting available for analysis. …”
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Phenome-wide diagnostic comparison among suicide deaths and living individuals with chronic pain diagnoses by Emily DiBlasi, Erin A. Kaufman, Sam Webster, Emily E. Hagn, Andrey A. Shabalin, Danli Chen, Seonggyun Han, Rana Jawish, Eric T. Monson, Michael J. Staley, Brooks R. Keeshin, Anna R. Docherty, Amanda V. Bakian, Akiko Okifuji, Hilary Coon

“…Models were also stratified by sex. Results Chronic pain diagnoses were nearly three times more prevalent in individuals who died by suicide compared with those who did not. …”
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Postprandial triglyceride-rich lipoproteins as predictors of carotid atherosclerosis in individuals with normal fasting lipid profiles: a prospective follow-up study by Yilin Hou, Yilin Hou, Peipei Tian, Peipei Tian, Guangyao Song, Guangyao Song, Guangyao Song, An Song, Dandan Liu, Dandan Liu, Zhimin Wang, Zhimin Wang, Yihe Shi, Yihe Shi, Yale Tang, Yale Tang, Xiaoyu Wang, Xiaoyu Wang, Luxuan Li, Luxuan Li, Luping Ren, Luping Ren, Luping Ren

“…This study explores the oral fat tolerance test (OFTT) for its predictive value in CAS, using postprandial TRL levels as a diagnostic biomarker.MethodsA total of 107 volunteers with normal fasting lipid profiles and no CAS at baseline were included. …”
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ISG15 as a Potent Immune Adjuvant in MVA-Based Vaccines Against Zika Virus and SARS-CoV-2 by Juan García-Arriaza, Michela Falqui, Patricia Pérez, Rocío Coloma, Beatriz Perdiguero, Enrique Álvarez, Laura Marcos-Villar, David Astorgano, Irene Campaña-Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Carmen Elena Gómez, Susana Guerra

“…Finally, we evaluated the magnitude and functional quality of the elicited antigen-specific cellular immune responses in vivo. <b>Results:</b> Analysis of early innate responses revealed both platform- and variant-specific effects. …”
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Evaluating Cardiac Impairment From Abnormal Respiratory Patterns: Insights From a Wireless Radar and Deep Learning Study by Chun-Chih Chiu, Wen-Te Liu, Jiunn-Horng Kang, Chun-Chao Chen, Yu-Hsuan Ho, Yu-Wen Huang, Zong-Lin Tsai, Rachel Chien, Ying-Ying Chen, Yen-Ling Chen, Nai-Wen Chang, Hung-Wen Lu, Kang-Yun Lee, Arnab Majumdar, Shu-Han Liao, Ju-Chi Liu, Cheng-Yu Tsai

“…Thus, this study analyzed respiratory patterns from a wireless radar framework to explore their associations with echocardiographic (2D-echo) measurements. Methods: Background details, 2D-echo parameters, and biochemical data were collected from patients in a cardiology ward in northern Taiwan. …”
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Universal Fab-Fc masked cytokine prodrug platform: αPD-L1/IL-15 prodrug activates CD44+ CD8+ T cells in tumor-draining lymph nodes to enhance antitumor immunity by Wei Li, Ying Qin, Zejian Wang, Luyao Song, Gen Qi, Wenqiang Shi, Qiongya Zeng, Zilan Song, Ao Zhang, Huili Lu

“…Antitumor efficacy of P-T was assessed in two murine cold tumor models. A comprehensive immune correlate analysis was conducted in the tumor and tumor-draining lymph node (TDLN) to identify key effector cells responsible for overcoming resistance, followed by further confirmation with egression of T cell blockade, surgical excision of TDLN, and adoptive transfer experiments. …”
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Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients by Ahmad A Tarhini, Zhihua Chen, Dongliang Du, Joshua Davis, Justin C Boucher, Katarzyna A Rejniak, Jose A Guevara-Patino, Timothy I Shaw, Alyssa Obermayer, Mate Z Nagy, Lourdes B Plaza-Rojas, Elena Kostenko, Anna L Austin, Awino Maureiq E Ojwang'

“…As T cell-based therapies often fail to work in solid tumors, this study aims to investigate the effects of hypoxia on T cell topo-distribution in the TME, gene expression association with T cell states, and clinical responses in melanoma.Methods To generate detailed information on tumor oxygenation and T cell accessibility, we used mathematical modeling of human melanoma tissue microarrays that incorporate oxygen supply from vessels, intratumoral diffusion, and cellular uptake. …”
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Long-term associations of PM1 versus PM2.5 and PM10 with asthma and asthma-related respiratory symptoms in the middle-aged and elderly population by Xue-yan Zheng, Shu-jun Guo, Jian-xiong Hu, Rui-lin Meng, Yan-jun Xu, Yun-hong Lv, Ye Wang, Ni Xiao, Chuan Li, Xiao-jun Xu, De-jian Zhao, Hong-ye Zhou, Jia-hui He, Xiao-min Tan, Jing Wei, Li-feng Lin, Wei-jie Guan

“…Using logistic regression models, we presented the associations as odds ratios and 95% confidence intervals, for each interquartile range (IQR) increase in PM1/PM2.5/PM10 concentration. …”
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Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas by Jin Xu, Andrew Knight, Jonathan Nguyen, Hong Wang, Walter J Storkus, Cindy Sander, John M Kirkwood, Jiqiang Yao, Xiaofei Song, Jane Messina, James J Mulé, Lilit Karapetyan, Carlos Moran-Segura, Aofei Li, Marion Joy, Sabrina Bruno, Hassan M Abushukair, Danielle Vargas De Stefano, Ayah N Al-Bzour, Caroline Layding

“…In this study, we examined characteristics and the prognostic utility of LA and TLS status in histological samples from patients with melanoma.Methods We assessed The Cancer Genomic Atlas-skin cutaneous melanoma digital slides and melanoma specimens from the University of Pittsburgh for the presence of LA and TLS using H&amp;E staining, multiplex immunofluorescence (mIF) and transcriptomic analyses. …”
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Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis by Xinwen Yan, Xinlong Lin, Jianhua Wu, Lijun Zheng, Yangyang Liu, Fang Wu, Ying Lin, Yishi Lu, Chongyang Huang, Binhai Shen, Hongbin Liu, Ruo Huang, Fengyi Hou, Qian Zhou, Mengyao Song, Ke Liu, Fangqing Zhu, Sheng Li, Yuqing Lin, Wei Wang, Ping Li, Wangjun Liao, Fachao Zhi

“…Mechanistic studies were conducted in murine models, complemented by IEC-6 cells and intestinal organoid experiments to elucidate microbiota-host interactions. …”
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Residential greenness, genetic susceptibility, and asthma risk: Mediating roles of air pollution in UK and Chinese populations by Mingkai Huang, Junjie Wen, Chenyang Lu, Xuliang Cai, Changxing Ou, Zhenan Deng, Xinyi Huang, Enli Zhang, Kian Fan Chung, Jie Yan, Nanshan Zhong, Qingling Zhang

“…Cox proportional hazard models and logistics regression models were used to assess the association between residential greenness and asthma incidence, and mediation analysis was conducted to explore potential mediators. …”
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Endovascular treatment for cerebral venous thrombosis: a multicenter study in China by He-Tao Bian, Xia Wang, Gui-You Liu, Chen Zhou, Ran Meng, Lan Liu, Jian-Gang Duan, Feng Yan, Chuan-Hui Li, Min Li, Wen Hui, Xu-Xiang Zhang, Dong Zhao, Ya-Peng Li, Qi Fang, De-Zhi Kang, Hong-Liang Zeng, Zhi-Jian Liang, Zheng-Hao Shi, Wei Yue, Qin-Jian Sun, Gui-Sheng Chen, Jian-Long Song, Zhong-Rui Yan, Qiu-Hong Ji, Kai-Jie Wang, Lu-Sha Tong, Xiao Hu, Wen-Feng Cao, Wei Yan, Rui-Jiang Gao, Qi Li, Jian-Yi Wang, Yi Liu, Bao-Jun Wang, Xiao-Hua Wang, Sheng-Tao Yao, Ye Lang, Hai-Peng Li, Craig S. Anderson, Xun-Ming Ji, on behalf of the RETAIN-CH Investigators and Coordinators

“…Abstract Background Endovascular treatment (EVT) is gaining popularity for the management of severe forms of cerebral venous thrombosis (CVT), but the evidence supporting its efficacy and safety is limited. Methods This multicenter study included patients with CVT admitted to 104 hospitals in 31 provinces/cities in China between January 2018 and June 2022. …”
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PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration by Wentao Jiang, Wentao Jiang, Wentao Jiang, Wentao Jiang, Shuhan Duan, Shuhan Duan, Shuhan Duan, Shuhan Duan, Weiping Li, Huijiao Yan, Huijiao Yan, Huijiao Yan, Huijiao Yan, Chenli Si, Chenli Si, Chenli Si, Ningwei Xu, Ningwei Xu, Ningwei Xu, Ningwei Xu, Yishuai Li, Yishuai Li, Yishuai Li, Yishuai Li, Wenjie Zhang, Wenjie Zhang, Wenjie Zhang, Wenjie Zhang, Shensheng Gu, Shensheng Gu, Shensheng Gu, Shensheng Gu

“…Through Single-cell RNA sequencing (scRNA-seq) analysis of human dental pulp, we discovered a PDGF (+) mesenchymal subset exhibiting enhanced angiogenic signatures, suggesting targeted cell selection could overcome this bottleneck.MethodsScRNA-seq identified PDGF (+) subpopulation in human pulp samples, validated through multiplex immunohistochemical of the localization of PDGF/CD73/CD31. …”
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Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells by Ye Yang, Ye Yang, Jieyun Zhou, Qiaoying Lv, Qicheng Ni, Qicheng Ni, Baichun Hu, Yulong Wang, Shuning Qu, Guoting Li, Wenjie Yang, Ruihua Zhong, Xiaojun Chen, Yan Zhu

“…In vivo, nude mouse xenograft models were used to evaluate the efficacy of CANA and MPA. …”
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hBMSC-EVs alleviate weightlessness-induced skeletal muscle atrophy by suppressing oxidative stress and inflammation by Mengyuan Chang, Ruiqi Liu, Bingqian Chen, Jin Xu, Wei Wang, Yanan Ji, Zihui Gao, Boya Liu, Xinlei Yao, Hualin Sun, Feng Xu, Yuntian Shen

“…Extracellular vesicles derived from bone marrow mesenchymal stem cells (BMSC-EVs) possess anti-inflammatory and antioxidant properties, offering a potential strategy for combating weightless muscular atrophy. Methods In this study, human BMSCs-EVs (hBMSC-EVs) were isolated using super-centrifugation and characterized. …”
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Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SI... by Charles Hillman, Talha Syed, Dominika M Pindus, Tomasz S Ligeza, Jin Kuang, Scott Paluska, Joseph So, Miroslaw Wyczesany, Jesus Sarol, Flor B Quiroz, Ramiya Shanmugam, Maciej Kos, Naiman Khan, Art Kramer

“…The study will address three aims: (1) to assess feasibility, acceptability, fidelity and safety of HIIT breaks to improve neurocognitive function in middle-aged and older adults; (2) to quantify the differences between conditions in the change in the amplitude and latency of the P3b component of event-related potentials (a marker for frontoparietal function) and (3) to explore the differences between conditions in attentional control, episodic memory and FC of the FPN and DMN in middle-aged and older adults.Methods and analysis 54 healthy adults, aged 40–75 years, will be recruited from the local community and randomly assigned to a condition sequence (HIIT, LIIT vs LIIT and HIIT). …”
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Associations of reallocating sedentary leisure-time to alternative discretionary movement behaviours with incident cardiometabolic diseases in 0.5 million Chinese adultsResearch in... by Paul J. Collings, Mengyao Wang, Harrison Hin Sheung Ho, Shiu Lun Au Yeung, Parco M. Siu, Benjamin J. Cowling, Stephen J. Sharp, Søren Brage, Nicholas J. Wareham, Huaidong Du, Derrick A. Bennett, Youngwon Kim

“…This study aimed to estimate the implications of reallocating sedentary leisure-time to non-sedentary behaviours for incident cardiometabolic diseases. Methods: A prospective cohort study of 462,370 Chinese adults (mean age 51 years; 59% female) who were free from diabetes and cardiovascular diseases at baseline. …”
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Tumor mutational burden and survival on immune checkpoint inhibition in >8000 patients across 24 cancer types by Vivek Subbiah, Samuel J Klempner, Neeraj Agarwal, David P Carbone, Amit Mahipal, Shilpa Gupta, David Fabrizio, Jeffrey S Ross, Gerald Li, David R Gandara, Miles C Andrews, Jonathan W Riess, Ramez N Eskander, Ryon P Graf, Geoffrey R Oxnard, Sarah Sammons, Jeremy Snider, Lilia Bouzit, Cheryl Cho-Phan, Megan Price, Julia C F Quintanilha, Richard Sheng Poe Huang

“…Following a prespecified analysis plan, rwOS by TMB level was assessed using Cox PH models adjusted for Eastern Cooperative Oncology Group performance status, prior treatment, microsatellite instability, sex, age, opioid rx pretherapy, and socioeconomic assessment.Results 8440 patients met inclusion criteria. …”
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