Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkins... by Dang Wei, Anna Freydenzon, Octave Guinebretiere, Karim Zaidi, Fen Yang, Weimin Ye, Niklas Hammar, Karin Modig, Naomi R. Wray, Maria Feychting, Nadine Hamieh, Bruno Ventelou, Beranger Lekens, Laurene Gantzer, Stanley Durrleman, Allan McRae, Baptiste Couvy-Duchesne, Fang Fang, Thomas Nedelec, Stanley Durrleman, Bruno Ventelou, Thomas Nedelec, Octave Guinebretiere, Karim Zaidi, Fang Fang, Dang Wei, Fen Yang, Allan McRae, Naomi Wray, Baptiste Couvy-Duchesne, Anna Freydenzon, Lydie Tran, Evans Cheruiyot

“…Conditional logistic regression models and meta-analysis were applied to assess the associations between these factors and the risk of receiving a diagnosis of AD, PD, or ALS. …”
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Relevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study by Yinan Hu, Yanhong Ren, Yinzhen Han, Zhen Li, Weiqing Meng, Yuhui Qiang, Mengyuan Liu, Huaping Dai

“…SOD1 had the highest importance score in ML-based LP predictive models. Additionally, advanced age may be associated with higher mortality in LP. …”
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Exposure to a mixture of arsenic species and growth indicators in 6–12-year-old children from the cycles 2007–2020 NHANES by Miguel García-Villarino, Rocío Fernández-Iglesias, Ana Victoria García, Elsa Villa-Fernández, Lucía Fernández-Arce, Isolina Riaño-Galán, Carmen Lambert, Vicente Martín, Margaret R. Karagas, Elías Delgado-Álvarez, Ana Fernández-Somoano, Antonio J. Signes-Pastor

“…Linear regression and BKMR models were applied to identify adverse effects, nonlinear associations, interactions, and combined effects. …”
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Association of surrogate adiposity markers with prevalence, all-cause mortality and long-term survival of heart failure: a retrospective study from NHANES database by Fan-Shun Guo, Fan-Shun Guo, Chen Guo, Chen Guo, Jia-Hao Dou, Jia-Hao Dou, Jun-Xiang Wang, Rui-Yun Wu, Rui-Yun Wu, Shou-Fang Song, Shou-Fang Song, Xue-Lu Sun, Xue-Lu Sun, Yi-Wei Hu, Yi-Wei Hu, Jin Wei, Jin Wei

“…Cox proportional hazards models and restricted cubic spline (RCS) analysis were employed to assess the association between surrogate adiposity markers and all-cause mortality in HF patients. …”
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Effects of Carnosine Supplementation on Cognitive Outcomes in Prediabetes and Well-Controlled Type 2 Diabetes: A Randomised Placebo-Controlled Clinical Trial by Rohit Hariharan, Aya Mousa, Kirthi Menon, Jack Feehan, Barbara Ukropcová, Jozef Ukropec, Martin Schön, Arshad Majid, Giancarlo Aldini, Maximilian de Courten, James Cameron, Simon M. Bell, Barbora de Courten

“…The aim of this study is to assess the effects of carnosine on cognitive function in individuals with prediabetes or well-controlled T2DM. <b>Methods:</b> This is a secondary analysis of a double-blind randomised controlled trial (RCT), whereby 49 adults with prediabetes or early-stage well-controlled T2DM were randomised to receive 2 g of carnosine or identical placebo daily for 14 weeks. …”
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Global Burden of Oral Diseases in Adolescents and Young Adults Aged 10–24 Years by Wei Lu, Bing Wang, Mi Du, Shaohua Ge

“…Objectives: This study aims to analyse global trends in the burden of oral diseases, including dental caries and noncarious oral diseases (NCODs), in individuals aged 10 to 24 from 1990 to 2021 and project future trends up to 2050. Methods: Using data from the Global Burden of Disease Study (GBD) 2021, this trend analysis examines the number, age-standardised rates (ASRs), and average annual percentage changes (AAPCs) in prevalence, incidence, and disability-adjusted life years for oral diseases across different age groups, sexes, social-development index (SDI) levels, regions, and nations. …”
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C1Q+ TPP1+ macrophages promote colon cancer progression through SETD8-driven p53 methylation by Veronica Veschi, Francesco Verona, Sebastiano Di Bella, Alice Turdo, Miriam Gaggianesi, Simone Di Franco, Laura Rosa Mangiapane, Chiara Modica, Melania Lo Iacono, Paola Bianca, Ornella Roberta Brancato, Caterina D’Accardo, Gaetana Porcelli, Vincenzo Luca Lentini, Isabella Sperduti, Elisabetta Sciacca, Peter Fitzgerald, David Lopez-Perez, Pierre Martine, Kate Brown, Giuseppe Giannini, Ettore Appella, Giorgio Stassi, Matilde Todaro

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Meta-analyses of IL1A polymorphisms and the risk of several autoimmune diseases published in databases. by Hang Su, Na Rei, Lei Zhang, Jiaxiang Cheng

“…<h4>Background</h4>Based on published data, we aimed to quantitatively elucidate the possible genetic influence of rs17561 G/T and rs1800587 C/T polymorphisms of the IL1A (interleukin 1 alpha) gene in the susceptibility to several autoimmune diseases.<h4>Methods</h4>A series of meta-analyses were carried out. …”
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Frequency of Tumor Necrosis Factor-α, Interleukin-6, and Interleukin-10 Gene Polymorphisms in Mexican Patients with Diabetic Retinopathy and Diabetic Kidney Disease by Patricia Elvira Sánchez-Valencia, Juan Daniel Díaz-García, Margarita Leyva-Leyva, Fabiola Sánchez-Aguillón, Nelly Raquel González-Arenas, Jesús Guillermo Mendoza-García, Erika Karina Tenorio-Aguirre, Mercedes Piedad de León-Bautista, Aurora Ibarra-Arce, Pablo Maravilla, Angélica Olivo-Díaz

“…The aim of the present study was to determine the frequency of polymorphisms of Tumor Necrosis Factor-α, interleukin-6, and interleukin-10 (<i>TNF-α</i>, <i>IL-10,</i> and <i>IL-6</i>), as well as to describe the clinical and laboratory characteristics of T2D association with these microvascular complications. Methods: This study included 203 patients with T2D, of which 102 had microvascular complications: 95 with DR, 50 with DKD, and 15 with diabetic neuropathy (the latter were not included in the statistical analysis); those with T2D without confirmed microvascular complications were considered as controls. …”
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Clinical Features and Outcomes of Neuropsychiatric Systemic Lupus Erythematosus in China by Shangzhu Zhang, Meng Li, Li Zhang, Ziqian Wang, Qiang Wang, Hui You, Yanhong Wang, Mengtao Li, Xiaofeng Zeng

“…Survival rates were evaluated using the Kaplan-Meier curves, log-rank test, and Cox proportional hazards modeling. Cranial MRI results were also studied. Results. …”
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Prevalence of major adverse cardiovascular events among Saudi patients with systemic lupus erythematosus compared with the general population: updates from the national SLE and PUR... by Jiandong Su, Khalid F Alhabib, Ibrahim Almaghlouth, Najma Khalil, Kawther Ghassan Bohuliga, Boshra Alanazi, Bushra Khaled Alhawsa, Abdulaziz Mohammed Alabdulkareem, Wael Alqarawi, Kazi Nur Asfina, Hebatallah Hamed Ali, Mohammed Bedaiwi, Aos Aboabat, Tariq Asef Alam, Fehaid Ghali Alanazi, Mohammed A Omair, Abdurhman S Alarfaj, Haya M Almalag, Mostafa Al Shamiri

“…MACE was defined as myocardial infarction (MI), stroke or angina. The analysis was adjusted for demographics, traditional cardiovascular risk factors and SLE diagnosis through logistic regression models.Results The PURE and national SLE cohorts comprised 488 and 746 patients, respectively. …”
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Ashwagandha (Withania somnifera (L.) Dunal) for promoting recovery in long covid: protocol for a randomised placebo-controlled clinical trial (APRIL Trial) by Kamlesh Khunti, Shailen Sutaria, Poppy Alice Carson Mallinson, Sanjay Kinra, Rohini Mathur, Anoop SV Shah, Tim Clayton, Judith Lieber, Alexander Perkins, Shereen Allaham, Nick Birk, Lily Hopkins, Manisha Joshi, Mahesh Mathpathi, Arandeep Dhillon, Sidra S Beg, Archie Khan, Vanessa TW Kam, Galib R, S Rajagopala, Amarjeet Bhamra, Geetha Krishnan G Pillai, Tanuja Nesari

“…Withanolides, a family of steroid-derived molecules unique to Ashwagandha, have been shown to modulate inflammatory pathways in animal models, and several small randomised trials in humans support its effectiveness for reducing symptoms that are also associated with long covid. …”
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Characterizing spatial immune architecture in metastatic melanoma using high-dimensional multiplex imaging by Joel Eliason, Santhoshi Krishnan, Yasunari Fukuda, Matias A. Bustos, Dan Winkowski, Sungnam Cho, Akshay Basi, Akshay Basi, Regan Baird, Elizabeth A. Grimm, Michael A. Davies, Dave S. B. Hoon, Arvind Rao, Arvind Rao, Arvind Rao, Arvind Rao, Jared K. Burks, Jared K. Burks, Suhendan Ekmekcioglu

“…Understanding how the spatial architecture of immune and inflammatory components changes across disease stages may reveal novel prognostic biomarkers and therapeutic targets.MethodsWe performed high-dimensional spatial profiling of two melanoma tissue microarrays (TMAs), representing Stage III (n = 157) and Stage IV (n = 248) metastatic tumors. …”
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Environmental phenol mixture during pregnancy and child sleep quality in the ECHO cohort by Sarah D. Geiger, Sarah D. Geiger, Xiaoshuang Xun, Cai Zhang, Cai Zhang, Aruna Chandran, Kritika Madan, Grace Kim, Fatima Naveed, Megan Woodbury, Dana E. Goin, Stephanie M. Eick, Courtney K. Blackwell, Maxwell Mansolf, Max Aung, Akram Alshawabkeh, Dana Dabelea, Anne L. Dunlop, Assiamira Ferrara, Jonika B. Hash, Monique Hedderson, Erica Jansen, Monique LeBourgeois, Louise O’Brien, Yeyi Zhu, Susan L. Schantz, Susan L. Schantz

“…The present analysis was conducted in 2023–2024. Using single-pollutant and mixture models, we examined associations between prenatal phenol concentrations and three key child sleep quality outcomes: sleep problems, disturbance, and impairment. …”
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Exposure to volatile organic compounds and chronic respiratory disease mortality, a case-cohort study by Mahdi Nalini, Hossein Poustchi, Deepak Bhandari, Benjamin C. Blount, Brandon M. Kenwood, Cindy M. Chang, Amy Gross, Christopher Ellison, Masoud Khoshnia, Akram Pourshams, Mitchell H. Gail, Barry I. Graubard, Sanford M Dawsey, Farin Kamangar, Paolo Boffetta, Paul Brennan, Christian C. Abnet, Reza Malekzadeh, Neal D. Freedman, Arash Etemadi

“…Data of the associations between specific volatile organic compounds (VOCs), a major component of air pollution and tobacco smoke, and subsequent CRD mortality in the general population are scarce. Methods In a case-cohort analysis within the population-based Golestan cohort study (n = 50045, aged 40–75 years, 58% women, enrollment: 2004–2008, northeastern Iran), we included all participants who died from CRD during follow-up through 2018 (n = 242) as cases and stratified them into 16 strata defined by age, sex, residence, and tobacco smoking. …”
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A Novel Formulation Based on Resveratrol and Water Extracts from <i>Equisetum arvense</i>, <i>Crataegus curvisepala</i>, <i>Vitex agnus-castus</i>, and <i>Glycine max</i> Inhibits... by Simonetta Cristina Di Simone, Alessandra Acquaviva, Maria Loreta Libero, Nilofar Nilofar, Fatma Tunali, Mariachiara Gabriele, Angelica Pia Centulio, Gianluca Genovesi, Davide Ciaramellano, Lucia Recinella, Sheila Leone, Luigi Brunetti, Gokhan Zengin, Giustino Orlando, Luigi Menghini, Annalisa Chiavaroli, Claudio Ferrante

“…According to the ecotoxicological models’ results, the formulation was revealed to be non-toxic, with a LC₅₀ value > 1 mg/mL. …”
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Tumor-derived lactate inhibit the efficacy of lenvatinib through regulating PD-L1 expression on neutrophil in hepatocellular carcinoma by Ming Zhao, Qifeng Chen, Wenhua Lu, Ning Lyu, Zhenfeng Zhang, Qiankun Xie, Haijing Deng, Anna Kan, Meng He, Shuang Qiao, Shaolong Li, Huiming Chen, Jinfa Lai, Xiongying Jiang, Shousheng Liu

“…In this study, we elucidate the stimulators of PD-L1+ neutrophils in tumor microenvironment (TME) and explore the optimal combination to enhance the effect of lenvatinib by inhibiting PD-L1+ neutrophils in hepatocellular carcinoma.Methods Neutrophil infiltration after lenvatinib treatment was examined with RNA sequencing and multicolor flow cytometry analysis in patient samples, subcutaneous and orthotopic mouse models. …”
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Risk and protective factors for coronavirus disease 2019 (COVID-19) in allergic rhinitis patients: a national survey in China by Xiaozhe Yang, Xiaozhe Yang, Xiaozhe Yang, Yutong Sima, Yutong Sima, Yutong Sima, Jinming Zhao, Jinming Zhao, Jinming Zhao, Jing Zhang, Jing Zhang, Jing Zhang, Xiangdong Wang, Xiangdong Wang, Xiangdong Wang, Luo Zhang, Luo Zhang, Luo Zhang, Luo Zhang

“…Binary logistic regression and analysis of covariance (different adjusted models) were conducted.ResultsIn all, 830 AR patients were included; 627 patients (75.54%) were infected with SARS-CoV-2. …”
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Impact of multidimensional assessment on anti-fracture treatment decisions in patients with fragility hip fractures within a Fracture Liaison Service by Chiara Ceolin, Stefania Sella, Cristina Simonato, Ester Bukli, Giulia Bano, Valentina Camozzi, Anna Bertocco, Marco Onofrio Torres, Alberta Cecchinato, Martin Diogo, Mor Peleg Falb, Francesca Guidolin, Maria Grazia Rodà, Michele Cannito, Antonio Berizzi, Andrea Venturin, Vito Cianci, Elisa Pala, Mariachiara Cerchiaro, Deris Gianni Boemo, Maria Vittoria Nesoti, Gaetano Paride Arcidiacono, Paolo Simioni, Pietro Ruggieri, Giuseppe Sergi, Sandro Giannini, Marina De Rui, on behalf of the Hip-POS working group

“…This study aimed to identify the primary factors influencing anti-fracture therapy decisions in older patients with fragility fractures, using a multidimensional geriatric assessment approach integrated into our FLS program. Methods A retrospective analysis was conducted on patients aged 65 and above with hip fractures admitted to Azienda Ospedale-Università Padova. …”
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Early-life tobacco smoke elevating later-life osteoporosis risk: Mediated by telomere length and interplayed with genetic predisposition by Dongsheng Di, Haolong Zhou, Zhangbo Cui, Jianli Zhang, Qian Liu, Tingting Yuan, Tingting Zhou, Xiao Luo, Danyang Ling, Qi Wang

“…Linear, Cox, and Laplace regression models were mainly used for data analysis. Results: Individuals with IUTSE showed a higher OP risk [hazard ratio (HR): 1.06, 95 % confidence interval (CI): 1.01, 1.11] and experienced earlier OP onset by 0.30 years [50th percentile difference = -0.30, 95 % CI: −0.51, −0.09] compared to those without. …”
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