Association of Circulating Phenylacetylglutamine With Multi‐Vessel Coronary Disease Severity and Outcomes in ST‐Segment–Elevation Myocardial Infarction by Peng Zhao, Nana Dong, Yan Wang, Suhong Zhao, Yanan Tian, Zhifeng Qin, Xiaofang Ban, Feiyuan Han, Li Meng, Fan Yang, Yidan Wang, Yunfei Wu, Zhongzhi Yu, Qinglu Xu, Xinyue Li, Shuo Li, Huibin Liu, Shaohong Fang, Wanqing Xie, Bo Yu, Xinxin Liu, Jinwei Tian

“…Quantitative coronary angiography analysis was performed using the QAngio XA 7.3 system. …”
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Frailty, Pitavastatin, and Major Adverse Cardiovascular Events Among People With HIV by Kristine M. Erlandson, MD, MS, Ariela R. Orkaby, MD, Triin Umbleja, MSc, Heather J. Ribaudo, PhD, Todd T. Brown, MD, PhD, Markella V. Zanni, MD, Marissa R. Diggs, AB, Sarah M. Chu, MSN, Kathleen V. Fitch, MSN, Carl J. Fichtenbaum, MD, Carlos Malvestutto, MD, MPH, Judith A. Aberg, MD, Gerald S. Bloomfield, MD, MPH, Judith S. Currier, MD, Karen T. Tashima, MD, Marcus Vinícius Guimarães de Lacerda, MD, PhD, Sonya L. Heath, MD, Michael T. Lu, MD, MPH, Alan Landay, PhD, George A. Kuchel, MD, Pamela S. Douglas, MD, Steven K. Grinspoon, MD

“…Objectives: The purpose of this study was to evaluate whether frailty is associated with MACE and whether pitavastatin prevents MACE regardless of frailty. Methods: We conducted a post hoc analysis of the REPRIEVE trial, a randomized, blinded trial of pitavastatin 4 mg vs placebo. …”
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Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape by Andrea Rodríguez-Agustín, Andrea Rodríguez-Agustín, Rubén Ayala-Suárez, Francisco Díez-Fuertes, Francisco Díez-Fuertes, María José Maleno, Izar de Villasante, Angelika Merkel, Mayte Coiras, Mayte Coiras, Víctor Casanova, Víctor Casanova, José Alcamí, José Alcamí, José Alcamí, José Alcamí, Núria Climent, Núria Climent, Núria Climent

“…We analysed whether Tat influences DNA methylation and subsequently impacts the transcriptional signature, contributing to inflammation and accelerated ageing.MethodsWe transfected Jurkat cells with full-length Tat (Tat101), Tat’s first exon (Tat72), or an empty vector (TetOFF). …”
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Gene-expression signature predicts autoimmune toxicity in metastatic melanoma by Michael Bailey, Andrew White, Francesca Sparano, Alessandra Cesano, Mariaelena Capone, Corrado Caracò, Ester Simeone, Lucia Festino, Alfredo Budillon, Sarah Warren, Domenico Mallardo, Paolo A Ascierto, Vito Vanella, Ernesta Cavalcanti, Claudia Trojaniello, Maria Grazia Vitale, Margaret Ottaviano, Paolo Chiodini, Mario Fordellone, Bianca Arianna Facchini, Maria Ingenito, Caterina Costa, Rosaria De Filippi

“…Gene-expression signatures were identified and validated using cross-validated sparse partial least squares modeling and principal component analysis, then correlated with toxicity occurrence.Results A total of 223 and 186 irAEs were observed in the AT and FLT groups, respectively, including arthralgia, colitis, and headache. …”
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The role of environmental access to exercise opportunities in cardiovascular mortality: evidence from a nationwide study by Xiaowen Wang, Yongshi Gu, Ying Wang, Yuqing Qiu, Tianling Chen, Philip K. Hopke, Kai Zhang, Shao Lin, Yanji Qu, Ziqiang Lin, Xinlei Deng, Jie Sun, Shuming Zhu, Xueqing Deng, Sizhe Li, Xian Lin, Zhicheng Du, Yuantao Hao, Wangjian Zhang

“…We explored the associations between county-level access to exercise opportunities and cardiovascular disease (CVD) mortality across US counties. Methods We conducted an ecological analysis using aggregated data from two primary sources: the County Health Rankings and Roadmaps data and CDC WONDER mortality data. …”
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Association Between Long Term Exposure to PM_2.5 and Its Components on Severe Obesity in Chinese Children and Adolescents: A National Study in China by Tongjun Guo, Tianjiao Chen, Li Chen, Jieyu Liu, Xinli Song, Yi Zhang, Ruolin Wang, Jianuo Jiang, Yang Qin, Ziqi Dong, Dengcheng Zhang, Zhiying Song, Wen Yuan, Yanhui Dong, Yi Song, Jun Ma

“…Background: The aim of this study was to explore the association between long-term exposure to particulate matter with an aerodynamic diameter <2.5 μm (PM_2.5) and its components and severe obesity in children and adolescents. Methods: Data for children and adolescents aged 9–18 in this cross-sectional study were obtained from the 2019 Chinese National Survey on Students’ Constitution and Health (CNSSCH). …”
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Positive rate and influencing factors of adolescent idiopathic scoliosis among school children aged 9 to 18 years in Xiamen, China by Zhongrui Peng, Yuanchao Li, Hong Yang, Yanfang Jiang, Yuqing Li, Mengyang Gao, Yangjingling Hua, Guimei Liu, Manqi Zhou, Tianmu Chen, Huarong Hong, Lei Li

“…Multivariable logistic regression models demonstrated age and sex (AOR: 5.00, 95% CI: 4.33–5.76) were associated with AIS. …”
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Health risk perception and behavioral decision-making among online-dating MSM in Shandong, China: perspectives on HIV and new psychoactive substances by Yuyao Chen, Haiying Yu, Xiaoyan Zhu, Ling Li, Lin Wang, Yangji Zhuoma, Na Zhang, Guoyong Wang, Wei Ma, Meizhen Liao

“…This study aims to explore the perceptions of MSM regarding the risks and harms associated with HIV and NPS in the context of online dating. Methods From April to July 2023, MSM were recruited from eight cities in Shandong Province using a combination of snowball sampling, venue-based recruitment, and online methods. …”
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Protocol of the TransformUs Secondary schools program: a type II hybrid implementation-effectiveness trial to increase adolescents’ physical activity and reduce sedentary time in s... by Harriet Koorts, Anna Timperio, Jo Salmon, David Revalds Lubans, Gavin Abbott, Nicola D Ridgers, Natalie Lander, Ana María Contardo Ayala, Emiliano Mazzoli

“…The aim of this paper is to describe the protocol for TransformUs Secondary in relation to implementation and scale-up across Australia, and the real-world effectiveness of the intervention on adolescents’ physical activity and sedentary time, as well as sitting time, sleep, well-being and class and school engagement.Methods and analysis A type II hybrid implementation-effectiveness trial will be conducted using a mixed-methods design. …”
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Dynamic gas supply mechanism and theoretical production modes of free gas-rich deep coal reservoirs by Shida CHEN, Taiyuan ZHANG, Dazhen TANG, Hao XU, Shu TAO, Song LI, Shuling TANG

“…By integrating the building of mathematical and numerical models, carbon isotope monitoring of methane, and the analysis of production curves, this study revealed the spatiotemporal evolutionary processes of production-induced pressure drop expansion, adsorbed gas desorption, and free gas seepage, as well as their production effects. …”
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Social determinants of recovery from ongoing symptoms following COVID-19 in two UK longitudinal studies: a prospective cohort study by Tim Spector, Adrian Hopper, Sebastien Ourselin, Emma L Duncan, Julia Brown, Carole H Sudre, Jie Deng, Christina Hu, Ruth C E Bowyer, Ellen J Thompson, Jonathan Wolf, Claire J Steves, Marc Modat, Benjamin Murray, Andy Guise, Nicholas Harvey, Deborah Hart, Alexander Hammers, Carole Sudre, Michela Antonelli, Liane S Canas, Erika Molteni, Eric Kerfoot, Claire Steves, Vicky Bowyer, Emma Duncan, Nathan Cheetham, Ayrun Nessa, Samuel Wadge, Nathan J Cheetham, María Paz García, J D Carpentieri, Rose S Penfold, Nicholas R Harvey, Khaled Rjoob, Liane Canas, Joan Capdevila Pujol, Lynn Cherkas, Katie Doores, Michael Malim

“…Causal effects of sociodemographic variables reflecting status prior to the COVID-19 pandemic on recovery were estimated with multivariable Poisson regression models, weighted for inverse probability of questionnaire participation and COVID-19 infection and adjusted for potential confounders. …”
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Lipoprotein(a) as an early marker of cardiovascular events in high-risk subjects: insights from the Moli-sani cohort study by Francesco Gianfagna, Simone Poli, Simona Costanzo, Simona Costanzo, Augusto Di Castelnuovo, Teresa Panzera, Amalia De Curtis, Sara Magnacca, Mariarosaria Persichillo, Lorenzo De Santi, Claudia Cristofani, Daniele Loffredo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Licia Iacoviello, the Moli-sani Study Investigators, Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati, Chiara Cerletti, Marialaura Bonaccio, Americo Bonanni, Simona Costanzo, Amalia De Curtis, Augusto Di Castelnuovo, Alessandro Gialluisi, Francesco Gianfagna, Mariarosaria Persichillo, Jos Vermylen, Renzo Pegoraro, Antonio G. Spagnolo, Deodato Assanelli, Livia Rago, Simona Costanzo, Sabatino Orlandi, Teresa Panzera, Augusto Di Castelnuovo, Marialaura Bonaccio, Francesca Bracone, Simona Costanzo, Giuseppe Di Costanzo, Simona Esposito, Alessandro Gialluisi, Anwal Ghulam, Francesco Gianfagna, Martina Morelli, Maria Loreto Muñoz Venegas, Antonietta Pepe, Emilia Ruggiero, Amalia De Curtis, Concetta Civitillo, Alisia Cretella, Sara Magnacca, Mariarosaria Persichillo, Francesca Bracone, Giuseppe Di Costanzo, Martina Morelli, Americo Bonanni

“…We analyzed the association between Lp(a) and the risk of a major cardiovascular event in subjects with previous CVD.MethodsThe analysis was conducted on the Moli-sani study population (24,325 individuals aged ≥35 years, recruitment from 2005 to 2010), focusing on subjects with prior CVD. …”
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Clinicopathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer over two decades: A population-based study. by Sandeep Samuel, Sarbajit Mukherjee, Nischala Ammannagari, Venkata K Pokuri, Boris Kuvshinoff, Adrienne Groman, Charles M LeVea, Renuka Iyer

“…<h4>Background</h4>There is limited literature about the clinicopathological characteristics and outcomes of rare histologic variants of gallbladder cancer (GBC).<h4>Methods</h4>Using SEER database, surgically managed GBC patients with microscopically confirmed adenocarcinoma, adenosquamous/squamous cell carcinoma and papillary carcinoma were identified from 1988 to 2009. …”
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The Interactive Effects of Fruit Intake Frequency and Serum miR-484 Levels as Biomarkers for Incident Type 2 Diabetes in a Prospective Cohort of the Spanish Adult Population: The D... by Ana Lago-Sampedro, Wasima Oualla-Bachiri, Cristina Maldonado-Araque, Sergio Valdés, Inmaculada González-Molero, Viyey Doulatram-Gamgaram, Elias Delgado, Felipe J. Chaves, Luis Castaño, Alfonso Calle-Pascual, Josep Franch-Nadal, Gemma Rojo-Martínez, Sara García-Serrano, Eva García-Escobar

“…Association analyses were performed using logistic regression models adjusted for potential confounders. Interaction effects were evaluated on the multiplicative and additive scales. …”
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The relationship between exercise and the occurrence of abdominal wall complications in patients on peritoneal dialysis by Xinqiu Li, Tiantian Ma, Jiayu Hao, Di Song, Hongyan Wang, Tianjiao Liu, Xiao Xu, Jie Dong

“…This study aims to investigate the association between exercise and abdominal wall complications in the PD population. Methods A retrospective data analysis of a prospective cohort. …”
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Peak systolic blood pressure during preparticipation exercise testing in 12,083 athletes: age, sex, and workload-indexed values and predictors by Petra Pesova, Petra Pesova, Bogna Jiravska Godula, Bogna Jiravska Godula, Otakar Jiravsky, Otakar Jiravsky, Libor Jelinek, Marketa Sovova, Katarina Moravcova, Jaromir Ozana, Ivan Ranic, Ivan Ranic, Radek Neuwirth, Radek Neuwirth, Radek Neuwirth, Roman Miklik, Matej Pekar, Matej Pekar, Libor Sknouril, Libor Sknouril, Vladimir Tuka, Eliska Sovova

“…In future studies, these findings may inform the development of personalised training strategies and risk stratification models in athletic populations.…”
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Effect of levothyroxine on major adverse cardiovascular events in patients with hypothyroidism and cardiovascular disease by Lijia Liu, Lijia Liu, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang, Xiaowei Chen, Xiaowei Chen, Zuoxiang Liu, Zuoxiang Liu, Houyu Zhao, Shizhan Ma, Shizhan Ma, Shizhan Ma, Meng Zhao, Meng Zhao, Meng Zhao, Peng Shen, Yexiang Sun, Hongbo Lin, Siyan Zhan, Siyan Zhan, Siyan Zhan, Jiajun Zhao, Jiajun Zhao, Jiajun Zhao, Feng Sun, Feng Sun

“…ObjectiveThis study aimed to evaluate the effectiveness of levothyroxine, compared to non-levothyroxine treatment, in preventing adverse cardiovascular events and mortality in patients with hypothyroidism and cardiovascular disease (CVD).MethodsThis is a retrospective study utilizing medical record data from the Yinzhou Regional Health Care Database. …”
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British Columbia CARMA-CHIWOS Collaboration (BCC3): protocol for a community-collaborative cohort study examining healthy ageing with and for women living with HIV by Joel Singer, Melanie Lee, Angela Kaida, Neora Pick, Valerie Nicholson, Rebecca Gormley, Shayda A Swann, Jason Brophy, Amber R Campbell, Allison Carter, Chelsea Elwood, Tsion Gebremedhen, Elizabeth M King, Vonnie Lee, Evelyn J Maan, Patience Magagula, Sheila Nyman, Davi Pang, Tetiana Povshedna, Jerilynn C Prior, Shelly Tognazzini, Melanie C M Murray, Helene C F Cote

“…This interdisciplinary cohort study aims to understand how biological, clinical and sociostructural determinants of health interact to modulate healthy ageing in WLWH.Methods and analysis The British Columbia Children and Women: AntiRetroviral therapy and Markers of Aging-Canadian HIV Women’s Sexual and Reproductive Health Cohort Study (CARMA-CHIWOS) Collaboration (BCC3) study will enrol WLWH (n=350) and sociodemographically matched HIV-negative women (n=350) living in British Columbia. …”
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Multimorbidity patterns and premature mortality in a prospective cohort: effect modifications by socioeconomic status and healthy lifestyles by Qingping Xue, Shanshan Zhang, Xue Yang, Yan-Bo Zhang, Yidan Dong, Fan Li, Shuo Li, Nianwei Wu, Tong Yan, Ying Wen, Chun-Xia Yang, Jason HY Wu, An Pan, Yunhaonan Yang, Xiong-Fei Pan

“…The latent class analysis was used to establish multimorbidity patterns based on 11 chronic conditions. …”
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Changes in the estimated glucose disposal rate and incident cardiovascular disease: two large prospective cohorts in Europe and Asia by Xiaowei Zheng, Wenyang Han, Yiqun Li, Minglan Jiang, Xiao Ren, Pinni Yang, Yiming Jia, Lulu Sun, Ruirui Wang, Mengyao Shi, Zhengbao Zhu, Yonghong Zhang

“…Cox proportional hazard models were used to calculate the hazard ratio (HR) and 95% confidence interval (95% CI) after adjusting for potential confounders. …”
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