ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity by Yiming Liu, Xingyu Jiang, Dongquan Jing, Yanting Lin, Rui Gao, Qixiang Zhao, Huijuan Da, Yiming Ren, Qiuhua Cao, Ning Liu, Xiaoyun Han, Juan Du, Xinghua Gao

“…Effects of ACSL4 were evaluated in CRC cells in vitro and in subcutaneous and orthotopic CRC models. Flow cytometry and immunofluorescence were used to evaluate immune cell infiltration. …”
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Association between Clinical Frailty Scale and mortality 24 months after hospitalisation in adult patients with COVID-19 by Julia Minnema, Melvin Lafeber, Roos S.G. Sablerolles, Janneke A.L. van Kempen, Lisanne Tap, Harmke A. Polinder-Bos, Bob P.A. van de Loo, Hugo van der Kuy, Miriam C. Faes, Jacomien Aleman, Jos Tournoy, Lorenz Van der Linden, Marco Gambera, Isabella Martignoni, Ronald Van Etten, Hein van Onzenoort, Mariette Kappers, Peter van Wijngaarden, Jose Verstijnen, Vera Theeuwes, Marleen Kemper, Elise Slob, Ferdi Sombogaard, Heshu Abdullah-Koolmees, Roland van den Berg, Hugo de Wit, Betul Dilek, Freija Hogenhuis, Vahid Buyukayten, Britt te Brake, Margriet Nieuwenhuijzen, Maria Scheeren, Madelief de Wit, Arjan Bulsink, Ingrid van Haelst, Peter ter Horst, Rosalie Moorlag, Anja Vos, Annemiek Otten-Helmers, Erik van Kan, Marije Voskamp, Marieke Ebbens, Marieke Ezinga, Cees van Nieuwkoop, Loes Visser, Caroline Ghazarian, Doranne Hilarius, Gonneke Hermanides, Carlinda Bresser, Judith Derijks-Engwegen, Ebbie Boemaars, Zahira Getrouw, Barbara Maat, Peter Wierenga, Tessa Bosch, Lisanne Krens, Kajie Liang, Langeza Saleh, Milou van Heuckelum, Linda Hendriksen, Paul van der Linden, Kaylen Guda, Kristel Crommentuijn, Ilse Cornelissen-Wesseling, Jeroen Diepstraten, Jacobien Ellerbroek, Saskia Coenradie, Debbie Deben, Kim Hurkens, Dennis Wong, Marion Vromen, Marjolein de Bock, Suzan Savelkoul, Saskia Wolters, Louise Andrews, Eefje Jong, Rosanne Kranenburg, Joana Soares, Fatima Falcao, Mariana Solano, Erica Viegas, Margarida Falcao, Helena Farinha, Dina Mendes, Joao Rijo, Marta Miarons, Maria Queralt Gorgas, Cristina García Yubero, Laura Portillo Horcajada, Kim Keijzers, Silke Lim, Linden Ashfield, Helen Bell, Naomi Fitzhugh, Glenda Fleming, Nicola Goodfellow, Joanne Hanley, Michael Scott, Simon P. Mooijaart, Jacobijn Gussekloo, Petra Elders, Geeske Peeters

“…We evaluated whether the CFS is associated with mortality 24 months after hospitalisation for COVID-19. Methods: The COvid MEdicaTion (COMET) study is an international, multicentre, observational cohort study, including adult patients hospitalised for COVID-19 between March 2020–July 2020. …”
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Tauroursodeoxycholic acid regulates macrophage/monocyte distribution and improves spinal microenvironment to promote nerve regeneration through inhibiting NF-κB signaling pathway i... by Yonghui Hou, Yonghui Hou, Yage Zhang, Yage Zhang, Lin Ma, Lin Ma, Dan Luo, Dan Luo, Wanshun Wang, Wanshun Wang, Shunmei E., Chengxi Huang, Yu Hou, Yu Hou, Shudong Chen, Shudong Chen, Jiheng Zhan, Jiheng Zhan, Liangliang Xu, Liangliang Xu, Dingkun Lin, Dingkun Lin

“…This study aims to investigate the effect of TUDCA on monocyte/macrophage distribution and nerve regeneration in the subacute stage of SCI.MethodsTranswell analysis, Bromodeoxyuridine (BrdU) staining, and TUNEL staining were performed to evaluate the effect of TUDCA on regulating the inflammatory response to impact spinal neural stem cells (NSCs) proliferation and migration, spinal neuron survival, and axon degeneration in vitro. …”
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Association of serum 25-hydroxyvitamin D with sleep disorders in individuals with prediabetes and diabetes: a prospective cohort study by Guodong Liu, Guodong Liu, Huaxue Li, Huaxue Li, Yicheng Ma, Yicheng Ma, Yingzhou Shi, Yingzhou Shi, Junming Han, Junming Han, Fei Li, Fei Li, Li Fang, Li Fang, Shengyu Tian, Shengyu Tian, Yiping Cheng, Yiping Cheng

“…In fully adjusted models, sufficient serum 25(OH)D concentrations reduced sleep disorder risk by 48% in prediabetes (HR = 0.52; 95% CI: 0.41–0.65) and 52% in diabetes (HR = 0.48; 95% CI: 0.34–0.67). …”
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Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe. by Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

“…We characterised school-age growth, cognitive and physical function in CBHF and CHU previously enrolled in the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe.<h4>Methods and findings</h4>The SHINE trial enrolled pregnant women between 2012 and 2015 across 2 rural Zimbabwean districts. …”
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Association between herbicide exposure and liver enzyme levels in a middle-aged and elderly population by Weiya LI, Zhuoya ZHAO, Xu CHENG, Jun AN, Shiyang ZHANG, Chengyong JIA, Meian HE

“…The relationship between baseline serum herbicide levels and the risk of liver enzyme abnormalities during follow-up was further analyzed using logistic regression models.ResultsThe positive rates of metolachlor, propham, and acetochlor were all higher than 80%, and their spiked rates of recovery ranged from 73.46% to 106.77%. …”
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The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study. by Adam Shardlow, Natasha J McIntyre, Simon D S Fraser, Paul Roderick, James Raftery, Richard J Fluck, Christopher W McIntyre, Maarten W Taal

“…Use of eGFRcys or eGFRcreat-cys did not improve discrimination in risk prediction models for CKD progression and all-cause mortality compared to similar models with eGFRcreat. …”
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Vitality attributes and their associations with intrinsic capacity, resilience, and happiness in community-dwelling adults: Results from Gan-Dau Healthy Longevity Plan Wave 2 by Kuan-Yu Peng, Zhi-Jun Chen, Fong-Ping Tang, Shu-Chiung Lee, Heng-Hsin Tung, Katelyn E. Chen, Liang-Kung Chen, Fei-Yuan Hsiao

“…This study examined associations between different vitality attributes and other domains of IC as well as psychosocial constructs including resilience and happiness in middle aged and older adults, as these associations were fundamental for establishing evidence-based interventions to promote healthy aging. Methods: This cross-sectional analysis included 981 participants (75.0% female and 49.2% aged between 65−74 years) from the Gan-Dau Healthy Longevity Plan wave 2 cohort. …”
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Urban pertussis epidemiological patterns in a highly vaccinated megacity: Policy impacts and control strategies in Chongqing, China, 2005-2024 by Rui Shen, Jiawei Xu, Yugang Li, Jianxing Yu, Na Sun, Zilu Xu, Xueying Xu, Xiao Liu, Yang Liu, Bosong Li, Li Qi, Luzhao Feng

“…We investigated epidemiological patterns and policy impacts in a densely populated urban setting in Chongqing, China. Methods: Using population-based surveillance data (2005-2024) from Chongqing (population 32.1 million; DTP3 coverage >97%), we conducted hierarchical Bayesian spatial modeling and age-structured Susceptible-Infected-Recovered-Vaccinated transmission analysis. …”
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Development and validation of a machine learning-based early warning system for predicting venous thromboembolism risk in hospitalized lymphoma patients undergoing chemotherapy: a... by Tingting Jiang, Zailin Yang, Xinyi Tang, Xinyi Tang, Na Fan, Zuhai Hu, Jieping Li, Tingting Liu, Yu Peng, Shuang Chen, Bingling Guo, Xiaomei Zhang, Yong Chen, Jun Li, Dehong Huang, Jun Liu, Yakun Zhang, Yakun Zhang, Xuefen Liu, Xia Wei, Zhanshu Liu, Haike Lei, Yao Liu

“…Variable importance was assessed using permutation analysis, and a nomogram was created to visualize VTE risk. …”
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Patient-reported outcomes between proton and photon therapy in nasopharyngeal carcinoma patients: A longitudinal cohort study by Ching-Nung Wu, Yu-Ming Wang, Wei-Chih Chen, Yun-Hsuan Lin, Shau-Hsuan Li, Chung-Feng Hwang, Bing-Shen Huang, Chung-Ying Lin, Sheng-Dean Luo

“…Newly diagnosed NPC patients were assessed using the modified 28-item symptom distress scale at seven time points, from baseline (T0) to one year post-radiotherapy (RT) (T6). The analysis focused on symptom changes during the acute phase (T0 to T3 [one month post-RT]) using linear mixed models. …”
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Disturbed hierarchy and mediation in reward-related circuits in depression by Ruikun Yang, Junxia Chen, Suping Yue, Yue Yu, Jiamin Fan, Yuling Luo, Hui He, Mingjun Duan, Sisi Jiang, Dezhong Yao, Cheng Luo

“…Subsequently, the mediation effects of cortical regions on the interaction within reward-related circuits were further explored by constructing mediation models. Results: In both cohorts, sFC analysis revealed two reward-related pathways from the deepest DBS targets to intermediate regions including the thalamus, insula, and anterior cingulate cortex (ACC), then to the superficial cortical cortex including medial frontal cortex, posterior default mode network (pDMN), and right dorsolateral prefrontal cortex (DLPFC). …”
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Association between higher morning preference and better health-related quality of life in asthma by Neel Patel, BSc, Andy Deprato, BScKin, Tina Qian, BSc, Ana Adan, PhD, Metin Akgün, MD, Augustus Anderson, MClinImm, Amanda Brickstock, MD, Allie Eathorne, BSc, Arundhati Garud, MPH, Prasun Haldar, PhD, Aditya Jindal, DM, Surinder Kumar Jindal, MD, Bugra Kerget, MD, Saibal Moitra, MD, Rahul Mukherjee, MD, Alex Semprini, MBBS, Alice M. Turner, MD, Nicola Murgia, MD, Paige Lacy, PhD, Subhabrata Moitra, PhD

“…We analyzed the association between chronotype and HRQL using mixed-effect linear regression models. Results: Of all participants, 59% were female with a mean (standard deviation) age of 49 (17) years. …”
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Modified Saengmaeksan, an herbal formula containing six herbs, improves hypertension through RhoA/Rho kinase-mediated vasorelaxation by Young Mi Seok, Hye-Lin Kim, Hyo In Kim, Hobin Moon, Yohan Han, Eun Sang Cho, Hyun Hee Leem, Hyo Jung Kim, Sujin Shin, Se-Jin Kim, Jin Ki Jung, Wei Huang, Kyung Oh Jung, Doo Suk Lee, Sung Giu Jin, Hyunwoo Kim, Changsop Yang, Kyungjin Lee, Jinbong Park

“…The molecular mechanisms were explored through Western blot analysis and GTP-RhoA assays. Results: mSMS significantly reduced systolic and diastolic blood pressure in both hypertensive models, with the ethanol extract demonstrating superior efficacy. mSMS inhibited the RhoA/Rho kinase pathway, leading to reduced phosphorylation of MYPT1 and CPI17, and improved vascular relaxation. …”
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Comparative adverse event profiles of triplet therapy versus docetaxel-based therapy in patients with metastatic prostate cancer: a multicenter retrospective study by Fumihiko Urabe, Hirokazu Kagawa, Takafumi Yanagisawa, Hidetsugu Takahashi, Masaki Hashimoto, Shuhei Hara, Wataru Fukuokaya, Yu Imai, Kosuke Iwatani, Taro Igarashi, Mahito Atsuta, Kojiro Tashiro, Masaya Murakami, Shunsuke Tsuzuki, Brendan A. Yanada, Toshihiro Yamamoto, Kenichi Hata, Hiroki Yamada, Jun Miki, Takahiro Kimura

“…Additionally, we sought to identify risk factors for severe AEs associated with these treatment regimens. Materials and methods: In this retrospective, multicenter study, we included 359 patients diagnosed with metastatic castration-sensitive prostate cancer (mCSPC) or metastatic castration-resistant prostate cancer (mCRPC) who were treated with docetaxel. …”
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Context-Specific Impact Of Antimicrobial Stewardship On Antibiotic Use And Antibiotic Resistance In Hospitals In A Lower-Middle Income Country - Results From Implementation Study W... by Trang Quynh Le, Dung Tien Viet Vu, Quang Minh Le, Huyen Thi Thu Nguyen, Vinh Hai Vu, Duc Minh Chau, Em Thi Hoang Dung Vo, Tu Thi Cam Nguyen, Quan Anh Truong, Khanh Hong Nguyen, Hoa Nguyen Minh Le, Thomas Kesteman, Elizabeth Dodds Ashley, Deverick J. Anderson, Hugo C. Turner, Thach Ngoc Pham, Ben S. Cooper, Choisy Marc, H Rogier Van Doorn, Huong Thi Lan Vu

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Affective bias predicts changes in depression during deep brain stimulation therapy by Brian Cui, Madaline M. Mocchi, Brian A. Metzger, Prathik Kalva, John F. Magnotti, Jess G. Fiedorowicz, Allison Waters, Christopher K. Kovach, Yvonne Y. Reed, Raissa K. Mathura, Camille Steger, Bailey Pascuzzi, Kourtney Kanja, Ashan Veerakumar, Vineet Tiruvadi, Vineet Tiruvadi, Andrea Crowell, Lydia Denison, Christopher J. Rozell, Nader Pouratian, Wayne Goodman, Patricio Riva Posse, Helen S. Mayberg, Kelly Rowe Bijanki

“…Positive valence trials showed significant improvement post-DBS, while negative valence trials showed no notable change. A control analysis indicated that stimulation status did not significantly affect bias scores, and thus stimulation status was excluded from further modeling. …”
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Global Methane Budget 2000–2020 by M. Saunois, A. Martinez, B. Poulter, Z. Zhang, Z. Zhang, P. A. Raymond, P. Regnier, J. G. Canadell, R. B. Jackson, P. K. Patra, P. K. Patra, P. Bousquet, P. Ciais, E. J. Dlugokencky, X. Lan, X. Lan, G. H. Allen, D. Bastviken, D. J. Beerling, D. A. Belikov, D. R. Blake, S. Castaldi, M. Crippa, B. R. Deemer, F. Dennison, G. Etiope, G. Etiope, N. Gedney, L. Höglund-Isaksson, M. A. Holgerson, P. O. Hopcroft, G. Hugelius, A. Ito, A. K. Jain, R. Janardanan, M. S. Johnson, T. Kleinen, P. B. Krummel, R. Lauerwald, T. Li, X. Liu, K. C. McDonald, J. R. Melton, J. Mühle, J. Müller, F. Murguia-Flores, Y. Niwa, Y. Niwa, S. Noce, S. Pan, R. J. Parker, C. Peng, C. Peng, M. Ramonet, W. J. Riley, G. Rocher-Ros, J. A. Rosentreter, M. Sasakawa, A. Segers, S. J. Smith, S. J. Smith, E. H. Stanley, J. Thanwerdas, J. Thanwerdas, H. Tian, A. Tsuruta, F. N. Tubiello, T. S. Weber, G. R. van der Werf, D. E. J. Worthy, Y. Xi, Y. Yoshida, W. Zhang, W. Zhang, B. Zheng, B. Zheng, Q. Zhu, Q. Zhu, Q. Zhuang

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Metabolic Acidosis Is Associated With an Accelerated Decline of Allograft Function in Pediatric Kidney Transplantation by Agnieszka Prytula, Rukshana Shroff, Ineke van Gremberghe, Kai Krupka, Justine Bacchetta, Elisa Benetti, Ryszard Grenda, Isabella Guzzo, Nele Kanzelmeyer, Bahar Büyükkaragöz, Birgitta Kranz, Hülya Nalçacıoğlu, Jun Oh, Lars Pape, Mohan Shenoy, Anne-Laure Sellier-Leclerc, Burkhard Tönshoff, Gema Ariceta, Atif Awan, Sevcan Bakkaloğlu, Marjolein Bonthuis, Charlotte Bootsma Robroeks, Antonia Bouts, Martin Christian, Marlies Cornelissen, Ali Duzova, Nasrin Esfandiar, Luciana Ghio, Ryszard Grenda, Isabella Guzzo, Maria Herrero Goni, Julien Hogan, Nattaphorn Hongsawong, Nele Kanzelmeyer, Aysun Karabay Bayazit, Gülşah Kaya Aksoy, Noel Knops, Linda Koster Kamphuis, Daniella Levy Erez, Victor Lopez-Baez, Alvaro Madrid, Stephen Marks, Anette Melk, Luisa Murer, Lars Pape, Licia Peruzzi, Edita Petrosyan, Evgenia Preka, Nikoleta Printza, Andreea Liana Rachisan, Ann Raes, Mohan Shenoy, Oguz Soylemezoglu, Luca Dello Strologo, Ana Teixeira, Rezan Topaloglu, Markus Weitz, Jakub Zieg, Galia Zlatanova, Christian Patry, Jerome Harambat, Ayşe Ağbaş, Varvara Askiti, Marina Avramescu, Justine Bacchetta, Sevcan Bakkaloglu, Marjolein Bontuis, Caroline Booth, Laurene Dehoux, Giacomo Dizazzo, Dorota Drozdz, Ismail Dursun, Michaela Gessner, Jaap Groothoff, Giuliana Guido, Isabella Guzzo, Aysun Karabay Bayazit, Guenter Klaus, Linda Koster-Kamphuis, Alexander Lalayiannis, Maren Leifheit-Nestler, Sinha Manish, Chiara Matteucci, Jun Oh, Ozan Ozkaya, Edita Petrosyan, Christine Pietrement, Agnieszka Prytula, George Reusz, Franz Schaefer, Claus Peter Schmitt, Anne Schön, Fatma Lale Sever, Stella Stabouli, Serra Sürmeli Döven, Camilla Tondel, Enrico Verrina, Enrico Vidal, Dean Wallace, Zainab Arslan, M. Bald, H. Fehrenbach, D. Haffner, M. Hansen, C. Hempel, U. John, G. Klaus, J. König, B. Lange-Sperandio, D. Müller, J. Oh, L. Pape, M. Pohl, K. Sauerstein, G. Schalk, H. Staude, P. Strotmann, L.T. Weber, M. Weitz, L. Berta, K. Heindl-Rusai

“…Introduction: We investigated the relationship between metabolic acidosis over time and allograft outcome in pediatric kidney transplantation (KTx). Methods: This registry study collected data up to 10 years posttransplant. …”
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STING regulates NETs formation by activating GSDMD in influenza viral pneumonia by Rongrong Huang, Rongrong Huang, Rongrong Huang, Ranran Chen, Ranran Chen, Ranran Chen, Lijuan Xing, Lijuan Xing, Lijuan Xing, Lianhao Wu, Lianhao Wu, Lianhao Wu, Wenwen Zhu, Junsong Jing, Junsong Jing, Junsong Jing, Ting Zhou, Yueguo Wu, Sheng Zhang, Zhenqiang You, Zhenqiang You, Zhenqiang You

“…To elucidate the mechanisms of viral pneumonia progression and potential targets for its treatment.MethodsViral pneumonia models were induced by the PR8 virus strain in wild-type (WT) and STING knockout (STING-KO) mice. …”
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