Current status and prospects of mining technology in metal mines by Liancheng WANG, Anlin SHAO, Fuming QU, Xingtong YUE, Huaiyuan WANG, Xingfan ZHANG, Xiaobo LIU

“…This gap is particularly noticeable in ultra-deep mining, where practical experience is especially lacking. (2) Future mining technologies that require urgent attention can be categorized into four types based on their criticality and urgency: bottleneck technologies, foundational technologies, urgent technologies, and forward-looking technologies. (3) The current “bottleneck” technical challenges facing China’s mining sector include the development of intelligent and unmanned technologies for open-pit mining, advanced deep mining technologies for underground operations, and the research and application of specialized mining software. (4) The urgent technologies identified in this study include precise detection and safety management technologies for goaf areas, ultra-large-scale filling mining technologies for metallic mines, and intelligent ore grade detection technologies. (5) Foundational technologies encompass rock mechanics modeling for deep mining, multi-scale fracture simulation processes under geothermal system rock–hydraulic coupling, and dynamic control theories for managing disasters associated with deep mining activities. (6) Forward-looking technologies include a range of innovations, such as new transportation technologies for deep open-pit mines, advanced deep-well lifting techniques, novel efficient rock-breaking technologies, integrated mining and beneficiation technologies, co-extraction methods for both mineral and geothermal resources, and fluidized mining techniques for metallic minerals. …”
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Glioma-Associated Mesenchymal Stromal/Stem Cells Derived Exosomal miR-191 Promotes the Proneural-to-Mesenchymal Transition in Glioblastoma Cells via PTEN/PI3K/AKT Signaling by Lv P, Zhang Y, Zhao Z, Wu W, Zhou Y, Liu Z, Wang H, Jiang X, Li S, Yan P, Huang X, Xiang W, Fu P

“…Further analysis demonstrated that GaMSC-Exos, isolated from GaMSCs-CM, promoted both the tumorigenicity and PMT of glioma cells, both in vitro and in vivo. …”
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Phoenix dactylifera seed-derived biochar as a sustainable and environmentally feed supplement in camel: impacts gas production, methane emissions, nutrient degradability and fermen... by Hesham S. Ghazzawy, Nashi K. Alqahtani, Nashi K. Alqahtani, Nashi K. Alqahtani, Abdullah Sheikh, Mohamed Shawky El Sayed, Roshmon Thomas Mathew, Hassan M. Ali-Dinar, Ehab El-Haroun, Mohamed M. A. Abd-Elkarim, Sameh A. Abdelnour, Ali S. A. Saleem

“…This study investigated the potential of date palm seed-derived biochar as a sustainable feed additive for dromedary camels to reduce methane (CH₄) emissions and improve gas production, nutrient degradability, fermentation parameters, and performance predictions using in vitro models.MethodsThe PSB was synthesized and stored at 4°C until use. …”
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Stress and Hypertension Among African American Female Family Caregivers of Persons Living With Alzheimer Disease and Related Dementias: Protocol for a Pilot Internet-Based Randomiz... by Kathy D Wright, Ingrid K Richards Adams, Nathan P Helsabeck, Karen M Rose, Karen O Moss, Donya Nemati, Navia Palmer, Bohyun Kim, Sunita Pokhrel Bhattarai, Christopher Nguyen, Daniel Addison, Maryanna D Klatt

“…Quantitative data will be analyzed using descriptive statistics, CIs, and mediation models. ResultsThis study was approved by the institutional review board in April 2022 and funded in May 2022. …”
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Blood lactate as a predictor of clinical outcomes and health-care resource needs in combat abdominal injuries by І.В. Собко, О.В. Рабощук, А.В. Верба, С.А. Асланян, Г.П. Хитрий, В.М. Мошківський, І.П. Кураченко, Т.С. Бордюг

“…The aim of this study is to determine the predictive efficacy of serum lactate regarding the risk of death and health-care resources needs in patients with CAI. Materials and methods. We examined 86 injured servicemen with CAI who were randomized into two groups — survivors and nonsurvivors. …”
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Step up to triple therapy versus switch to dual bronchodilator therapy in patients with COPD on an inhaled corticosteroid/long-acting β2-agonist: post-hoc analyses of KRONOS by Dave Singh, Mona Bafadhel, Niki Arya, Jonathan Marshall, Himanshu Parikh, Dobrawa Kisielewicz, Charlotta Movitz, Karin Bowen, Mehul Patel

“…However, the effect of stepping up to ICS/LAMA/LABA versus switching to LAMA/LABA on exacerbation risk is unclear. This analysis evaluated the effect of escalating to ICS/LAMA/LABA versus switching to LAMA/LABA or staying on ICS/LABA on lung function and exacerbation rates in symptomatic individuals with COPD without a recent exacerbation history from KRONOS. …”
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Abstract 224: Morphological characteristics of carotid webs associated with stroke risk and clot burden by Pedro N. Martins, Mateus D. Monteiro, Mohamed A. Tarek, Fadi Nahab, Jaydevsinh Dolia, Jason Allen, Michael Frankel, Raul Nogueira, Diogo Haussen

“…We aim to evaluate the associations between CaW morphological features evaluated via computed tomography angiography (CTA) with clinical and radiological variables. Methods This is a retrospective analysis of a prospectively collected mechanical thrombectomy database. …”
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Correlation Between the Online Visiting Time and Frequency Increase in Telemedicine Services Offered by Health Care Providers Before, During, and After the COVID-19 Pandemic in Chi... by Weiyi Wang, Yuntian Chu, Fangfang Cui, Xiaobing Shi, Xu Zhang, Dongxu Sun, Jinming Shi, Jie Zhao

“…Chi-square tests were applied to compare general differences in the between-group telemedicine frequency. Regression models were performed to analyze correlations between the frequency change and the time spent in online versus in-person visits. …”
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Comparison of dried blood spot (DBS) and plasma HIV-1 viral load measurements using Roche COBAS AmpliPrep/COBAS TaqMan assay, Northwest Ethiopia by Firehiwot Kebede, Getu Girmay, Gezahegn Bewket, Muluneh Assefa, Tadelo Wondmagegn, Mulualem Lemma, Nega Berhane

“…In addition, the level of agreement and the presence of proportional bias between sample measurements were performed using the Bland–Altman plot and linear regression models, respectively. A p-value of ≤ 0.05 with a 95% confidence interval was considered statistically significant. …”
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The association between stress hyperglycemia ratio and 1-year outcomes in patients with acute myocardial infarction: a retrospective large sample cohort study by Ning Yan, Peng Wu, Peng Wu, Zhengjun Zhang, Mohan Wang, Juan Ma, Ali Ma, Dapeng Chen, Xueping Ma, Xiaocheng Li

“…This study explores the relationship between SHR and 1-year outcomes after AMI using a large cohort analysis.MethodsThis retrospective study enrolled 4012 AMI patients from General Hospital of Ningxia Medical University(2016-2019). …”
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Vaccine effectiveness against SARS-CoV-2 infection or COVID-19 hospitalization with the Alpha, Delta, or Omicron SARS-CoV-2 variant: A nationwide Danish cohort study. by Mie Agermose Gram, Hanne-Dorthe Emborg, Astrid Blicher Schelde, Nikolaj Ulrik Friis, Katrine Finderup Nielsen, Ida Rask Moustsen-Helms, Rebecca Legarth, Janni Uyen Hoa Lam, Manon Chaine, Aisha Zahoor Malik, Morten Rasmussen, Jannik Fonager, Raphael Niklaus Sieber, Marc Stegger, Steen Ethelberg, Palle Valentiner-Branth, Christian Holm Hansen

“…VE estimates including 95% confidence intervals (CIs) were calculated (1-hazard ratio∙100) using Cox proportional hazard regression models with underlying calendar time and adjustments for age, sex, comorbidity, and geographical region. …”
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Culturally Adapted Guided Internet-Based Cognitive Behavioral Therapy for Hong Kong People With Depressive Symptoms: Randomized Controlled Trial by Jia-Yan Pan, Jonas Rafi

“…These scales were administered at preintervention, postintervention, and at 3-month and 6-month follow-up assessments. Data analysis was conducted using linear mixed effects modeling, adhering to the intent-to-treat principle. …”
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Protection afforded by post-infection SARS-CoV-2 vaccine doses: A cohort study in Shanghai by Bo Zheng, Bronner P Gonçalves, Pengfei Deng, Weibing Wang, Jie Tian, Xueyao Liang, Ye Yao, Caoyi Xue

“…We compared reinfection incidence by post-infection vaccination status in individuals initially infected during the April–May 2022 Omicron variant surge in Shanghai and who had been vaccinated before that period. Cox models were fit to estimate adjusted hazard ratios (aHRs). …”
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Clinical significance of primary tumor progression in metastatic hormone-sensitive prostate cancer by Yasutaka Yamada, Shinichi Sakamoto, Takuya Tsujino, Sinpei Saito, Kodai Sato, Kazuki Nishimura, Tatsuo Fukushima, Ko Nakamura, Yuki Yoshikawa, Tomohisa Matsunaga, Ryoichi Maenosono, Manato Kanesaka, Takayuki Arai, Tomokazu Sazuka, Yusuke Imamura, Kazumasa Komura, Kazuo Mikami, Kazuyoshi Nakamura, Satoshi Fukasawa, Kazuto Chiba, Yukio Naya, Maki Nagata, Atsushi Komaru, Hiroomi Nakatsu, Haruhito Azuma, Tomohiko Ichikawa

“…Student's t-test, Cox proportional hazards models, and Kaplan-Meier methods were utilized to validate the clinical significance. …”
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Starfield’s 4Cs of NCD management in primary healthcare: a conceptual framework development from a case study of 19 countries by Helena Legido-Quigley, Eva Turk, Juan Carlos Rivillas, Tiara Marthias, Darius Erlangga, Jasper Tromp, Pami Shrestha, Chuan De Foo, Kim Bao Giang, Maria Eugenia Esandi, Laura Antonietti, Shangzhi Xiong, Likke Prawidya Putri, Aungsumalee Pholpark, Natchaya Ritthisirikul, Piya Hanvoravongchai, Krishaa Logan, Elliot Eu, Ewa Kosycarz, Marcela Schenck, Wilson Benia, Doan Thi Thuy Duong, Supri Shrestha

“…Therefore, this study aims to explore and elucidate the key themes and subthemes related to and extending beyond Starfield’s 4Cs of PHC by integrating findings from a comprehensive literature review and a qualitative study.Methods In this case study analysis, case studies of PHC systems from 19 countries were purposefully selected to represent a range of income levels and diversity in health systems and PHC landscapes. …”
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Growth-promoting hormonal alterations in pregnant women living with HIV receiving dolutegravir-based antiretroviral treatment are associated with lower infant 1-year weight z-score... by Kathleen M. Powis, Kathleen M. Powis, Kathleen M. Powis, Jennifer Jao, Jennifer Jao, Jennifer Jao, Justine Legbedze, Caroline Dunk, Keolebogile N. Mmasa, Samuel W. Kgole, Gosego Masasa, Terence Mohammed, Joseph Makhema, Sikhulile Moyo, Mitchell E. Geffner, Elaine J. Abrams, Lena Serghides, Lena Serghides

“…BackgroundSeveral maternal hormones regulate fetal growth, but concentrations of these hormones in pregnancy among women living with HIV and associations between hormone levels and infant anthropometrics is limited.MethodsPregnant women with HIV receiving dolutegravir/tenofovir/emtricitabine and HIV-seronegative women and their infants prospectively enrolled in the Botswana-based Tshilo Dikotla study were included in this analysis. …”
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Study protocol for the BRAIN Training Trial: a randomised controlled trial of Balance, Resistance, And INterval training on cognitive function in older adults with mild cognitive i... by Teresa Liu-Ambrose, Ulrik Wisløff, Maria Fiatarone Singh, Yorgi Mavros, Perminder S Sachdev, Ryan S Falck, Dorthe Stensvold, Jeff S Coombes, Trinidad Valenzuela, Nicole Kochan, Wei Wen, Jeffrey Hausdorff, Jiyang Jiang, Emily C Smith, Matthew Hollings, Tess C Hawkins, Nicholas J Ashley, Natan Feter, Guy C Wilson, Isabel Hui En Shih, Yareni Guerrero, Tom Bailey

“…The aim of the Balance, Resistance, And INterval (BRAIN) Training Trial is to determine the effects of two forms of exercise, high-intensity aerobic interval training (HIIT) and high-intensity power training (POWER) each compared with a sham exercise control group on cognition in older adults with MCI.Methods and analysis One hundred and sixty community-dwelling older (≥ 60 years) people with MCI have been randomised into the trial. …”
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Variations of Lipoprotein(a) Levels in the Metabolic Syndrome: A Report from the Maracaibo City Metabolic Syndrome Prevalence Study by Valmore Bermúdez, Joselyn Rojas, Juan Salazar, Luis Bello, Roberto Áñez, Alexandra Toledo, Maricarmen Chacín, Miguel Aguirre, Marjorie Villalobos, Mervin Chávez, María Sofía Martínez, Wheeler Torres, Yaquelin Torres, José Mejías, Edgardo Mengual, Liliana Rojas, Milagro Sánchez de Rosales, Ana Quevedo, Raquel Cano, Mayela Cabrera, Rafael París, Adonías Lubo, María Montiel, Climaco Cano

“…Multiple logistic regression models were utilized for analyzing factors associated with elevated serum Lp(a) levels and MS. …”
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Natural immunity and protection against variants in South African children through five COVID-19 waves: A prospective study by Heather J. Zar, Lesley Workman, Rae MacGinty, Maresa Botha, Marina Johnson, Adam Hunt, Tiffany Burd, Mark P. Nicol, Stefan Flasche, Billy J. Quilty, David Goldblatt

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Plasma club cell secretory protein reflects early lung injury: comprehensive epidemiological evidence by Jiajun Wei, Jinyu Wu, Hongyue Kong, Liuquan Jiang, Yong Wang, Ying Guo, Quan Feng, Jisheng Nie, Yiwei Shi, Xinri Zhang, Xiaomei Kong, Xiao Yu, Gaisheng Liu, Fan Yang, Jun Dong, Jin Yang

“…First, restricted cubic spline (RCS) models were used to compare the trends of changes in lung function indicators and plasma CC16 levels after dust exposure. …”
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