Association of phenotypic aging, lifestyle, and genetic risk with incidence of atrial fibrillation: A large prospective cohort study in the UK Biobank by Tingting Lin, Ximin Fan, Liangtang Zeng, Qiang Li, Feilong Wang, Hao Lu

“…Cox proportional hazards models were employed to assess both independent and combined effects of PhenoAgeAccel, HLS, and PRS with AF risk. …”
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Outcome differences in acute vs. acute on chronic heart failure and cardiogenic shock by Tara L. Jones, Michael C. Tan, Vidang Nguyen, Kathleen E. Kearney, Charles C. Maynard, Emily Anderson, Claudius Mahr, James M. McCabe

“…Initial haemodynamic and laboratory data were collected for analysis. The primary outcome was in‐hospital mortality. …”
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Correlation Between Learning and Memory Impairment and Changes in Cerebral White Matter Nerve Fibers and Pericytes in Rats with Chronic Cerebral Ischemia by HUANG Jia, WANG Mengxue, NI Jinglei, LIANG Shengxiang, LIN Bingbing

“…The sham operation group were treated with bilateral common carotid arteries separation without ligation, and chronic cerebral ischemia models were established by ligation of bilateral common carotid arteries in the 28 days after operation group and the 56 days after operation group. …”
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GOLD(I)-BASED COMPLEX AUDMAP: A PROMISING ANTIPROLIFERATIVE AGENT FOR MELANOMA TREATMENT by Isabela Carvalho Diniz, Fernanda Van Petten de Vasconcelos Azevedo, Camilla Abbehausen, Jennyfer Castro da Silva, Carmen Silvia Passos Lima

“…Given these promising results, further studies will focus on cell cycle analysis and death mechanisms to better understand the biological effects of AuDMAP. …”
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The impact of detention on the health of asylum seekers: An updated systematic review: A systematic review by Trine Filges, Elizabeth Bengtsen, Edith Montgomery, Malene Wallach Kildemoes

“…Data collection and analysis Of 22,226 potential studies, 14 met the inclusion criteria. …”
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RECENT STRONG EARTHQUAKES IN CENTRAL ASIA: REGULAR TECTONOPHYSICAL FEATURES OF LOCATIONS IN THE STRUCTURE AND GEODYNAMICS OF THE LITHOSPHERE. PART 1. MAIN GEODYNAMIC FACTORS PREDET... by S. I. Sherman, Ma Jin, E. A. Gorbunova

“…Our analysis of the locations of М≥8 earthquakes shows that in the past two centuries such earthquakes took place in areas of the dynamic influence of large deep faults in the western regions of Central Asia. …”
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A 5-Year Follow-Up of Patient-Reported Outcome Measures Following External Beam Radiotherapy or Radical Prostatectomy in Localised Prostate Cancer by Rowan V. David, Peter L. Stapleton, Arman A. Kahokehr, Jason Lee, David I. Watson, John Leung, Michael E. O’Callaghan

“…Multivariable mixed-effects linear modelling was performed to compare differences between EPIC-26 domains over time between ERBT and RP patients. …”
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The association between vision impairment and multi-site pain in middle-aged and older adults in China: results from the China health and retirement longitudinal study by Tianyi Luo, Cunzi Li, Lan Zhou, Lan Zhou, Yingrui Liu, Hongyan Sun, Ming Ming Yang

“…Two logistic regression models were constructed to analyze the relationship between VI and the coexistence of pain in different body sites and multi-site pain.ResultsParticipants with VI had a higher probability of experiencing pain across 15 body sites compared to those without VI. …”
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Study on the characteristics and influencing factors on non-marital non-commercial heterosexual transmission of HIV/AIDS in Anhui Province, China, 2015–2022 by Jin Zhang, Ziwei Wang, Yangguang Wang, Yongsheng Ye, Jinling Song, Liping Gong, Seying Dai, Yinguang Fan

“…Multivariate binary unconditional logistic regression models were conducted to explore the factors influencing HIV infection by NMNCHC. …”
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[18F]F-FMISO and [18F]F-FLT PET/CT dual-nuclide imaging for in vivo prediction of drug resistance in pancreatic cancer by SUN Chenwei, HAI Wangxi, QU Qian, XI Yun

“…Subcutaneous xenograft models of pancreatic cancer were established by injecting male BALB/c nude mice with pancreatic cancer cells into the left axillary subcutaneous region. …”
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Minimum and optimal combined variations in sleep, physical activity, and nutrition in relation to all-cause mortality risk by Emmanuel Stamatakis, Nicholas A. Koemel, Raaj K. Biswas, Matthew N. Ahmadi, Margaret Allman-Farinelli, Stewart G. Trost, Elif Inan-Eroglu, Borja del Pozo Cruz, Yu Sun Bin, Svetlana Postnova, Mitch J. Duncan, Dorothea Dumuid, Helen Brown, Carol Maher, Luigi Fontana, Stephen Simpson, Peter A. Cistulli

“…We examined the combined associations of SPAN and the minimum between-individual variations associated with meaningfully lower all-cause mortality risk. Methods This prospective cohort analysis included 59,078 participants from the UK Biobank (median age: 64.0 years; 45.4% male) who wore trackers for 7 days and self-reported dietary data. …”
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Protocol for a multisite randomised controlled trial assessing the effect of the Telehealth for Early Developmental Intervention in babies born very preterm (TEDI-Prem) programme o... by Alicia J Spittle, Peter J Anderson, Angela T Morgan, Rachel Schembri, Li Huang, Kim Dalziel, Rod W Hunt, Katherine Lee, Anne E Holland, Karli Treyvaud, Abbey L Eeles, Stacey Dusing, Shaaron Brown, Susan M Fehring, Gillian Henty, Elizabeth Kozaris

“…Here we present the protocol outlining a multicentre, pragmatic, parallel-group, randomised controlled trial to determine the efficacy of TEDI-Prem plus usual care, compared with usual care alone.Methods and analysis We will recruit 466 VPT infants from the neonatal units of five hospitals in Victoria, Australia. …”
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Neurologists’ Openness to Evidence-Based Innovation in Multiple Sclerosis Care: Individual and Structural Determinants by Monreal E, Gómez-Ballesteros R, Meca-Lallana V, Caminero AB, Meca-Lallana JE, Martínez-Yélamos S, Landete L, García-Domínguez JM, Agüera E, García-Arcelay E, Medrano N, Villar LM, Maurino J

“…Logistic and linear regression models were conducted to identify predictors of openness to innovation.Results: One hundred and sixteen neurologists were studied. …”
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Tumor gene expression signatures associated with outcome in large B−cell lymphoma treated with CD19-directed CAR T−cell therapy (axicabtagene ciloleucel) by Yuan Tian, Justin Budka, Frederick L. Locke, Jason R. Westin, Christina To, Gayatri Tiwari, Daqin Mao, Davide Bedognetti, Rhine R. Shen, Jorge Andrade, Simone Filosto

“…Herein, we leveraged the ZUMA-7 phase III randomized trial of relapsed/refractory large B-cell lymphoma (LBCL) patients treated with axicabtagene ciloleucel (axi-cel; CD19-targeting CAR T cells) to discover tumor gene expression signatures (GES) associated with outcome.MethodsWith tumor transcriptomics from 134 axi-cel patients, we employed multivariate penalized Cox models analyzing event-free survival (EFS), progression-free survival (PFS), and duration of response (DOR).Results and DiscussionWe identified two novel GES, a six-gene/transcript signature (6-GES; CD19, CD45RA, CCL22, KLRK1, SOX11, SIGLEC5) correlated with improved outcome after axi-cel (HR: 0.27, 95% CI: 0.16–0.44 for EFS), representing lymphomas with abundant target antigen (CD19) expression, adhesion molecules, and relatively low immune infiltration mostly composed of cytotoxic lymphocytes (T and NK cells) and DCs, and secondly, a 17-gene/transcript signature (17-GES; CD45RO, BCL2, IL-18R1, TNFSF4 [OX40L], KLRB1 [CD161], KIR3DL2, ITGB8, DUSP5, GPC4, PSMB5, RPS6KB1, SERPINA9, NBN,GLUD1, ESR1, ARID1A, and SLC16A1) correlated with disease progression after axi-cel (HR: 6.12, 95% CI: 3.57–10.50 for EFS), consistent with high immune inflammation and escape mechanisms, such as the upregulation of genes involved in repair of damaged DNA or chromatin remodeling, inhibition of apoptosis, and a metabolically restrictive environment. …”
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A study on the relationship between depression, treatment side effects, and marital quality in cervical cancer patients undergoing radiotherapy and chemotherapy (宫颈癌放化疗患者抑郁与治疗副反应和婚... by LI Yuhuan (李玉环), ZENG Ya (曾娅), XING Yuzhen (邢育珍)

“…Results Depression in cervical cancer patients treated with radiotherapy was significantly and positively correlated with treatment side-effects and neurotic personality (P＜0. 01), and significantly and negatively correlated with marital relationship and quality of life (P＜0. 01). Analysis of structural equation modelling indicated that the relationship between treatment side-effects and depression in patients treated with radiotherapy and or chemotherapy for cervical cancer was moderated by the role of neurotic personality and quality of life, and was not mediated by the role of marital relationship. …”
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The Relationship Between Psychosocial Factors and Response to Epidural Steroid Injection for Chronic Lumbosacral Radicular Pain: A Prospective Pilot Study by Stensland M, Sanford E, Houle TT, McGeary C, Cobos BA, Lugosi S, Lehman L, Nabity PS, Covell C, Fitzgerald E, Mojallal M, Reed DE, Pangarkar S, Eapen BC, Nanda U, McCormick ZL, McGeary D

“…Data were analyzed using principal component analysis and generalized linear mixed-effects modeling.Results: A total of 40 patients (age 52 ± 13.05) participated in this study. …”
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Novel multimodal mechanical stimulation is superior to TENS to treat and prevent chronic low back pain: a randomized controlled trial by Amy Lynn Baxter, Amy Lynn Baxter, Jena L. Etnoyer-Slaski, Owen Tucker, Jessica Allia Rice Williams, Kevin Swartout, Lindsey L. Cohen, M. Louise Lawson

“…Over time, Linear Mixed Models (intention-to-treat) showed M-Stim significantly improved pain and disability for both aLBP and cLBP, (p < .001 to p = .024). …”
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Anticancer Activity of Phospholipid-Dexibuprofen Conjugates Loaded in Nanostructured Lipid Carriers by Thiruchenthooran V, Świtalska M, Maciejewska G, Palko-Łabuz A, Bonilla-Vidal L, Espina M, Luisa Garcia M, Wietrzyk J, Souto EB, Sánchez-López E, Gliszczyńska A

“…Vaikunthavasan Thiruchenthooran,1 Marta Świtalska,2 Gabriela Maciejewska,3,4 Anna Palko-Łabuz,5 Lorena Bonilla-Vidal,6,7 Marta Espina,6,7 Maria Luisa Garcia,6,7 Joanna Wietrzyk,2 Eliana B Souto,8 Elena Sánchez-López,6,7 Anna Gliszczyńska1 1Department of Food Chemistry and Biocatalysis, Wrocław University of Environmental and Life Sciences, Wrocław, Poland; 2Department of Experimental Oncology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland; 3Central Laboratory of the Instrumental Analysis, Wrocław University of Technology, Wrocław, Poland; 4Omics Research Center, Wrocław Medical University, Wrocław, Poland; 5Department of Biophysics and Neuroscience, Wrocław Medical University, Wrocław, Poland; 6Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, University of Barcelona, Barcelona, Spain; 7Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain; 8UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, D04 V1W8, IrelandCorrespondence: Anna Gliszczyńska, Email anna.gliszczynska@upwr.edu.pl Elena Sánchez-López, Email esanchezlopez@ub.eduPurpose: In our work, we focused on the development of nanostructured lipid carriers (NLCs) loaded with dexibuprofen (DXI) and their application for cancer therapy by proposing the binding of phospholipids with this non-steroidal anti-inflammatory drug (NSAID) to obtain new delivery systems.Methods: We successfully synthesized seven conjugates with good yields, four of which are new, and have not been previously published in the literature. …”
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Resepsi audiens terhadap “Soft Masculinity” Boygroup Kpop by Raden Roro Nur Himma Sophia Syamwakumala

“…Qualitative descriptive research methods are used to describe the phenomenon in depth and critically. …”
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Association between outdoor light at night exposure and preterm birth and effect modification by pre-pregnancy stress: A national population-based retrospective cohort study by Manman Chen, Qiongjie Zhou, Yuanyuan Li, Qu Lu, Anying Bai, Fangyi Ruan, Yandan Liu, Yu Jiang, Xiaotian Li

“…Stratified analysis was also conducted to explore differences across socioeconomic status. …”
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