Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies by Dean A Lee, Jeremiah L Oyer, Md Faqrul Hasan, Tayler J Croom-Perez, Liza D Robles-Carrillo, Sanjana Kumar, Brendan W Andersen, Brian P Tullius, Alicja J Copik, Amanda R Campbell, Thomas A Dieffenthaller, Catherine A Cash, Jonathan E Eloriaga, Meisam Naeimi Kararoudi

“…Since NK cells express TIGIT and Fc-receptor CD16, Fc-active anti-TIGIT may deplete NK cells via fratricide, which has not been studied.Methods CRISPR-Cas9-based TIGIT knockout (KO) was performed in expanded NK cells. …”
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Low-dose radiotherapy enhances the efficacy of PD-L1 blockade and induces the abscopal effect by Pierre-Antoine Laurent, Eric Deutsch, Charlotte Robert, Antonin Levy, Michele Mondini, Marine Gerbé De Thoré, Winchygn Liu, Lydia Meziani, Céline Clémenson, Flavie Naulin, Liu Shi, Lisa Bouarroudj, Nathan Benzazon, Marine Aglave, Paul Bergeron, Lisa Sitterlé, Daphné Morel

“…Notably, the ability of low-dose RT to enhance the efficacy of immune-checkpoint inhibitors (ICI) in distant, unirradiated tumors is debated.Methods We used a stepwise preclinical approach in immunocompetent mice bearing different murine tumor models (MC38 or CT26), with one or two tumors per mouse. …”
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What influences the implementation of health checks in the prevention and early detection of chronic diseases among Aboriginal and Torres Strait Islander people in Australian prima... by Uday Narayan Yadav, Stefan Thottunkal, Jason Agostino, Victoria Sinka, Rosemary Wyber, Belinda Hammond, Danielle C. Butler, Mary Belfrage, Kate Freeman, Megan Passey, Emma Walke, Matthew Smith, Benjamin Jones, Raymond Lovett, Kirsty A. Douglas

“…The extracted data were summarized using a content analysis approach, applying strength-based approaches. …”
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GPS-based street-view greenspace exposure and wearable assessed physical activity in a prospective cohort of US women by Li Yi, Jaime E. Hart, Grete Wilt, Cindy R. Hu, Marcia Pescador Jimenez, Pi-I Debby Lin, Esra Suel, Perry Hystad, Steve Hankey, Wenwen Zhang, Jorge E. Chavarro, Francine Laden, Peter James

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Prospects for the Use of Amaranth Grain in the Production of Functional and Specialized Food Products by Dana Toimbayeva, Saule Saduakhasova, Svetlana Kamanova, Amirsana Kiykbay, Sayagul Tazhina, Indira Temirova, Marat Muratkhan, Bakhyt Shaimenova, Linara Murat, Dina Khamitova, Gulnazym Ospankulova

“…This work provides a detailed analysis of amaranth’s chemical composition and bioactive components, along with its evaluation of therapeutic and preventive properties. …”
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METTL3-mediated SNHG1 m6A modification promotes proliferation and migration through transcriptional regulation of WDR74 in osteosarcoma by Guanzhen Qiu, Yuxin Bao, Yuanzhuang Zhang, Yeqiu Xu, Tianhua Qiao, Chenghao Li, Hanjie Zhai, Zhenjun Chen, Fu Ren, Yong Wang

“…However, the role of METTL3 and small nucleolar RNA host gene 1 (SNHG1) playing in osteosarcoma (OS) remains largely unknown.MethodsBioinformatics analysis, RT-qPCR, western blotting assays were used to detect the expression of METTL3, SNHG1, RNA binding motif protein 15 (RBM15), WD repeat domain 74 (WDR74) and EWS RNA binding protein 1 (EWSR1) accordingly. …”
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Cross-sectional association between the isocaloric replacement of carbohydrates with protein and fat in relation to fat compartments distribution and hepatic lipid content in recen... by Alexander Lang, Edyta Schaefer, Yuliya Kupriyanova, Janina Goletzke, Katharina S. Weber, Anette E. Buyken, Sabine Kahl, Oana-Patricia Zaharia, Christian Herder, Vera B. Schrauwen-Hinderling, Oliver Kuss, Robert Wagner, Michael Roden, Sabrina Schlesinger, German Diabetes Study Group

“…Therefore, the aim was to investigate the isocaloric substitution of carbohydrates with fat and protein in relation to subcutaneous (SAT) and visceral adipose tissue (VAT) and hepatic lipid (HL) content in individuals with recent-onset type 1 (T1D) and type 2 diabetes (T2D), accounting for macronutrient quality. Methods This cross-sectional analysis includes participants with T1D (n = 137) and T2D (n = 170) from the German Diabetes Study (GDS). …”
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BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease by Laura Gallardo-Nuell, Jordi Blanch, Yenny Leal, Daniel E Coral, Talita Duarte-Salles, Giuseppe N. Giordano, Paul W. Franks, Ewan R. Pearson, Geltrude Mingrone, Carel W le Roux, Rafael Ramos, José Manuel Fernández-Real

“…Biomarkers associated with cardiovascular risk—including serum glucose, HbA1c, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, blood pressure, serum ferritin, leukocyte, and monocyte counts—were examined. Clustering analysis was applied to identify patient subgroups, and Cox proportional hazards models were used to assess associations with cerebrovascular events, coronary events, and composite MACE. …”
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Longitudinal trajectory of plasma p-tau217 in cognitively unimpaired subjects by Francisco Martínez-Dubarbie, Armando Guerra-Ruiz, Sara López-García, Carmen Lage, Marta Fernández-Matarrubia, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Enrique Marco de Lucas, Marta Drake-Pérez, María Teresa García-Unzueta, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez

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Association of Lipoprotein(a) With Major Adverse Limb Events and All‐Cause Mortality Following Revascularization for Chronic Limb‐Threatening Ischemia: A Substudy of the BEST‐CLI T... by Alexander E. Sullivan, Shi Huang, Suman Kundu, Victoria E. Thomas, Daniel G. Clair, Aaron W. Aday, Matthew T. Menard, Alik Farber, Kenneth Rosenfield, Jonathan D. Newman, Jeffrey S. Berger, Quinn S. Wells, Matthew S. Freiberg, MacRae F. Linton, Joshua A. Beckman

“…We investigated the relationship between Lp(a) and prespecified cardiovascular outcomes. Methods A subgroup of patients from the BEST‐CLI trial (as part of the TIDE [The Impact of Diabetes on Revascularization] study) underwent blinded, core‐laboratory assessment of Lp(a) levels and were included in this analysis. …”
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Socio-economic contextual determinants and behavioral changes during pregnancy: evidence from the "MAMI-MED" cohort by Francesca Bitonti, Angelo Mazza, Martina Barchitta, Andrea Maugeri, Roberta Magnano San Lio, Giuliana Favara, Claudia La Mastra, Maria Clara La Rosa, Fabiola Galvani, Elisa Pappalardo, Carla Ettore, Giuseppe Ettore, Federico Mertoli, Carmela Elita Schillaci, Antonella Agodi

“…Mann–Whitney test, Kruskal–Wallis tests, logistic regressions and mixtures of regressions models with concomitant variables are implemented 1) to investigate the associations between contextual covariates and individual responses, 2) to assess the presence of latent sub-groups of the population reacting differently to the same contextual factors. …”
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Beyond overweight, visceral adiposity is associated with estimation of cardiovascular risk in patients living with type 1 diabetes: findings from the SFDT1 cohort by Laurence Salle, Jean-Baptiste Julla, Guy Fagherazzi, Pierre Gourdy, Erika Bezerra Parente, Hélène Hanaire, Sopio Tatulashvili, Emmanuel Disse, Sylvia Franc, Samy Hadjadj, Etienne Larger, Caroline Sanz, Patricia Vaduva, René Valero, Amélie Bonnefond, Emmanuel Cosson, Gloria A. Aguayo, Jean-Pierre Riveline, the SFDT1 group

“…The distribution of CV risk was assessed using density plots. In multivariable analysis, the association between BMI, WHtR, and high estimated 10-year CV risk was studied using spline regression models with sex stratification. …”
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M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression by Liqun Ling, Tianqi Hu, Chenkang Zhou, Yingjie Dai, Lijuan Hu, Yuxin Chen, Zhaoting Hu, Kate Huang, Jie Chen, Yumin Wang

“…In vivo validation using xenograft models demonstrated that the circRAPGEF5/IGF2BP2/NUP160 signaling axis promotes tumor growth and metastatic dissemination through autophagy suppression. …”
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Cardiometabolic index predicts cardiovascular events in aging population: a machine learning-based risk prediction framework from a large-scale longitudinal study by Yuanxi Luo, Yuanxi Luo, Zhiyang Yin, Xin Li, Xin Li, Chong Sheng, Ping Zhang, Dongjin Wang, Dongjin Wang, Yunxing Xue

“…Following baseline characteristic comparisons and CVD incidence rate calculations, we implemented multiple Cox regression models to assess CMI’s cardiovascular risk prediction capabilities. …”
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LAPTM4B enhances the stemness of CD133+ liver cancer stem-like cells via WNT/β-catenin signaling by Jiahong Wang, Jianping Liao, Ye Cheng, Meirong Chen, Aimin Huang

“…Therefore, we investigated the effects of LAPTM4B on the stemness regulation of cluster of differentiation 133 (CD133)+ liver cancer stem-like cells (CSLCs). Methods: We used RNA interference and overexpression techniques in both in vitro and in vivo models. …”
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Sodium butyrate inhibits the expression of virulence factors in Vibrio cholerae by targeting ToxT protein by Sushmita Kundu, Suman Das, Priyanka Maitra, Prolay Halder, Hemanta Koley, Asish K. Mukhopadhyay, Shin-ichi Miyoshi, Shanta Dutta, Nabendu Sekhar Chatterjee, Sushmita Bhattacharya

“…Screening various compounds using in silico methods led to the identification of a small molecule, SB, that inhibits the virulence cascade in V. cholerae. …”
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Radiomic features of PET/CT imaging of large B cell lymphoma lesions predicts CAR T cell therapy efficacy by Yoganand Balagurunathan, Zhouping Wei, Jin Qi, Zachary Thompson, Erin Dean, Erin Dean, Hong Lu, Hong Lu, Saran Vardhanabhuti, Salvatore Corallo, Jung W. Choi, Jenny J. Kim, Mike Mattie, Michael Jain, Frederick L. Locke

“…Principal component (PC) analysis was performed to reduce the dimensionality in feature-based functional categories: size (n=38), shape (n=9), and texture (n=259). …”
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Somatostatin analogue continuation upon progression in patients with gastroenteropancreatic neuroendocrine tumour (SAUNA trial): a randomised controlled trial protocol by Suzanne Polinder, Ivan Borbath, Marc Peeters, Philippe Beutels, Elke Smits, Iris Verhaegen, Ella Roelant, Wouter Dercksen, Stella Heemskerk, Siddharth Chhajlani, Jelka Kuiper, Christophe M Deroose, Isolde Van der Massen, Annemiek Walenkamp, Wouter W de Herder, Johannes Hofland, Timon Vandamme

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Mortality and recovery following moderate and severe acute malnutrition in children aged 6-18 months in rural Jharkhand and Odisha, eastern India: A cohort study. by Audrey Prost, Nirmala Nair, Andrew Copas, Hemanta Pradhan, Naomi Saville, Prasanta Tripathy, Rajkumar Gope, Shibanand Rath, Suchitra Rath, Jolene Skordis, Sanghita Bhattacharyya, Anthony Costello, Harshpal S Sachdev

“…We then used Cox-proportional models to estimate mortality hazard ratios (HRs) for MAM and SAM. …”
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Ethnic inequalities in COVID-19 vaccine uptake and comparison to seasonal influenza vaccine uptake in Greater Manchester, UK: A cohort study. by Ruth Elizabeth Watkinson, Richard Williams, Stephanie Gillibrand, Caroline Sanders, Matt Sutton

“…We used Cox proportional hazards models to estimate ethnic inequalities in time to COVID-19 vaccination amongst people eligible for vaccination on health or age (50+ years) criteria between 1 December 2020 and 18 April 2021 (138 days of follow-up). …”
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