Enhanced recovery pathway for older people with hip fracture and cognitive impairment in acute hospitals: the PERFECTED research programme including an RCT by Chris Fox, Simon P Hammond, Lee Shepstone, Fiona Poland, Catherine Henderson, Tamara Backhouse, Bridget Penhale, Simon Donell, Martin Knapp, Douglas Lewins, Alasdair MacLullich, Martyn Patel, Opinder Sahota, Toby O Smith, Justin Waring, Jane L Cross

“…Logarithmic transformation was applied to these data and the models refitted. None then showed any statistically significant difference except the model for length of stay. …”
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SH3GL1‐activated FTH1 inhibits ferroptosis and confers doxorubicin resistance in diffuse large B‐cell lymphoma by Zi‐Wen Duan, Wei‐Ting Wang, Yan Wang, Rong Wang, Wei Hua, Chun‐Yu Shang, Rui Gao, Hao‐Rui Shen, Yue Li, Jia‐Zhu Wu, Hua Yin, Li Wang, Jian‐Yong Li, Wei Xu, Jin‐Hua Liang

“…Nevertheless, a subset of patients experiences refractory or relapsed disease, highlighting the need for new therapeutic strategies. Methods Depmap database based on CRISPR/Cas9 knock out analysis was employed to identify the essential gene SH3GL1, which encodes endophilin A2, as crucial for the proliferation and survival of DLBCL cells. …”
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Association between estimated glucose disposal rate and prediabetes reversion and progression: a nationwide cohort study of middle-aged and elderly people in China by Xin Huang, Xin Huang, Shiming He, Shiming He, Chao Wang, Chao Wang, Guoan Jian, Kun Jiang, Zihao Lu, Wei Wang, Guotai Sheng, Yang Zou

“…This study aims to investigate the association between a novel marker of insulin resistance-the estimated glucose disposal rate (eGDR)-and the reversion of prediabetes to normoglycaemia or progression to diabetes in a Chinese population.MethodsThis prospective cohort study utilized baseline data from the 2011 China Health and Retirement Longitudinal Study involving 2,600 prediabetic participants aged 45 years and older, along with follow-up data from 2015. …”
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Branch Duct IPMN-Associated Acute Pancreatitis in a Large Single-Center Cohort Study by Nicolò de Pretis, Luigi Martinelli, Antonio Amodio, Federico Caldart, Salvatore Crucillà, Maria Sole Battan, Alberto Zorzi, Stefano Francesco Crinò, Maria Cristina Conti Bellocchi, Laura Bernardoni, Giulia De Marchi, Pietro Campagnola, Roberto Salvia, Armando Gabbrielli, Alessandro Marcon, Luca Frulloni

“…Cox proportional hazard models were used to analyze the time to recurrence after the first occurrence of AP. …”
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Impact of hospital-based early detection on management in chronic kidney disease: the CKD Stewardship study (CKD-S) – protocol for a prospective, multicentre, observational cohort... by John Saunders, Brendan Smyth, Amy Kang, Steven Chadban, Shaundeep Sen, George Mangos, Lisa Tienstra, Sarah Norris, Lilijana Gorringe, Lucinda Alix Wynter, Carmen Moroney, Kylie Turner, Sreeram Venugopal, Rowena Monteverde, Leyla Aouad

“…CKD Stewardship (CKD-S) aims to identify hospital inpatients with undiagnosed mid-stage to late-stage CKD with the goal of facilitating diagnosis and initiating guideline-based therapies.Methods and analysis This prospective, multicentre, cohort study compares two models of care, CKD-S and standard care, for identification and management of CKD, across six public hospitals in metropolitan Sydney, Australia. …”
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Cancer, genetic susceptibility and risk of coronary artery disease: A prospective study by Yidan Wang, Shan Zhong, Na Sun, Yunfei Wu, Jun Lyu, Minghui Piao, Wenbo Qu, Xueyu Wang, Wenjun Ni, Xia Gu, Tianshu Han, Jinwei Tian

“…CAD-PRS was categorized as low (lowest tertile), intermediate (tertile 2), and high (highest tertile). Adjusted Cox models assessed the joint and interaction effects of cancer status and CAD-PRS on CAD outcomes. …”
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Curcumin-like Compound Inhibits Proliferation of Adenocarcinoma Cells by Inducing Cell Cycle Arrest and Senescence by Rafael Fonseca, Yasmin dos Santos Louzano, Cindy Juliet Cristancho Ortiz, Matheus de Freitas Silva, Maria Luiza Vieira Felix, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Bruno Zavan, Claudio Viegas, Marisa Ionta

“…<b>Objectives:</b> We investigated the pharmacological potential of a series of curcumin-like compounds using two lung adenocarcinoma cell lines as models. <b>Methods and Results:</b> Cell viability assay led to the identification of PQM-214 as the hit compound, and other methodologies were employed to investigate the mechanisms underlying its antitumor potential, including cell cycle analysis, mitotic index determination, assessment of clonogenic capacity, senescence-associated β-galactosidase and annexin V assays, quantitative PCR, and Western blot analyses. …”
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Identifying inflammatory phenotypes associated with lung involvement in systemic sclerosis: k-means clustering approach by Laura Cano-García, Laura Cano-García, Aimara García-Studer, Aimara García-Studer, Aimara García-Studer, Sara Manrique-Arija, Sara Manrique-Arija, Sara Manrique-Arija, Fernando Ortiz-Marquez, Fernando Ortiz-Marquez, Fernando Ortiz-Marquez, Rocío Redondo-Rodríguez, Rocío Redondo-Rodríguez, Paula Borregón-Garrido, Paula Borregón-Garrido, Natalia Mena-Vázquez, Natalia Mena-Vázquez, Antonio Fernández-Nebro, Antonio Fernández-Nebro, Antonio Fernández-Nebro

“…Objectiveto assess the prognostic impact of clusters of hematologic and biochemical indices on interstitial lung disease (ILD) and respiratory damage associated with systemic sclerosis (SSc)MethodsDesign: We conducted a cross-sectional, uncontrolled study. …”
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Association between physical activity and executive function of Chinese adolescents aged 13–18 by Yuan Liu, Xiaojian Yin, Yi Sun, Feng Zhang, Feng Zhang, Cunjian Bi, Yaru Guo, Yaru Guo, Pengwei Sun, Pengwei Sun, Hong Jun, Hong Jun, Yanyan Hu, Yanyan Hu, He Liu, He Liu

“…Data were analyzed using one-way ANOVA, Pearson correlation analysis, and 30-minute isotemporal substitution models (ISM) to assess the association between PA and EF.ResultsDaily moderate-to-vigorous physical activity (MVPA) time in both boys and girls was negatively correlated with inhibitory control RTs (r = −0.279, −0.173, P &lt; 0.01), 2back-RTs (r = −0.367, −0.268, P &lt; 0.01), and cognitive flexibility RTs (r = −0.283, −0.305, P &lt; 0.01). …”
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Incorporation of Metabolic Dysfunction‐Associated Steatotic Liver Disease in the Health Stage of Cardiovascular‐Kidney‐Metabolic Syndrome Improves Predictive Ability for Coronary A... by Wataru Kawaharata, Marenao Tanaka, Tatsuya Sato, Yukinori Akiyama, Itaru Hosaka, Hiroki Aida, Rie Matsumori, Kei Nakata, Keitaro Nishizawa, Toru Suzuki, Hidemichi Kouzu, Nagisa Hanawa, Masato Furuhashi

“…Results Kaplan–Meier survival curve analysis showed that the modified classification more effectively stratified the risk of CAD than did the original CKM health stage. …”
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Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis by Jialin Li, Jialin Li, Fang Xiao, Fang Xiao, Bingsen Lin, Bingsen Lin, Zhilei Huang, Mingyue Wu, Huan Ma, Ruoxu Dou, Xiaodong Song, Zhongxing Wang, Changjie Cai, Xiangdong Guan, Jie Xu, Jie Xu, Fu-Li Xiang, Fu-Li Xiang

“…Our study aims to elucidate the role of Fer-1 in the acute phase of peritonitis sepsis induced cardiac injury.Methods and ResultsCLP was used to induce peritonitis sepsis in mice. …”
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Early intranasal medication administration in out‐of‐hospital cardiac arrest: Two randomized simulation trials by Stephen R. Dowker, Madison L. Downey, Noor K. Majhail, Isabella G. Scott, Jonah Mathisson, Daniel Rizk, Brad Trumpower, Debra Yake, Michelle Williams, Emilee I. Coulter‐Thompson, Christine M. Brent, Graham C. Smith, Robert Swor, David A. Berger, Deborah M. Rooney, Robert W. Neumar, Charles P. Friedman, James M. Cooke, Amanda L. Missel

“…We fit linear regression models adjusted for CPR training in the LR group and service years in the FR group. …”
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Improvement of alexithymia in patients treated in mental health services for personality disorders: a longitudinal, observational study by Hanna Sayar, Theresa Wilberg, Theresa Wilberg, Ingeborg Ulltveit-Moe Eikenæs, Andreas Ekberg, Andreas Ekberg, Kai Leitemo, Katharina Teresa Enehaug Morken, Katharina Teresa Enehaug Morken, Eileen Oftedal, Eileen Oftedal, Siri Omvik, Dag Anders Ulvestad, Dag Anders Ulvestad, Geir Pedersen, Elfrida Hartveit Kvarstein, Elfrida Hartveit Kvarstein

“…Supplementary outcomes included global psychosocial function and health-related life quality. Linear mixed models were applied for data analysis.ResultsAlexithymia was highly prevalent in the sample: 53% of subjects reported high levels and 20% moderate levels. …”
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Nanostructured Lipoxin A4: Understanding Its Biological Behavior and Impact on Alzheimer’s Disease (Proof of Concept) by Natália Cristina Gomes-da-Silva, Isabelle Xavier-de-Britto, Marilia Amável Gomes Soares, Natalia Mayumi Andrade Yoshihara, Derya Ilem Özdemir, Eduardo Ricci-Junior, Pierre Basílio Almeida Fechine, Luciana Magalhães Rebelo Alencar, Maria das Graças Muller de Oliveira Henriques, Thereza Christina Barja-Fidalgo, Cristian Follmer, Ralph Santos-Oliveira

“…In vivo biodistribution and pharmacokinetic profiles were evaluated using technetium-99m-labeled nano-lipoxin A4 in rodent models. Hepatic biochemical parameters were also measured to assess potential systemic effects. …”
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Peer support enhanced behavioural crisis response teams in the emergency department: protocol for a stepped-wedge cluster-randomised controlled trial by Ambrose H Wong, James D Dziura, Mark Sevilla, Yue Hu, Megan Evans, Bidisha Nath, Rebekah Heckmann, Riddhi Desai, Anusha Kumar, Isaac V Faustino, Anthony J Pavlo, Joan M Cook, Kendra Davis-Plourde, Richard Youins, Kimberly Guy, Pastor Evelyn Smith, Pastor Dana Smith, Karen Kangas, Lou Hart, Seth Powsner, Chyrell Bellamy

“…The goal of this study is to evaluate if the implementation of a Peer support enhanced Agitation Crisis response Team (PACT) for behavioural crisis management in the ED is more effective than usual care to reduce restraint use and improve outcomes among patients presenting to the ED with behavioural crises.Methods and analysis We will first conduct a stakeholder-informed needs assessment to codesign the protocol and then train staff and peers in PACT intervention readiness. …”
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Screen time exposure and academic performance, anxiety, and behavioral problems among school children by Mohammad Sidiq, Balamurugan Janakiraman, Faizan Kashoo, Rayan Jastania, Abdullah Ibrahim Alhusayni, Abdullah Alzahrani, Aksh Chahal, Alagappan Thiyagarajan, Imran Khan, Chandan Kumar, Rajkumar Krishnan Vasanthi, Fahad Alanazi, Mehrunnisha Ahmad, Chhavi Arora Sehgal, Shabnam Khan, Mshari Alghadier

“…We employed multivariate linear regression models to estimate the association between children’s screen time and the predictor variables with 0.05 alpha as level of significance. …”
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Acute bacterial meningitis without cerebrospinal fluid pleocytosis in children: results from a nationwide prospective surveillance system between 2001 and 2022 by Lama Jaber, Corinne Levy, Naïm Ouldali, Emmanuelle Varon, Muhamed-Kheir Taha, Stéphane Bonacorsi, Stéphane Béchet, François Angoulvant, Robert Cohen, Alexis Rybak

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Comparative pharmacokinetic study of dosage forms with morpholinium 2-[5-(pyridin-4-yl)-1,2,4-triazol-3-ylthio] acetate by I. V. Bushueva, V. V. Gladyshev, О. I. Panasenko, E. G. Knish

“…Using mathematical models of income distribution and excretion of drugs greatly enhances the interpretation of the results of biopharmaceutical research. …”
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Performance of Artificial Intelligence in Addressing Questions Regarding the Management of Pediatric Supracondylar Humerus Fractures by John D. Milner, MD, Matthew S. Quinn, MD, Phillip Schmitt, BS, Ashley Knebel, BA, Jeffrey Henstenburg, MD, Adam Nasreddine, MD, Alexandre R. Boulos, MD, MPH, Jonathan R. Schiller, MD, Craig P. Eberson, MD, Aristides I. Cruz, Jr., MD, MBA

“…We hypothesized that both ChatGPT and Gemini would demonstrate high-quality, evidence-based responses with no significant difference between the models across evaluation criteria. Methods: The responses from ChatGPT and Gemini to responses based on the 14 AAOS guidelines were evaluated by seven fellowship-trained pediatric orthopaedic surgeons using a questionnaire to assess five key characteristics on a scale from 1 to 5. …”
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Prediction for cardiac and pulmonary toxicity in a multicentric cohort of advanced stage NSCLC patients using sub-regions of the heart by Albrecht Weiß, Steffen Löck, Ting Xu, Zhongxing Liao, Miguel Garrett Fernandes, René Monshouwer, Johan Bussink, Esther G.C. Troost

“…Results: In univariate modeling, the Mean Lung Dose (MLD) significantly predicted CAE grade ≥ 3 in the training-set (pMLD = 0.02, AUCtrain = 0.69), which was confirmed in validation (AUCval, = 0.77). …”
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