Dental Arch Development of Chinese Adolescents: A Retrospective Cross-Sectional Study by Chao Liu, Jieyi Chen, Mengjuan Cui, Zhengliang Wang, Wentao Shi, Siyuan Du, Yang Feng, Manfei Zhang, Zhenxia Li, Shufei Ge, Bing Fang

“…However, large-scale, region-specific analyses based on big data are scarce.This study aimed to identify the dental arch growth patterns of Chinese adolescents to refine early orthodontic treatment strategies. Methods: A retrospective cross-sectional analysis was conducted using 3D digital impressions from 5951 Chinese adolescents, collected between July 2020 and June 2021. …”
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Changes in Soil Microbial Community Structure and Assembly Process Under Different Forest Restoration Strategies in Cold Temperate Forests of Northeastern China by Rongze Luo, Mingyu Wang, Youjia Zhang, Hong Wang, Xiangyu Meng, Xin Gao, Yuhe Zhang, Xin Sui, Maihe Li

“…Community assembly analyses indicated that that soil microbial (bacterial and fungal) communities were primarily driven by deterministic processes in both restoration models. In short, our study improves our comprehension of how soil microbial communities respond to different restoration methods in temperate forest ecosystems, providing valuable insights for their sustainable management.…”
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An exploratory study of the relevance of therapy format and therapist’ training in individual cognitive behavioral therapy for psychosis by Oda Skancke Gjerdalen, Manuela Zucknick, Manuela Zucknick, Ingvild Tvedt Westlie, Helen Bull, Stig Evensen, Erik Falkum, Marit Grande, Marit Grande, Roger Hagen, Roger Hagen, Roger Hagen, Kristin Lie Romm, Kristin Lie Romm, Lene Hunnicke Jensen, Petter Andreas Ringen, Petter Andreas Ringen, Olivia Schjøtt-Pedersen, Nasrettin Sönmez, Torill Ueland, Torill Ueland, Tiril Østefjells, Jan Ivar Røssberg, Jan Ivar Røssberg, June Ullevoldsæter Lystad, June Ullevoldsæter Lystad, June Ullevoldsæter Lystad

“…Using a series of mixed effects models for repeated measurements, we examined differences between the groups in terms of general functioning and psychiatric symptom severity. …”
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Composite dietary antioxidant index and lung cancer risk: insights from the UK biobank by Yi Feng, Xiuxia Fu, Bo Cheng, Peiling Chen, Zixun Wang, Juan He, Xiangyuan Zheng, Xinyi Wu, Xin Bi, Minyu Dong, Jianxing He, Wenhua Liang

“…This study aimed to investigate the association between the composite dietary antioxidant index (CDAI), which calculated the dietary intake of manganese, selenium, zinc, vitamins A, C and E, and the risk of lung cancer. Methods Using prospective data from the UK Biobank, this study employed Cox proportional hazards regression models to evaluate the relationship between CDAI and lung cancer risk, and restricted cubic spline analyses were used to explore potential nonlinear associations. …”
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Targeting FASN enhances cisplatin sensitivity via SLC7A11-mediated ferroptosis in cervical cancer by Xiaojun Wang, Qiqiao Du, Qiuwen Mai, Qiaojian Zou, Shuyi Wang, Xiaoying Lin, Qianrun Chen, Mengxun Wei, Chudan Chi, Zhangqing Peng, Karima Abdugheni, Liu Du, Yili Chen, Shuzhong Yao, Junxiu Liu

“…Results: Fatty acid synthase (FASN) was identified as a key driver of cisplatin resistance in CC through transcriptome sequencing and Gene Expression Omnibus (GEO) data analysis. The clinically safe FASN inhibitor TVB-2640 was found to restore cisplatin sensitivity, resulting in synergistic tumor growth attenuation in xenograft models. …”
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The meaning of ‘quality’ of homecare for older people: a scoping review by Alex Hall, Vanessa Davey, Lisa McGarrigle, Jayne Astbury, Kimberly Lazo Green, Nisar Ahmed, Oleta Williams, Fiona Beyer, Barbara Hanratty, Debora Price

“…Data were summarised using a qualitative content analysis approach to identify key dimensions of quality. …”
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Achieving inclusive healthcare through integrating education and research with AI and personalized curricula by Amir Bahmani, Kexin Cha, Arash Alavi, Amit Dixit, Antony Ross, Ryan Park, Francesca Goncalves, Shirley Ma, Paul Saxman, Ramesh Nair, Ramin Akhavan-Sarraf, Xin Zhou, Meng Wang, Kévin Contrepois, Jennifer Li-Pook-Than, Emma Monte, David Jose Florez Rodriguez, Jaslene Lai, Mohan Babu, Abtin Tondar, Sophia Miryam Schüssler-Fiorenza Rose, Ilya Akbari, Xinyue Zhang, Kritika Yegnashankaran, Joseph Yracheta, Kali Dale, Alison Derbenwick Miller, Scott Edmiston, Eva M. McGhee, Camille Nebeker, Joseph C. Wu, Anshul Kundaje, Michael Snyder

“…The widespread adoption of large language models (LLMs) such as Generative Pretrained Transformer (GPT) and Claude highlights the importance of making complex data accessible to non-specialists. …”
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Subclinical myocardial changes in rheumatoid arthritis: cardiovascular magnetic resonance evidence of immuno-inflammatory remodeling by Zoltan Tarjanyi, Liliana Szabo, Liliana Szabo, Liliana Szabo, Nikoletta Mong, Adil Mahmood, Adil Mahmood, Zsofia Dohy, Zsofia Dora Drobni, Alexisz Panajotu, Laszlo Tothfalusi, Agnes Szappanos, Agnes Szappanos, Zahra Raisi-Estabragh, Zahra Raisi-Estabragh, Bela Merkely, Bela Merkely, Gyorgy Nagy, Gyorgy Nagy, Gyorgy Nagy, Hajnalka Vago, Hajnalka Vago

“…CMR assessed myocardial structure, function, and tissue characteristics, including native T1/T2 mapping, ventricular volumes, strain analysis, and late gadolinium enhancement. Linear regression models adjusted for age, sex, hypertension, and diabetes evaluated associations between RA characteristics and CMR parameters.ResultsRA patients exhibited elevated native T1 values (980 ± 34 ms vs. 955 ± 33 ms; P < 0.01), indicative of subclinical myocardial fibrosis. …”
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P-78 DECOMPENSATED CIRRHOSIS IN A LARGE MULTINATIONAL COHORT IN LATIN AMERICA: MORTALITY IS TOO HIGH IN THE REGION REGARDLESS OF ETIOLOGY AND COUNTRY by Mario Alvares-Da-Silva Reis, Aldo Torre, Carlos Benitez, Jacqueline Cordova-Gallardo, Alberto Farias Queiroz, Sarai Gonzalez-Hueso, Rene Male Velazquez, Sebastian Marciano, Gustavo Pereira, Jose Luis Perez-Hernandez, Jose Antonio Velarde-Ruiz, Marco Arrese, Araceli Bravo Cabrera, Francisco Felix-Tellez, Adrian Gadano, Oscar Morales Gutierrez, Matheus Michalczuk, Lilian Torres, Scott Silvey, Brian Bush, Jasmohan Bajaj S

“…Patients / Materials and Methods: Non-elective cirrhosis admissions from Nov 2021 to Aug 2022 in sites from Mexico, Brazil, Argentina and Chile were included. …”
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Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities by Qing-shan Chen, Rui-zhao Cai, Yan Wang, Ge-hao Liang, Kai-ming Zhang, Xiao-Yu Yang, Dong Yang, De-Chang Zhao, Xiao-Feng Zhu, Rong Deng, Jun Tang

“…This study aims to investigate SE heterogeneity in TNBC and its influence on BETi effectiveness, with the goal of advancing BETi precision treatment strategies and enhancing therapeutic efficacy. Methods We conducted a comprehensive analysis of H3K27ac ChIP-Seq data from TNBC cell lines and clinical samples, integrating multiple bulk RNA-Seq, scRNA-Seq, and stRNA-Seq datasets to characterize the SE landscape and heterogeneity in TNBC. …”
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Methodology of the brodalumab assessment of hazards: a multicentre observational safety (BRAHMS) study by Øystein Karlstad, Alexander Egeberg, Kari Furu, Ulrike Haug, Wiebke Schäfer, Johan Reutfors, Mette Reilev, Jesper Hallas, Ron Herings, Valeria Belleudi, Gianluca Trifirò, Rosa Gini, Ursula Kirchmayer, Henrik Støvring, Peter Bjødstrup Jensen, Lise Skov Ranch, Karin Gembert, David Hagg, Sarina Schwartz, Elisabeth Smits, Emily Holthius, Alessandro Cesare Rosa

“…The European Medicines Agency requested a postauthorisation safety study of brodalumab to address potential safety issues raised during drug development regarding major adverse cardiovascular events, suicidal conduct, cancer and serious infections.Methods and analysis BRodalumab Assessment of Hazards: A Multinational Safety is a multicentre observational safety study of brodalumab running from 2017 to 2029 using population-based healthcare databases from Denmark, Sweden, Norway, Netherlands, Germany and three different centres in Italy. …”
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Catheter-associated urinary tract infections in urethral stricture patients indwelling suprapubic catheter: Insights from a retrospective investigation into specific antibiogram an... by Jiahao Lin, Changhao Hou, Yubo Gu, Wei Yuan, Xianjie Xiu, Zhenwei Yu, Ruihang Zhang, Guangyu Mao, Qiang Fu, Lujie Song

“…Objectives: This study aimed to evaluate the incidence and risk factors of suprapubic catheter-associated bacteriuria (SPCAB) and multidrug-resistant bacteria (MDRB) in patients with urethral strictures, and compare antimicrobial resistance patterns between pathogens isolated from urinary samples and suprapubic catheters. Methods: A retrospective analysis was performed on patients with urethral strictures who had urethral reconstructive surgery with suprapubic catheters from January 2010 to June 2023. …”
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Phase II study of concomitant radiotherapy with atezolizumab in oligometastatic soft tissue sarcomas: STEREOSARC trial protocol by Nicolas Penel, Dominique Vaur, Juliette Thariat, Alexandre Escande, Jennifer le Guevelou, Colin Debaigt, Esma Saada-Bouzid, Julien Viotti, Nazim Khalladi, David Thibouw, Marie Pierre Sunyach, Laurence Moureau-Zabotto, Mohamed Benchalal, Ovidiu Veresezan, Anne Ducassou, Cecile le Pechoux, Maria Jolnerovski, Celine Bazille, Raphael Serre, Christine Lovera

“…In order to shift the balance towards antitumour immunity by multisite irradiation, radiation could be combined with inhibitors of the immunosuppressive pathways.Methods and analysis STEREOSARC is a prospective, multicentric, randomised phase II, designed to evaluate the efficacy of SBRT associated with immunotherapy versus SBRT only. …”
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MAPT-A152T mutation drives neuronal hyperactivity through Fyn-NMDAR signaling in human iPSC-Derived neurons: Insights into Alzheimer's pathogenesis by Maika Itsuno, Hirokazu Tanabe, Etsuko Sano, Takashi Sasaki, Chisato Oyama, Hiroko Bannai, Koichi Saito, Kazuhiko Nakata, Setsu Endoh-Yamagami, Hideyuki Okano, Sumihiro Maeda

“…Among tau-coding microtubule associated protein tau (MAPT) gene mutations, the A152T mutation is reported to increase the risk of AD and neuronal excitability in mouse models. Methods: To investigate the effects of MAPT gene expression and its mutations on neuronal activity in human neurons, we employed genome editing technology to introduce the A152T or P301S mutations into induced pluripotent stem cells (iPSCs). …”
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Two sides of the same coin: recruitment performance and perceived workload in primary care trials-insights from the AgeWell.de study by Linda Sanftenberg, Robert Philipp Kosilek, Lorenz Birnberger, Hannah Schillok, Felix Wittmann, Melanie Luppa, Anne Blawert, Melanie Boekholt, Christian Brettschneider, Hans-Helmut König, Alexander Bauer, Solveig Weise, Thomas Frese, Hanna Kaduszkiewicz, Juliane Döhring, Catharina Escales, Jochen René Thyrian, Birgitt Wiese, Steffi G. Riedel-Heller, Jochen Gensichen

“…We used correlation analysis and uni- and multivariable regression models to explore determinants of study engagement in terms of recruitment performance and perceived workload. …”
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The effects of stand spatial structure on the aboveground biomass allocation in Chinese fir (Cunninghamia lanceolata) plantations by Xiang Huang, Xiang Huang, Yao Zhang, Yao Zhang, Jianwei Geng, Jianwei Geng, Xiangyu Chen, Xiangyu Chen, Zhihui Yu, Zhihui Yu, Shuhan Yu, Shuhan Yu, Kunyong Yu, Kunyong Yu, Fan Wang, Fan Wang, Jian Liu, Jian Liu

“…Biomass models for different components of Chinese fir were developed using 20 harvested trees, and stem mass fraction (SMF), branch mass fraction (BMF), and leaf mass fraction (FMF) were calculated. …”
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Comparison of the long-term prognostic value of different frailty instruments in older inpatients: a 5-year prospective cohort study by Min Zeng, Yu-Hao Wan, Yao-Dan Liang, Jing Shi, Zhi-Kai Yang, Ting Wang, Chen Ji, Wei He, Ning Sun, Di Guo, Ling-Ling Cui, Lin Yang, Jie-Fu Yang, Hua Wang

“…The predictive value of different frailty scales was compared using Kaplan–Meier (K–M) survival analysis, COX regression models, and the receiver operating characteristic (ROC) curves. …”
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Arterial stiffness and shortened QTc interval are associated with androgen and ACTH levels in classic congenital adrenal hyperplasia by Lorenzo Campioni, Lorenzo Campioni, Maria Chiara Di Carlo, Maria Chiara Di Carlo, Chiara Sola, Chiara Sola, Beatrice Bergoglio, Beatrice Bergoglio, Martina Bollati, Martina Bollati, Giulia Montesano, Federico Ponzetto, Federico Ponzetto, Chiara Lopez, Chiara Lopez, Giovanna Motta, Giovanna Motta, Mirko Parasiliti-Caprino, Mirko Parasiliti-Caprino, Roberta Giordano, Roberta Giordano

“…Propensity score-matched analysis with 1:2 matching ratio, based on the same regression models, confirmed that CAH diagnosis was associated with AASI (p<0.001) and QTc (p=0.004).ConclusionsAdults with classic CAH show increased arterial stiffness and altered cardiac repolarization, likely linked to chronic hormonal imbalance. …”
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Radiomics feature similarity: A novel approach for characterizing brain network changes in patients with behavioral variant frontotemporal dementia by Salvatore Nigro, Marco Filardi, Benedetta Tafuri, Roberto De Blasi, Maria Teresa Dell’Abate, Alessia Giugno, Valentina Gnoni, Giammarco Milella, Daniele Urso, Chiara Zecca, Stefano Zoccolella, Giancarlo Logroscino

“…Introduction: Network modeling is increasingly used to study brain alterations in neurological disorders. …”
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Designing of a Novel Aerolysin-based Multiepitope Vaccine against Aeromonas hydrophila Isolated from Osphronemus goramy Using Reverse Vaccinology: an in Silico Approaches by Rozi, Wiwiek Tyasningsih, Jola Rahmahani, Eduardus Bimo Aksono, Muchammad Yunus, Mohammad Anam Al-Arif, Suryo Kuncorojati, Rahayu Kusdarwati, Putri Desi Wulan Sari, Mohammad Noor Azmai Amal, Annas Salleh, Nadeem Khanand, Suwarno

“…. • Computational methods identified and optimized B-cell and T-cell epitopes, focusing on their ability to trigger immune responses without causing toxicity or allergenicity…”
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