Transmission of community- and hospital-acquired SARS-CoV-2 in hospital settings in the UK: A cohort study. by Yin Mo, David W Eyre, Sheila F Lumley, Timothy M Walker, Robert H Shaw, Denise O'Donnell, Lisa Butcher, Katie Jeffery, Christl A Donnelly, Oxford COVID infection review team, Ben S Cooper

“…Associations between infectious SARS-CoV-2 individuals and infection risk were quantified using logistic, generalised additive and linear mixed models. Cases were classified as community- or hospital-acquired using likely incubation periods of 3 to 7 days. …”
Get full text

GALNT14 Genetic Variants Harbor Differential Prognostic Values Linking to Distinct Macrophage Cell Types in Hepatocellular Carcinoma by Chu YD, Ho PH, Chen WT, Shih YL, Lai MW, Hsu CW, Yeh CT

“…Prognostic evaluation was performed using Kaplan-Meier survival analysis and Cox proportional hazards models, with statistical significance set at P < 0.05.Results: GWAS identified 39 SNP loci linked to rs9679162 and associated with postoperative prognosis. …”
Get full text

Targeted inhibition of gastric cancer progression via a chitosan-RNU11 siRNA nanoparticle delivery system: mechanistic insights and therapeutic potential by Peng Cheng, Zhengrong Zhong, Yanling Wang, Caituan Feng, Jitong Zheng, SuogaoWang, Xiangjun Meng, Dong Wang

“…GC cell lines (AGS and HGC27) were treated with various formulations, and functional assays, including EdU proliferation, Transwell invasion/migration, and cell cycle/apoptosis analysis, were conducted. The in vivo efficacy of Si-RNU11 + CH-NP was evaluated in GC xenograft mouse models. …”
Get full text

The triglyceride-glucose index and acute kidney injury risk in critically ill patients with coronary artery disease by Yi Zhang, Gang Li, Junjie Li, Bohao Jian, Keke Wang, Jiantao Chen, Jian Hou, Jianbo Liao, Zhuoming Zhou, Zhongkai Wu, Mengya Liang

“…Additionally, the restricted cubic spline analysis revealed a non-linear association between the TyG index and the risk of AKI (P for non-linear =0.637). …”
Get full text

Intraocular pressure correlation to progressive retinal nerve fiber layer loss in primary open angle glaucoma as measured by standard and modified goldmann applanation tonometers by Sean McCafferty, Manjool Shah, Anupam Laul, Khin Kilgore

“…Outcome measures Pearson correlation coefficients and random coefficient models were used to evaluate the relationship between mean standard and modified IOP measurements and RNFL thickness measurements over time in POAG subjects. …”
Get full text

Comparison of Smile Parameters, Maxillary Arch Changes and Perceived Smile Attractiveness in Patients Treated with Conventional and Self-ligating Bracket Systems: An Observational... by Rieshy Vasudevan, Selvapriya Selvam, Shweta Nagesh

“…Pre- and post-treatment digital models were used to assess changes in intermolar and intercanine widths. …”
Get full text

Association between sleep disorder and delirium in adult patients undergoing cardiac surgery: a retrospective cohort study by Beibei Wang, Qiao Liu, Dou Dou, Dongyun Bie, Ran An, Yuan Jia, Su Yuan, Fuxia Yan

“…Multivariate logistic regression analysis was used to evaluate the effect of sleep disorders on delirium. …”
Get full text

Amivantamab versus standard therapies among patients with advanced non-small cell lung cancer and epidermal growth factor receptor exon 20 insertion mutations after platinum-based... by Lan Shen, Guangyuan Hu, Yan Wang, Jing Zhao, Xin Li, Jianmin Zhuo, Grace Kah Mun Low, Shun Lu

“…Patients from CHRYSALIS and EC cohort were included in the analysis at each qualifying line of therapy (n = 114 and n = 87). …”
Get full text

Correlations Between TyG-Related Indices and Bone Health: A Cross-Sectional Study of Osteoporosis in a Rural Chinese Population by Jia F, Lu Y, Wen H, Tu J, Ning X, Wang J, Li P

“…Multivariate regression models and restricted cubic spline (RCS) curves were used to assess the relationships between TyG indices and OP.Results: A total of 437 individuals were included in the final analysis, with 38 diagnosed with osteoporosis (prevalence of 8.7%). …”
Get full text

From gaps to compliance: a 12-year retrospective cohort study of trends in mismatch repair protein testing and Lynch syndrome identification in colorectal cancer in Central Switzer... by Bettina Marturet Fendt, Celina Geiss, Muriel Elhai, Joachim Diebold, Alexander Vogetseder

“…METHODS: This retrospective study enrolled 2602 patients with 2673 histologically confirmed colorectal cancers. …”
Get full text

Uptake of DU145 and LNCaP prostate cancer cell line derived extracellular vesicles is inversely correlated with blood–brain barrier integrity in vitro by Ana Špilak, Adrián Klepe, Sophia Theresa Kriwanek, Heinz-Peter Friedl, Andreas Brachner, Christa Nöhammer, Winfried Neuhaus

“…Methods Systematic optimization of the cell culture membrane insert set-up for sEV transport studies was accomplished with inserts with different pore sizes, varied coating procedures and medium compositions. …”
Get full text

Comparing survival outcomes of anti-fibrotic therapy for idiopathic pulmonary fibrosis with and without emphysema: a multi-center real-world study from Taiwan by Yu-Hung Fang, Yi-An Hsieh, Yen-Fu Chen, Yu-Chi Chiu, Yu-Ching Lin, Kuo-Tung Huang, Yung-Chia Huang, Yu-Feng Wei, Chien-Wen Huang, Pin-Kuei Fu, Taiwan Multi-Centre Interstitial Lung Disease Research Consortium

“…Cox proportional hazards models were used for multivariable analysis to identify factors associated with overall mortality during the follow-up period. …”
Get full text

Coordinated regulation of IGF1R by HIF1α and HIF2α enhances chemoresistance in glioblastoma by Bin Liao, Bin Liao, Pan Wang, Sheng Gong, Lu Zhao, Lu Zhao, Jie Liu, Jie Liu, Nan Wu, Nan Wu

“…Immunohistochemistry (IHC) was performed to detect the expression of HIF1α, HIF2α, and IGF1R in GBM tissues and cells, as well as oxygen tension. Cell cycle analysis, apoptosis assays, lactate dehydrogenase (LDH) release measurements, Western blotting, and xenograft tumor models were employed to explore the synergistic regulation of IGF1R by HIF1α and HIF2α, focusing on activation of the PI3K/AKT signaling pathway and its contribution to GBM drug resistance. …”
Get full text

Predicting right ventricular failure after left ventricular assist device implant: A novel approach by Carissa E. Livingston, Dale Kim, Lacey Serletti, Andrea Jin, Sriram Rao, Michael V. Genuardi, Eliot G. Peyster

“…Lastly, pre‐implant metrics were used to generate models for predicting post‐implant RVF phenogroup. …”
Get full text

Risks of All‐Cause Mortality in Adults With Chronic Kidney Disease With Sarcopenia or Obesity: A Population‐Based Study by Jin'e Li, Hua Tu, Yuying Zhang, Shiqi Yang, Peng Yu, Jianping Liu

“…Multivariable Cox proportional hazards models were constructed to explore the relationship between sarcopenia, fat mass and all‐cause mortality, with nonlinear relationships assessed using restricted cubic splines. …”
Get full text

Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer’s disease and dementia with lewy bodies by Jinghuan Gan, Ziming Xu, Chen Wen, Hao Wu, Zhichao Chen, Zhihong Shi, Hao Lu, Yajie Wang, Shuai Liu, Yong Ji

“…Demographic, clinical, and neuropsychological data were collected. The mediation analysis models were used to calculate the mediating effect of Aβ on the associations between orexin-A and BBB permeability in GP (reflected by K trans or Vp values). …”
Get full text

Dietary inflammatory index and mortality in middle-aged and elderly patients with metabolic syndrome by Xiangmei Li, Lei Liu, Xing Li, Long Yang, Li Men

“…Cox proportional hazards regression models were employed to assess the relationship between DII and mortality, with adjustments made for potential confounding factors. …”
Get full text

Sex differences in chronic kidney disease awareness among US adults, 1999 to 2018. by Sebastian Hödlmoser, Wolfgang C Winkelmayer, Jarcy Zee, Roberto Pecoits-Filho, Ronald L Pisoni, Friedrich K Port, Bruce M Robinson, Robin Ristl, Simon Krenn, Amelie Kurnikowski, Michał Lewandowski, Allison Ton, Juan Jesus Carrero, Eva S Schernhammer, Manfred Hecking

“…We aimed to investigate trends in CKD awareness and the association between individual characteristics and CKD awareness among US men versus women.<h4>Methods and findings</h4>We conducted a serial, cross-sectional analysis of 10 cycles (1999-2018) from the National Health and Nutrition Examination Survey (NHANES). …”
Get full text

Combined effects of nutrition, inflammatory status, and sleep quality on mortality in cancer survivors by Tingyu Zhao, Hui Zhao, Xiao Zhang, Xingyu Jiang, Qi Liang, Siqi Ni, Yi Jiao, Jiamei Yu, Jianghong Dai, Mulong Du, Lingxiang Liu

“…Weighted multivariable Cox proportional hazards regression models were utilized to explore the independent and combined effects of ALI and sleep quality on mortality outcomes. …”
Get full text

Uncovering the mechanistic basis of Rheum palmatum L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular docking, a... by Wenjing He, Zhen Wei, Siwei Li, Songji Han, Jing Ma, Lei Wu, Dan Lu, Guang Ta

“…In CKD rat models, rhubarb significantly improved renal function by reducing blood urea nitrogen (BUN), serum creatinine (SCr), and uric acid (UA) levels (p < 0.05). …”
Get full text