Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway by Zhixiong Jiang, Yating Yang, Jinchi Zhou, Xin Li, Qingqing Meng, Xiangyi Yu, Yaxin Xue, Mengyu Li, Yichen Cai, Pengchun Han, Mingjun Jiang, Huizhen Wang, Congrong Liu, Jing Zhao, Lixin Wan, Dengke Bao

“…However, its role in the metastasis of ESCC remains to be fully elucidated. Methods This study utilized database analysis and immunohistochemistry to evaluate the expression of Drp1 in ESCC tissues. …”
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Noradrenaline for progressive supranuclear palsy syndromes (NORAPS): a randomised, double-blind, placebo-controlled, crossover Phase IIb clinical trial evaluating the efficacy and... by Robert Durcan, Christopher Kobylecki, Lee Shepstone, James B Rowe, Alistair Church, Duncan Street, Vicky Marshall, Charlotte Russell, Luca Passamonti, Juliet High, Christopher T Rodgers, Boyd C P Ghosh, Kelly Grant, Natalia Igosheva, Hugo Paula, Colin McAlister, Simon P Jones, Rong Ye, Chrystalina Antoniades

“…Apathy and impulsivity are very common, often coexistent in PSP, and negatively predict survival. In preclinical models and other diseases, apathy and impulsivity are associated with noradrenergic deficits, which can be severe in PSP.Methods and analysis Noradrenaline for Progressive Supranuclear Palsy Syndromes trial is a randomised, double-blind, placebo-controlled, crossover design, Phase IIb clinical trial to evaluate the efficacy and safety of oral atomoxetine for the treatment of cognitive and behavioural changes in PSP. …”
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What is the effect of the Informed Health Choices secondary school intervention on the ability of students in Rwanda to think critically about health choices after one-year follow-... by Michael Mugisha, Laetitia Nyirazinyoye, Dieudonne Kayiranga, Clarisse Marie Claudine Simbi, Faith Chesire, Ronald Senyonga, Matt Oxman, Allen Nsangi, Christopher James Rose, Jenny Moberg, Astrid Dahlgren, Margaret Kaseje, Simon Lewin, Nelson K. Sewankambo, Sarah Rosenbaum, Andrew D. Oxman

“…We conducted an intention to treat analysis using generalized linear mixed models, accounting for the cluster design using random intercepts. …”
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High concordance of human immunodeficiency virus-1 genotypic drug resistance generated from paired cerebrospinal fluid and plasma in antiretroviral therapy -naive or -experienced p... by Xizi Deng, Jiaojiao Li, Ruiying He, Yingfen Wen, Yaqing Lin, Liya Li, Xuemei Ling, Fengyu Hu, Linghua Li, Yun Lan

“…To determine the HIV-1 genotypes, sequences were assessed with the Context-based Modelling for Expeditious Typing (COMET) tool, and the neighbour-joining (NJ) phylogenetic tree was used to confirm the results. …”
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Factors associated with head circumference and indices of cognitive development in early childhood by Matthew R Grigsby, William Checkley, Tahmeed Ahmed, Zulfiqar Ahmed Bhutta, Laura Nicolaou, Pascal Bessong, Margaret Kosek, Aldo A M Lima, Sanjaya Shrestha, Ram Chandyo, Estomih R Mduma, Laura Murray-Kolb, Brooks Morgan

“…To disentangle the associations between risk factors and HC from linear growth and to distinguish the direct and indirect effects of these risk factors on cognitive function, we conducted mediation analysis using longitudinal models to account for all data measured during follow-up.Results Average HC-for-age Z-score (HCAZ) was −0.54 (95% CI −0.47 to −0.62) near birth and −1.01 (95% CI −0.94 to −1.08) at 24 months. …”
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Probability of Starting Two-Drug Regimen (2DR) vs. Three-Drug Regimen (3DR) in ART-Naïve and ART-Experienced Person with HIV (PWH) Across the First Wave of COVID-19 Pandemic by Alessandra Vergori, Nicola Gianotti, Alessandro Tavelli, Camilla Tincati, Andrea Giacomelli, Elena Matteini, Giuseppe Lapadula, Lucia Taramasso, Loredana Sarmati, Antonella D’Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri, on behalf of the ICONA Foundation Study

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Autophagy and exosome dynamics in Radiation-Induced pulmonary fibrosis: the critical role of TRIB3 by Na Li, Wenyue Zhao, Jiale Li, Dengfeng Zhang, Kejun Li, Mengmeng Yang, Xinran Lu, Liqing Du, Chang Xu, Qiang Liu

“…We established mouse models with alveolar epithelial type II cells (AEC II)-specific knockdown or overexpression of TRIB3 to elucidate its role in RIPF progression. …”
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A nationwide retrospective cohort study of the association between acupuncture exposure and clinical outcomes of idiopathic Parkinson’s disease using health insurance claim data in... by Ye-Chae Hwang, Jungkuk Lee, Dongwoo Kang, Han-Gyul Lee, Seungwon Kwon, Seung-Yeon Cho, Seong-Uk Park, Woo-Sang Jung, Sang-Kwan Moon, Jung-Mi Park, Jungtae Leem, Chang-Nam Ko

“…Propensity score matching (PSM) was applied, and Cox proportional hazards models were used for survival analysis. During a 6-year follow-up, hazard ratios (HRs) were estimated for overall and cause-specific mortality, emergency room visits, fractures, and the first deep brain stimulation (DBS) procedure, using the non-acupuncture group as the reference. …”
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Same-visit hepatitis C testing and treatment to accelerate cure among people who inject drugs (the QuickStart Study): a cluster randomised cross-over trial protocol by Andrew B Forbes, Jessica Kasza, Thomas L Snelling, David Anderson, Joseph S Doyle, Peter Higgs, Margaret E Hellard, Nick Scott, Alisa E Pedrana, Alexander J Thompson, Jessica Howell, Timothy Spelman, Beatriz Camesella, Imogen Elsum, Kico Chan, Mark A Stoové, Paul M Dietze, Mellissa Bryant, Katherine Heath, Rodney Guzman, Caitlin Douglass, Amanda Wade, Kate Allardice, Sally Von Bibra, Jacqui Richmond, Nada Andric, Rachel Sacks‐Davis

“…Increasing DAA uptake by PWID is important for interrupting transmission and reducing incidence, as well as reducing morbidity and mortality and improving quality of life of PWID and meeting Australia’s hepatitis C elimination targets.Methods and analysis A cluster randomised cross-over trial will be conducted with three intervention arms and a control arm. …”
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Cerebrospinal fluid pressure dynamics as a biomechanical marker for quantification of spinal cord compression: Conceptual framework and systematic review of clinical trials by Najmeh Kheram, Madeleine A. Bessen, Claire F. Jones, Benjamin M. Davies, Mark Kotter, Mazda Farshad, Markus Hupp, Daniel Nanz, Patrick Freund, Martin Schubert, Vartan Kurtcuoglu, Armin Curt, Carl M. Zipser

“…Research question: Evidence for safety and feasibility of CSFP dynamics in clinical trials as well as interrelations with neuroimaging and intraspinal pressure, and relation to preclinical CSFP models. Material and methods: Systematic review. This review followed PRISMA guidelines, risk of bias assessment with ROBINS-I tool, PROSPERO registration (CRD42024545629). …”
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Development of a pan-genotypic monoclonal antibody-based competitive ELISA for the detection of antibodies against Bovine viral diarrhea virus by Shuhui Qi, Shuhui Qi, Jing Wang, Jing Wang, Ting Le, Chao Sun, Jitao Chang, Jitao Chang, Zhigang Jiang, Xin Yin, Quanhai Pang

“…IntroductionBovine viral diarrhea virus (BVDV), a positive-sense single-stranded RNA virus, causes significant economic losses in the cattle industry. Current diagnostic methods for BVDV exhibit variable sensitivity and specificity, underscoring the need for more rapid and accurate detection approaches. …”
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Metabolomic studies reveal and validate potential biomarkers of diabetic retinopathy in two Chinese datasets with type 2 diabetes: a cross-sectional study by Xingchen Zhou, Guixue Hou, Xin Wang, Zhaoyi Peng, Xiaoming Yin, Jing Yang, Shan Wang, Yayi He, Yue Wang, Jing Sui, Wei Qiang, Hui Guo, Yanan Wang, Liang Lin, Bingyin Shi, Mingqian He

“…Here, we aimed to identify serum metabolites as reliable biomarkers for the presence of DR in type 2 DM (T2DM) patients. Methods We performed untargeted and targeted metabolomic studies using liquid chromatography‒mass spectrometry (LC‒MS) and multiple reaction monitoring (MRM) methods on the serum samples of T2DM patients. …”
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Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study by Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

“…We used linear regression to identify determinants of impaired RV myocardial strain and Cox proportional hazards models to evaluate their associations with clinical outcomes. …”
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Can conventional brain MRI support the attribution process in neuropsychiatric SLE? A multicentre retrospective study by Carlo Alberto Scirè, Alessandra Bortoluzzi, Marcello Govoni, Matteo Piga, Antonis Fanouriakis, George Bertsias, Greta Carrara, Ettore Silvagni, Enrico Fainardi, Simone Appenzeller, Antonio Marangoni, Carlo Garaffoni

“…Univariable and multivariable logistic regression models were performed. A sensitivity analysis was performed using a revised AA, which excluded the item ‘presence of abnormal MRI’ from the list of favouring factors.Results Among 154 patients, 88 (57%) had NP events attributed to SLE by CJ and 85 (55%) by AA. …”
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Impact of the Composite Allocation Score on Lung Transplant Waitlist and Posttransplant Outcomes by Ye In Christopher Kwon, BA, Holly Caboti-Jones, BS, Michael Keller, BS, Andrew Min-Gi Park, BA, Alan Lai, BS, Rachit D. Shah, MD, Zachary Fitch, MD, Vigneshwar Kasirajan, MD, Vipul Patel, MD, Zubair A. Hashmi, MD

“…Recipient/donor characteristics and mortality risk factors were assessed with Cox models. Survival was evaluated with Kaplan-Meier analysis. …”
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Association between dietary patterns and sarcopenia among community-dwelling older adults in five provinces of China: a cross-sectional study by Rongchang Pu, Shanshan Jia, Xiaona Zhang, Qingqing Man, Qingqing Man, Dongmei Yu, Shuya Cai, Pengkun Song, Pengkun Song, Jian Zhang, Jian Zhang

“…Appendicular skeletal muscle mass (ASM), muscle strength and physical performance were assessed according to the Asian Sarcopenia Working Group (AWGS2019) criteria. Exploratory factor analysis was used to identify dietary patterns. Logistic regression models were used to examine the association between dietary patterns and sarcopenia.ResultsA total of 1,967 participants over the age of 65 were included in the study, and the prevalence of sarcopenia was 17.0%. …”
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Evaluation of two luteal support regimens, intramuscular progesterone and progesterone vaginal gel, for vitrified-warmed embryo transfer in women with chronic salpingitis: a single... by Li Yu, Yifan Luo, Pengyuan He, Mingzhu Bai, Liqun Lou, Juanjuan Yu, Mu Lv, Xinbao Zhang, Zuoshu Qin, Zhenbo Zhang

“…Univariate and multivariate logistic regression models were conducted to analyze pregnancy outcomes. …”
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Poor performance of PHQ-9 and GAD-7 in screening clinical depression and anxiety among a large sample of Chinese children and adolescents by Sifan Wang, Jin Lu, Guiqing Zheng, Yandie He, Shuqing Liu, Yi Xiang, Xinyi Liu, Xiang Wang, Yuanyuan Xiao

“…We aim to investigate the performance and optimal cut-offs of PHQ-9 and GAD-7 in Chinese children and adolescents in screening clinical depression and anxiety, and to discuss the influencing factors of the cut-offs. Methods The study subjects were chosen from 3 sites of the Mental Health Survey for Children and Adolescents in Yunnan (MHSCAY), a total of 2,237 participants who had been screened positive by self-administered questionnaire and further diagnosed by using the gold standard were included in the final analysis. …”
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In-person vs mobile app facilitated life skills education to improve the mental health of internally displaced persons in Nigeria: protocol for the RESETTLE-IDPs cluster randomized... by Ejemai Eboreime, Chisom Obi-Jeff, Rita Orji, Tunde M Ojo, Ihoghosa Iyamu, Bala I Harri, Jidda M Said, Funmilayo Oguntimehin, Abdulrahman Ibrahim, Omolayo Anjorin, Andem Effiong Etim Duke, Umar Baba Musami, Linda Liebenberg, Raquel Crider, Lydia Wagami, Asmau MC Dahiru, Jesse C. Uneke, Sanni Yaya, Vincent IO Agyapong

“…Quantitative data will be analyzed using mixed-effects linear regression models, while qualitative data will be examined through reflexive thematic analysis. …”
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The endothelial activation and stress index is a potential prognostic indicator for patients with acute pancreatitis managed in the intensive care unit: a retrospective study by Jianjun Wang, Jianjun Wang, Xi Chen, Chuan Qin, Xintao Zeng, Xiaobo Du, Decai Wang, Decai Wang

“…Hence, we investigated the prognostic value of EASIX in AP.MethodsThis was a retrospective study, using patient information obtained from the Medical Information Market for Intensive Care-IV (MIMIC-IV) database. …”
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