Prognostic value of the vasoactive-inotropic score in predicting outcomes following LVAD implantation by Taylor Pickering, DO, Kyle A. McCullough, MD, Cody W. Dorton, DO, David A. Rawitscher, MD, J. Michael DiMaio, MD, Nitin Kabra, MD, Greg Milligan, MD, Akash Rusia, MD, Patrick Ogbue, MD, Aasim Afzal, MD, Timothy J. George, MD

“…The vasoactive-inotropic score (VIS), which quantifies vasoactive support, may predict outcomes in this population. Methods: A retrospective analysis of 146 patients undergoing HeartMate 3 LVAD implantation from 2017 to 2024 at a single institution was performed. …”
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Does Empirical Antibiotic Use Improve Outcomes in Ventilated Patients with Pandemic Viral Infection? A Multicentre Retrospective Study by Elisabeth Papiol, Julen Berrueta, Juan Carlos Ruíz-Rodríguez, Ricard Ferrer, Sara Manrique, Laura Claverias, Alejandro García-Martínez, Pau Orts, Emili Díaz, Rafael Zaragoza, Marco Marotta, María Bodí, Sandra Trefler, Josep Gómez, Ignacio Martín-Loeches, Alejandro Rodríguez

“…<b>Objective:</b> To evaluate whether EAT at ICU admission reduces ventilator-associated pneumonia (VAP) incidence or ICU mortality in critically ill patients with pandemic viral pneumonia, stratified by presence of COI. <b>Methods:</b> This retrospective analysis combined two national multicentre ICU registries in Spain, including 4197 adult patients requiring invasive mechanical ventilation for influenza A(H1N1) or COVID-19 between 2009 and 2021. …”
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Evaluating the Efficacy of Gelatin-Chitosan-Tetraethyl Orthosilicate Calcium Hydroxide Composite as a Dental Pulp Medicament on  COX-2, PGP 9.5, TNF-α Expression and Neutrophil num... by Yulita Kristanti, Mh Busra Fauzi, Bidhari Pidhatika, Iwa Sutardjo Rus Sudarso, Retno Ardhani, Al-qatta Ghadah Abdulrahman, Endytiastuti Endytiastuti, Heni Susilowati, Juni Handajani

“…The objective of this study was to evaluate the effect of composites containing gelatin (G), chitosan (CH), tetraethyl orthosilicate (TEOS), and Ca(OH)2, namely G-CH-TEOS-Ca (OH)2 (Extended data) on inflammation of the dental pulp (expression of COX-2, PGP 9.5, TNF-α, and neutrophil number). Materials and methods A total of 16 Wistar rat models of acute pulp injury were prepared and divided into two groups, treatment and control, 8 with each. …”
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The relationship between vitamin D levels and Alzheimer’s disease risk: insights from a centenarian study of Chinese women by Yupeng Li, Xujie Wang, Mei Yu, Fei Wang, Dong Song, Musong Liu, Xu Liang, Hongzhou Liu, Jiangbo Liu, Shihui Fu, Shihui Fu, Xuhui Liu

“…Serum 25(OH)D and biochemical markers were measured using standardized laboratory protocols. Logistic regression models (unadjusted and progressively adjusted) assessed associations between 25(OH)D and AD. …”
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Statins for extension of disability-free survival and primary prevention of cardiovascular events among older people: protocol for a randomised controlled trial in primary care (ST... by Rory Wolfe, Christopher M Reid, Andrew Tonkin, John J McNeil, Mark Nelson, Sophia Zoungas, Stephanie A Ward, Stephen J Nicholls, Geoffrey Cloud, Ingrid Hopper, Andrea Curtis, Joanne Ryan, Lawrence Beilin, Anthony Wierzbicki, Simone Spark, Trevor T-J Chong, Alissia Kost

“…This paper presents the protocol for the STAtins in Reducing Events in the Elderly (STAREE) trial, a randomised double-blind placebo-controlled trial examining the effects of statins in community dwelling older people without CVD, diabetes or dementia.Methods and analysis We will conduct a double-blind, randomised placebo-controlled trial among people aged 70 years and over, recruited through Australian general practice and with no history of clinical CVD, diabetes or dementia. …”
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Effectiveness of bright light therapy and combination with myopic defocus for controlling myopic eye growth in schoolchildren: study protocol for a randomised controlled trial (pha... by Dennis Yan-yin Tse, Rachel Ka Man Chun, Chi Ho To, Ian G Morgan, Jinxiao Lian, Carly SY Lam, Wai-Ching Lam, Christopher Kai Shun Leung, Lai Ming Ho, Ying Hon, Billy Kin Kwok Cheung, Desmond Man Kit Lam, Andy Chi Wai Kong, Thomas C Lam

“…This study hypothesises that bright light therapy (BLT), delivered via a home-based device mimicking sunlight, could slow myopia progression in schoolchildren.Methods and analysis We propose a 2-year, double-masked, randomised controlled trial to investigate the effectiveness of BLT and its combination with myopia control treatment in schoolchildren. …”
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Contemporary carotid artery stenting practices and peri-procedural outcomes in different European countries: ROADSAVER study multicentric insights by Stefan Müller-Hülsbeck, Zsolt Vajda, Piotr Odrowąż-Pieniążek, Zoltán Ruzsa, Roel Beelen, Aleksandar Gjoreski, Koen Deloose, Sérgio Castro, Benjamin Faurie, Alejandro Tomasello Weitz, Arne Schwindt, Paweł Latacz, Antonio Orgaz Pérez-Grueso, Vladimir Cvetić, Ralf Langhoff, Sasko Kedev, all ROADSAVER study investigators

“…The primary outcome measure was the 30-day rate of major adverse events, defined as any death or stroke occurring within 30 days post-procedure. This sub-analysis compared patient characteristics and procedural techniques across 13 participating countries and investigated differences in outcomes via logistic regression modelling. …”
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A practice and exploration of blended learning in medical morphology during the post-COVID-19 pandemic era by Qinlai Liu, Na Yuan, Yongan Wang, Beibei Sun, Leiying Yang, Zhaopeng Wang, Chen Fang, Wenping Sun, Baihua Luo, Yaling Liu, Xin Liu, Li Ge

“…It also has substantial promotional instructive modeling value. Clinical trial registration Not applicable.…”
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Comparison of robustness, resilience and intrinsic capacity including prediction of long-term adverse health outcomes: The KORA-Age study by Michaela Rippl, Marie-Theres Huemer, Lars Schwettmann, Eva Grill, Annette Peters, Michael Drey, Barbara Thorand

“…We therefore aimed to assess which concept is most useful for determining long-term health of older adults. Methods: Analyses were based on the KORA (Cooperative Health Research in the Region of Augsburg)-Age study (n = 940, 65–93 years). …”
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Effectiveness of CONUT and NRI as nutritional risk screening tools in peritoneal dialysis: a multicenter study by Wenlong Qiu, Wenlong Qiu, Rui Chu, Rui Chu, Yaqi Ma, Yaqi Ma, Jiaxin Xue, Jiaxin Xue, Qingdong Xu, Yueqiang Wen, Xiaojiang Zhan, Fenfen Peng, Xiaoyang Wang, Juan Wu, Ning Su, Xiaoran Feng, Xingming Tang, Xianfeng Wu, Qian Zhou, Na Tian, Na Tian

“…This study investigates whether different nutritional assessment methods, like the Controlling Nutritional Status (CONUT) score and Nutritional Risk Index (NRI), correlate with patient prognosis, highlighting the importance of selecting appropriate screening tools to improve clinical outcomes in PD patients.MethodsThis multicenter retrospective cohort study initially collected data from 2,427 patients across 10 centers, but ultimately included a cohort of 2,105 PD patients to evaluate the prevalence of malnutrition assessed using both the CONUT and NRI and its independent effects on all-cause mortality. …”
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Innovation Ecosystem of Iran's Tourism Industry with Emphasis on Supply Chain by Azizolah Jafari, mahdi alaei kerahrudi

“…On the other hand, innovation ecosystems have gained increasing importance in the last decade, and so far, numerous studies and models of innovation ecosystems have been presented in different industries and sectors. …”
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Using Nebular Near-infrared Spectroscopy to Measure Asymmetric Chemical Distributions in 2003fg-like Thermonuclear Supernovae by J. O’Hora, C. Ashall, M. Shahbandeh, E. Hsiao, P. Hoeflich, M. D. Stritzinger, L. Galbany, E. Baron, J. DerKacy, S. Kumar, J. Lu, K. Medler, B. Shappee

“…We quantify the asymmetry of these features using five methods: velocity at peak flux, profile tilts, residual testing, velocity fitting, and comparison to deflagration–detonation transition models. …”
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JWST COMPASS: NIRSpec/G395H Transmission Observations of the Super-Earth TOI-776 b by Lili Alderson, Sarah E. Moran, Nicole L. Wallack, Natasha E. Batalha, Nicholas F. Wogan, Anne Dattilo, Hannah R. Wakeford, Jea Adams Redai, Munazza K. Alam, Artyom Aguichine, Natalie M. Batalha, Anna Gagnebin, Peter Gao, James Kirk, Mercedes López-Morales, Annabella Meech, Johanna Teske, Angie Wolfgang

“…For both reductions, a flat line is preferred for Visit 1 while a flat line with an offset between the NRS1 and NRS2 detectors is preferred for Visit 2; however, we are able to correct for this offset during our modeling analysis following methods outlined in previous works. …”
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Effectiveness of oral step-down therapy and early oral switch for bloodstream infections caused by Enterobacterales: A post hoc emulation trial of the SIMPLIFY trial by Emanuele Rando, Mercedes Delgado-Valverde, Josune Goikoetxea Aguirre, Laura Guio Carrión, María José Blanco Vidal, José Luis Barrios Andrés, María Teresa Pérez Rodríguez, Lucía Martínez Lamas, Francisco Arnaiz de las Revillas, Carlos Armiñanzas, Carlos Ruiz de Alegría-Puig, Patricia Jiménez Aguilar, María del Carmen Martínez-Rubio, Carmen Sáez-Béjar, Carmen de las Cuevas, Andrés Martín-Aspas, Fátima Galán, José Ramón Yuste, José Leiva-León, Germán Bou, Patricia Capón González, Lucía Boix-Palop, Mariona Xercavins-Valls, Miguel Ángel Goenaga-Sánchez, Diego Vicente Anza, Juan José Castón, Manuel Recio Rufián, Esperanza Merino, Juan Carlos Rodríguez, Belén Loeches, Clara Rosso-Fernández, José María Bravo-Ferrer, Pilar Retamar-Gentil, Jesús Rodríguez-Baño, Luis Eduardo López Cortés

“…Objectives: We investigated the effectiveness of early oral switch for treating Enterobacterales bloodstream infection (BSI) by performing a post hoc emulation trial of the SIMPLIFY trial. Methods: We conducted a post hoc analysis of a randomized controlled trial. …”
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Machine learning approaches to identify neonates and young children at risk for postdischarge mortality in Dar es Salaam, Tanzania and Monrovia, Liberia by Rodrick Kisenge, Todd A. Florin, Cynthia G. Whitney, Michelle Niescierenko, Julia Kamara, Abraham Samma, Evance Godfrey, Chris A. Rees, Readon C. Ideh, Ye-Jeung G. Coleman-Nekar, Hussein K. Manji, Christopher R. Sudfeld, Adrianna L. Westbrook, Claudia R. Morris, Karim P. Manji, Christopher P. Duggan, Rishikesan Kamaleswaran

“…Our objective was to determine if machine learning models would have greater discriminatory value to identify neonates and young children at risk for postdischarge mortality.Methods We conducted a planned secondary analysis of a prospective observational cohort at Muhimbili National Hospital in Dar es Salaam, Tanzania and John F. …”
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Functional Improvement Trajectories After Surgery (FIT After Surgery) study: protocol for a multicentre prospective cohort study to evaluate significant new disability after major... by E Jacobsohn, Duminda N Wijeysundera, Gerald Lebovic, M Davis, Martine T E Puts, Shabbir M H Alibhai, Karim S Ladha, C Wong, Daniel I McIsaac, C Hanley, T Barnes, G Lorello, N Siddiqui, P Serrano, Tyler R Chesney, S Choi, J Van Vlymen, D Sussman, D Macdonald, P Jüni, Emily Hladkowicz, C David Mazer, M Bosch, CD Mazer, A Jerath, J Pazmino-Canizares, E Kennedy, R Spence, V Lyon, Alice C Wei, Julian F Daza, Sahar Ehtesham, Janet M van Vlymen, DN Wijeysundera, KS Ladha, JF Daza, G Mattina, E Hladkowicz, M Tessier, S Ehtesham, S Nnorom, SMH Alibhai, M Puts, G Lebovic, TR Chesney, AC Wei, S Drozdz, M Louridas, RH Breau, M Lalu, S Abdellatif, S Gagne, E Duceppe, K Zarnke, D Dumerton, M Karizhenskaia, H El Beheiry, F Bonazza, A Zahavich, M Thorleifson, S L Russell, H Bagry, SY MacDonell, J Dale-Gandar, L Kaustov, A Fleet, E Al Azazi, M Parotto, S A McCluskey, H Poonawala, D Dillane, Di McIsaac, S Avramescu, S Shabeen

“…We propose that postoperative disability is an important patient-centred outcome to measure intermediate-to-long recovery after major surgery in older adults.Methods and analysis The Functional Improvement Trajectories After Surgery (FIT After Surgery) study is a multicentre cohort study of 2000 older adults (≥65 years) having major non-cardiac surgery. …”
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Tacrolimus IPV Group Membership Does Not Consistently Track With Electronically Monitored or Self-reported Adherence in Adolescent and Young Adult Kidney Transplant Recipients by Cyd K. Eaton, PhD, Cozumel S. Pruette, MD, MHS, Kristin A. Riekert, PhD, Nazanin Yousefzadeh, MS, Ahna L. Pai, PhD, Sandra Amaral, MD, MHS, Vikas R. Dharnidharka, MD, MPH, Bärbel Knäuper, PhD, Jodi M. Smith, MD, MPH, Susan L. Furth, MD, PhD, Bethany J. Foster, MD, MSCE

“…However, the association between tacrolimus IPV and electronically monitored or self-reported adherence is unknown. Methods. This secondary analysis of the TAKE-IT (Teen Adherence in Kidney Transplant Effectiveness of Intervention Trial) compared electronically monitored and self-reported adherence between participants with high and low tacrolimus IPV among 103 adolescent and young adult kidney transplant recipients (mean age = 15.18 y, 59% male, 60% White, 65% >1-y posttransplant). …”
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CRO-INSIGHT: Utilization of Implantable Cardioverter Defibrillators in Non-ischemic and Ischemic Cardiomyopathy in a Single Croatian Tertiary Hospital Centre by Mislav Puljevic, Eugen Ciglenecki, Vedran Pasara, Ivan Prepolec, Mia Dubravcic Dosen, Pero Hrabac, Ana-Marija Brekalo, Martina Lovric Bencic, Miroslav Krpan, Richard Matasic, Borka Pezo-Nikolic, Davor Puljevic, Davor Milicic, Vedran Velagic

“…Statistical analyses included a detailed descriptive analysis, Kaplan–Meier survival estimates, and Cox regression models. …”
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Do preoperative interventions affect patient satisfaction or expectation fulfilment following total hip arthroplasty? A systematic review by April-Rose Matt, Joanne L. Kemp, Andrea B. Mosler, Lucy Salmon, Diogo Almeida Gomes, Alysha De Livera, Erica Hateley, Adam L. Semciw

“…Methods: MEDLINE, EMBASE, Cochrane Register of Clinical Trials, CINAHL and Sports Discus were searched from inception to May 2023. …”
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The Synthesis and Characterization of CdS Nanostructures Using a SiO₂/Si Ion-Track Template by Aiman Akylbekova, Kyzdarkhan Mantiyeva, Alma Dauletbekova, Abdirash Akilbekov, Zein Baimukhanov, Liudmila Vlasukova, Gulnara Aralbayeva, Ainash Abdrakhmetova, Assyl-Dastan Bazarbek, Fariza Abdihalikova

“…For the first time, CdS nanostructures with orthorhombic crystal structure were obtained using track templating synthesis, and the density of electronic states was modeled using quantum–chemical calculations. Comparative analysis of experimental and calculated data of nanostructure parameters showed good agreement and are confirmed by the results of other authors.…”
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