Progression of the first stage of spontaneous labour: A prospective cohort study in two sub-Saharan African countries. by Olufemi T Oladapo, Joao Paulo Souza, Bukola Fawole, Kidza Mugerwa, Gleici Perdoná, Domingos Alves, Hayala Souza, Rodrigo Reis, Livia Oliveira-Ciabati, Alexandre Maiorano, Adesina Akintan, Francis E Alu, Lawal Oyeneyin, Amos Adebayo, Josaphat Byamugisha, Miriam Nakalembe, Hadiza A Idris, Ola Okike, Fernando Althabe, Vanora Hundley, France Donnay, Robert Pattinson, Harshadkumar C Sanghvi, Jen E Jardine, Özge Tunçalp, Joshua P Vogel, Mary Ellen Stanton, Meghan Bohren, Jun Zhang, Tina Lavender, Jerker Liljestrand, Petra Ten Hoope-Bender, Matthews Mathai, Rajiv Bahl, A Metin Gülmezoglu

“…We independently applied survival analysis and multistate Markov models to estimate the duration of labour centimetre by centimetre until 10 cm and the cumulative duration of labour from the cervical dilatation at admission through 10 cm. …”
Get full text

The Effect of Randomized Beta-Carotene Supplementation on CKD in Men by Api Chewcharat, Pol Chewcharat, Kathryn M. Rexrode, Robert J. Glynn, Julie E. Buring, John Michael Gaziano, Howard D. Sesso

“…Previous studies in animal models have demonstrated a potential protective effect of 30 mg/kg BC supplementation on renal ischemia or reperfusion injury and subsequently improved kidney function. …”
Get full text

Cardiovascular risk in childhood and young adulthood is associated with the hemodynamic response function in midlife: The Bogalusa Heart Study by Kai-Cheng Chuang, Maryam Naseri, Sreekrishna Ramakrishnapillai, Kaitlyn Madden, Julia St Amant, Kevin McKlveen, Kathryn Gwizdala, Ramasudhakar Dhullipudi, Lydia Bazzano, Owen Carmichael

“…The HRF has the potential to quantify neurovascular mechanisms by which cardiovascular risks modify brain health, but relationships among HRF characteristics, brain health, and cardiovascular modifiers of brain health have not been well studied to date. Methods: One hundred and thirty-seven middle-aged participants (mean age: 53.6 ± 4.7, female (62 %), 78 % White American participants and 22 % African American participants) in the exploratory analysis from Bogalusa Heart Study completed clinical evaluations from childhood to midlife and an adaptive Stroop task during fMRI in midlife. …”
Get full text

Associations between smartphone GPS data and changes in psychological health and burden outcomes among family caregivers and patients with advanced cancer: an exploratory longitudi... by J. Nicholas Odom, Kyungmi Lee, Erin R. Harrell, Kristen Allen Watts, Avery C. Bechthold, Sally Engler, Frank Puga, Natashia Bibriescas, Arif H. Kamal, Christine S. Ritchie, George Demiris, Alexi A. Wright, Marie A. Bakitas, Andres Azuero

“…After pre-processing raw GPS data into daily GPS features (e.g., time spent at home, distance traveled/day), computing biweekly moving averages and standard deviations, and conducting a principal components analysis (PCA) of the resulting variables, within-person regression models were used to assess associations between changes in PRO measures and changes in PCA scores, with adjusted-R2 as the measure of effect size (small = 0.02, medium = 0.13, large = 0.26). …”
Get full text

Insights into structure and activity of a UDP-GlcNAc 2-epimerase involved in secondary cell wall polymer biosynthesis in Paenibacillus alvei by Cordula Stefanović, Max S. G. Legg, Nick Mateyko, Jakob J. Ender, Tea Kuvek, Chris Oostenbrink, Christina Schäffer, Stephen V. Evans, Fiona F. Hager-Mair

Get full text

Seasonal Variation of Length-Weight Relationship and Some Biological Parameters in the Fish Cyprinion watsoni (Day, 1872) of Sarbaz River by Mohammad Borhani, Mohammadreza Rahmani, Mohammad Purki, Bagher Nezami Balochi

“…Therefore, obtaining information about the relationship length-weight, along with fecundity and gonadal indices, especially during one year, is effective not only in estimating models for the evaluation of aquatic resources but also in understanding their biological aspects, which are a sign of the sustainable dynamics of their population and the health of aquatic ecosystems.Materials and Methods: According to the little available data about Sheydaar fish (Cyprinion watsoni), to understand the annual fluctuations of the length-weight relationship and some other parameters, 100 Cyprinion watsoni fish were collected between May 2015 and July 2016 using fishing nets from the Sarbaz River. …”
Get full text

Preoperative level of sex hormones as a predictor (prognostic factor) of the morphological characteristics of testicular malignancies by R. F. Kholbobozoda, A. A. Kostin, N. V. Vorobyev, A. O. Tolkachev, A. A. Krasheninnikov, I. A. Taraki, A. D. Kaprin

“…Aim of the study: to analyze the relationship between hormone levels and the clinical stage and histological characteristics of the tumor in patients with testicular cancer and to develop prognostic models. Material and Methods. This prospective single-center study included 66 patients with testicular cancer. …”
Get full text

The extracellular matrix protein type I collagen and fibronectin are regulated by β-arrestin-1/endothelin axis in human ovarian fibroblasts by Ilenia Masi, Flavia Ottavi, Valentina Caprara, Danila Del Rio, Martina Kunkl, Francesca Spadaro, Valerio Licursi, Loretta Tuosto, Anna Bagnato, Laura Rosano’

Get full text

Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia by Maksim Mamonkin, Malcolm K Brenner, Norihiro Watanabe, Pinar Ataca Atilla, Mary K McKenna, Haruko Tashiro, Madhuwanti Srinivasan, Feiyan Mo, Brian Wesley Simons, Alexandra McLean Stevens, Michele S Redell, Helen E Heslop, Erden Atilla

“…Here, we optimized our CLL-1 CAR for anti-leukemic activity in mouse xenograft models of aggressive AML.Methods First, we optimized the CLL-1 CAR using different spacer, transmembrane and costimulatory sequences. …”
Get full text

Video game-based application for fall risk assessment: a proof-of-concept cohort studyResearch in context by Antao Ming, Tanja Schubert, Vanessa Marr, Jaqueline Hötzsch, Sebastian Stober, Peter R. Mertens

“…By data analyses using binary machine learning models a classification of participants was achieved and compared with actual fall events reported for the past 24 months. …”
Get full text

Effectiveness of a Mobile Phone-Delivered Multiple Health Behavior Change Intervention (LIFE4YOUth) in Adolescents: Randomized Controlled Trial by Anna Seiterö, Pontus Henriksson, Kristin Thomas, Hanna Henriksson, Marie Löf, Marcus Bendtsen, Ulrika Müssener

“…Effects were estimated using multilevel models with adaptive intercepts (per individual) and time by group interactions, adjusted for baseline age, sex, household economy, and self-perceived importance, confidence, and know-how to change behaviors. …”
Get full text

ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function by Yang Wang, Wei Zhang, Yu Zhang, Ling Chen, Shiyu Wang, Kun Song, Feng Yu, Jing Ouyang, Shan Cao, Cong Peng, Dongbo Liu, Yingying Dai, Wenwu Pei, Ziyang Hong, Weihua Huang, Yijing He, Panpan Liu, Hanying Yi, Gan Zhou, Howard McLeod

“…Inhibiting ADRB2 with β-blockers has demonstrated potential in boosting the effectiveness of immune checkpoint inhibitors across a spectrum of cancers, yet the precise mechanisms remain to be fully elucidated.Methods In vivo and in vitro experiments were performed to evaluate the role of ADRB2 in melanoma models, including its effects on T cells. …”
Get full text

Psychological Well-Being in Adults Across the COVID-19 Pandemic: A Two-Year Longitudinal Study by Melanie Ehrler, Melanie Ehrler, Melanie Ehrler, Alexandra Vogt, Alexandra Vogt, Dominique Eichelberger, Matthias Greutmann, Cornelia F. Hagmann, Cornelia F. Hagmann, Oskar G. Jenni, Oskar G. Jenni, Oskar G. Jenni, Oliver Kretschmar, Oliver Kretschmar, Markus A. Landolt, Markus A. Landolt, Markus A. Landolt, Markus A. Landolt, Beatrice Latal, Beatrice Latal, Beatrice Latal, Beatrice Latal, Flavia M. Wehrle, Flavia M. Wehrle, Flavia M. Wehrle

“…Latent variable mixture modelling identified subgroups with distinct trajectories of well-being. …”
Get full text

Aurora kinase A promotes hepatic stellate cell activation and liver fibrosis through the Wnt/β-catenin pathway by Guanqi Dai, Guanqi Dai, Junhao Lin, Yuchuan Jiang, Yuchuan Jiang, Xinhui Liu, Peng Chen, Yixiao Zhang, Zhenghui Song, Xuefen Zhuang, Jinge Cong, Yingchun Li, Xuanjia Hong, Yun Liu, Dong Xiao, Dong Xiao, Aimin Li, Yue Luo

“…This study aimed to investigate the impact and underlying mechanism of AURKA on liver fibrosis and to assess the therapeutic potential of MLN8237, a small-molecule AURKA inhibitor, in preventing liver fibrosis in mice.MethodsThe research used bioinformatics analysis and immunohistochemistry staining on fibrotic liver tissues from human and mouse models to assess AURKA expression. …”
Get full text

Allergen-specific circulating CLA+ memory T cells stratify IL-22 response in atopic dermatitis skin by Irene García-Jiménez, Irene García-Jiménez, Lídia Sans-de San Nicolàs, Sandra Díez-Ribas, Laia Curto-Barredo, Marta Bertolín-Colilla, Ana Vivancos-Melenchón, Ignasi Figueras-Nart, Montserrat Bonfill-Ortí, Anna Ryzhkova, Marta Ferran, Tali Czarnowicki, Ramon M. Pujol, Luis F. Santamaria-Babí

“…BackgroundCurrent understanding of IL-22 in atopic dermatitis (AD) mostly relies on animal models, intracellular staining of polyclonally activated peripheral lymphocytes, and biological therapies.MethodsWe evaluated the IL-22 response to house dust mite (HDM) extract in 58 patients with moderate-to-severe AD using a coculture system made of circulating memory cutaneous lymphocyte associated antigen (CLA)+/− T cells with autologous lesional epidermal cells. …”
Get full text

The state of the science of interprofessional collaborative practice: A scoping review of the patient health-related outcomes based literature published between 2010 and 2018. by May Nawal Lutfiyya, Linda Feng Chang, Cynthia McGrath, Clark Dana, Martin S Lipsky

“…Eight outcome categories emerged from a content analysis of the findings of the reviewed studies.<h4>Conclusions</h4>The results suggest a need for more research on the measurable impact of interprofessional collaborative practice and/or care on patient health-related outcomes to further document its benefits and to explore the models, systems and nature of collaborations that best improve population health, increase patient satisfaction, and reduce cost of care.…”
Get full text

Rationale and design of healthy at home for COPD: an integrated remote patient monitoring and virtual pulmonary rehabilitation pilot study by Laurel O’Connor, Stephanie Behar, Seanan Tarrant, Pamela Stamegna, Caitlin Pretz, Biqi Wang, Brandon Savage, Thomas Thomas Scornavacca, Jeanne Shirshac, Tracey Wilkie, Michael Hyder, Adrian Zai, Shaun Toomey, Marie Mullen, Kimberly Fisher, Emil Tigas, Steven Wong, David D. McManus, Eric Alper, Peter K. Lindenauer, Eric Dickson, John Broach, Vik Kheterpal, Apurv Soni

“…This paper details the recruitment, methods, and analysis plan for the study, which is recruiting 100 participants in its pilot phase. …”
Get full text

Use of real-world data to study health services utilisation and comorbidities in long-term breast cancer survivors (the SURBCAN study): study protocol for a longitudinal population... by Xavier Castells, Beatriz Poblador-Plou, Alexandra Prados-Torres, Maria Sala, Javier Gorricho, Anna Jansana, Isabel Del Cura, Teresa Sanz Cuesta, A Gimeno Miguel, Manuela Lanzuela, Berta Ibañez, Ibai Tamayo, Conchi Moreno-Iribas, María Padilla-Ruiz, Maximino Redondo, Mercè Comas, Laia Domingo, Antonio Díaz-Holgado, Francisco Javier Salamanca, Mercè Abizanda, Talita Duarte, Javier Louro, María del Carmen Martínez, Cristóbal Molina, Guillermo Pérez, Ana María Muñoz, Óscar Toldos, Javier Baquedano, Rossana Burgui

“…The aim of the SURBCAN study is to describe comorbidity, healthcare services use and adherence to preventive recommendations in long-term breast cancer survivors and to compare them with those in women without this diagnosis in order to improve and adapt the care response to this group of survivors.Methods and analysis Population-based retrospective cohort study using real-world data from cancer registries and linked electronic medical records in five Spanish regions. …”
Get full text

EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines by Bin Xu, Xiangnan Liang, Wuguang Liu, BaiTong Wu, Qiuxiang Wang, Gong Kai, Chun Han, Binwen Sun, Bing Dong, Chengyong Dong, Liming Wang

“…Additionally, we established xenograft tumor models to explore the impact of EPHX1 on the in vivo efficacy of regorafenib. …”
Get full text

Maternal exposure to per- and polyfluoroalkyl substances and epitope level antibody response to vaccines against measles and rubella in children from the Boston birth cohort by Xiumei Hong, William R. Morgenlander, Kari Nadeau, Guoying Wang, Pamela A. Frischmeyer-Guerrerio, Colleen Pearson, William G. Adams, Hongkai Ji, H. Benjamin Larman, Xiaobin Wang

“…However, research about the impact of PFAS exposure on antibody responses to the measles, mumps, rubella (MMR) vaccine is limited and inconsistent. Methods: This report includes 748 mother–child pairs from the Boston Birth Cohort, with 8 PFAS compounds measured in maternal plasma shortly after delivery. …”
Get full text