Bone bruising severity after anterior cruciate ligament rupture predicts elevation of chemokine MCP‐1 associated with osteoarthritis by Lukas G. Keil, Douglas S. Onuscheck, Lincoln F. Pratson II, Ganesh V. Kamath, Robert A. Creighton, Daniel B. Nissman, Brian G. Pietrosimone, Jeffrey T. Spang

“…We sought to characterize the severity of bone bruising following acute anterior cruciate ligament injury and determine if it correlates with synovial fluid and serum levels of the proinflammatory chemokine monocyte chemoattractant protein‐1 associated with posttraumatic osteoarthritis. Methods This was a retrospective analysis of data collected prospectively from January 2014 through December 2016. …”
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Skills Development and Graduate Employability in the Tourism and Hospitality Sector of Southwestern Uganda: A Case of Kabale District by Tushabe, Sylivia Byarugaba

“…This study investigated the relationship between skills development and graduate employability, with a focus on alumni from higher education institutions (HEIs) in Kabale District, southwestern Uganda. A mixed-methods approach, integrating correlational and case study designs, was employed to capture both statistical relationships and contextual insights. …”
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Symptomatic, biochemical and radiographic recovery in patients with COVID-19 by Onn Min Kon, Chloe I Bloom, Felicity Liew, Kartik Kumar, Clare Ross, laura Martin, Jian Chen, Jamilah Meghji, Dominic Hampson, Patrick Mallia, Brandon Wong, Victoria Pilkington, Shaan Chhabra, Ben Russell, Karthikan Srikanthan, Mirae Park, Harriet Owles, Joana Alcada, Meg Coleman, Sarah Elkin, Shweta Agrawal, Thomas Gardiner, Aaron Bell, Alice White, Gauri Vithlani, Kavina Manalan, Solange Bramer, Alejandra Martin Segura, Anushree Kucheria, Prashanthi Ratnakumar, Alexander Sheeka, Lavanya Anandan, Susan Copley, Georgina Russell

“…Background The symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.Methods Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. …”
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Sex-specific associations of adiposity with cardiometabolic traits in the UK: A multi-life stage cohort study with repeat metabolomics. by Linda M O'Keeffe, Joshua A Bell, Kate N O'Neill, Matthew A Lee, Mark Woodward, Sanne A E Peters, George Davey Smith, Patricia M Kearney

“…Using linear regression models, sex-specific associations of adiposity measures at each time point (9 y, 15 y, and 18 y) with cardiometabolic traits 3 to 6 y later were examined in G1. …”
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PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1 by Lu Liu, Lan Liu, Chenjing Yue, Shiyu Du, Jiayu Liu, Zhenhai Yu

“…Statistical analyses were conducted using GraphPad Prism 7.0, employing parametric tests for normally distributed data and non-parametric methods otherwise, with Benjamini-Hochberg correction for multiple comparisons. …”
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Applications of BCI and VR in cognitive diagnosis and treatment by Xianglong WAN, Anfeng FU, Yiduo YAO, Tiange LIU, Dingna DUAN, Xueguang XIE, Hao YU, Danyang LI, Dong WEN

“…Various BCI diagnostic methods based on Electroencephalogram (EEG), fMRI, and fNIRS, as well as VR-based diagnostic methods, will be introduced, and the advantages and limitations of these technologies will be discussed. …”
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hiPSC-derived cardiac fibroblasts dynamically enhance the mechanical function of hiPSC-derived cardiomyocytes on an engineered substrate by Mitchell Josvai, Mitchell Josvai, Jodi Lawson, Jodi Lawson, Harshal Kanade, Harshal Kanade, Meghana Kalluri, Meghana Kalluri, Corey L. Anderson, Jianhua Zhang, Alana Stempien, Alana Stempien, Lee L. Eckhardt, Timothy J. Kamp, Timothy J. Kamp, Wendy C. Crone, Wendy C. Crone, Wendy C. Crone, Wendy C. Crone

“…Coculture of CFs and human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (CMs) enhances CM mechanical output, yet the mechanism remains unclear.MethodsHere, we use an in vitro engineered platform to compare the effects on CM mechanical function of direct CM-CF Coculture and soluble signaling alone through CF Conditioned Medium to a CM Only monoculture. …”
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B4GALT5 inhibits CD8+ T-cell response by downregulating MHC-I level through ERAD pathway in PDAC by Hui Li, Hao Zhang, Xiao-Mei Yang, Xue-Li Zhang, Zhigang Zhang, Yan Yang, Xin Xing, Shi-Qi Yin, Xia-Qing Li, Hong-Tai Ma, Aziguli Tulamaiti, Shu-Yu Xiao, Yu-Tong Liu, Yan-Miao Huo

“…This study aims to investigate the role of beta-1,4-galactosyltransferase-5 (B4GALT5) in immune evasion by pancreatic cancer cells and evaluate its potential as an immunotherapeutic target.Methods We conducted a comprehensive analysis using RNA sequencing data and tissue microarrays from patients with PDAC to investigate the association between B4GALT5 expression and patient prognosis. …”
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DIFFERENCES IN EX-VIVO CHEMOSENSITIVITY TO ANTHRACYCLINES IN FIRST LINE ACUTE MYELOID LEUKEMIA by Juan Eduardo Megias-Vericat, David Martínez-Cuadrón, Joaquin Martínez López, Juan Miguel Bergua, Mar Tormo, Josefina Serrano, Ataulfo González, Jaime Pérez de Oteyza, Susana Vives, Belen Vidriales, Pilar Herrera, Juan Antonio Vera, Aurelio López Martínez, Adolfo De la Fuente, María Lourdes Amador, José Ángel Hernández-Rivas, María Ángeles Fernández, Carlos Javier Cerveró, Daniel Morillo, Pilar Hernández Campo, Julián Gorrochategui, Daniel Primo, José Luis Rojas, Margarita Guenova, Joan Ballesteros, Miguel Ángel Sanz, Pau Montesinos

“…Ex vivo drug sensitivity analysis was made using the PharmaFlow platform maintaining the BM microenvironment. …”
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Pediatric, adult, and late onset multiple sclerosis: Cognitive phenotypes and gray matter atrophy by Ermelinda De Meo, Emilio Portaccio, Rosa Cortese, Luis Ruano, Benedetta Goretti, Claudia Niccolai, Francesco Patti, Clara Chisari, Paolo Gallo, Paola Grossi, Angelo Ghezzi, Marco Roscio, Flavia Mattioli, Chiara Stampatori, Marta Simone, Rosa Gemma Viterbo, Raffaello Bonacchi, Assunta Maria Rocca, Elisa Leveraro, Antonio Giorgio, Nicola De Stefano, Massimo Filippi, Matilde Inglese, Maria Pia Amato

“…A subset of 222 MS patients and 92 controls underwent 3T‐MRI scan for brain atrophy and lesion analysis. Multinomial probabilistic models identified likelihood of belonging to cognitive phenotypes (“preserved‐cognition,” “mild verbal memory/semantic fluency,” “mild multi‐domain,” “severe attention/executive,” and “severe multi‐domain”) and experiencing MRI abnormalities based on disease duration and age at onset. …”
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Targeting HK3 in tumor-associated macrophages enhances antitumor immunity through augmenting antigen cross-presentation in cervical cancer by Hui Wang, Ying Chen, Min Wu, Jian Liu, Jingyu Wang, Yifan Yang, Chaoyang Sun, Shan He, Shen Qu, Xun Tian, Jinglan Chen, Han Jiang, Liting Liu, Yafei Huang

“…In vivo tumor models were established to assess the functional impact of HK3-expressing cells on the TME, with interventions including Hk3 knockout and CD8+ T-cell depletion. …”
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A cross-sectional study on the correlation between fasting blood glucose and bone turnover markers in Chinese patients with osteoporotic fractures by Meng-cheng Zhu, Meng-cheng Zhu, Min-zhe Xu, Min-zhe Xu, Chang-xuan Li, Chang-xuan Li, Jia-hao Wang, Jia-hao Wang, Chong Li, Chong Li, Ya-qin Gong, Ya-qin Gong, Jian Jin, Ke Lu, Ke Lu, Yan-ming Hao, Yan-ming Hao

“…This study examined the association between FBG levels and bone turnover markers (BTMs) in patients hospitalized for OPFs requiring surgical intervention.MethodsA retrospective cross-sectional analysis was conducted on 888 patients treated for OPFs at Kunshan Hospital affiliated with Jiangsu University from November 2018 to August 2023. …”
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The rising burden of diabetes and state-wise variations in India: insights from the Global Burden of Disease Study 1990–2021 and projections to 2031 by Shubham Chauhan, Mahalaqua Nazli Khatib, Suhas Ballal, Pooja Bansal, Kiran Bhopte, Abhay M. Gaidhane, Balvir S. Tomar, Ayash Ashraf, M. Ravi Kumar, Ashish Singh Chauhan, Muhammed Shabil, Diptismita Jena, Ganesh Bushi, Prakasini Satapathy, Lara Jain, Vaibhav Jaiswal, Manvi Pant

“…Autoregressive Integrated Moving Average (ARIMA) models were employed to project diabetes trends up to 2031.While the GBD data provide robust national and regional estimates, their modeled nature may not capture the full spectrum of local epidemiological variations.ResultsDiabetes incidence increased from 162.74 to 264.53 per 100,000 between 1990 and 2021, with an APC of 0.63%. …”
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SARS-CoV-2 lineage B.1.1.7 is associated with greater disease severity among hospitalised women but not men: multicentre cohort study by Judith Breuer, Catherine F Houlihan, Nick Freemantle, David Partridge, Gaia Nebbia, Jacqui Prieto, Gee Yen Shin, Andrew Copas, Oliver Stirrup, Kenneth Laing, Rachel Williams, Helen Wheeler, Paul Randell, Ana da Silva Filipe, Maria-Teresa Cutino-Moguel, Tommy Rampling, Tabassum Khan, James Price, Eleni Nastouli, Katie Johnson, Sharon Glaysher, Scott Elliott, Helen Umpleby, Emanuela Pelosi, Emma Thomson, Cristina Venturini, Anna Riddell, Alison Cox, Andrew C Hayward, Malin Bergström, David Harrington, Charlotte Williams, Tanzina Haque, Dianne Irish, Adrienn Angyal, Marios Margaritis, Moira Spyer, Florencia Boshier, José Afonso Guerra-Assunção, Adela Alcolea-Medina, Angela Beckett, Themoula Charalampous, Raghavendran Kulasegaran Shylini, Beatrix Kele, Irene Monahan, Guy Mollett, Matthew Parker, Sunando Roy, Joshua Taylor, Sophie Weller, Eleri Wilson-Davies, Phillip Wade, Joseph Hughes, Tabitha Mahungu, Cassie Pope, Samuel Robson, Kordo Saeed, Thushan de Silva, Luke Snell, Adam A Witney, James Blackstone, Leanne Hockey, Georgia Marley, Christine Peters, Flavia Flaviani, Bindi Patel, Tom G S Williams, Rahul Batra, Jonathan D Edgeworth, Pinglawathee Madona, Jennifer Hart, Juanita Pang, Helena Tutill, Nadua Bayzid, Marius Cotic, Luke Green, Benjamin Lindsey, Amy State, Alison Cope, Peijun Zhang, Max Whiteley, Marta Gallis Ramalho, Stella Christou, Stavroula Louka, Hailey Hornsby, Benjamin Foulkes, Paige Wolverson, Joe Heffer, Nikki Smith, Salman Goudarzi, Chris Fearn, Kate Cook, Katie Loveson, Adhyana Mahamana, Buddhini Samaraweera, Siona Silveira, Stephen Aplin, Sarah Jeremiah, Matthew Harvey, Thea Sass, Ngee Keong Tan, Claudia Cardoso Pereira, Dan Frampton, Matt Byott, Judith Heaney, Emilie Sanchez, Stavroula M Paraskevopoulou

“…Associations between the variant and the outcomes of all-cause mortality and intensive therapy unit (ITU) admission were evaluated using mixed effects Cox models adjusted by age, sex, comorbidities, care home residence, pregnancy and ethnicity.Findings Sequences were obtained from 2341 inpatients (HOCI cases=786) and analysis of clinical outcomes was carried out in 2147 inpatients with all data available. …”
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Pain and depression are associated with both physical and mental fatigue independently of comorbidities and medications in primary Sjögren’s syndrome by Nagui Gendi, Costantino Pitzalis, Paul Emery, Kate L Hackett, Kristen Davies, Jessica Tarn, Rebecca Bragg, Ben Hargreaves, Samira Miyamoto, Peter McMeekin, Sheryl Mitchell, Simon Bowman, Elizabeth J Price, Colin Pease, Jacqueline Andrews, Peter Lanyon, John Hunter, Monica Gupta, Michele Bombardieri, Nurhan Sutcliffe, John McLaren, Annie Cooper, Marian Regan, Ian Giles, David Isenberg, Saravan Vadivelu, David Coady, Bhaskar Dasgupta, Neil McHugh, Steven Young-Min, Robert Moots, Mohammed Akil, Bridget Griffiths, Dennis W Lendrem, Wan-Fai Ng

“…Using multiple regression analysis, we modelled the relationship between Profile of Fatigue and Discomfort physical and mental fatigue scores and potentially related variables.Results Pain, depression and daytime sleepiness scores were closely associated with both physical and mental fatigue (all p ≤ 0.0001). …”
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Development and validation of a diabetes mellitus and prediabetes risk prediction function for case finding in primary care in Hong Kong: a cross-sectional study and a prospective... by Kathryn Choon Beng Tan, Carlos King Ho Wong, Esther Yee Tak Yu, Cindy Lo Kuen Lam, Emily Tsui Yee Tse, Weng Yee Chin, David Vai Kiong Chao, Eric Ho Man Tang, Weinan Dong, Will Ho Gi Cheng, Yuqi Mi, Laura Elizabeth Bedford, Welchie Wai Kit Ko

“…Data of 1857 Chinese adults without self-reported DM/Pre-DM will be extracted from the PHS 2014/2015 to develop DM/Pre-DM risk models using logistic regression and machine learning methods. 1014 Chinese adults without a known history of DM/Pre-DM will be recruited from public and private primary care clinics in Hong Kong. …”
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PD-L2 act as an independent immune checkpoint in colorectal cancer beyond PD-L1 by Lvyun Zhu, Ying Qu, Junru Yang, Tong Shao, Jingyu Kuang, Chuanyang Liu, Yanhua Qi, Ming Li, Ming Li, Yingying Li, Sujuan Zhang, Jingyang Wang, Yu Liu, Jiali Liu, Yanming Hu, Lingyun Zhu, Tao Hou

“…Nonetheless, many CRC patients exhibit limited responses to such immunotherapy, and the resistance mechanisms remain incompletely understood.MethodsWe conducted experiments with C57BL/6 mice, and used the MC38 cell line for ICB treatment studies in syngeneic mouse models. …”
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Personalized information support for hypertension management: an open-label cluster randomized controlled trial in rural Anhui, ChinaResearch in context by Xingrong Shen, Ruirui Cui, Nana Li, Xin Yang, Tongqing Xu, Shumin Zeng, Xuanhe Liu, Yuning Wang, Ying Li, Dongying Xiao, Xuewu Zhang, Rong Liu, Tingting Zhang, Xiyan Kong, Jing Chai, Dongxiao Gu, Debin Wang

“…These measures were analyzed using mainly generalized linear mixed modeling controlled for clustering with or without imputation. …”
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Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness: Lessons from a contemporary single institution radical prostatectomy series by Zachary B. Koloff, Daniel A. Hamstra, John T. Wei, Jeffrey S. Montgomery, Scott A. Tomlins, Angela J. Wu, Todd M. Morgan, Javed Siddiqui, Kellie Paich, Arul M. Chinnaiyan, Felix Y. Feng, Alon Z. Weizer, Lakshmi P. Kunju, Brent K. Hollenbeck, David C. Miller, Ganesh S. Palapattu, Rohit Mehra

“…Further studies are needed to evaluate the role of tertiary patterns in prognostic models.…”
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Associating Patient Responses with Drug Sensitivity in Non-Small Cell Lung Carcinoma Using an Immunoassay on Patient-Derived Cell Cultures by Ana Podolski-Renić, Sofija Jovanović Stojanov, Dragana Marić, Jelena Dinić, Miodrag Dragoj, Ana Stepanović, Ema Lupšić, Milica Pajović, Sofija Glumac, Maja Ercegovac, Milica Pešić

“…A promising approach involves using patient-derived cellular models, which provide insights into the unique biology of individual tumors and their responsiveness to treatment. …”
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