ARM-X: an adaptable mesenchymal stromal cell-based vaccination platform suitable for solid tumors by Jean Pierre Bikorimana, Nehme El-Hachem, Gabrielle A. Mandl, Daniela Stanga, Jamilah Abusarah, Roudy Farah, Marina P. Gonçalves, Perla Matar, Malak Lahrichi, Sebastien Talbot, Moutih Rafei

“…Analysis of endosomal escape and the effect of various anti-oxidant compounds were used to decipher the AccuTOX® mode of action in MSCs. …”
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Aminoquinazolin-4(3H)-one derivatives as multitargeting therapeutics in Alzheimer's disease by Tajamul Hussain, Salman Alrokayan, Dilawar Hussain, Khurram Shoaib, Syeda Abida Ejaz, Steven Ford, Jamshed Iqbal

“…Additionally, in-silico ADME modeling was utilized to analyze the pharmacokinetic profile. …”
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Elevated remnant cholesterol and triglycerides are predictors of increased total mortality in a primary health care population of 327,347 patients by Anna Elise Engell, Lise Bathum, Volkert Siersma, Christen Lykkegaard Andersen, Bent Struer Lind, Henrik Løvendahl Jørgensen

“…Cox proportional hazards models with restricted cubic splines were used to evaluate the association between all-cause mortality and lipid levels. …”
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Cardiac biomarkers for screening and prognostication of cardiac dysfunction in critically ill patients by Oscar Cavefors, Freyr Einarsson, Jakob Holmqvist, Odd Bech‐Hanssen, Sven‐Erik Ricksten, Björn Redfors, Jonatan Oras

“…Abstract Aims This study aimed to assess the use of high‐sensitivity troponin T (hsTNT) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) in screening for cardiac dysfunction [left ventricular (LV) systolic or diastolic dysfunction or right ventricular (RV) dysfunction] in mixed intensive care unit (ICU) patients and establish whether these biomarkers are independently associated with an increased risk of death. Methods We performed a secondary analysis of a single‐centre prospective observational study in which consecutive ICU patients were examined with transthoracic echocardiography (TTE) and cardiac biomarkers. …”
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Outdoor light spending time, genetic predisposition and incident Parkinson’s disease: the mediating effect of lifestyle and vitamin D by Yumei Huang, Shufan Tian, Kangli Qiu, Jinchi Xie, An Pan, Gang Liu, Yunfei Liao

“…Multivariate Cox proportional hazard regression models were used. The polygenic risk score (PRS) for PD comprised 44 single-nucleotide variants. …”
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Cardiovascular Diseases Increase Cancer Mortality in Adults: NHANES‐Continuous Study by Omar M. Makram, Tochukwu Okwuosa, Daniel Addison, Jorge Cortes, Susan Dent, Malcolm Bevel, Sarju Ganatra, Sadeer Al‐Kindi, Catherine C Hedrick, Neal L Weintraub, Xiaoling Wang, Avirup Guha

“…We also conducted a comprehensive risk factor analysis as secondary exposure. The main outcome was cancer mortality data collected from Medicare and National Death Index. …”
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Evaluation of Self-Regulating Doped Ferrite Nanoparticles with Glucose, Chitosan, and Poly-Ethylene Glycol Coatings for Hyperthermia and Dual Imaging by Negri A, Conti A, Milan E, Forlin E, Gherlinzoni F, Morana G, Gottardi M, Matteazzi P, Speghini A, Bongers A, Marzola P

“…Following intravenous administration, MRI and MPI functionalities were analyzed through phantom studies and in vivo murine models.Results: Coated M55 NPs displayed high colloidal stability in water and effective functionalization. …”
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Explorative Study of Modulatory Effects of Notochordal Cell‐Derived Extracellular Vesicles on the IL‐1β‐Induced Catabolic Cascade in Nucleus Pulposus Cell Pellets and Explants... by J. C. vanMaanen, F. C. Bach, J. W. Snuggs, K. Ito, M. H. M. Wauben, C. L. Le Maitre, M. A. Tryfonidou

“…Therefore, this study explores whether NC‐EVs modulate interleukin (IL)‐1β‐mediated pro‐inflammatory responses in the degenerating disc. Methods This study utilized two IL‐1β induced pro‐catabolic culture models; a dog 3D nucleus pulposus (NP) cell pellet culture and a human patient‐derived, ex vivo NP tissue culture system. …”
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Early diagnosis and survival outcomes in silicosis: a retrospective cohort study of 11,809 patients in Guangdong Province, China (1956–2020) by Chunyue Fan, Yuhao Wang, Yuhao Wang, Jingjing Chen, Qiaoli Wei, Shijie Hu, Lihua Xia, Jiawen Huang, Weihui Liang, Lin Wu, Xudong Li

“…Cox proportional hazards models adjusted for covariates (sex, age, region, industry, exposure duration) were used to assess mortality risks across stages I–III. …”
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Prognostic value of albumin-corrected anion gap in critically ill patients with sepsis-associated liver injury: a retrospective study by Jianjun Wang, Yonghai Peng, Zhaohui Hu, Xi Chen, Sirui Chen, Pei Yang, Xintao Zeng, Decai Wang

“…The optimal cutoff value for ACAG was established using R statistical software. Kaplan-Meier analysis was conducted to compare mortality risks between the two groups, while multivariable Cox proportional hazards regression models were employed to examine the association between ACAG and mortality risk in SALI patients. …”
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Awareness and intention to use event‐driven and long‐acting injectable pre‐exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil... by Laio Magno, Beo Oliveira Leite, Alexandre Grangeiro, Lorenza Dezanet, Fabiane Soares, Inês Dourado

“…Binomial logistic regression models analysed factors associated with the intention to use event‐driven and long‐acting injectable PrEP. …”
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The incidence and influencing factors of type 2 diabetes mellitus in Chinese adults in 10 provinces: a prospective cohort study by Shujuan Li, Tingfang Ai, Run Zhang, Xiaoqing You, Jianhong Li

“…Sensitivity analysis was conducted to confirm the associations between the influencing factors and DM. …”
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DEVELOPING YOUTH RESILIENCE IN CONDITIONS OF SOCIAL INSTABILITY AND WAR by Vira Syniakova, Yuliia Bokhonkova, Mykyta Minin

“…Future research should focus on the long-term effects of resilience development programs and explore scalable models for broader implementation across educational and social institutions. …”
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Urban greenspace and cardiovascular disease comorbidity at breast cancer diagnosis in the US: regional, racial/ethnic, and socioeconomic variations among older women by Jean C. Bikomeye, Emily L. McGinley, Yuhong Zhou, Sergey Tarima, Jamila L. Kwarteng, Andreas M. Beyer, Tina W.F. Yen, Aaron N. Winn, Kirsten M.M. Beyer

“…Objective To investigate the association between urban greenspace and cardiovascular disease (CVD) comorbidity at breast cancer (BC) diagnosis among older women, and explore regional, racial/ethnic, and socioeconomic differences.Study design A cross-sectional analysis of population-based registry data.Methods Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database, data on women aged 66-90 diagnosed with BC (2010-2017) were analyzed. …”
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Development of a Mobile Intervention for Procrastination Augmented With a Semigenerative Chatbot for University Students: Pilot Randomized Controlled Trial by Seonmi Lee, Jaehyun Jeong, Myungsung Kim, Sangil Lee, Sung-Phil Kim, Dooyoung Jung

“…User experience was quantified based on the usability, feasibility, and acceptability of and satisfaction with the app, whereas thematic analysis explored the users’ subjective responses to app use. …”
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Understanding Challenges and Emotions of Informal Caregivers of General Older Adults and People With Alzheimer Disease and Related Dementia: Comparative Study by Nova Mengxia Huang, Liang Ze Wong, Shirley S Ho, Bryan Timothy

“…Using topic modeling, we identified topics discussed by caregivers in the collected posts. …”
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Effects of the Duration of Wheat and Maize Straw Returning on Rill Erosion Resistance in Brown Soil in the Earth-rocky Mountainous Area of Northern China by ZHANG Hanyu, LI Jiaqian, ZHAO Yajie, LI Jingjiang, LIU Zhihua, FANG Nufang, LIU Qianjin

“…［Objective］ Research on the effects of the duration of straw returning on rill erosion resistance can provide scientific evidence for rill erosion modeling and controlling in sloping farmland. ［Methods］ Taking straw returning durations of 0 years (CK), 3—4 years (R1), 5—6 years (R2), 7—8 years (R3), 9—10 years (R4), 15 years (R5), and 20 years (R6) as the study subjects, soil samples were collected and analyzed. …”
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Dairy intake and cognitive function in older adults in three cohorts: a mendelian randomization study by Natalia Ortega, Nick J. Mueller, Abbas Dehghan, Tosca O. E. de Crom, Armin von Gunten, Martin Preisig, Pedro Marques-Vidal, Marco Vinceti, Trudy Voortman, Nicolas Rodondi, Patricia O. Chocano-Bedoya

“…Second, we used the estimated dairy consumption in linear regression models on general cognition, assessed by the Mini-Mental State Examination (MMSE) and the Mental Alternation Test, executive function, verbal fluency, verbal learning, and memory. …”
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Seasonal variation of Microsporidia MB infection in Anopheles gambiae and Anopheles coluzzii in two different geographical localities in Benin by Genevieve Tchigossou, Michel Lontsi-Demano, Eric Tossou, Pierre-Marie Sovegnon, Romaric Akoton, Danahe Adanzounon, Camille Dossou, Massioudou Koto, Azarath Ogbon, Marie Gouété, Godfrey Nattoh, Rousseau Djouaka

“…Further investigations might be necessary, and modelling of the prevalence and characteristics of breeding sites could help predict the presence of this symbiont in other locations and countries.…”
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Strategies to Improve Health Care Provider Prescription of and Patient Adherence to Guideline-Recommended Cardiovascular Medications for Atherosclerotic Occlusive Disease: Protocol... by Aidan M Kirkham, Dean A Fergusson, Justin Presseau, Daniel I McIsaac, Risa Shorr, Derek J Roberts

“…ObjectiveWe aim to systematically review and meta-analyze RCTs examining the effectiveness of implementation or adherence-supporting strategies for improving health care provider prescription of, or patient adherence to, guideline-recommended cardiovascular medications in patients with atherosclerotic occlusive disease. MethodsWe designed and reported the protocol according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis-Protocols) statement. …”
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