From colorless to pink: Structural insights into vitamin B12-induced color change in monoclonal antibodies by Kai-feng He, Hao-dong Cui, Wen-hui Deng, Na Xing, Guo-jian Liu, Abdallah Iddy Chaurembo, Li-dan Fu, Yuan Li, Xin-yue Tong, Han-bin Lin, Chun-he Wang

“…Peptide mapping and 3D structural modeling using protenix and autodock vina software identified the binding sites and spatial requirements. …”
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Biomarker combinations from different modalities predict early disability accumulation in multiple sclerosis by Vinzenz Fleischer, Tobias Brummer, Muthuraman Muthuraman, Muthuraman Muthuraman, Falk Steffen, Milena Heldt, Maria Protopapa, Muriel Schraad, Gabriel Gonzalez-Escamilla, Sergiu Groppa, Stefan Bittner, Frauke Zipp

“…Second, we applied structural equation modeling (SEM) to the single biomarkers in order to determine their causal inter-relationships.ResultsBaseline GMV on its own allowed identification of subsequent EDSS progression based on ROC analysis. …”
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Anti-CTGF/PD-1 bispecific antibody Y126S restrains desmoplastic and immunosuppressive microenvironment in pancreatic cancer by Wei Chen, Hai Huang, Wang Peng, Jingwen Liang, Shiru Chen, Yuchong Zhao, Mengdie Cao, Yilei Yang, Shuya Bai, Qiaodan Zhou, Jiamei Jiang, Yilin Gu, Ronghua Wang, Bin Cheng

“…TME remodeling, antibody distribution, and therapeutic efficacy were assessed using flow cytometry, immunohistochemical/Masson staining, atomic force microscopy, positron emission tomography (PET) imaging, distribution analysis, and other experimental techniques.Results Here, Y126S was characterized in vitro and its antitumor efficacy was evaluated and validated in orthotopic PDAC mice and KPC mouse models. …”
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Prevalence and Clinical Parameters Associated With Chronic Total Occlusions in Patients With Chronic Coronary Syndromes: Insights From a Nationwide Registry by Armin Attar, Mehrab Sayadi, Alireza Hosseinpour, Emmanouil S. Brilakis, Fereshte Mehdizade, Zahra Namvar, Alireza Khosravi, Maryam Boshtam, Feridoun Noohi, Ahmadreza Assareh, Toba Kazemi, Hossein Farshidi, Arsalan Khaledifar, Maryam Abbaszadeh, Nizal Sarrafzadegan

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Patient and clinician experiences with the implementation of telemedicine and related adaptations in office-based buprenorphine treatment during the COVID-19 pandemic: a qualitativ... by Melissa Davoust, Angela R. Bazzi, Samantha Blakemore, Juliana Blodgett, Anna Cheng, Sarah Fielman, Kara M. Magane, Jacqueline Theisen, Richard Saitz, Alicia S. Ventura, Zoe M. Weinstein

“…To date, relatively few prior studies have combined patient and clinician perspectives to examine the implementation of telemedicine and related care adaptations, particularly in safety-net settings. Methods Qualitative methods were used to explore clinician and patient experiences with telemedicine in an office-based buprenorphine treatment clinic affiliated with an urban safety-net hospital. …”
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Optimising Psychological Well-Being in Chinese-Australian Adolescents: A 24-Hour Movement Guidelines Approach by Wei-Cheng Chao, Asaduzzaman Khan, Jui-Chi Shih, Wen Li, Ching-Lin Wu, Kuan-Chung Chen, Bill Cheng

“…This study used multiple linear regression modelling to examine the associations between meeting or not meeting recommendations. …”
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Cross-sectional study on the association between 24-hour urinary potassium excretion and the risk of H-type hypertension and non-H-type hypertension in Chinese adults by Qingfang He, Xiaofu Du, Xiangyu Chen, Lixin Wang, Yujia Fang, Jieming Zhong

“…We aimed to describe the relationship between 24-hour (h) urinary potassium excretion and the risk of H-type hypertension and non-H-type hypertension, thus to guide personal and public health campaigns including dietary recommendations to lower H-type hypertension and non-H-type hypertension in China.MethodsIn 2020 in Zhejiang, China, a cross-sectional survey on Salt Reduction and Prevention of Hypertension was conducted by using a stratified multistage random sampling strategy, with participants aged 21 to 72 years. …”
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Optimization design of an acoustic cover layer for a cylindrical cavity based on porous materials by Bohan ZHANG, Jili RONG, Xiuyan CHENG

“…This research combines experimental approaches, including impedance tube experiments, with numerical methods, such as acoustic finite element analysis, to enhance the noise control capabilities of porous materials. …”
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Impact of Medical Conditions and Area Deprivation on Fundraising Success in Online Crowdfunding: Cross-Sectional Study by Steven S Doerstling, Matthew M Engelhard, Dennis Akrobetu, Caroline E Sloan, Ada Campagna, Thuy-Vi Nguyen, Farrah Madanay, Felicia Chen, Peter A Ubel

“…Last, we sought to understand the effect of these features on donation behavior in terms of number of donations and donation amount. MethodsWeb scraping was used to collect medical crowdfunding campaigns on GoFundMe that were based in the United States and created between 2010 and 2020. …”
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Patterns of Myopia Progression in European Adults by Michael Moore, PhD, MSc, Gareth Lingham, PhD, Daniel I. Flitcroft, DPhil, MBBS, James Loughman, PhD

“…Patients aged 18 to 39 years, inclusive, at baseline and attending >1 eye examination with an interval of ≥11 months between visits and that were myopic at the final visit were included in the analysis. Annualized myopia progression in diopter (D)/year was assessed using linear mixed models with age, sex, baseline spherical equivalent refraction, and previous myopic progression as fixed effect covariates. …”
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Hyrax versus transverse sagittal maxillary expander: An assessment of arch changes on dental casts. A retrospective study by C. Maspero, D. Cavagnetto, A. Fama, L. Giannini, G. Galbiati, M. Farronato

“…Patients were randomly divided in two groups: patients in group 1 were treated with HPE as they presented only transverse deficiency of the maxilla and in group 2 were treated with TSME. Plaster models have been measured with a Verniere caliper to evaluate the differences in maxillary expansion of the two devices. …”
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Triglyceride-glucose index correlates with the incidences and prognoses of cardiac arrest following acute myocardial infarction: data from two large-scale cohorts by Huiruo Liu, Liangshan Wang, Hong Wang, Xing Hao, Zhongtao Du, Chenglong Li, Xiaotong Hou

“…The current study aims for clarifying the link of TyG with the incidences and prognoses of cardiac arrest (CA) following acute myocardial infarction (AMI). Methods Our analysis is a multicenter, retrospective study utilizing data from the Medical Information Mart for Intensive Care IV and the eICU Collaborative Research Database. …”
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Obesity-fertility cohort study: protocol for the assessment of children aged 6–12 years and their mothers by Marie-Eve Mathieu, Jean-Patrice Baillargeon, Patrice Perron, Anne-Sophie Morisset, Farrah Jean-Denis, Frederic Dallaire, Alexandra Thibodeau, Soren Harnois-Leblanc, Martin Brochu

“…This manuscript details the study protocol.Methods and analysis This is an ancillary nested cohort study of the obesity-fertility RCT. …”
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Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron diseaseResearch in context by Cory J. Holdom, Rakesh Pilkar, Christine C. Guo, Ruben P.A van Eijk, Nadia Sethi, Robert D. Henderson, Shyuan T. Ngo, Frederik J. Steyn

“…Accelerometer data were processed using ActiLife and GGIR. Joint models were used to simultaneously investigate the longitudinal change in ALS Functional Rating Scale-Revised (ALSFRS-R) scores and accelerometer-derived outcomes alongside their relationship with overall survival. …”
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Characteristics and correlates of the use of social media for nutrition among young adults in the United Arab Emirates by Sharfa Khaleel, Nada Abbas, Dalia Niazi, Husn Aljundi, Raghad Alrouh, Yara Abugharbiyeh, Mona Hashim, Mohamad Alameddine, Farah Naja

“…Descriptives and logistic regressions were used in data analysis. Within the regression models, the outcome variable was whether participants used SM to obtain nutrition information. …”
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Prevalence of HIV drug resistance, its correlates and common mutations among people living with HIV failing on ART in northern Uganda: A cross-sectional study. by Francis Kayinda, Phyllis Awor, Twaha Mahaba, Alex M Muganzi, Joanita Kigozi, Patrick Odong Olwedo, Esther M Nasuuna, Robert Mutumba, Rhoda Wanyenze

“…We estimated the prevalence of HIV drug resistance, described the HIV drug resistance mutations and evaluated the factors associated with HIVDR among PLHIV with virological failure in the West-Nile region of Uganda.<h4>Methods</h4>We conducted a retrospective cross-sectional analysis of HIVDR data in the West-Nile region of Uganda across the 161 health facilities that offer comprehensive Anti-retroviral therapy (ART) services. …”
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The Impact of Earning Smoothing through Real Activities and its Components on Labor Force Investment Efficiency by Batool Ismael Hasan, Mehdi Heydari, Hamzeh Didar

“…This sample was then subjected to analysis using multivariate regression models.   Results The findings indicate that as the degree of real earnings smoothing rises, there is a corresponding increase in labor investment efficiency. …”
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Sialylated IgG expressed in triple-negative breast cancer cells promotes cancer progression by promoting glycolysis by Chenyang Hu, Shenghua Zhang, Fugang Duan, Xinmei Huang, Jing Huang, Zhu Zhu, Xiaoning Mo, Weiyan Xu, Lina Wu, Zhimin Fan, Xiaoyan Qiu

“…Here, we aimed to investigate the expression frequency and procancer mechanisms of SIA-IgG in TNBC, and determine whether the SIA-IgG is a key factor that promotes TNBC and a novel target for TNBC therapy. Methods Immunohistochemical staining, immunofluorescence, and TCGA database analysis were performed to analyze the frequency of SIA-IgG expression in TNBC and the correlation between SIA-IgG expression and patient prognosis. …”
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Sex difference in the relationship between childhood obesity and abnormal lipid profiles in young adults by Keyang Zheng, Yinkun Yan, Linlin Ma, Rufei Liu, Tianzhu Zhao, Yuxuan Wei, Zixu Zhao, Hong Cheng, Dongqing Hou, Junting Liu, Xiaoyuan Zhao, Wenli Cheng, Jie Mi

“…This study aimed to examine the association between childhood obesity and abnormal lipid metabolism in young adults, specifically focusing on sex differences. Methods Data were obtained from the Beijing Blood Pressure Cohort Study, which included 1220 participants aged 28–45 years. …”
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Left bundle branch block in coronary artery disease: toward novel electrocardiographic markers by Yuri N. Fedulaev, Irina V. Makarova, Alisa V. Grigorieva, Dzhamilya R. Kapitonova, Gulfiya A. Khairetdinova

“…MATERIALS AND METHODS: The study included 45 hospitalized patients with coronary artery disease (mean age 76±8 years). …”
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