Circulating miRNA-486 as a novel diagnostic biomarker for right ventricular remodeling by Huiling Cai, Huiling Cai, Cheng Yu, Xiuchuan Li, Xuenan Wang, Xuenan Wang, Yongjian Yang, Yongjian Yang, Yongjian Yang, Cong Lan, Cong Lan

“…This study systematically screened and identified candidate serum miRNAs as potential diagnostic biomarkers for RV remodeling in PH patients.MethodsPulmonary artery banding (PAB) was performed in Sprague-Dawley (SD) rats and RV modeling was measured by echocardiographic and histological analyses 4 weeks after surgery. …”
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PLZF-expressing CD4+ T cells promote tissue-resident memory T cells in breaking immune tolerance in allergic asthma via IL-15/IL-15Rα signaling by Meng Zhang, Sheng-ce Tao, Na Li, Jingjing Feng, Tianyun Shi, Yunxia Yu, Xiaoting Ren, Jiafeng Sha, Zhoufang Mei, Zhijun Jie

“…Therefore, in the current study, we explore the role of CD4+ TRM cells in asthmatic immune tolerance and as well as the regulatory role of PLZF in this process. Methods To elucidate the role of CD4+ TRM cells in immune tolerance, asthma memory mouse models were treated with the immunomodulator FTY720. …”
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Fatty Acids of Erythrocyte Membranes and Blood Serum in Differential Diagnosis of Inflammatory Bowel Diseases by M. V. Kruchinina, I. O. Svetlova, M. F. Osipenko, N. V. Abaltusova, A. A. Gromov, M. V. Shashkov, A. S. Sokolova, I. N. Yakovina, A. V. Borisova

“…The study of FA levels in groups with different nosological forms of IBDs using complex statistical analysis, including machine learning methods, made it possible to create diagnostic models that differentiate CD, UC and UCC in the acute stage with high accuracy. …”
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Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review by Bashir MBA, Milani GP, De Cosmi V, Mazzocchi A, Zhang G, Basna R, Hedman L, Lindberg A, Ekerljung L, Axelsson M, Vanfleteren LEGW, Rönmark E, Backman H, Kankaanranta H, Nwaru BI

“…Most studies used hierarchical clustering, with some employing latent class modeling, mixture models, and factor analysis. The comprehensiveness of variable reporting was the best quality indicator, while reproducibility measures were often lacking.Conclusion: Variations in phenotyping methods, study settings, participant profiles, and variables contribute to significant differences in characterizing asthma, severe asthma, COPD, ACO, and rhinitis phenotypes across studies. …”
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Experimental study of cyclic fatigue of nickel-titanium rotating endodontic instruments with controlled shape memory T C-Files Gold STEA (V ideya) by V. V. Tairov, А. А. Adamchik, E. Yu. Mendosa, L. А. Mamedova, M. D. Filippova, V. V. Dorogan, M. V. Savina

“…Experimental evaluation of the cyclic fatigue resistance of new endodontic rotary instruments TC-Files Gold STEA (manufactured by VIDEYA, China), made from CM-Wire alloy, using models that simulate root canals of varying anatomical complexity depending on the angle of curvature and radius of root curvature.MATERIALS AND METHODS. …”
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New Insights into the Anticancer Effects and Toxicogenomic Safety of Two β-Lapachone Derivatives by José Rivaldo De Lima, Alexandre José Da Silva Góes, Elizabeth Fernanda De Oliveira Borba, Meykson Alexandre da Silva, Rodrigo Ribeiro Alves Caiana, Maria do Desterro Rodrigues, Mariza Severina De Lima Silva, Cristiano Aparecido Chagas, Blandine Baratte, Thomas Robert, Stéphane Bach, Isabelle Ourliac-Garnier, Pascal Marchand, Teresinha Gonçalves Da Silva

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‘Every Touch Point Is an Opportunity’: Tobacco Control Experts' Views on How to Implement Smoking Cessation Interventions Within an Australian Lung Cancer Screening Program by Nathan J. Harrison, Diane Riddiford‐Harland, Sarah York, Henry M. Marshall, Joel J. Rhee, Emily Stone, Mei Ling Yap, Ashleigh R. Sharman, Marianne Weber, Susan A. McCullough, Terri Byrne, Christine L. Paul, Jacqueline A. Bowden, Billie Bonevski, Nicole M. Rankin

“…Individual/pair interviews explored factors that may influence acceptability and feasibility, potential delivery models, and implementation strategies. We interpreted interview data using codebook thematic analysis, then mapped key topics against the Consolidated Framework for Implementation Research and previous LCS expert‐identified determinants. …”
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To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux by Chenglin Jia, Biying Hong, Yujie Jiang, Chao Ma, Wei Liu, Wei Liu, Wei Liu, Yicheng Xu, Jian Chen, Yan Xie, Yan Xie, Yan Xie, Guangbo Ge, Guangbo Ge, Guangbo Ge, Ye-min Cao, Tianhua Yan, Yongbing Cao

“…Aim of the studyTo investigate the effect of Ruanjian Qingmai granules (RJQM) on arteriosclerotic obliterans (ASO) and identify its potential bioactive components.Materials and methodsSeparate zebrafish atherosclerosis models and cellular lipid metabolism disorder models were established, and RJQM was administered at different concentrations for intervention. …”
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Synergistic effects of MK-1775 and gemcitabine on cytotoxicity in non-small cell lung cancer by Chiao-Ping Chen, Tsai-Hsien Hung, Ping-Chih Hsu, Chun-Nan Yeh, Wen-Kuan Huang, Yi-Ru Pan, Yu-Tien Hsiao, Chih-Hong Lo, Chiao-En Wu

“…In xenograft models, the combination significantly inhibited tumor growth without significant toxicity. …”
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Prognostic significance of severe mitral annular calcification in aortic stenosis: implications for aortic valve replacement outcome by Valeria Pergola, Dan-Alexandru Cozac, Maria Teresa Savo, Saima Mushtaq, Raffaella Motta, Roberto Pedrinelli, Pasquale Perrone-Filardi, Gianfranco Sinagra, Morena De Amicis, Maria Vittoria Chiaruttini, Gabriele Cordoni, Giulia Lorenzoni, Giuseppe Tarantini, Gino Gerosa, Dario Gregori, Giorgio De Conti, Domenico Corrado, Gianluca Pontone

“…This study aims to assess the impact of cardiac CT-derived MAC on cardiovascular outcomes in this population. Methods: Pre-procedural contrast-enhanced CCT was performed, and Guerrero CCT-derived MAC score was used to quantify the MAC severity. …”
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Burden of non-CO poisoning in 204 countries and territories, 1990–2021: results from the global burden of disease study 2021 by Rong Lei, Chaofu Yue, Feng Yue, Hong Gao, Xing He, Qinyong Yan, Zhigang Yang, Wei Bao, Caimei Hu, Qingsong Ma, Mei Yang

“…However, there is a lack of comprehensive analysis regarding the global burden and trends of non-CO poisoning.MethodsData from the Global Burden of Disease (GBD) 2021 study were used to assess the global, regional, and national prevalence, mortality, and disability-adjusted life years (DALYs) associated with non-CO poisoning from 1990 to 2021. …”
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CPEB4 modulates liver cancer progression by translationally regulating hepcidin expression and sensitivity to ferroptosis by M. Eugenia Delgado, Salvador Naranjo-Suarez, Marta Ramírez-Pedraza, Beatriz I. Cárdenas, Carmen Gallardo-Martínez, Alexandra Balvey, Eulalia Belloc, Judit Martín, Mark Boyle, Raúl Méndez, Mercedes Fernandez

“…While much of the previous research has focused on transcriptional changes, this study examines translational alterations, specifically the role of cytoplasmic polyadenylation element binding protein 4 (CPEB4), a key regulator of translation. Methods: We analyzed publicly available patient databases and conducted studies using human and mouse liver cancer cells, xenograft and allograft models, mouse models of high-fat diet-related liver cancer, and CPEB4 knockout and knockdown mice and cell lines. …”
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Efficacy and safety of Pueraria lobata radix as an adjuvant therapy for type 2 diabetes mellitus: rationale, design and protocol for a randomised controlled trial by Yan Zhang, Chenxi Li, Jiancheng Wang, Xu Zhou, Xiang Ye, Weifeng Zhu, Jianrong Chen, Lixia Yuan, Qiuyun Xue, Jieyi Zhou, Qihui Fan, Ruting Feng, Zhengfeng Li

“…The aim of this study is to investigate the efficacy and safety of using PLR solely as an adjuvant therapy for T2DM.Methods and analysis This study is a multicentre, randomised, double-blind, placebo-controlled trial. 200 patients with T2DM will be randomly allocated to either the PLR group or the placebo group for a consecutive 12-week intervention. …”
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Quantitative evaluation of electrographic response to electroconvulsive therapy in super-refractory status epilepticus by Raphaël Christin, Harrison Hines, Lauren Hophing, Ankit N. Khambhati, Edilberto Amorim, Edilberto Amorim, Manu Hegde, Manu Hegde, Elan L. Guterman, Elan L. Guterman, Jonathan K. Kleen, Jonathan K. Kleen

“…Here, we use quantitative approaches on electroencephalography (EEG) data to evaluate the neurophysiological influences of ECT and how they may relate to patient survival.MethodsThis was a single center study of adult patients who underwent bi-frontal ECT for treatment of SRSE between 2007 and 2021. …”
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Bone-Specific Alkaline Phosphatase as a Complementary Diagnostic Marker for the Assessment of Children and Adolescents with Secondary Osteoporosis by Eunha Bae, Soo Yeun Sim, Su Jin Park, Sung Eun Kim, Seulki Kim, Shin-Hee Kim, Won Kyoung Cho, Kyoung Soon Cho, Min Ho Jung, Byung-Kyu Suh, Moon Bae Ahn

“…The logistic regression models showed that after adjusting for underlying diseases and sex, as BsALP increased, the probability of LSBMD Z-score being ≤−2 increased with an odds ratio of 1.043 (<i>p</i> = 0.048). …”
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Long-term Outcomes of Lupus Nephritis in Comparison to Other CKD Etiologies by Charikleia Chrysostomou, Francesca Faustini, Iva Gunnarsson, Mårten Segelmark, Juan-Jesús Carrero, Peter Barany, Anne-Laure Faucon, Marie Evans

“…Introduction: Little is known regarding the comparison of cardiovascular and kidney outcomes between lupus nephritis (LN) and other etiologies of chronic kidney disease (CKD). Methods: Using data from the Swedish Renal Registry (2006–2021), we compared long-term outcomes between patients with LN-CKD and patients with CKD due to primary glomerular diseases (PGD) and other CKD causes (Other-CKD, mainly diabetes and nephroangiosclerosis). …”
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Impact of Time-To-Treatment on Outcomes in Autoimmune Membranous Nephropathy by Patrick Hamilton, Sebastian Bate, Omar Ragy, Mrityunjay Hiremath, Samar Bukhari, Anirudh Rao, Arif Khwaja, Durga Anil K Kanigicherla

“…Cox proportional hazard models were used to assess association of outcomes with baseline categories. …”
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Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A2A receptor by Yuanfeng Gu, Wenjun He, Wenxuan Li, Jingshu Cai, Zhuyun Wang, Kemeng Li, Guangcheng Qin, Xiaojie Gu, Xiaojing Lin, Li Ma, Xiaoqiu Xiao, Yi Hou, Ting Luo

“…Arctiin (ARC), a lignan compound known for its anti-inflammatory, anti-tumor, and hypoglycemic properties, has not been fully elucidated regarding its effects and mechanisms on obesity. Methods In the present study, we established both high-fat diet-induced obese mouse models and mature adipocyte cultures to comprehensively investigate the therapeutic effects of ARC on obesity. …”
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The evolution of sprinting performance: Technological and regulatory influences from 1976 to 2024 by Dariusz Tadeusz SKALSKI, Magdalena PROŃCZUK, Kinga ŁOSIŃSKA, Ewelina LULIŃSKA, Joanna MOTOWIDŁO, Petr STASTNY, Adam MASZCZYK, Grzegorz TRYBEK

“…Understanding these factors is essential for assessing how sprint times have evolved and what future trends might emerge. Materials and methods: Utilizing a comprehensive dataset from international athletics federations, this research applies time series analysis, regression modeling, and variance testing to assess trends, gender disparities, and performance variability. …”
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Multicentre, longitudinal, observational cohort study to examine the relationship between neutrophil function and sepsis in adults and children with severe thermal injuries: a prot... by Jonathan R B Bishop, Paul Harrison, Janet M Lord, Naiem S Moiemen, Amy Bamford, Yvonne Wilson, David Barnes, Jon Hazeldine, Kirsty C McGee, Khaled Al-Tarrah, Tarek Hassouna, Krupali Patel, Rizwana Imran

“…The Scientific Investigation of the Biological Pathways Following Thermal Injury-2 study aims to prospectively validate neutrophil phagocytic activity, IG count and plasma cfDNA levels as early prognostic biomarkers of sepsis in thermally injured adult and paediatric patients.Methods and analysis This multicentre, longitudinal, observational cohort study will enrol 245 paediatric and adult patients with moderate to severe burns within 24 hours of injury. …”
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