Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial by Amy Y. X. Yu, Shabnam Vatanpour, Aravind Ganesh, Thalia S. Field, Philip A. Barber, Philip M. C. Choi, Brian Buck, Timothy Kleinig, Carlos A. Molina, Bruce C. V. Campbell, Ramana Appireddy, Keith W. Muir, Michael D. Hill, Shelagh B. Coutts

“…We used generalized linear modeling with a Poisson distribution adjusted for baseline differences to calculate adjusted risk ratios (aRR) and 95% CIs. …”
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Evaluating GPT-4o in infectious disease diagnostics and management: A comparative study with residents and specialists on accuracy, completeness, and clinical support potential by Lili Zhan, Xiumin Dang, Zhenghua Xie, Chaoying Zeng, Weixing Wu, Xiaoyu Zhang, Li Zhang, Xinjian Cai

“…Background Artificial intelligence (AI), particularly GPT models like GPT-4o (omnimodal), is increasingly being integrated into healthcare for providing diagnostic and treatment recommendations. …”
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Enlarged choroid plexus is linked with poorer physical function in rural older adults: a population-based study by Qianqian Xie, Ziwei Chen, Jiafeng Wang, Huisi Zhang, Yan Wang, Xiaoyu Wang, Chunyan Li, Yongxiang Wang, Lin Cong, Daniel Ferreira, Anna-Karin Welmer, Lin Song, Yifeng Du, Chengxuan Qiu

“…However, no population-based studies have thus far examined the association of ChP with physical function in older people. Methods This population-based cross-sectional study included 1217 participants (age ≥ 60 years; 57.35% women) in the MRI substudy of the Multimodal Interventions to delay Dementia and disability in rural China. …”
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Maternal neonicotinoid pesticide exposure impairs glucose metabolism by deteriorating brown fat thermogenesis by Wenwen Zhu, Jiali Fang, Chenbo Ji, Hong Zhong, Tianying Zhong, Xianwei Cui

“…We here aimed to investigate the association between NEOs exposure and GDM occurrence. Methods: 100 pregnant women who completed a 75 g oral glucose tolerance test (OGTT) at 24–28 weeks of gestation were enrolled. …”
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The efficacy and peripheral blood predictors in recurrent platinum-resistant ovarian cancer patients treated with immune checkpoint inhibitors by Baoyue Pan, Xiaojing Zheng, Yongwen Huang, Wei Wei, Shije Xu, Siyu Chen, Jiaxin Yin, Yu Zhang, Jundong Li, Min Zheng

“…Both univariate and multivariate models were constructed using pretreatment clinical variables and cytokines. …”
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Modified Alliance-Focused Training with Doubling as an integrative approach to improve therapists’ competencies in dealing with alliance ruptures and prevent negative outcomes in p... by Anne Daubmann, Antonia Zapf, Antje Gumz, Frank Jacobi, Denise Kästner, Laurence Reuter, Carmen Martinez Moura, Klarissa Ehlers, Catherine F Eubanks, John Christopher Muran, Timothy Anderson, Ramona Stöckl, Georg Schwanitz, Lena Stegemann, Lana Rohr, Ulrike Willutzki

“…The Alliance-Focused Training (AFT) is a promising transtheoretical approach to enhance therapists’ skills in dealing with alliance ruptures.Methods and analysis To evaluate the effectiveness of Modified AFT with doubling (MAFT-D), a randomised, patient and evaluator-blinded, multicentre trial was designed comparing MAFT-D (delivered to trainee therapists and supervisors) and psychotherapy training/treatment as usual (TAU) for therapists (n=120) and their patients with depressive disorders (n=240). …”
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Policies for type 2 diabetes and non-communicable disease management during the COVID-19 pandemic in Kenya and Tanzania: a desk review and views of decision-makers by Frances Mair, Gershim Asiki, Shukri F Mohamed, Christopher Bunn, Sally M Mtenga, Cindy Gray, Peter Binyaruka, Lyagamula Kisia, Richard E Sanya, Caroline H Karugu, Irene Mashiashi, Jennifer P Wisdom, Peter M Kibe

“…This study aimed to identify policy gaps, if any, in the management of NCDs, particularly diabetes, during COVID-19 in Kenya and Tanzania to inform recommendations for priority actions for NCD management during any future similar crises.Methods We undertook a desk review of pre-existing and newly developed national frameworks, policy models and guidelines for addressing NCDs including type 2 diabetes. …”
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IFITM3 enhances immunosensitivity via MHC-I regulation and is associated with the efficacy of anti-PD-1/-L1 therapy in SCLC by Yanan Cui, Tianyu Qiu, Jiale Wang, Xinyu Liu, Libo Luo, Jizhong Yin, Xinxin Zhi, Wanying Wang, Gaohua Feng, Chunyan Wu, Zhikai Zhao, Hua Zhang, Fei Li, Fengying Wu, Shengxiang Ren

“…This study aimed to elucidate the regulatory mechanisms underlying MHC-I expression and potential combination strategies. Methods Single-cell and bulk RNA sequencing data from SCLC patients were analyzed. …”
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SLNP-based CDK4- targeted nanotherapy against glioblastoma by Uzma Ghani, Fareeha Khalid Ghori, Muhammad Usman Qamar, Muhammad Usman Qamar, Hina Khan, Basit Azad, Sabahat Habib, Saira Justin, Ishaq N. Khan, Ishaq N. Khan, Tawaf Ali Shah, Gamal A. Shazly, Mohammed Bourhia, Fouzia Perveen, Aneela Javed

“…Innovative treatments targeting the pRB pathway with efficient delivery vehicles are required to treat glioblastoma.MethodsFor this purpose, a library of 691 plant extracts previously tested in vitro for anti-cancerous, anti inflammatory, and anti-proliferative characteristics was created after thorough literature investigations. …”
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Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy by Louis Boon, Matheus H W Crommentuijn, Sjoerd T T Schetters, Laura J W Kruijssen, Yvette van Kooyk, Ernesto Rodriguez, Jan Van den Bossche, Joke M M Den Haan

“…It is still unclear how these APCs develop and function before and during αPD1 ICB or how they are associated with tumor rejection.Methods Here, we used B16 mouse melanoma and MC38 colorectal carcinoma tumor models, which show differential responses to αPD1 ICB. …”
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Association of fall risk-increasing drugs with falls in generally healthy older adults: a 3-year prospective observational study of the DO-HEALTH trial by Caroline de Godoi Rezende Costa Molino, Catherine K. Forster, Maud Wieczorek, E. John Orav, Reto W. Kressig, Bruno Vellas, Andreas Egli, Gregor Freystaetter, Heike A. Bischoff-Ferrari, the DO-HEALTH Research Group

“…The aim of this study was to investigate the association between FRID use at baseline and the prospective incidence rates of total, injurious and recurrent falls in community-dwelling older adults. Methods This is a 3-year observational analysis of DO-HEALTH, a randomized controlled trial, among community-dwelling adults aged ≥ 70 years without major diseases at baseline. …”
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Predictive Validity of Hospital-Associated Complications of Older People Identified Using Diagnosis Procedure Combination Data From an Acute Care Hospital in Japan: Observational S... by Seigo Mitsutake, Tatsuro Ishizaki, Shohei Yano, Takumi Hirata, Kae Ito, Ko Furuta, Yoshitomo Shimazaki, Hideki Ito, Alison Mudge, Kenji Toba

“…Generalized linear regression models were used to examine the associations between HAC-OP-DPC and LOS, and logistic regression models were used to examine the associations between HAC-OP-DPC and discharge to other hospitals and long-term care facilities (LTCFs). …”
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A cross-sectional and longitudinal evaluation of serum creatinine as a biomarker in spinal muscular atrophy by Xin Zhao, Zhenxiang Gong, Han Luo, Zehui Li, Rong Gao, Kangqin Yang, Wenhua Deng, Sirui Peng, Li Ba, Yang Liu, Min Zhang

“…The association between Crn and disease severity was investigated through partial rank correlation analysis and linear mixed models while accounting for age, gender, and BMI. …”
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Association of cardiovascular health with reproductive lifespan and pregnancy loss: insights from NHANES 2005–2018 by Yang Yan, Jiajia Chen, Jinlong Qin, Min Yu, Meirong Du, Meirong Du

“…We conducted multivariable linear regression models and zero-inflated negative binomial regression models to investigate the prospective association of CVH with reproductive lifespan and pregnancy loss while accounting for various potential confounders. …”
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Removing seasonal confectionery from prominent store locations and purchasing behaviour within a major UK supermarket: Evaluation of a nonrandomised controlled intervention study. by Carmen Piernas, Georgina Harmer, Susan A Jebb

“…Here, we evaluated a grocery store intervention to remove seasonal confectionery from prominent locations within a major UK supermarket.<h4>Methods and findings</h4>A nonrandomised controlled intervention study with interrupted time series (ITS) analysis was used. …”
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Diagnostic Efficacy of ¹²³Iodo-Metaiodobenzylguanidine SPECT/CT in Cardiac vs. Neurological Diseases: A Comparative Study of Arrhythmogenic Right Ventricular Cardiomyopa... by Johannes M. Hagen, Maximilian Scheifele, Mathias J. Zacherl, Sabrina Katzdobler, Alexander Bernhardt, Matthias Brendel, Johannes Levin, Günter U. Höglinger, Sebastian Clauß, Stefan Kääb, Andrei Todica, Guido Boening, Maximilian Fischer

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Antenatal group-based psychoeducation to improve postpartum depression literacy in primary health care institutions in Ethiopia: a cluster randomized controlled trial by Marta Tessema, Muluemebet Abera, Zewdie Birhanu

“…General linear models and mixed-effect models assessed intervention effects and outcome variable predictors, respectively.ResultsThe overall response rate was 92.9%. …”
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Comparison of AI and resident doctors in diagnosing and managing acute respiratory cases: a retrospective study by Abdurrahmaan Manga, Saher Sultan, Ammarah Yasmeen, Fasihul Khan

“…This study aimed to evaluate how the diagnostic and management decisions made by resident doctors and ChatGPT compared to a consultant-defined gold standard within a tertiary hospital setting. Methods: A retrospective analysis was conducted on 45 patients admitted to the respiratory admissions unit. …”
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Metal mixtures exposure with risk of elevated serum neurofilament light chain concentrations in U.S. general adults, NHANES 2013–2014 by Yan Wang, Keyi Zhang, Hao Li, Si Liu, Linyao Ying, Lu Xiang, Na Liang, Liangkai Chen, Lin Xiao, Gang Luo

“…Cd (69.6 %) and Pb (8.9 %) were the primary drivers of the association between metal mixtures exposure and sNfL concentrations. Analysis of WQS and BKMR models showed a positive association between metal mixtures exposure and sNfL concentrations, especially in older, and male participants. …”
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Impact of prenatal triclosan exposure on ADHD-like symptoms in school-aged children by Jingjing LI, Xiaomeng CHENG, Yan ZHANG, Luanluan LI, Xiaodan YU, Ying TIAN, Yu GAO

“…Nevertheless, relevant research in China remains limited.ObjectiveTo investigate the impact of early pregnancy TCS exposure on ADHD-like symptoms in 7-year-old children.MethodsThis study was based on the Shanghai Birth Cohort (SBC) and included 662 mother-child pairs. …”
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